Tom van Wezel

Tom van Wezel

UNVERIFIED PROFILE

Are you Tom van Wezel?   Register this Author

Register author
Tom van Wezel

Tom van Wezel

Publications by authors named "Tom van Wezel"

Are you Tom van Wezel?   Register this Author

100Publications

3045Reads

19Profile Views

The missing heritability of familial colorectal cancer.

Mutagenesis 2019 Oct 12. Epub 2019 Oct 12.

Department of Pathology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mutage/gez027DOI Listing
October 2019

The complexity of screening PMS2 in DNA isolated from formalin-fixed paraffin-embedded material.

Eur J Hum Genet 2019 Oct 15. Epub 2019 Oct 15.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-019-0527-xDOI Listing
October 2019

Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer.

Cancers (Basel) 2019 Aug 15;11(8). Epub 2019 Aug 15.

Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11081185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721552PMC
August 2019

Allelic Switching of , , and during Colorectal Cancer Tumorigenesis.

Int J Genomics 2019 10;2019:1287671. Epub 2019 Apr 10.

Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/ijg/2019/1287671/
Publisher Site
http://dx.doi.org/10.1155/2019/1287671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481143PMC
April 2019

Molecular Analysis of Gene Fusions in Bone and Soft Tissue Tumors by Anchored Multiplex PCR-Based Targeted Next-Generation Sequencing.

J Mol Diagn 2018 09 20;20(5):653-663. Epub 2018 Aug 20.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2018.05.007DOI Listing
September 2018

ROS-induced near-homozygous genomes in thyroid cancer.

Endocr Relat Cancer 2018 01 24;25(1):83-97. Epub 2017 Oct 24.

Department of Pathology Leiden University Medical CenterLeiden, Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-17-0288DOI Listing
January 2018

Chemosensitivity of BRCA1-Mutated Ovarian Cancer Cells and Established Cytotoxic Agents.

Int J Gynecol Cancer 2017 10;27(8):1571-1578

*Department of Gynecology, †Department of Pathology, Leiden University Medical Center; and ‡Department of Gynecology, Medical Center Haaglanden, The Hague, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IGC.0000000000001052DOI Listing
October 2017

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Science 2017 10 14;358(6360):234-238. Epub 2017 Sep 14.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, 3584CT Utrecht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aao3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038908PMC
October 2017

POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer.

Oncotarget 2017 Apr;8(16):26732-26743

Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Catalonia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.15810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432293PMC
April 2017

Promoter methylation and mRNA expression of HLA-G in relation to HLA-G protein expression in colorectal cancer.

Hum Immunol 2016 Sep 28;77(9):764-72. Epub 2016 May 28.

Dept. of Surgery, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humimm.2016.05.023DOI Listing
September 2016

Imprinted survival genes preclude loss of heterozygosity of chromosome 7 in cancer cells.

J Pathol 2016 09;240(1):72-83

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4756DOI Listing
September 2016

Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients.

Anticancer Drugs 2015 Sep;26(8):872-7

Departments of aClinical Oncology bClinical Pharmacy and Toxicology cPathology, Leiden University Medical Center dDepartment of Internal Medicine, Diaconessenhuis Leiden, Leiden eDepartment of Internal Medicine, Reinier de Graaf Hospital, Delft fDepartment of Internal Medicine and Clinical Oncology, Haga Hospital, The Hague, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CAD.0000000000000255DOI Listing
September 2015

Formalin-fixed, paraffin-embedded (FFPE) tissue epigenomics using Infinium HumanMethylation450 BeadChip assays.

Lab Invest 2015 Jul 13;95(7):833-42. Epub 2015 Apr 13.

1] Division of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands [2] GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands [3] Institute of Pathology, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/labinvest201553
Publisher Site
http://dx.doi.org/10.1038/labinvest.2015.53DOI Listing
July 2015

Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.

Gastroenterology 2015 Jun 28;148(7):1427-37.e8. Epub 2015 Feb 28.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.02.052DOI Listing
June 2015

Synergistic effects of the sesquiterpene lactone, EPD, with cisplatin and paclitaxel in ovarian cancer cells.

J Exp Clin Cancer Res 2015 Apr 25;34:38. Epub 2015 Apr 25.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://jeccr.biomedcentral.com/articles/10.1186/s13046-015-0
Publisher Site
http://dx.doi.org/10.1186/s13046-015-0157-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472250PMC
April 2015

Target-enriched next-generation sequencing reveals differences between primary and secondary ovarian tumors in formalin-fixed, paraffin-embedded tissue.

J Mol Diagn 2015 Mar 26;17(2):193-200. Epub 2014 Dec 26.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2014.10.006DOI Listing
March 2015

Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.

J Clin Endocrinol Metab 2015 Feb 11;100(2):E360-4. Epub 2014 Nov 11.

