Tomas Olsson

Tomas Olsson

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Tomas Olsson

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Age at Menarche and Risk of Multiple Sclerosis: Current Progress From Epidemiological Investigations.

Front Immunol 2018 13;9:2600. Epub 2018 Nov 13.

Cardiovascular group, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fimmu.2018.02600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243025PMC
October 2019

The influence of human leukocyte antigen-DRB1*15:01 and its interaction with smoking in MS development is dependent on DQA1*01:01 status.

Mult Scler 2019 Oct 1:1352458519877685. Epub 2019 Oct 1.

Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458519877685DOI Listing
October 2019

Delayed Clinical Manifestation of Parkinson's Disease Among Physically Active: Do Participants in a Long-Distance Ski Race Have a Motor Reserve?

J Parkinsons Dis 2019 Oct 9. Epub 2019 Oct 9.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, Lund, Sweden.

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http://dx.doi.org/10.3233/JPD-191762DOI Listing
October 2019

Environmental and genetic risk factors for MS: an integrated review.

Ann Clin Transl Neurol 2019 Sep 7;6(9):1905-1922. Epub 2019 Aug 7.

Clinical & Translational Neuroscience, Kaiser Permanente/Southern California Permanente Medical Group, Los Angeles, California.

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http://dx.doi.org/10.1002/acn3.50862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764632PMC
September 2019

Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis.

Mult Scler Relat Disord 2019 Sep 26;36:101414. Epub 2019 Sep 26.

Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, Box 8056, S-104 20 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.msard.2019.101414DOI Listing
September 2019

Myelin oligodendrocyte glycoprotein revisited-sensitive detection of MOG-specific T-cells in multiple sclerosis.

J Autoimmun 2019 Aug 1;102:38-49. Epub 2019 May 1.

Therapeutic Immune Design, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine L8:02, 171 76, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411193003
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http://dx.doi.org/10.1016/j.jaut.2019.04.013DOI Listing
August 2019

IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.

J Immunol 2019 Aug 10;203(4):888-898. Epub 2019 Jul 10.

Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.4049/jimmunol.1900400DOI Listing
August 2019

Comparative effectiveness of dimethyl fumarate as the initial and secondary treatment for MS.

Mult Scler 2019 Aug 8:1352458519866600. Epub 2019 Aug 8.

Department of Clinical Neuroscience, Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.

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http://journals.sagepub.com/doi/10.1177/1352458519866600
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http://dx.doi.org/10.1177/1352458519866600DOI Listing
August 2019

Factors associated with and long-term outcome of benign multiple sclerosis: a nationwide cohort study.

J Neurol Neurosurg Psychiatry 2019 Jul 1;90(7):761-767. Epub 2019 Mar 1.

The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Centre for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1136/jnnp-2018-319913DOI Listing
July 2019

Sensitive detection of antigen-specific T-cells using bead-bound antigen for in vitro re-stimulation.

MethodsX 2019 8;6:1635-1641. Epub 2019 Jul 8.

Therapeutic Immune Design, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine L8:02, 171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.mex.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651840PMC
July 2019

Long-term Cognitive Outcomes in Patients With Pediatric-Onset vs Adult-Onset Multiple Sclerosis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2019.1546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580443PMC
June 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Lifestyle and Environmental Factors in Multiple Sclerosis.

Cold Spring Harb Perspect Med 2019 Apr 1;9(4). Epub 2019 Apr 1.

Neuroimmunology Unit, Center for Molecular Medicine, Karolinska Hospital, Solna, 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1101/cshperspect.a028944DOI Listing
April 2019

Predicting diagnosis and cognition with F-AV-1451 tau PET and structural MRI in Alzheimer's disease.

Alzheimers Dement 2019 Apr 25;15(4):570-580. Epub 2019 Jan 25.

Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.12.001DOI Listing
April 2019

The association between multiple sclerosis and pain medications.

