Dr. Tomás Herraiz, PhD - Spanish National Research Council (CSIC)

Dr. Tomás Herraiz

PhD

Spanish National Research Council (CSIC)

Madrid | Spain

Additional Specialties: bioactive molecules; molecular toxicology; alkaloids; beta-carbolines; antioxidants and free radicals; food science and nutrition

ORCID logohttps://orcid.org/0000-0003-3682-9227

Dr. Tomás Herraiz, PhD - Spanish National Research Council (CSIC)

Dr. Tomás Herraiz

PhD

Education

Universidad Complutense de Madrid
PhD Chemistry
Biochemistry

Experience

Instituto de Ciencia y tecnologia de Alimento y Nutricion (CSIC)
Scientific Researcher

Publications

100Publications

395Reads

5Profile Views

133PubMed Central Citations

Identification, occurrence and activity of quinazoline alkaloids in Peganum harmala.

Food Chem Toxicol 2017 May 7;103:261-269. Epub 2017 Mar 7.

Centro de Espectroscopía de RMN (CERMN), CAI Químicas - Facultad de Farmacia, Universidad de Alcalá (UAH), 28805 Alcalá de Henares, Madrid, Spain.

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http://dx.doi.org/10.1016/j.fct.2017.03.010DOI Listing
May 2017
20 Reads
2.900 Impact Factor

N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids.

Authors:
Tomás Herraiz

Food Chem Toxicol 2016 Nov 11;97:23-39. Epub 2016 Aug 11.

Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Spanish National Research Council (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2016.08.009DOI Listing
November 2016
6 Reads
2 Citations
2.900 Impact Factor

Hydroxyl radical reactions and the radical scavenging activity of β-carboline alkaloids.

Food Chem 2015 Apr 28;172:640-9. Epub 2014 Sep 28.

Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Spanish National Research Council (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.foodchem.2014.09.091DOI Listing
April 2015
8 Reads
3 Citations
3.391 Impact Factor

5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO).

Drug Test Anal 2014 Jul-Aug;6(7-8):607-13. Epub 2013 Sep 20.

Spanish National Research Council (CSIC), Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Juan de la Cierva 3, 28006, Madrid, Spain.

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http://dx.doi.org/10.1002/dta.1530DOI Listing
March 2015
10 Reads
1 Citation
2.820 Impact Factor

Naturally-occurring tetrahydro-β-carboline alkaloids derived from tryptophan are oxidized to bioactive β-carboline alkaloids by heme peroxidases.

Biochem Biophys Res Commun 2014 Aug 15;451(1):42-7. Epub 2014 Jul 15.

Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN-CSIC), Spanish National Research Council (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2014.07.047DOI Listing
August 2014
8 Reads
4 Citations
2.300 Impact Factor

Metabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes.

Biomed Res Int 2013 28;2013:248608. Epub 2013 Jul 28.

Instituto de Ciencia y Tecnología de Alimentos y Nutrición, Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1155/2013/248608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745933PMC
March 2014
7 Reads
2 Citations

Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents.

Authors:
Tomás Herraiz

J Enzyme Inhib Med Chem 2012 Dec 12;27(6):810-7. Epub 2011 Oct 12.

Spanish National Research Council, (CSIC), Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Madrid, Spain.

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http://dx.doi.org/10.3109/14756366.2011.616946DOI Listing
December 2012
7 Reads
1 Citation
2.383 Impact Factor

Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.

Food Chem Toxicol 2011 Aug 29;49(8):1773-81. Epub 2011 Apr 29.

Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), Spanish Council for Scientific Research (CSIC), Juan de la Cierva, Madrid, Spain.

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http://dx.doi.org/10.1016/j.fct.2011.04.026DOI Listing
August 2011
2 Reads
5 Citations
2.900 Impact Factor

Characterization of a nitroreductase with selective nitroreduction properties in the food and intestinal lactic acid bacterium Lactobacillus plantarum WCFS1.

J Agric Food Chem 2009 Nov;57(21):10457-65

Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jf9024135DOI Listing
November 2009
32 Reads
6 Citations
2.912 Impact Factor

Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).

Free Radic Res 2009 Oct 7;43(10):975-84. Epub 2009 Aug 7.

Instituto de Fermentaciones Industriales, Spanish Council for Scientific Research, Madrid, Spain.

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http://dx.doi.org/10.1080/10715760903159170DOI Listing
October 2009
5 Reads
1 Citation

Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.

J Chromatogr A 2008 Nov 16;1210(1):115-20. Epub 2008 Sep 16.

School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, P.O. Box 88, Manchester M60 1QD, UK.

