Publications by authors named "Tom L Blundell"

100Publications

Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.

Authors:
Asma Munir Michael T Wilson Steven W Hardwick Dimitri Y Chirgadze Jonathan A R Worrall Tom L Blundell Amanda K Chaplin

Structure 2021 Jan 4. Epub 2021 Jan 4.

Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK. Electronic address:

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January 2021

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.

Authors:
Vitor Mendes Simon R Green Joanna C Evans Jeannine Hess Michal Blaszczyk Christina Spry Owain Bryant James Cory-Wright Daniel S-H Chan Pedro H M Torres Zhe Wang Navid Nahiyaan Sandra O'Neill Sebastian Damerow John Post Tracy Bayliss Sasha L Lynch Anthony G Coyne Peter C Ray Chris Abell Kyu Y Rhee Helena I M Boshoff Clifton E Barry Valerie Mizrahi Paul G Wyatt Tom L Blundell

Nat Commun 2021 01 8;12(1):143. Epub 2021 Jan 8.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

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January 2021

SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets.

Authors:
Ali F Alsulami Sherine E Thomas Arian R Jamasb Christopher A Beaudoin Ismail Moghul Bridget Bannerman Liviu Copoiu Sundeep Chaitanya Vedithi Pedro Torres Tom L Blundell

Brief Bioinform 2021 Jan 8. Epub 2021 Jan 8.

Department of Biochemistry, University of Cambridge.

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January 2021

Mechanism of efficient double-strand break repair by a long non-coding RNA.

Authors:
Roopa Thapar Jing L Wang Michal Hammel Ruiqiong Ye Ke Liang Chengcao Sun Ales Hnizda Shikang Liang Su S Maw Linda Lee Heather Villarreal Isaac Forrester Shujuan Fang Miaw-Sheue Tsai Tom L Blundell Anthony J Davis Chunru Lin Susan P Lees-Miller Terence R Strick John A Tainer

Nucleic Acids Res 2020 Dec 18. Epub 2020 Dec 18.

Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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December 2020

HARP: a database of structural impacts of systematic missense mutations in drug targets of .

Authors:
Sundeep Chaitanya Vedithi Sony Malhotra Marcin J Skwark Asma Munir Marta Acebrón-García-De-Eulate Vaishali P Waman Ali Alsulami David B Ascher Tom L Blundell

Comput Struct Biotechnol J 2020 19;18:3692-3704. Epub 2020 Nov 19.

Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 1GA, UK.

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November 2020

Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM.

Authors:
Shikang Liang Amanda K Chaplin Antonia Kefala Stavridi Robert Appleby Ales Hnizda Tom L Blundell

Prog Biophys Mol Biol 2020 Dec 4. Epub 2020 Dec 4.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, Cambridgeshire, UK. Electronic address:

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December 2020

Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance.

Authors:
Asma Munir Sundeep Chaitanya Vedithi Amanda K Chaplin Tom L Blundell

Front Genet 2020 4;11:965. Epub 2020 Sep 4.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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September 2020

Dimers of DNA-PK create a stage for DNA double-strand break repair.

Authors:
Amanda K Chaplin Steven W Hardwick Shikang Liang Antonia Kefala Stavridi Ales Hnizda Lee R Cooper Taiana Maia De Oliveira Dimitri Y Chirgadze Tom L Blundell

Nat Struct Mol Biol 2021 Jan 19;28(1):13-19. Epub 2020 Oct 19.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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January 2021

Mechanism of efficient double-strand break repair by a long non-coding RNA.

Authors:
Roopa Thapar Jing L Wang Michal Hammel Ruiqiong Ye Ke Liang Chengcao Sun Ales Hnizda Shikang Liang Su S Maw Linda Lee Heather Villarreal Isaac Forrester Shujuan Fang Miaw-Sheue Tsai Tom L Blundell Anthony J Davis Chunru Lin Susan P Lees-Miller Terence R Strick John A Tainer

Nucleic Acids Res 2020 11;48(19):10953-10972

Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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November 2020

Interdisciplinary research in physics, chemistry and biology is central to understanding biological processes.