Pain 2019 Feb;160(2):424-432

Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://Insights.ovid.com/crossref?an=00006396-900000000-9882
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http://dx.doi.org/10.1097/j.pain.0000000000001429DOI Listing
February 2019

Cognitive function is a major determinant of income among multiple sclerosis patients in Sweden acting independently from physical disability.

Mult Scler 2019 01 16;25(1):104-112. Epub 2017 Nov 16.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital, Stockholm, Sweden/Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517740212DOI Listing
January 2019

Cognitive function predicts work disability among multiple sclerosis patients.

Mult Scler J Exp Transl Clin 2019 Jan-Mar;5(1):2055217318822134. Epub 2019 Jan 14.

Department of Clinical Neuroscience, Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1177/2055217318822134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350142PMC
January 2019

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 20;5(5):e491. Epub 2018 Aug 20.

Partners Multiple Sclerosis Center (K.R., B.C.H., A.P., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), Brigham and Women's Hospital; Department of Neurology, Harvard Medical School (B.C.H., C.D.-C., B.I.G., T.C., H.L.W, R.G.), Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital; Biostatistics Center (B.C.H.); Massachusetts General Hospital, Boston, MA; Department of Clinical Neuroscience, Neuroimmunology Unit (M.J., F.P., T.O., M.K.), Karolinska Institute, Stockholm, Sweden; Department of Neurology (S.H., J.O.), School of Medicine, University of California, San Francisco; and Nehme and Therese Tohme Multiple Sclerosis Center (S.J.K.), Faculty of Medicine, American University of Beirut Medical Center, Lebanon.

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http://dx.doi.org/10.1212/NXI.0000000000000491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117192PMC
September 2018

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.

Mult Scler 2018 07 19;24(8):1046-1054. Epub 2017 Jun 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517715132DOI Listing
July 2018

Organic solvents and MS susceptibility: Interaction with MS risk HLA genes.

Neurology 2018 07 3;91(5):e455-e462. Epub 2018 Jul 3.

From the Department of Clinical Neuroscience and Institute of Environmental Medicine (A.K.H., L.A.), and Department of Clinical Neuroscience and Center for Molecular Medicine (I.K., T.O.), Karolinska Institutet, Stockholm; Mathematical Statistics (O.H.), Stockholm University, Sweden; UCL/Farr Institute of Health Informatics Research (M.K.), London, UK; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000005906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093765PMC
July 2018

Prion-like seeding and nucleation of intracellular amyloid-β.

Neurobiol Dis 2018 05 4;113:1-10. Epub 2018 Feb 4.

Experimental Dementia Research Unit, Dept. of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.01.015DOI Listing
May 2018

Association of Pre-Disease Body Mass Index With Multiple Sclerosis Prognosis.

Front Neurol 2018 11;9:232. Epub 2018 May 11.

Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fneur.2018.00232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958198PMC
May 2018

Immune profile in relation to sex steroid cyclicity in healthy women and women with multiple sclerosis.

J Reprod Immunol 2018 04 2;126:53-59. Epub 2018 Mar 2.

Clinical Immunology and Transfusion Medicine, Department of Clinical and Experimental Medicine, Linköping University, SE-58185, Linköping, Sweden.

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http://dx.doi.org/10.1016/j.jri.2018.02.006DOI Listing
April 2018

Multiple sclerosis treatment effects on plasma cytokine receptor levels.

Clin Immunol 2018 02 21;187:15-25. Epub 2017 Sep 21.

Department of Clinical Neuroscience and Centrum for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.08.023DOI Listing
February 2018

The national incidence of PML in Sweden, 1988-2013.

Neurology 2018 02 10;90(6):e498-e506. Epub 2018 Jan 10.

From the Department of Clinical Neuroscience, Division of Neurology (E.I., R.H., T.O., L.B.), Neuroimmunology Unit, Center for Molecular Medicine, Department of Clinical Neuroscience (T.O., L.B.), and Center for Pharmacoepidemiology (S. Burkill, S. Bahmanyar, C.B.) and Clinical Epidemiology Unit (M.F., S.M.), Department of Medicine, Solna, Karolinska Institutet, Stockholm; Clinical Epidemiology and Biostatistics (S.M.), School of Medical Sciences, Örebro University, Sweden; and Department of Epidemiology and Public Health (S.M.), University College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818018PMC
February 2018

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

Mult Scler 2018 02 20;24(2):96-120. Epub 2018 Jan 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458517751049DOI Listing
February 2018

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein.