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http://dx.doi.org/10.1016/j.chroma.2008.09.036DOI Listing
November 2008
12 Reads
1 Citation
4.170 Impact Factor

Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes.

Chem Res Toxicol 2008 Nov;21(11):2172-80

Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de Cierva, 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/tx8002565DOI Listing
November 2008
4 Reads
2 Citations
3.530 Impact Factor

Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO).

Authors:
Tomás Herraiz

J Agric Food Chem 2007 Oct 21;55(21):8534-40. Epub 2007 Sep 21.

Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jf0719151DOI Listing
October 2007
5 Reads
2 Citations
2.912 Impact Factor

N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic beta-carbolinium cations by heme peroxidases.

Biochem Biophys Res Commun 2007 Apr 26;356(1):118-23. Epub 2007 Feb 26.

Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2007.02.089DOI Listing
April 2007
7 Reads
4 Citations
2.300 Impact Factor

Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.

Toxicol Appl Pharmacol 2006 Nov 15;216(3):387-98. Epub 2006 Jun 15.

Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006, Madrid, Spain.

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http://dx.doi.org/10.1016/j.taap.2006.06.003DOI Listing
November 2006
16 Reads
6 Citations
3.705 Impact Factor

Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants.

J Chromatogr A 2006 Jul 28;1120(1-2):237-43. Epub 2005 Dec 28.

Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.chroma.2005.12.009DOI Listing
July 2006
5 Reads
5 Citations
4.170 Impact Factor

Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee.

Life Sci 2006 Jan 31;78(8):795-802. Epub 2005 Aug 31.

Spanish Council for Scientific Research. CSIC. Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.lfs.2005.05.074DOI Listing
January 2006
7 Reads
10 Citations
2.702 Impact Factor

Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors.

Biochem Biophys Res Commun 2005 Jan;326(2):378-86

Spanish Council for Scientific Research, CSIC, Instituto de Fermentaciones Industriales, Juan de la Cierva, 3, 28006, Madrid, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2004.11.033DOI Listing
January 2005
4 Reads
18 Citations
2.300 Impact Factor

Identification and occurrence of tryptamine- and tryptophan-derived tetrahydro-beta-carbolines in commercial sausages.

J Agric Food Chem 2004 May;52(9):2652-8

Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva, 3, 28006, Madrid, Spain.

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http://dx.doi.org/10.1021/jf0354601DOI Listing
May 2004
8 Reads
2.912 Impact Factor

Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay.

Free Radic Res 2004 Mar;38(3):323-31

Spanish Council for Scientific Research (CSIC), Instituto de Fermentaciones Industriales, Juan de la Cierve 3, 28006, Madrid, Spain.

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http://dx.doi.org/10.1080/10611860310001648167DOI Listing
March 2004
5 Reads
6 Citations

Tetrahydro-beta-carboline alkaloids occur in fruits and fruit juices. Activity as antioxidants and radical scavengers.

J Agric Food Chem 2003 Nov;51(24):7156-61

Spanish Council for Scientific Research, Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jf030324hDOI Listing
November 2003
5 Reads
8 Citations
2.912 Impact Factor

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.

Pharmacogenetics 2003 Jun;13(6):307-19

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1097/01.fpc.0000054094.48725.b7DOI Listing
June 2003
55 Reads
35 Citations

L-tryptophan reacts with naturally occurring and food-occurring phenolic aldehydes to give phenolic tetrahydro-beta-carboline alkaloids: activity as antioxidants and free radical scavengers.

J Agric Food Chem 2003 Apr;51(8):2168-73

Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jf0210066DOI Listing
April 2003
5 Reads
6 Citations
2.912 Impact Factor

Identification and occurrence of the novel alkaloid pentahydroxypentyl-tetrahydro-beta-carboline-3-carboxylic acid as a tryptophan glycoconjugate in fruit juices and jams.

J Agric Food Chem 2002 Jul;50(16):4690-5

Instituto de Fermentaciones Industriales, CSIC, Juan de la Cierva, 3, 28006, Madrid, Spain.

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http://dx.doi.org/10.1021/jf020090mDOI Listing
July 2002
6 Reads
2.912 Impact Factor

Top co-authors

Juan Galisteo
Juan Galisteo

Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN)

9
Vicente J Aran
Vicente J Aran

Instituto de Química Médica

4
Jeffrey R Idle
Jeffrey R Idle

National Cancer Institute

2
Frank J Gonzalez
Frank J Gonzalez

Laboratory of Metabolism

2
Simon D Brandt
Simon D Brandt

Liverpool John Moores University

2
Florence Miller
Florence Miller

Université Paris Descartes

1
John F Alder
John F Alder

Liverpool John Moores University

1

Followers

Roanna Vine
Roanna Vine

Mayo Clinic