Laboratory of Cancer Epigenome (W.Y., H.L.H., A.G., D.H., S.L.P., C.K.O., B.T.T.), Division of Medical Sciences, National Cancer Centre Singapore, 169610 Singapore; Division of Cancer and Stem Cell Biology (W.Y., J.R.M., H.L.H., D.H., S.L.P., C.K.O., S.G.R., P.T., B.T.T.), Duke-National University of Singapore Graduate Medical School, 169857 Singapore; National University of Singapore Graduate School for Integrative Sciences and Engineering (W.Y.), 117456 Singapore; Academic Endocrine Unit, Nuffield Department of Clinical Medicine (M.S., P.N., R.V.T.), Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, OX3 7LJ Oxford, United Kingdom; Department of Pathology (R.v.E., D.R., T.v.W., H.M.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Molecular Endocrinology Group, Molecular Pathobiology Research Centre Unit (U.I.P.M.) (B.C.) of the Portuguese Institute of Oncology from Lisbon Francisco Gentil (IPOLFG) and Chronic Diseases Research Centre (CEDOC), Faculty of Medical Sciences (FCM), New University of Lisbon (UNL), 1099-023 Lisbon, Portugal; Genome Institute of Singapore (P.T.), 138672 Singapore; and Cancer Science Institute of Singapore (P.T., B.T.T.), National University of Singapore, 117599 Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2014-3238DOI Listing
February 2015

Near-haploidization significantly associates with oncocytic adrenocortical, thyroid, and parathyroid tumors but not with mitochondrial DNA mutations.

Genes Chromosomes Cancer 2014 Oct 7;53(10):833-44. Epub 2014 Jun 7.

Department of Pathology, Leiden University Medical Center, RC, Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.22194DOI Listing
October 2014

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Gastroenterology 2014 Jul 3;147(1):196-208.e13. Epub 2014 Apr 3.

Department of Gastroenterology and Hepatology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.03.052DOI Listing
July 2014

Anticancer activity of novel pyrido[2,3-b]indolizine derivatives: the relevance of phenolic substituents.

Anticancer Res 2014 Apr;34(4):1673-7

Albinusdreef 2, 2333ZA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
April 2014

Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.

J Natl Cancer Inst 2014 Apr 26;106(5). Epub 2014 Apr 26.

Affiliations of authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK (BK, RSH); Department of Medicine I, University Hospital Dresden, Dresden, Germany (SB); Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia, Spain (SCB); Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council (MRC) Human Genetics Unit, Edinburgh, UK (MGD, SMF); German Cancer Research Center, Heidelberg, Germany (AF, KH); Department of Internal Medicine I, Hospital Schleswig-Holstein, Kiel, Germany (JH); Leeds Cancer Research UK Centre, Section of Epidemiology and Biostatistics, Leeds Institute of Cancer Studies and Pathology, St James's University Hospital, Leeds, UK (EN, DTB); Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK (CP, IT); Department of Genetics, Portugese Oncology Institute, Porto, Portugal (MP, MRT); Galician Public Foundation of Genomic Medicine, Centro de Investigación Biomédica en Rad de Enfermedades Rares, Genomics Medicine Group, Hospital Clínico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain (CRP); Department of General and Thoraci Surgery, University Hospital Schleswig-Holstein, Kiel, Germany (CS); University of Gronigen, University Medical Centre Gronigen, Department of Genetics, Gronigen, The Netherlands (HW, RMWH); Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands (RMWH); Leiden Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (TW).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/dju086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677263PMC
April 2014

Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy.

Clin Cancer Res 2013 Jul 28;19(14):3796-807. Epub 2013 May 28.

Ludwig Center at Dana-Farber/Harvard and Center for Sarcoma and Bone Oncology, Department of Medical Oncology, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-12-3647DOI Listing
July 2013

Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue for KRAS, and BRAF somatic mutation analysis.

Exp Mol Pathol 2013 Feb 29;94(1):121-5. Epub 2012 Jun 29.

Department of Pathology, Leiden University Medical Center, P.O.box 9600, L1-Q, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2012.06.004DOI Listing
February 2013

BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer.

Clin Epigenetics 2013 Jan 16;5(1). Epub 2013 Jan 16.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1868-7083-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599401PMC
January 2013

Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.

Fam Cancer 2012 Dec;11(4):671-3

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10689-012-9565-zDOI Listing
December 2012

A review of the genetic background and tumour profiling in familial colorectal cancer.

Mutagenesis 2012 Mar;27(2):239-45

Department of Pathology, LUMC, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/mutage/ger071DOI Listing
March 2012

Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers.

Mutagenesis 2012 Mar;27(2):247-53

Department of Pathology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

View Article

Download full-text PDF

Source
https://academic.oup.com/mutage/article-lookup/doi/10.1093/m
Publisher Site
http://dx.doi.org/10.1093/mutage/ger077DOI Listing
March 2012

Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma.

Mod Pathol 2011 May 14;24(5):688-97. Epub 2011 Jan 14.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/modpathol2010236
Publisher Site
http://dx.doi.org/10.1038/modpathol.2010.236DOI Listing
May 2011

Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.

Cancer Epidemiol Biomarkers Prev 2009 Nov 20;18(11):3062-7. Epub 2009 Oct 20.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-09-0601DOI Listing
November 2009

Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment.

Cancer Res 2009 Aug 14;69(15):6216-22. Epub 2009 Jul 14.

Department of Pathology and Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-4801DOI Listing
August 2009

Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.

Genes Chromosomes Cancer 2009 May;48(5):410-8

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.20648DOI Listing
May 2009