Neurology 2017 Nov 27;89(22):2230-2237. Epub 2017 Oct 27.

From the Department of Clinical Neuroscience (L.N., M.A., C.M., J.L.) and Department of Psychiatry and Neurochemistry (H.Z., K.B.), Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, London, UK; Department of Pharmacology and Clinical Neuroscience (P.S.), Umeå University; University Department of Clinical Neuroscience (M.K., T.O., F.P.), Neuroimmunology Unit, and Department of Clinical Sciences (A.S.), Danderyd Hospital, Karolinska Institutet, Stockholm; and Department of Neurology (M.G.), Faculty of Medicine and Health, Örebro University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705244PMC
November 2017

Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship.

Sci Rep 2017 11 6;7(1):14589. Epub 2017 Nov 6.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-017-14788-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674007PMC
November 2017

Concussion in adolescence and risk of multiple sclerosis.

Ann Neurol 2017 Oct 25;82(4):554-561. Epub 2017 Sep 25.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.25036DOI Listing
October 2017

Reply to "concussion may not cause multiple sclerosis".

Ann Neurol 2017 10;82(4):652-653

Department of Clinical Neuroscience, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.25062DOI Listing
October 2017

Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms.

Biol Sex Differ 2017 10 25;8(1):34. Epub 2017 Oct 25.

Unit of Experimental Rheumatology, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13293-017-0153-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657123PMC
October 2017

Dynamics and heterogeneity of brain damage in multiple sclerosis.

PLoS Comput Biol 2017 Oct 26;13(10):e1005757. Epub 2017 Oct 26.

Center for Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1371/journal.pcbi.1005757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657613PMC
October 2017

Individualised Lu-DOTATATE treatment of neuroendocrine tumours based on kidney dosimetry.

Eur J Nucl Med Mol Imaging 2017 Aug 22;44(9):1480-1489. Epub 2017 Mar 22.

Department of Oncology and Pathology, Clinical Sciences, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1007/s00259-017-3678-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506097PMC
August 2017

Mortality trends for multiple sclerosis patients in Sweden from 1968 to 2012.

Neurology 2017 Aug 7;89(6):555-562. Epub 2017 Jul 7.

From the Clinical Epidemiology Unit (S.B., S.M., M.H., S.B) and Centre for Pharmacoepidemiology (S.B., S.B.), Department of Medicine, Solna, Karolinska Institutet, Stockholm; Clinical Epidemiology and Biostatistics (S.M.), School of Medical Sciences, Örebro University, Sweden; Department of Epidemiology and Public Health (S.M.), University College London, UK; Division of Neurology (J.H.) and Neuroimmunology Unit (T.O.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; and Biostatistics and Epidemiology Unit (M.H., S.B.), Health Faculty, Golestan University of Medical Sciences, Golestan, Iran.

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http://dx.doi.org/10.1212/WNL.0000000000004216DOI Listing
August 2017

IL-22 binding protein regulates murine skin inflammation.

Exp Dermatol 2017 05 23;26(5):444-446. Epub 2017 Mar 23.

Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/exd.13225DOI Listing
May 2017

Modeling Strategies for Quantification of In Vivo F-AV-1451 Binding in Patients with Tau Pathology.

J Nucl Med 2017 04 20;58(4):623-631. Epub 2016 Oct 20.

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden

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http://dx.doi.org/10.2967/jnumed.116.174508DOI Listing
April 2017

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis.

J Neurochem 2017 04 29;141(2):296-304. Epub 2016 Nov 29.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.13881DOI Listing
April 2017

Effects of C2ta genetic polymorphisms on MHC class II expression and autoimmune diseases.