Authors:
Tom L Blundell

Prog Biophys Mol Biol 2020 10;156:1-2

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK. Electronic address:

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October 2020

Systematic Investigation of the Data Set Dependency of Protein Stability Predictors.

Authors:
Octav Caldararu Rukmankesh Mehra Tom L Blundell Kasper P Kepp

J Chem Inf Model 2020 Oct 24;60(10):4772-4784. Epub 2020 Aug 24.

DTU Chemistry, Technical University of Denmark, Building 206, 2800 Kgs. Lyngby, Denmark.

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October 2020

Correction to Fragment-Based Design of InhA Inhibitors.

Authors:
Mohamad Sabbah Vitor Mendes Robert G Vistal David M G Dias Monika Záhorszká Katarína Mikušová Jana Korduláková Anthony G Coyne Tom L Blundell Chris Abell

J Med Chem 2020 Aug 22;63(15):8650. Epub 2020 Jul 22.

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August 2020

Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations.

Authors:
Arooma Maryam Rana Rehan Khalid Sundeep Chaitanya Vedithi Abdulilah Ece Suleyman Selim Çınaroğlu Abdul Rauf Siddiqi Tom L Blundell

Comput Struct Biotechnol J 2020 12;18:1625-1638. Epub 2020 Jun 12.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Rd., Cambridge CB2 1GA, UK.

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June 2020

Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions.

Authors:
Tom L Blundell Munishwar N Gupta Seyed E Hasnain

Prog Biophys Mol Biol 2020 10 3;156:34-42. Epub 2020 Jul 3.

Jamia Hamdard Institute of Molecular Medicine, Jamia Hamdard, Hamdard Nagar, New Delhi, India; Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Prof C.R. Rao Road, Hyderabad, India. Electronic address:

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October 2020

The Genome3D Consortium for Structural Annotations of Selected Model Organisms.

Authors:
Vaishali P Waman Tom L Blundell Daniel W A Buchan Julian Gough David Jones Lawrence Kelley Alexey Murzin Arun Prasad Pandurangan Ian Sillitoe Michael Sternberg Pedro Torres Christine Orengo

Methods Mol Biol 2020 ;2165:27-67

Institute of Structural and Molecular Biology, University College London, London, UK.

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January 2020

Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from .

Authors:
João A Ribeiro Alexander Hammer Gerardo A Libreros-Zúñiga Sair M Chavez-Pacheco Petros Tyrakis Gabriel S de Oliveira Timothy Kirkman Jamal El Bakali Silvana A Rocco Mauricio L Sforça Roberto Parise-Filho Anthony G Coyne Tom L Blundell Chris Abell Marcio V B Dias

ACS Infect Dis 2020 08 10;6(8):2192-2201. Epub 2020 Jul 10.

Department of Microbiology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1474, São Paulo, SP 05508-000, Brazil.

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August 2020

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.

Authors:
Sherine E Thomas Andrew J Whitehouse Karen Brown Sophie Burbaud Juan M Belardinelli Jasper Sangen Ramanuj Lahiri Mark Daben J Libardo Pooja Gupta Sony Malhotra Helena I M Boshoff Mary Jackson Chris Abell Anthony G Coyne Tom L Blundell Rodrigo Andres Floto Vítor Mendes

Nucleic Acids Res 2020 08;48(14):8099-8112

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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August 2020

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining.

Authors:
Antonia Kefala Stavridi Robert Appleby Shikang Liang Tom L Blundell Amanda K Chaplin

Essays Biochem 2020 10;64(5):791-806

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB21GA, Cambridgeshire, U.K.

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October 2020

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.

Authors:
Takashi Ochi Valentina Quarantotti Huawen Lin Jerome Jullien Ivan Rosa E Silva Francesco Boselli Deepak D Barnabas Christopher M Johnson Stephen H McLaughlin Stefan M V Freund Andrew N Blackford Yuu Kimata Raymond E Goldstein Stephen P Jackson Tom L Blundell Susan K Dutcher Fanni Gergely Mark van Breugel

Structure 2020 06 5;28(6):674-689.e11. Epub 2020 May 5.

MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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June 2020

Common mechanism of thermostability in small α- and β-proteins studied by molecular dynamics.

