Tom van der Poll

Tom van der Poll

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Tom van der Poll

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Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.

J Pathol 2020 Jan 25;250(1):95-106. Epub 2019 Nov 25.

Center of Experimental & Molecular Medicine, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.5354DOI Listing
January 2020

Current gaps in sepsis immunology: new opportunities for translational research.

Lancet Infect Dis 2019 Dec 17;19(12):e422-e436. Epub 2019 Oct 17.

Hospital Universitario Río Hortega, Valladolid, Spain; Group for Biomedical Research in Sepsis, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30567-5DOI Listing
December 2019

Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study.

Crit Care 2019 12 12;23(1):408. Epub 2019 Dec 12.

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1186/s13054-019-2687-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909511PMC
December 2019

Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia.

J Leukoc Biol 2019 Nov 7;106(5):1153-1160. Epub 2019 Jul 7.

Center for Experimental Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/JLB.4A0219-050RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852106PMC
November 2019

Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation.

J Thromb Haemost 2019 Nov 13;17(11):1989-1994. Epub 2019 Aug 13.

University College London Hospitals NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/jth.14578DOI Listing
November 2019

Tenascin C Plasma Levels in Critically Ill Patients with or Without Sepsis: A Multicentre Observational Study.

Shock 2019 Nov 19. Epub 2019 Nov 19.

Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001481DOI Listing
November 2019

Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis.

Eur J Clin Microbiol Infect Dis 2019 Oct 26;38(10):1829-1836. Epub 2019 Jun 26.

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s10096-019-03616-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778535PMC
October 2019

Effect of C1-inhibitor in adults with mild asthma: A randomized controlled trial.

Allergy 2019 Sep 19. Epub 2019 Sep 19.

Center of Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/all.14053DOI Listing
September 2019

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis.

Infect Immun 2019 08 23;87(8). Epub 2019 Jul 23.

Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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http://dx.doi.org/10.1128/IAI.00409-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652761PMC
August 2019

An Integrated Safety Summary of Omadacycline, a Novel Aminomethylcycline Antibiotic.

Clin Infect Dis 2019 Aug;69(Supplement_1):S40-S47

Paratek Pharmaceuticals, Inc., King of Prussia, Pennsylvania.

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http://dx.doi.org/10.1093/cid/ciz398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669290PMC
August 2019

Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia.

NPJ Syst Biol Appl 2019 1;5:26. Epub 2019 Aug 1.

1Division of Infectious Diseases, Department of Medicine, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1038/s41540-019-0105-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672010PMC
August 2019

C3a signaling is not involved in eosinophil migration during experimental allergic lung inflammation in mice.

Allergy 2019 Aug 13. Epub 2019 Aug 13.

Center of Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/all.14021DOI Listing
August 2019

Robustness of sepsis-3 criteria in critically ill patients.

J Intensive Care 2019 29;7:46. Epub 2019 Aug 29.

8Department of Medical Microbiology and Immunology, Rijnstate Hospital, Arnhem, the Netherlands.

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http://dx.doi.org/10.1186/s40560-019-0400-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716896PMC
August 2019

Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles.

Am J Respir Crit Care Med 2019 Jul;200(1):42-50

1 Intensive Care, Laboratory of Experimental Intensive Care and Anesthesiology.

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http://dx.doi.org/10.1164/rccm.201809-1808OCDOI Listing
July 2019

Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.

Thromb Haemost 2019 Jun 14;119(6):930-940. Epub 2019 Mar 14.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1055/s-0039-1681046DOI Listing
June 2019

Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?

Crit Care 2019 06 20;23(1):226. Epub 2019 Jun 20.

Center of Infection and Immunity Amsterdam (CINIMA), Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13054-019-2513-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585071PMC
June 2019

Recombinant Human Soluble Thrombomodulin in Patients With Sepsis-Associated Coagulopathy: Another Negative Sepsis Trial?

Authors:
Tom van der Poll

JAMA 2019 05;321(20):1978-1980

Center of Experimental and Molecular Medicine, Division of Infectious Diseases, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1001/jama.2019.5792DOI Listing
May 2019

Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis.

Platelets 2019 12;30(3):296-304. Epub 2018 Mar 12.

a Center for Experimental and Molecular Medicine, Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1445841DOI Listing
April 2019

Neutrophils mitigate the systemic host response during endotoxemia in mice.

Immunology 2019 03 18;156(3):277-281. Epub 2018 Dec 18.

Center of Experimental & Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://doi.wiley.com/10.1111/imm.13026
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http://dx.doi.org/10.1111/imm.13026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376271PMC
March 2019

Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis.

Intensive Care Med Exp 2019 Mar 12;7(1):14. Epub 2019 Mar 12.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, the Netherlands.