Immunology 2017 04 22;150(4):408-417. Epub 2016 Dec 22.

Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/imm.12692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343355PMC
April 2017

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Neurology 2017 Apr 29;88(17):1623-1629. Epub 2017 Mar 29.

From the Division of Epidemiology, School of Public Health (M.A.G., X.S., E.X., H.Q., D.Q., C.M., L.F.B.), and Computational Biology Graduate Group (B.R.), University of California, Berkeley; Department of Clinical Neuroscience and Center for Molecular Medicine (P.S.), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden; Department of Neurology (J.S.G., E.W.) and Regional Pediatric MS Center, Neurology (J.H., S.C.), University of California, San Francisco; Partners Pediatric Multiple Sclerosis Center (T.C.), Massachusetts General Hospital for Children, Boston; Division of Neurology (A.W.), Children's Hospital of Philadelphia, PA; Blue Bird Circle Multiple Sclerosis Center (T.L.), Baylor College of Medicine, Houston, TX; Children's Hospital Colorado (T.S.), University of Colorado, Denver; Lourie Center for Pediatric Multiple Sclerosis (A.B., L.K.), Stony Brook Children's Hospital, NY; Department of Neurology (B.G.), University of Texas Southwestern, Dallas; Pediatric Multiple Sclerosis Center (B.W.-G.), Jacobs Neurological Institute, SUNY Buffalo, NY; Pediatric MS Center at Loma Linda University Children's Hospital (G.A.), CA; Mayo Clinic's Pediatric Multiple Sclerosis Center (J.M.T., M.R.), Rochester, MN; University of Alabama Center for Pediatric-onset Demyelinating Disease (J.N., Y.H.), Children's Hospital of Alabama, Birmingham; Department of Pediatric Neurology (J.R.), Northwestern Feinberg School of Medicine, Chicago, IL; Primary Children's Hospital (M.C.), University of Utah, Salt Lake City; Boston Children's Hospital (M.G., L.B.), MA; Pediatric-onset Demyelinating Diseases and Autoimmune Encephalitis Center (S.M.), St. Louis Children's Hospital, Washington University School of Medicine, MO; Children's National Medical Center (I.K.), Washington, DC; Departments of Neurology (J.R.) and Pediatrics (S.R., T.C.C.), University of Utah School of Medicine, Salt Lake City; Kaiser Permanente Division of Research (L.S., C.S., L.F.B.), Oakland, CA; Institute of Environmental Medicine (J.H., M.B., A.H., T.O., I.K., L.A.), Karolinska Institutet; Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Stockholm, Sweden; and Research Program on Genes, Environment and Health (C.S.), Kaiser Permanente, Oakland, CA.

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http://dx.doi.org/10.1212/WNL.0000000000003849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405763PMC
April 2017

Overexpression of the Cytokine BAFF and Autoimmunity Risk.