Authors:
Kalyanashis Jana Rukmankesh Mehra Budheswar Dehury Tom L Blundell Kasper P Kepp

Proteins 2020 09 19;88(9):1233-1250. Epub 2020 May 19.

DTU Chemistry, Technical University of Denmark, Lyngby, Denmark.

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September 2020

Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.

Authors:
Hugo Larose Nina Prokoph Jamie D Matthews Michaela Schlederer Sandra Högler Ali F Alsulami Stephen P Ducray Edem Nuglozeh Feroze M S Fazaludeen Ahmed Elmouna Monica Ceccon Luca Mologni Carlo Gambacorti-Passerini Gerald Hoefler Cosimo Lobello Sarka Pospisilova Andrea Janikova Wilhelm Woessmann Christine Damm-Welk Martin Zimmermann Alina Federova Andrea Malone Owen Smith Mariusz Wasik Giorgio Inghirami Laurence Lamant Tom L Blundell Wolfram Klapper Olaf Merkel G A Amos Burke Shahid Mian Ibraheem Ashankyty Lukas Kenner Suzanne D Turner

Haematologica 2020 Apr 23. Epub 2020 Apr 23.

Department of Pathology, University of Cambridge, Cambridge, UK;

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April 2020

Fragment-Based Design of InhA Inhibitors.

Authors:
Mohamad Sabbah Vitor Mendes Robert G Vistal David M G Dias Monika Záhorszká Katarína Mikušová Jana Korduláková Anthony G Coyne Tom L Blundell Chris Abell

J Med Chem 2020 05 15;63(9):4749-4761. Epub 2020 Apr 15.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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May 2020

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.

Authors:
Peter R Curran Chris J Radoux Mihaela D Smilova Richard A Sykes Alicia P Higueruelo Anthony R Bradley Brian D Marsden David R Spring Tom L Blundell Andrew R Leach William R Pitt Jason C Cole

J Chem Inf Model 2020 04 2;60(4):1911-1916. Epub 2020 Apr 2.

The Cambridge Crystallographic Data Centre (CCDC), 12 Union Road, Cambridge, CB2 1EZ, U.K.

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April 2020

Editorial overview: Macromolecular assemblies.

Authors:
Xiaodong Zhang Tom L Blundell

Curr Opin Struct Biol 2020 04 9;61:vi-viii. Epub 2020 Mar 9.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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April 2020

Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in .

Authors:
Sundeep Chaitanya Vedithi Carlos H M Rodrigues Stephanie Portelli Marcin J Skwark Madhusmita Das David B Ascher Tom L Blundell Sony Malhotra

Comput Struct Biotechnol J 2020 17;18:271-286. Epub 2020 Jan 17.

Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 1GA, UK.

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January 2020

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools.

Authors:
Victor Sebastian-Perez Alfonso García-Rubia Sayed H Seif El-Din Abdel-Nasser A Sabra Naglaa M El-Lakkany Samia William Tom L Blundell Louis Maes Ana Martinez Nuria E Campillo Sanaa S Botros Carmen Gil

J Enzyme Inhib Med Chem 2020 Dec;35(1):511-523

Centro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.

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December 2020

A platform for target prediction of phenotypic screening hit molecules.

Authors:
Nadine Homeyer Ruud van Deursen Bernardo Ochoa-Montaño Kathrin Heikamp Peter Ray Fabio Zuccotto Tom L Blundell Ian H Gilbert

J Mol Graph Model 2020 03 24;95:107485. Epub 2019 Oct 24.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, United Kingdom. Electronic address:

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March 2020

Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.

Authors:
Vítor Mendes Marta Acebrón-García-de-Eulate Nupur Verma Michal Blaszczyk Márcio V B Dias Tom L Blundell

mBio 2019 11 26;10(6). Epub 2019 Nov 26.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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November 2019

Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH).

Authors:
Ana Trapero Angela Pacitto Daniel Shiu-Hin Chan Chris Abell Tom L Blundell David B Ascher Anthony G Coyne

Bioorg Med Chem Lett 2020 01 9;30(2):126792. Epub 2019 Nov 9.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. Electronic address:

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January 2020

Structural biology of multicomponent assemblies in DNA double-strand-break repair through non-homologous end joining.

