Tom Taghon

Tom Taghon

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HES1 and HES4 have non-redundant roles downstream of Notch during early human T cell development.

Haematologica 2020 Jan 9. Epub 2020 Jan 9.

Cancer Research Institute Ghent (CRIG),Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium;

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http://dx.doi.org/10.3324/haematol.2019.226126DOI Listing
January 2020

ZEB2 in T-cells and T-ALL.

Adv Biol Regul 2019 12 27;74:100639. Epub 2019 Jul 27.

Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2019.100639DOI Listing
December 2019

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms.

Haematologica 2019 Aug 24;104(8):1608-1616. Epub 2019 Jan 24.

Mammalian Functional Genetics Group, Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3324/haematol.2018.207837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669144PMC
August 2019

Generation of adult human T-cell progenitors for immunotherapeutic applications.

J Allergy Clin Immunol 2018 04 5;141(4):1491-1494.e4. Epub 2017 Dec 5.

Human Lymphohaematopoiesis Laboratory, INSERM U1163, Paris, France; University of Paris Descartes-Sorbonne Paris Cité, IMAGINE Institute, Paris, France; Biotherapy Clinical Investigation Centre, Necker Children's Hospital, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887055PMC
April 2018

Human T cell development notched up a level.

Nat Methods 2017 04;14(5):477-478

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/nmeth.4277DOI Listing
April 2017

T-ALL and thymocytes: a message of noncoding RNAs.

J Hematol Oncol 2017 03 7;10(1):66. Epub 2017 Mar 7.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1186/s13045-017-0432-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341419PMC
March 2017

The checkpoint for agonist selection precedes conventional selection in human thymus.

Sci Immunol 2017 Feb;2(8)

Faculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1126/sciimmunol.aah4232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569900PMC
February 2017

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.

Cancer Immunol Immunother 2016 11 1;65(11):1365-1375. Epub 2016 Sep 1.

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00262-016-1894-6DOI Listing
November 2016

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

J Exp Med 2016 09 22;213(10):1973-81. Epub 2016 Aug 22.

Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center, 9052 Ghent, Belgium Department of Rheumatology, Ghent University, Ghent University Hospital, 9000 Ghent, Belgium

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http://dx.doi.org/10.1084/jem.20151065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030796PMC
September 2016

Characterization and Isolation of Human T Cell Progenitors.

Methods Mol Biol 2016 ;1323:221-37

The Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent University, De Pintelaan 185 Blok A-4, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-2809-5_19DOI Listing
May 2016

Approaches to Study Human T Cell Development.

Methods Mol Biol 2016 ;1323:239-51

The Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent University, De Pintelaan 185 Blok A-4, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-2809-5_20DOI Listing
May 2016

Humanized Mice to Study Human T Cell Development.

Methods Mol Biol 2016 ;1323:253-72

The Department of Hematology and Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent University, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-2809-5_21DOI Listing
May 2016

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.

Nat Commun 2016 Apr 6;7:11171. Epub 2016 Apr 6.

Faculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, 4BlokA, De Pintelaan 185, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1038/ncomms11171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823830PMC
April 2016

Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination.

Pediatr Allergy Immunol 2016 Feb 1;27(1):93-6. Epub 2015 Oct 1.

Department of Pediatric Immunology and Pulmonology, Ghent University Hospital, Ghent, Belgium.

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http://doi.wiley.com/10.1111/pai.12455
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http://dx.doi.org/10.1111/pai.12455DOI Listing
February 2016

Epigenetics in T-cell acute lymphoblastic leukemia.

Immunol Rev 2015 Jan;263(1):50-67

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://doi.wiley.com/10.1111/imr.12237
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http://dx.doi.org/10.1111/imr.12237DOI Listing
January 2015

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Nat Commun 2015 Jan 7;6:5794. Epub 2015 Jan 7.

1] Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University, Ghent B-9052, Belgium [2] Department for Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium [3] Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1038/ncomms6794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354161PMC
January 2015

Notch3 activation is sufficient but not required for inducing human T-lineage specification.

J Immunol 2014 Dec 7;193(12):5997-6004. Epub 2014 Nov 7.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, B-9000 Ghent, Belgium; and

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http://dx.doi.org/10.4049/jimmunol.1400764DOI Listing
December 2014

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.

J Leukoc Biol 2013 May 8;93(5):699-711. Epub 2013 Mar 8.