N Engl J Med 2017 04;376(17):1615-1626

From Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato (M.S., V.O., M.L.I., M. Pitzalis, M. Pala, C.S., V.F., M.F., M. Deiana, I.A., E.P., A. Mulas, M.G.P., M. Lobina, S.L., Mara Marongiu, V.S., Michele Marongiu, G.S., F.B., A. Maschio, F.D., M. Dei, F.V., S.O., A.A., M.B.W., A. Meloni, S. Sanna, E.F., M.Z., F.C.), Center for Advanced Studies, Research, and Development in Sardinia, Parco Scientifico e Tecnologico della Sardegna (I.Z., M.F., R.C., G. Cuccuru), Struttura Complessa Disciplina di Ematologia e Centro Trapianto Cellule Staminali Emopoietiche Wilma Deplano, Ospedale Oncologico di Riferimento Regionale Armando Businco (M. Pani), Dipartimento di Sanità Pubblica, Medicina Clinica e Molecolare, Università di Cagliari (E.C., J.F., G. Coghe, L.L., G. Fenu), Azienda Ospedaliera Brotzu, S.C. Neurologia (P.F., M. Melis), Division of Rheumatology, University and University Hospital of Cagliari (M. Piga, A. Mathieu), Department of Medical Sciences M. Aresu, University of Cagliari (D.F., S.D.G., M.G.M.), Azienda Ospedaliera Brotzu, U.S. Gastroenterologia Pediatrica Ospedale Pediatrico Microcitemico A. Cao (M.C.), and Nephrology, Dialysis, and Transplantation Unit, Giuseppe Brotzu Hospital (A.P.), Cagliari, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari (M.F., F.P., F.C.), Unit of Neurology, Department of Clinical and Experimental Medicine, University of Sassari (G. Farina, G.R.), and Servizio Trasfusionale (M.A.S.) and Clinica Medica (A.D.), Azienda Ospedaliero Universitaria di Sassari, Sassari, Neurology B, Department of Neurological, Biomedical, and Movement Sciences, University of Verona, Verona (G. Farina), Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases, University of Eastern Piedmont, Novara (N.B., S.D.), SC Neurologia, Dipartimento di Scienze Mediche, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo (M. Leone), Don C. Gnocchi Foundation IRCCS (F.R.G.), and Referral Center for Systemic Autoimmune Diseases Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico and University of Milan (M. Marchini), Milan, and Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche e Ospedali Riuniti, Ancona (M.G.D.) - all in Italy; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore (M.L.I., M.G., D.S.); the Department of Clinical Neurosciences (M.B., S. Sawcer) and JDRF-Wellcome Trust Diabetes and Inflammation Laboratory, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research (J.A.T.), University of Cambridge, Cambridge, United Kingdom; Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Solna (I.K., I.L.B., T.O., J.H.), Institute of Environmental Medicine (L.A.) and Institute of Environmental Medicine, Unit of Immunology and Chronic Disease (M.E.A.R.), Karolinska Institute, and Center for Occupational and Environmental Medicine, Stockholm County Council (L.A.), Stockholm; Department of Functional Biology, University of Oviedo, Oviedo (A.S.), Rheumatology Department, Hospital Universitario 12 de Octubre, Madrid (P.E.C.), Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Seville (M.J.C.-P.), Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela (A.G.), and Centro de Genómica e Investigación Oncológica, Pfizer-Universidad de Granada-Junta de Andalucía, Granada (M.E.A.R.) - all in Spain; Department of Human Genetics, University of Chicago, Chicago (J.H.M., J.N.); Centro Hospitalar do Porto-Hospital Santo Antonio and Unit for Multidisciplinary Research in Biomedicine-Unidade Multidisciplinar de Investigação Biomédica, Porto, Portugal (B.M.S.); Departments of Pathology and Genetics, Stanford University, Stanford, CA (S.B.M.); and Center for Statistical Genetics, University of Michigan, Ann Arbor (G.R.A.).

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http://dx.doi.org/10.1056/NEJMoa1610528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605835PMC
April 2017

Effect of high-dose vitamin D supplementation on antibody responses against Epstein-Barr virus in relapsing-remitting multiple sclerosis.

Mult Scler 2017 Mar 11;23(3):395-402. Epub 2016 Jul 11.

Department of Neurology, Akershus University Hospital, Lørenskog, Norway/Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1177/1352458516654310DOI Listing
March 2017

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis.

Mult Scler 2017 01 11;23(1):62-71. Epub 2016 Jul 11.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458516639384DOI Listing
January 2017

Increased basal ganglia binding of F-AV-1451 in patients with progressive supranuclear palsy.

Mov Disord 2017 01 6;32(1):108-114. Epub 2016 Oct 6.

Lund University, Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.

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http://dx.doi.org/10.1002/mds.26813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204612PMC
January 2017

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.

Nat Rev Neurol 2017 Jan 9;13(1):25-36. Epub 2016 Dec 9.

Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrneurol.2016.187DOI Listing
January 2017

Immunohistochemical Analysis in the Rat Central Nervous System and Peripheral Lymph Node Tissue Sections.

J Vis Exp 2016 11 14(117). Epub 2016 Nov 14.