Authors:
Amanda K Chaplin Tom L Blundell

Curr Opin Struct Biol 2020 04 14;61:9-16. Epub 2019 Nov 14.

Department of Biochemistry, University of Cambridge, CB2 1GA, Cambridge, United Kingdom. Electronic address:

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April 2020

Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation.

Authors:
Ian Sillitoe Antonina Andreeva Tom L Blundell Daniel W A Buchan Robert D Finn Julian Gough David Jones Lawrence A Kelley Typhaine Paysan-Lafosse Su Datt Lam Alexey G Murzin Arun Prasad Pandurangan Gustavo A Salazar Marcin J Skwark Michael J E Sternberg Sameer Velankar Christine Orengo

Nucleic Acids Res 2020 01;48(D1):D314-D319

Institute of Structural and Molecular Biology, UCL, Gower Street, London WC1E 6BT, UK.

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January 2020

Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning.

Authors:
Arun Prasad Pandurangan Tom L Blundell

Protein Sci 2020 01 25;29(1):247-257. Epub 2019 Nov 25.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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January 2020

Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus.

Authors:
Marcin J Skwark Pedro H M Torres Liviu Copoiu Bridget Bannerman R Andres Floto Tom L Blundell

Database (Oxford) 2019 01;2019(1)

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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January 2019

ProCarbDB: a database of carbohydrate-binding proteins.

Authors:
Liviu Copoiu Pedro H M Torres David B Ascher Tom L Blundell Sony Malhotra

Nucleic Acids Res 2020 01;48(D1):D368-D375

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK.

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January 2020

SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange.

Authors:
Daniel J Saltzberg Morgan Hepburn Kala Bharath Pilla David C Schriemer Susan P Lees-Miller Tom L Blundell Andrej Sali

Prog Biophys Mol Biol 2019 10 27;147:92-102. Epub 2019 Sep 27.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, USA.

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October 2019

Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.

Authors:
Daniel Shiu-Hin Chan Jeannine Hess Elen Shaw Christina Spry Robert Starley Claudio Dagostin Marcio V B Dias Ramesh Kale Vitor Mendes Tom L Blundell Anthony G Coyne Chris Abell

Biochem J 2019 11;476(21):3125-3139

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

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November 2019

Editorial overview: Theory and simulation: demystifying GPCRs - structure, function and drug design.

Authors:
Shoba Ranganathan Tom L Blundell

Curr Opin Struct Biol 2019 04;55:vi-viii

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. Electronic address:

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April 2019

Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census.

Authors:
Sony Malhotra Ali F Alsulami Yang Heiyun Bernardo Montano Ochoa Harry Jubb Simon Forbes Tom L Blundell

PLoS One 2019 19;14(7):e0219935. Epub 2019 Jul 19.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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March 2020

Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India.

Authors:
Asma Munir Narender Kumar Suresh Babu Ramalingam Sembulingam Tamilzhalagan Siva Kumar Shanmugam Alangudi Natarajan Palaniappan Dina Nair Padma Priyadarshini Mohan Natarajan Srikanth Tripathy Uma Devi Ranganathan Sharon J Peacock Julian Parkhill Tom L Blundell Sony Malhotra

Sci Rep 2019 07 16;9(1):10283. Epub 2019 Jul 16.

Department of Biochemistry, University of Cambridge, Tennis Court. Rd., Cambridge, CB2 1GA, UK.

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July 2019

Development of Inhibitors against tRNA (mG37) Methyltransferase (TrmD) Using Fragment-Based Approaches.

Authors:
Andrew J Whitehouse Sherine E Thomas Karen P Brown Alexander Fanourakis Daniel S-H Chan M Daben J Libardo Vitor Mendes Helena I M Boshoff R Andres Floto Chris Abell Tom L Blundell Anthony G Coyne

J Med Chem 2019 08 19;62(15):7210-7232. Epub 2019 Jul 19.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.

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August 2019

Multicomponent assemblies in DNA-double-strand break repair by NHEJ.