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https://icm-experimental.springeropen.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s40635-019-0228-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419653PMC
March 2019

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Cell Metab 2019 01 4;29(1):211-220.e5. Epub 2018 Oct 4.

Department of Internal Medicine (463) and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183056
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http://dx.doi.org/10.1016/j.cmet.2018.09.003DOI Listing
January 2019

Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model.

Am J Physiol Lung Cell Mol Physiol 2019 01 25;316(1):L187-L196. Epub 2018 Oct 25.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00162.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859420PMC
January 2019

What's new in immunostimulating strategies in the ICU.

Intensive Care Med 2019 01 19;45(1):110-112. Epub 2018 Nov 19.

Division of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-018-5462-8DOI Listing
January 2019

Correction to: What's new in immunostimulating strategies in the ICU.

Intensive Care Med 2019 01;45(1):137

Division of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-018-5482-4DOI Listing
January 2019

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia.

Mol Med 2019 01 15;25(1). Epub 2019 Jan 15.

Center for Experimental and Molecular Medicine (CEMM), Amsterdam UMC, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-132, 1105, AZ, Amsterdam, the Netherlands.

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https://molmed.biomedcentral.com/articles/10.1186/s10020-018
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http://dx.doi.org/10.1186/s10020-018-0069-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332549PMC
January 2019

Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

J Innate Immun 2019 17;11(2):168-180. Epub 2018 Dec 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000494147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738263PMC
December 2018

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study.

Crit Care 2018 12 18;22(1):348. Epub 2018 Dec 18.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands.

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http://dx.doi.org/10.1186/s13054-018-2261-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299562PMC
December 2018

Initiation of renal replacement therapy in patients with sepsis: more to it than meets the eye.

Ann Transl Med 2018 Dec;6(Suppl 2):S130

Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.21037/atm.2018.12.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330630PMC
December 2018

MRP8/14 does not contribute to dissemination or inflammation in a murine model of Lyme borreliosis.

Immunobiology 2018 11 17;223(11):694-698. Epub 2018 Jul 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.imbio.2018.07.017DOI Listing
November 2018

Inhibition of the extrinsic or intrinsic coagulation pathway during pneumonia-derived sepsis.

Am J Physiol Lung Cell Mol Physiol 2018 11 23;315(5):L799-L809. Epub 2018 Aug 23.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00014.2018DOI Listing
November 2018

Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis.

Arterioscler Thromb Vasc Biol 2018 08;38(8):1772-1784

From the Center for Experimental and Molecular Medicine (T.A.M.C., S.F.d.S., A.F.d.V., C.v.V., T.v.d.P.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311332DOI Listing
August 2018

Development and first evaluation of a novel multiplex real-time PCR on whole blood samples for rapid pathogen identification in critically ill patients with sepsis.

Eur J Clin Microbiol Infect Dis 2018 Jul 26;37(7):1333-1344. Epub 2018 Apr 26.

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Room F06.149, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s10096-018-3255-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015113PMC
July 2018

Expression and Function of Granzymes A and B in Peritonitis and Sepsis.

Mediators Inflamm 2017 12;2017:4137563. Epub 2017 Jun 12.

Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1155/2017/4137563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485334PMC
April 2018

Microglial Activation After Systemic Stimulation With Lipopolysaccharide and .

Front Cell Neurosci 2018 24;12:110. Epub 2018 Apr 24.

Department of Neurology, Center of Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fncel.2018.00110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932388PMC
April 2018

Limited role of kininogen in the host response during gram-negative pneumonia-derived sepsis.

Am J Physiol Lung Cell Mol Physiol 2018 03 9;314(3):L397-L405. Epub 2017 Nov 9.

Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00288.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842874PMC
March 2018

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria.

Blood 2018 02 29;131(8):864-876. Epub 2017 Nov 29.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2017-06-788067DOI Listing
February 2018

Are histones real pathogenic agents in sepsis?

Nat Rev Immunol 2018 02 27;18(2):148. Epub 2017 Dec 27.

Department of Internal Medicine, and the Center for Infectious Diseases, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, Netherlands.

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http://dx.doi.org/10.1038/nri.2017.157DOI Listing
February 2018

Myocardial Injury in Patients With Sepsis and Its Association With Long-Term Outcome.

Circ Cardiovasc Qual Outcomes 2018 02;11(2):e004040

From the Department of Epidemiology, Julius Center for Health Sciences and Primary Care (J.F.F., C.S., M.E.K.-B., M.J.M.B.), Department of Intensive Care Medicine (J.F.F., D.W.D., M.E.K.-B., I.W.S., D.S.Y.O., O.L.C.), Department of Medical Microbiology (D.S.Y.O., M.J.M.B.), and Department of Anesthesiology (W.A.v.K.), University Medical Center Utrecht, The Netherlands; Department of Mathematics, Utrecht University, The Netherlands (C.S.); Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands (J.H.); and Center for Experimental and Molecular Medicine (T.v.d.P.) and Division of Infectious Diseases (T.v.d.P.), Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.117.004040DOI Listing
February 2018

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice.