Department of Clinical Neuroscience, Neuroimmunology Unit, Center for Molecular Medicine, Karolinska Institutet.

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http://dx.doi.org/10.3791/50425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226232PMC
November 2016

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk.

Neurol Genet 2016 Oct 13;2(5):e97. Epub 2016 Sep 13.

Computational Biology Graduate Group (B.R.), Division of Epidemiology (M.G., A.M., X.S., H.Q., L.F.B.), School of Public Health, University of California, Berkeley; Institute of Environmental Medicine (M.B., A.K.H., L.A.), Karolinska Institutet, Stockholm, Sweden; Kaiser Permanente Division of Research (L.S., C.S., L.F.B.), Research Program on Genes, Environment, and Health (C.S.), Kaiser Permanente, Oakland, CA; Department of Clinical Neuroscience and Center for Molecular Medicine (J.L., A.G., T.O., J.H., I.K.), Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden; Department of Epidemiology and Biostatistics (M.M.G.), University of California, San Francisco; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/NXG.0000000000000097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022843PMC
October 2016

Autoantibody targets in vaccine-associated narcolepsy.

Autoimmunity 2016 09 20;49(6):421-433. Epub 2016 May 20.

a Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH-Royal Institute of Technology , Stockholm , Sweden.

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http://dx.doi.org/10.1080/08916934.2016.1183655DOI Listing
September 2016

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis.

Clin Immunol 2016 08 23;169:114-120. Epub 2016 Jun 23.

Respiratory Medicine Unit, Department of Medicine and Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clim.2016.06.006DOI Listing
August 2016

Absence of systemic oxidative stress and increased CSF prostaglandin F2α in progressive MS.

Neurol Neuroimmunol Neuroinflamm 2016 Aug 30;3(4):e256. Epub 2016 Jun 30.

Vascular Biology Division (M.A.L., G.J.M., R.S.), Victor Chang Cardiac Research Institute, Sydney; School of Medical Sciences (G.J.M., R.S.), University of New South Wales, Sydney, Australia; Neuroimmunology Unit (M.K., F.P., T.O.), Department of Clinical Neurosciences, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; and Department of Neurology (R.R., J.R.C., F.T.S.), Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1212/NXI.0000000000000256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929888PMC
August 2016

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.

Proc Natl Acad Sci U S A 2016 07 20;113(28):7864-9. Epub 2016 Jun 20.

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University, 81377 Munich, Germany

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http://www.pnas.org/content/early/2016/06/15/1522730113.full
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http://www.pnas.org/lookup/doi/10.1073/pnas.1522730113
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http://dx.doi.org/10.1073/pnas.1522730113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948369PMC
July 2016

Environmental factors and their interactions with risk genotypes in MS susceptibility.

Curr Opin Neurol 2016 06;29(3):293-8

aInstitute of Environmental Medicine, Karolinska Institutet bInstitute of Environmental Medicine, Karolinska Institutet, and Centre for Occupational and Environmental Health, Stockholm County Council, Stockholm cDepartment of clinical neuroscience and Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden.

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http://dx.doi.org/10.1097/WCO.0000000000000329DOI Listing
June 2016

Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Jun 20;3(3):e219. Epub 2016 Apr 20.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXI.0000000000000219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841644PMC
June 2016

Multiple sclerosis and risk of young-adult-onset Hodgkin lymphoma.

Neurol Neuroimmunol Neuroinflamm 2016 Jun 14;3(3):e227. Epub 2016 Apr 14.

Clinical Epidemiology and Biostatistics (S.M.), School of Medical Sciences, Örebro University, Sweden; Department of Epidemiology and Public Health (S.M.), University College London, UK; Clinical Epidemiology Unit (S.M., M.H.H., S. Burkill, S. Bahmanyar) and Centre for Pharmacoepidemiology (S. Bahmanyar), Department of Medicine, Solna, Karolinska Institutet; Department of Neurology (J.H., T.O.), Karolinska University Hospital Huddinge, Stockholm; Neuroimmunology Unit (J.H.), Department of Clinical Neuroscience and Centre for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden; and Faculty of Medicine (S. Bahmanyar), Golestan University of Medical Sciences, Gorgan, Iran.