Authors:
Aleš Hnízda Tom L Blundell

Curr Opin Struct Biol 2019 04 21;55:154-160. Epub 2019 May 21.

Department of Biochemistry, University of Cambridge, Tennis Court Rd., Cambridge, CB2 1GA, UK. Electronic address:

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April 2019

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.

Authors:
Vinayak Singh Angela Pacitto Stefano Donini Davide M Ferraris Sándor Boros Eszter Illyés Bálint Szokol Menico Rizzi Tom L Blundell David B Ascher Janos Pato Valerie Mizrahi

Eur J Med Chem 2019 Jul 15;174:309-329. Epub 2019 Apr 15.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7925, South Africa. Electronic address:

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July 2019

Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.

Authors:
Sherine E Thomas Patrick Collins Rory Hennell James Vitor Mendes Sitthivut Charoensutthivarakul Chris Radoux Chris Abell Anthony G Coyne R Andres Floto Frank von Delft Tom L Blundell

Philos Trans A Math Phys Eng Sci 2019 Jun;377(2147):20180422

1 Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB2 1GA , UK.

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June 2019

Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways.

Authors:
Qian Wu Shikang Liang Takashi Ochi Dimitri Y Chirgadze Juha T Huiskonen Tom L Blundell

Prog Biophys Mol Biol 2019 10 20;147:26-32. Epub 2019 Apr 20.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK. Electronic address:

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October 2019

The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa.

Authors:
Arooma Maryam Sundeep Chaitanya Vedithi Rana Rehan Khalid Ali F Alsulami Pedro Henrique Monteiro Torres Abdul Rauf Siddiqi Tom L Blundell

Comput Struct Biotechnol J 2019 6;17:378-389. Epub 2019 Mar 6.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Rd, Cambridge CB2 1GA, UK.

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March 2019

Editorial.

Authors:
Denis Noble Tom L Blundell Peter Kohl

Prog Biophys Mol Biol 2019 01;141:1-2

Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University of Freiburg, Elsasser Str 2Q, 90110, Freiburg, Germany. Electronic address:

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January 2019

Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.

Authors:
Vaishali P Waman Sundeep Chaitanya Vedithi Sherine E Thomas Bridget P Bannerman Asma Munir Marcin J Skwark Sony Malhotra Tom L Blundell

Emerg Microbes Infect 2019 ;8(1):109-118

a Department of Biochemistry , University of Cambridge , Cambridge , UK.

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July 2019

The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.

Authors:
Ryotaro Nishi Paul W G Wijnhoven Yusuke Kimura Misaki Matsui Rebecca Konietzny Qian Wu Keisuke Nakamura Tom L Blundell Benedikt M Kessler

Sci Rep 2018 12 17;8(1):17891. Epub 2018 Dec 17.

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, United Kingdom.

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December 2018

Progress in biophysics and molecular biology: A brief history of the journal.

Authors:
Denis Noble Tom L Blundell Peter Kohl

Prog Biophys Mol Biol 2018 12;140:1-4

Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University of Freiburg, Elsasser Str 2Q, 90110, Freiburg, Germany. Electronic address:

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December 2018

Arginine-deprivation-induced oxidative damage sterilizes .

Authors:
Sangeeta Tiwari Andries J van Tonder Catherine Vilchèze Vitor Mendes Sherine E Thomas Adel Malek Bing Chen Mei Chen John Kim Tom L Blundell Julian Parkhill Brian Weinrick Michael Berney William R Jacobs

Proc Natl Acad Sci U S A 2018 09 24;115(39):9779-9784. Epub 2018 Aug 24.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461;

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September 2018

Identification of new allosteric sites and modulators of AChE through computational and experimental tools.

Authors:
Carlos Roca Carlos Requena Víctor Sebastián-Pérez Sony Malhotra Chris Radoux Concepción Pérez Ana Martinez Juan Antonio Páez Tom L Blundell Nuria E Campillo

J Enzyme Inhib Med Chem 2018 Dec;33(1):1034-1047

a Centro de Investigaciones Biológicas (CIB-CSIC), C/Ramiro de Maeztu , Madrid , Spain.