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1189/jlb.0812378DOI Listing
May 2013

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

J Exp Med 2013 Apr 25;210(4):683-97. Epub 2013 Mar 25.

The Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1084/jem.20121798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620353PMC
April 2013

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.

J Immunol 2013 Mar 21;190(5):1982-90. Epub 2013 Jan 21.

Department of Clinical Chemistry, Ghent University, 9000 Ghent, Belgium.

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http://dx.doi.org/10.4049/jimmunol.1200354DOI Listing
March 2013

Notch signaling during human T cell development.

Curr Top Microbiol Immunol 2012 ;360:75-97

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1007/82_2012_230DOI Listing
January 2013

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.

Immunol Cell Biol 2011 Oct 1;89(7):803-11. Epub 2011 Feb 1.

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/icb.2010.171DOI Listing
October 2011

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes.

Blood 2011 Jul 25;118(2):339-47. Epub 2011 May 25.

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1182/blood-2011-01-331124DOI Listing
July 2011

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells.

Haematologica 2011 May 17;96(5):646-54. Epub 2011 Feb 17.

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, 4Blok A, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.3324/haematol.2010.036343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084910PMC
May 2011

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.

Blood 2011 Apr 3;117(17):4449-59. Epub 2011 Mar 3.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-06-29
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http://dx.doi.org/10.1182/blood-2010-06-290049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673751PMC
April 2011

In vitro generation of immune cells from pluripotent stem cells.

Front Biosci (Landmark Ed) 2011 Jan 1;16:1488-504. Epub 2011 Jan 1.

Department of Clinical Chemistry, University of Ghent, Ghent, Belgium.

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http://dx.doi.org/10.2741/3800DOI Listing
January 2011

Continuous CD27 triggering in vivo strongly reduces NK cell numbers.

Eur J Immunol 2010 Apr;40(4):1107-17

Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/eji.200939251DOI Listing
April 2010

Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.

Blood 2009 Apr 23;113(14):3254-63. Epub 2008 Oct 23.

Department of Clinical Chemistry, Microbiology, and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-07-16
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http://dx.doi.org/10.1182/blood-2008-07-168906DOI Listing
April 2009

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.

Blood 2009 Mar 3;113(13):2988-98. Epub 2008 Dec 3.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-06-16
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http://dx.doi.org/10.1182/blood-2008-06-164871DOI Listing
March 2009

Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development.

Semin Immunopathol 2008 Dec 17;30(4):383-98. Epub 2008 Oct 17.

Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University Hospital, Ghent University, De Pintelaan 185, 4 Blok A, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00281-008-0134-3DOI Listing
December 2008

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.

Blood 2007 Oct 13;110(7):2696-703. Epub 2007 Jul 13.

Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1182/blood-2007-03-082206DOI Listing
October 2007

Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34+ cord blood cells.

Exp Hematol 2007 Aug 5;35(8):1272-8. Epub 2007 Jun 5.

Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1016/j.exphem.2007.04.009DOI Listing
August 2007

Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3.

Nat Immunol 2007 Aug 1;8(8):845-55. Epub 2007 Jul 1.

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium.

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http://www.nature.com/articles/ni1486
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http://dx.doi.org/10.1038/ni1486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140173PMC
August 2007

Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.

J Immunol 2007 Jul;179(1):421-38

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.4049/jimmunol.179.1.421DOI Listing
July 2007

Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.

Proc Natl Acad Sci U S A 2006 Aug 31;103(32):11993-8. Epub 2006 Jul 31.

Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1073/pnas.0601188103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567686PMC
August 2006

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus.

Immunity 2006 Jan;24(1):53-64

Division of Biology, MC 156-29, California Institute of Technology, 1200 E California Boulevard, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1016/j.immuni.2005.11.012DOI Listing
January 2006

Molecular genetics of T cell development.

Annu Rev Immunol 2005 ;23:601-49

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1146/annurev.immunol.23.021704.115737DOI Listing
June 2005

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

Genes Dev 2005 Apr;19(8):965-78

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1101/gad.1298305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1080135PMC
April 2005

Active form of Notch imposes T cell fate in human progenitor cells.

J Immunol 2002 Sep;169(6):3021-9

Department of Clinical Chemistry, Microbiology, and Immunology, University of Ghent, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.4049/jimmunol.169.6.3021DOI Listing
September 2002

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor.

Blood 2002 Feb;99(4):1197-204

Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1182/blood.v99.4.1197DOI Listing
February 2002