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http://nn.neurology.org/lookup/doi/10.1212/NXI.0000000000000
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http://dx.doi.org/10.1212/NXI.0000000000000227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841639PMC
June 2016

Cell Fusion along the Anterior-Posterior Neuroaxis in Mice with Experimental Autoimmune Encephalomyelitis.

PLoS One 2015 24;10(7):e0133903. Epub 2015 Jul 24.

Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Public Dental Service at Gällö, Jämtland Härjedalen County Council, Gällö, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133903PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514791PMC
May 2016

Rat bone marrow-derived dendritic cells generated with GM-CSF/IL-4 or FLT3L exhibit distinct phenotypical and functional characteristics.

J Leukoc Biol 2016 Mar 29;99(3):437-46. Epub 2015 Oct 29.

Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital at Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1189/jlb.1AB0914-433RRDOI Listing
March 2016

High-intensity resistance training in multiple sclerosis - An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition.

J Neurol Sci 2016 Mar 3;362:251-7. Epub 2016 Feb 3.

Department of Clinical Neurosciences, K8, Karolinska Institutet, CMM L8:04, S-171 76 Stockholm, Sweden; Department of Neurology, R3:04, Karolinska University Hospital, S-171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.01.063DOI Listing
March 2016

Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination.

Neurol Neuroimmunol Neuroinflamm 2016 Feb 7;3(1):e191. Epub 2016 Jan 7.

Neuroimmunology Unit (F.A.N., M.K., S.A., T.O., F.P.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Institute of Infection, Immunity and Inflammation (C.E., C.L.), University of Glasgow, UK; Department of Pharmacology and Clinical Neuroscience (J.B., A.M.D., A.S.) and Neurosurgery (T.B.), Umeå University, Sweden; and Danish Multiple Sclerosis Center (J.R.C., F.S.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1212/NXI.0000000000000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708925PMC
February 2016

[New techniques can radically change health care].

Lakartidningen 2016 Feb 5;113. Epub 2016 Feb 5.

Karolinska - Stockholm, - .

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February 2016

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.

Brain Behav Immun 2016 Jan 17;51:47-55. Epub 2015 Jul 17.

Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbi.2015.07.016DOI Listing
January 2016

The Expression of BAFF Is Controlled by IRF Transcription Factors.

J Immunol 2016 Jan 20;196(1):91-6. Epub 2015 Nov 20.

Unit of Experimental Rheumatology, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden;

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http://dx.doi.org/10.4049/jimmunol.1501061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683359PMC
January 2016

Pooled safety and tolerability data from four placebo-controlled teriflunomide studies and extensions.

Mult Scler Relat Disord 2016 Jan 10;5:97-104. Epub 2015 Nov 10.

Comprehensive Multiple Sclerosis Center, Thomas Jefferson University Hospital, 900 Walnut Street, Ste. 200, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2015.11.006DOI Listing
January 2016

PML: The Dark Side of Immunotherapy in Multiple Sclerosis.

Trends Pharmacol Sci 2015 Dec 21;36(12):799-801. Epub 2015 Oct 21.

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Dusseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.09.006DOI Listing
December 2015

Translational utility of experimental autoimmune encephalomyelitis: recent developments.

J Inflamm Res 2015 13;8:211-25. Epub 2015 Nov 13.

Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2147/JIR.S76707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654535PMC
December 2015

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.

J Neuroinflammation 2015 Dec 18;12:235. Epub 2015 Dec 18.

Institute of Clinical Neuroimmunology, Biomedical Center (BMC) and University Hospital, Campus Martinsried-Grosshadern, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1186/s12974-015-0450-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683913PMC
December 2015

Effect of Smoking Cessation on Multiple Sclerosis Prognosis.

JAMA Neurol 2015 Oct;72(10):1117-23

Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2015.1788DOI Listing
October 2015