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December 2018

Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

Authors:
Sundeep Chaitanya Vedithi Sony Malhotra Madhusmita Das Sheela Daniel Nanda Kishore Anuja George Shantha Arumugam Lakshmi Rajan Mannam Ebenezer David B Ascher Eddy Arnold Tom L Blundell

Sci Rep 2018 May 23;8(1):8250. Epub 2018 May 23.

Department of Biochemistry, University of Cambridge, Tennis Court Rd., Cambridge, CB2 1GA, UK.

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May 2018

Dissection of DNA double-strand-break repair using novel single-molecule forceps.

Authors:
Jing L Wang Camille Duboc Qian Wu Takashi Ochi Shikang Liang Susan E Tsutakawa Susan P Lees-Miller Marc Nadal John A Tainer Tom L Blundell Terence R Strick

Nat Struct Mol Biol 2018 06 21;25(6):482-487. Epub 2018 May 21.

Institut Jacques Monod, Université Paris Diderot, CNRS, UMR 7592, Paris, France.

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June 2018

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

Authors:
Sundeep Chaitanya Vedithi Sony Malhotra Madhusmita Das Sheela Daniel Nanda Kishore Anuja George Shantha Arumugam Lakshmi Rajan Mannam Ebenezer David B Ascher Eddy Arnold Tom L Blundell

Sci Rep 2018 03 22;8(1):5016. Epub 2018 Mar 22.

Department of Biochemistry, University of Cambridge, Tennis Court Rd., Cambridge, CB2 1GA, UK.

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March 2018

Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.

Authors:
Ana Trapero Angela Pacitto Vinayak Singh Mohamad Sabbah Anthony G Coyne Valerie Mizrahi Tom L Blundell David B Ascher Chris Abell

J Med Chem 2018 04 23;61(7):2806-2822. Epub 2018 Mar 23.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.

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April 2018

TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species.

Authors:
Sony Malhotra Grace Mugumbate Tom L Blundell Alicia P Higueruelo

Database (Oxford) 2017 01;2017

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.

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January 2017

Target Identification of Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.

Authors:
Grace Mugumbate Vitor Mendes Michal Blaszczyk Mohamad Sabbah George Papadatos Joel Lelievre Lluis Ballell David Barros Chris Abell Tom L Blundell John P Overington

Front Pharmacol 2017 26;8:681. Epub 2017 Sep 26.

European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, United Kingdom.

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September 2017

Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry.

Authors:
Tom L Blundell

IUCrJ 2017 Jul 29;4(Pt 4):308-321. Epub 2017 Jun 29.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, England.

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July 2017

Decoding the similarities and differences among mycobacterial species.

Authors:
Sony Malhotra Sundeep Chaitanya Vedithi Tom L Blundell

PLoS Negl Trop Dis 2017 Aug 30;11(8):e0005883. Epub 2017 Aug 30.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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August 2017

Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome Oxidase in ".

Authors:
Kriti Arora Bernardo Ochoa-Montaño Patricia S Tsang Tom L Blundell Stephanie S Dawes Valerie Mizrahi Tracy Bayliss Claire J Mackenzie Laura A T Cleghorn Peter C Ray Paul G Wyatt Eugene Uh Jinwoo Lee Clifton E Barry Helena I Boshoff

Antimicrob Agents Chemother 2017 09 24;61(9). Epub 2017 Aug 24.

Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.

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September 2017

DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.

Authors:
Dimitri Y Chirgadze David B Ascher Tom L Blundell Bancinyane L Sibanda

Methods Enzymol 2017 3;592:145-157. Epub 2017 May 3.

University of Cambridge, Cambridge, United Kingdom.

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April 2018

Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections: A Paper Dedicated to John Kendrew.

Authors:
Sherine E Thomas Vitor Mendes So Yeon Kim Sony Malhotra Bernardo Ochoa-Montaño Michal Blaszczyk Tom L Blundell

J Mol Biol 2017 08 23;429(17):2677-2693. Epub 2017 Jun 23.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA UK. Electronic address:

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August 2017

SDM: a server for predicting effects of mutations on protein stability.