Eur J Immunol 2018 01 3;48(1):66-79. Epub 2017 Nov 3.

Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/eji.201646554DOI Listing
January 2018

Biomarkers in Sepsis.

Crit Care Clin 2018 Jan 12;34(1):139-152. Epub 2017 Oct 12.

Division of Laboratory Specialties, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands.

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http://dx.doi.org/10.1016/j.ccc.2017.08.010DOI Listing
January 2018

The host response in critically ill sepsis patients on statin therapy: a prospective observational study.

Ann Intensive Care 2018 Jan 18;8(1). Epub 2018 Jan 18.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13613-017-0349-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773465PMC
January 2018

Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi.

Infection 2017 Dec 7;45(6):893-896. Epub 2017 Aug 7.

Division of Infectious Diseases, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-105, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s15010-017-1057-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696439PMC
December 2017

Quantifying the Effects of Prior Acetyl-Salicylic Acid on Sepsis-Related Deaths: An Individual Patient Data Meta-Analysis Using Propensity Matching.

Crit Care Med 2017 Nov;45(11):1871-1879

1School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 2Victorian Infectious Diseases Service, The Doherty Institute, Melbourne, Victoria, Australia. 3Australian Institute of Tropical Medicine and Hygiene, James Cook University, Douglas, Queensland, Australia. 4Pharmaceutical Care Department, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia. 5Intensive Care Department, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. 6Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, Northern Ireland. 7Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, MN. 8Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. 9Division of Pulmonary and Critical Medicine, Chiayi Christian Hospital, Chiayi, Taiwan. 10Department of Nephrology, Taipei City Hospital Heping Fuyou Branch, Taipei, Taiwan, Republic of China. 11Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy. 12Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center, Bronx, NY. 13Department of Medicine, Albert Einstein College of Medicine, Bronx, NY. 14Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY. 15Department of Anesthesiology, Division of Critical Care Medicine, Mayo Clinic, Rochester, MN. 16Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. 17Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland. 18Louisiana State University Health Sciences Center, Department of Medicine, Section of Pulmonary and Critical Care Medicine, Baton Rouge, LA. 19Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland. 20Clinic for Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany. 21Department of Internal Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China. 22Department of Internal Medicine, Division of Critical Care Medicine, San Rafael Hospital, Alajuela, Costa Rica. 23Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 24Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 25Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. 26Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN. 27The Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 28College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia. 29Infectious Diseases Unit, The Townsville Hospital, Douglas, Queensland, Australia.

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http://dx.doi.org/10.1097/CCM.0000000000002654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640482PMC
November 2017

Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.

Crit Care Med 2017 11;45(11):1854-1862

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2The Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, the Netherlands. 4Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. 5Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands. 6Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. 7Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 8Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany. 9Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. 10Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 11Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002649DOI Listing
November 2017

Predictive value of the qSOFA score in patients with suspected infection in a resource limited setting in Gabon.

Travel Med Infect Dis 2017 Jan - Feb;15:76-77. Epub 2016 Nov 5.

Center of Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2016.10.014DOI Listing
October 2017

Diabetes Is Not Associated With Increased 90-Day Mortality Risk in Critically Ill Patients With Sepsis.

Crit Care Med 2017 Oct;45(10):e1026-e1035

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 4NICE foundation, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 5Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands. 6Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002590DOI Listing
October 2017

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Lancet Respir Med 2017 10 29;5(10):816-826. Epub 2017 Aug 29.

Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands; Division of Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/S2213-2600(17)30294-1DOI Listing
October 2017

Neutrophil extracellular traps in patients with pulmonary tuberculosis.

Respir Res 2017 10 30;18(1):181. Epub 2017 Oct 30.

Centre for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105, AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12931-017-0663-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663039PMC
October 2017

Myeloid-derived Suppressor Cells in Sepsis.

Authors:
Tom van der Poll

Am J Respir Crit Care Med 2017 08;196(3):256-258

1 Academic Medical Center University of Amsterdam Amsterdam, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201701-0046EDDOI Listing
August 2017

The immunopathology of sepsis and potential therapeutic targets.

Nat Rev Immunol 2017 Jul 24;17(7):407-420. Epub 2017 Apr 24.

Department of Internal Medicine, Radboud University Medical Center.

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http://dx.doi.org/10.1038/nri.2017.36DOI Listing
July 2017

Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.

Thromb Haemost 2017 07 11;117(8):1601-1614. Epub 2017 May 11.

Ingrid Stroo, Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, G2-1051105 AZ Amsterdam, the Netherlands, Tel.: +31 20 5666034, E-mail:

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http://dx.doi.org/10.1160/TH16-12-0920DOI Listing
July 2017

Expression of intra- and extracellular granzymes in patients with typhoid fever.

PLoS Negl Trop Dis 2017 Jul 27;11(7):e0005823. Epub 2017 Jul 27.

Department of Internal Medicine, Division of Infectious Diseases and Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0005823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549753PMC
July 2017

HIV infection rather than concurrent opportunistic infections drives most systemic procoagulant, vascular and damage responses - a prospective cohort study in central Africa.

Antivir Ther 2017 5;22(2):153-161. Epub 2017 Jan 5.

Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.3851/IMP3100DOI Listing
June 2017

Clinical Characteristics and Outcomes of Patients With Cellulitis Requiring Intensive Care.

JAMA Dermatol 2017 06;153(6):578-582

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands2Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands3Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamadermatol.2017.0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817617PMC
June 2017

Increased Early Systemic Inflammation in ICU-Acquired Weakness; A Prospective Observational Cohort Study.

Crit Care Med 2017 Jun;45(6):972-979

1Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.2Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.3Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.4Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.5Department of Rehabilitation, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002408DOI Listing
June 2017

Epidemiology of Multiple Herpes Viremia in Previously Immunocompetent Patients With Septic Shock.

Clin Infect Dis 2017 05;64(9):1204-1210

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/cid/cix120DOI Listing
May 2017

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Crit Care Med 2017 May;45(5):e524-e531

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands. 3Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 5Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002294DOI Listing
May 2017

An Unbalanced Inflammatory Cytokine Response Is Not Associated With Mortality Following Sepsis: A Prospective Cohort Study.

Crit Care Med 2017 May;45(5):e493-e499

1Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. 2Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. 3Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. 4Center for Infection and Immunity, Academic Medical Center, Amsterdam, The Netherlands. 5Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands. 6Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 7Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002292DOI Listing
May 2017

Nebulized Recombinant Human Tissue Factor Pathway Inhibitor Attenuates Coagulation and Exerts Modest Anti-inflammatory Effects in Rat Models of Lung Injury.

J Aerosol Med Pulm Drug Deliv 2017 Apr 15;30(2):91-99. Epub 2016 Dec 15.

1 Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam , Amsterdam, The Netherlands .

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http://dx.doi.org/10.1089/jamp.2016.1317DOI Listing
April 2017

Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.

Crit Care Med 2017 04;45(4):e457

Center for Experimental Molecular Medicine and Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;Center for Experimental Molecular Medicine and Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002214DOI Listing
April 2017

The gut microbiota as a modulator of innate immunity during melioidosis.

PLoS Negl Trop Dis 2017 04 19;11(4):e0005548. Epub 2017 Apr 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0005548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411098PMC
April 2017

Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis: A Prospective Observational Study.

Crit Care Med 2017 Mar;45(3):454-463

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2The Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Department of Clinical Epidemiology, Bioinformatics, and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 4Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 5Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 6Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. 7Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. 8Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002236DOI Listing
March 2017

Should all septic patients be given systemic anticoagulation? No.

Intensive Care Med 2017 Mar 13;43(3):455-457. Epub 2017 Feb 13.

Infectious Disease Division, Warren Alpert Medical School of Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1007/s00134-016-4607-xDOI Listing
March 2017

Increased Von Willebrand factor, decreased ADAMTS13 and thrombocytopenia in melioidosis.

PLoS Negl Trop Dis 2017 03 15;11(3):e0005468. Epub 2017 Mar 15.

Center for Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0005468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376340PMC
March 2017

Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.

Am J Physiol Lung Cell Mol Physiol 2017 Feb 2;312(2):L163-L171. Epub 2016 Dec 2.

Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1152/ajplung.00320.2016DOI Listing
February 2017

Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study.

Intensive Care Med 2017 Jan 11;43(1):59-68. Epub 2016 Nov 11.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-016-4613-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203863PMC
January 2017

Coagulation and sepsis.

Thromb Res 2017 Jan 19;149:38-44. Epub 2016 Nov 19.

Center for of Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.thromres.2016.11.007DOI Listing
January 2017

High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis.

J Cell Mol Med 2016 11 14;20(11):2029-2035. Epub 2016 Jun 14.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/jcmm.12891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082406PMC
November 2016

Immune Modulation in Sepsis: Is There a Place for Progranulin?

Am J Respir Crit Care Med 2016 11;194(10):1179-1180

4 Academic Medical Center University of Amsterdam Amsterdam, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201605-0945EDDOI Listing
November 2016

Risk factors, host response and outcome of hypothermic sepsis.

Crit Care 2016 10 14;20(1):328. Epub 2016 Oct 14.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13054-016-1510-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064908PMC
October 2016