Authors:
Arun Prasad Pandurangan Bernardo Ochoa-Montaño David B Ascher Tom L Blundell

Nucleic Acids Res 2017 07;45(W1):W229-W235

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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July 2017

Fragment Screening against the EthR-DNA Interaction by Native Mass Spectrometry.

Authors:
Daniel Shiu-Hin Chan Vitor Mendes Sherine E Thomas Brendan N McConnell Dijana Matak-Vinković Anthony G Coyne Tom L Blundell Chris Abell

Angew Chem Int Ed Engl 2017 06 31;56(26):7488-7491. Epub 2017 May 31.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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June 2017

XSuLT: a web server for structural annotation and representation of sequence-structure alignments.

Authors:
Bernardo Ochoa-Montaño Tom L Blundell

Nucleic Acids Res 2017 07;45(W1):W381-W387

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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July 2017

Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance.

Authors:
Arun Prasad Pandurangan David B Ascher Sherine E Thomas Tom L Blundell

Biochem Soc Trans 2017 04;45(2):303-311

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, U.K.

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April 2017

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.

Authors:
Petar O Nikiforov Michal Blaszczyk Sachin Surade Helena I Boshoff Andaleeb Sajid Vincent Delorme Nathalie Deboosere Priscille Brodin Alain R Baulard Clifton E Barry Tom L Blundell Chris Abell

ACS Chem Biol 2017 05 5;12(5):1390-1396. Epub 2017 Apr 5.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.

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May 2017

Structural insights into the EthR-DNA interaction using native mass spectrometry.

Authors:
Daniel Shiu-Hin Chan Wei-Guang Seetoh Brendan N McConnell Dijana Matak-Vinković Sherine E Thomas Vitor Mendes Michal Blaszczyk Anthony G Coyne Tom L Blundell Chris Abell

Chem Commun (Camb) 2017 Mar;53(25):3527-3530

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, UK.

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March 2017

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.

Authors:
Bancinyane L Sibanda Dimitri Y Chirgadze David B Ascher Tom L Blundell

Science 2017 02 2;355(6324):520-524. Epub 2017 Feb 2.

Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

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February 2017

Structure-guided, target-based drug discovery - exploiting genome information from HIV to mycobacterial infections.

Authors:
Sony Malhotra Sherine E Thomas Bernardo Ochoa Montano Tom L Blundell

Postepy Biochem 2016;62(3):262-272

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK.

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December 2017

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures.

Authors:
Harry C Jubb Alicia P Higueruelo Bernardo Ochoa-Montaño Will R Pitt David B Ascher Tom L Blundell

J Mol Biol 2017 02 10;429(3):365-371. Epub 2016 Dec 10.

Department of Biochemistry, Sanger Building, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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February 2017

Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health.

Authors:
Harry C Jubb Arun P Pandurangan Meghan A Turner Bernardo Ochoa-Montaño Tom L Blundell David B Ascher

Prog Biophys Mol Biol 2017 09 29;128:3-13. Epub 2016 Nov 29.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Department of Biochemistry, University of Melbourne, Melbourne, 3052, Australia. Electronic address:

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September 2017

Targeting tuberculosis using structure-guided fragment-based drug design.

Authors:
Vitor Mendes Tom L Blundell

Drug Discov Today 2017 03 11;22(3):546-554. Epub 2016 Oct 11.

Department of Biochemistry, University of Cambridge, Cambridge CB21GA, UK. Electronic address:

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March 2017

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.

Authors:
Howard H Y Chang Go Watanabe Christina A Gerodimos Takashi Ochi Tom L Blundell Stephen P Jackson Michael R Lieber

J Biol Chem 2016 Nov 4;291(47):24377-24389. Epub 2016 Oct 4.

From the Departments of Pathology, Biochemistry & Molecular Biology, and Molecular Microbiology & Immunology and the Section of Molecular & Computational Biology, Department of Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 and

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November 2016

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.

Authors:
Vinayak Singh Stefano Donini Angela Pacitto Claudia Sala Ruben C Hartkoorn Neeraj Dhar Gyorgy Keri David B Ascher Guillaume Mondésert Anthony Vocat Andréanne Lupien Raphael Sommer Hélène Vermet Sophie Lagrange Joe Buechler Digby F Warner John D McKinney Janos Pato Stewart T Cole Tom L Blundell Menico Rizzi Valerie Mizrahi

ACS Infect Dis 2017 01 8;3(1):5-17. Epub 2016 Sep 8.

MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town , Anzio Road, Observatory 7925, South Africa.

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January 2017

Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.

Authors:
Tommaso Moschetti Timothy Sharpe Gerhard Fischer May E Marsh Hong Kin Ng Matthew Morgan Duncan E Scott Tom L Blundell Ashok R Venkitaraman John Skidmore Chris Abell Marko Hyvönen

J Mol Biol 2016 11 8;428(23):4589-4607. Epub 2016 Oct 8.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK. Electronic address:

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November 2016

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Authors:
Yumi Park Angela Pacitto Tracy Bayliss Laura A T Cleghorn Zhe Wang Travis Hartman Kriti Arora Thomas R Ioerger Jim Sacchettini Menico Rizzi Stefano Donini Tom L Blundell David B Ascher Kyu Rhee Ardala Breda Nian Zhou Veronique Dartois Surendranadha Reddy Jonnala Laura E Via Valerie Mizrahi Ola Epemolu Laste Stojanovski Fred Simeons Maria Osuna-Cabello Lucy Ellis Claire J MacKenzie Alasdair R C Smith Susan H Davis Dinakaran Murugesan Kirsteen I Buchanan Penelope A Turner Margaret Huggett Fabio Zuccotto Maria Jose Rebollo-Lopez Maria Jose Lafuente-Monasterio Olalla Sanz Gracia Santos Diaz Joël Lelièvre Lluis Ballell Carolyn Selenski Matthew Axtman Sonja Ghidelli-Disse Hannah Pflaumer Markus Bösche Gerard Drewes Gail M Freiberg Matthew D Kurnick Myron Srikumaran Dale J Kempf Simon R Green Peter C Ray Kevin Read Paul Wyatt Clifton E Barry Helena I Boshoff

ACS Infect Dis 2017 01 17;3(1):18-33. Epub 2016 Oct 17.

Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.

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January 2017

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase.

Authors:
Rosaria Luciani Puneet Saxena Sachin Surade Matteo Santucci Alberto Venturelli Chiara Borsari Gaetano Marverti Glauco Ponterini Stefania Ferrari Tom L Blundell Maria Paola Costi

J Med Chem 2016 10 29;59(19):9269-9275. Epub 2016 Sep 29.

Department of Life Sciences, University of Modena and Reggio Emilia , Via Campi, 103, 41125 Modena, Italy.

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October 2016

Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling.

Authors:
Corentin Herbert Ulrich Schieborr Krishna Saxena Jarek Juraszek Frederik De Smet Chantal Alcouffe Marc Bianciotto Giorgio Saladino David Sibrac Denis Kudlinzki Sridhar Sreeramulu Alan Brown Patrice Rigon Jean-Pascal Herault Gilbert Lassalle Tom L Blundell Frederic Rousseau Ann Gils Joost Schymkowitz Peter Tompa Jean-Marc Herbert Peter Carmeliet Francesco Luigi Gervasio Harald Schwalbe Françoise Bono

Cancer Cell 2016 07 11;30(1):176-178. Epub 2016 Jul 11.

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July 2016

ATP half-sites in RadA and RAD51 recombinases bind nucleotides.

Authors:
May E Marsh Duncan E Scott Matthias T Ehebauer Chris Abell Tom L Blundell Marko Hyvönen

FEBS Open Bio 2016 05 6;6(5):372-85. Epub 2016 Apr 6.

Department of Biochemistry University of Cambridge UK.

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May 2016

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance.

Authors:
Douglas E V Pires Tom L Blundell David B Ascher

Sci Rep 2016 07 7;6:29575. Epub 2016 Jul 7.

Department of Biochemistry, Sanger Building, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

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July 2016

Identifying Interactions that Determine Fragment Binding at Protein Hotspots.

Authors:
Chris J Radoux Tjelvar S G Olsson Will R Pitt Colin R Groom Tom L Blundell

J Med Chem 2016 05 11;59(9):4314-25. Epub 2016 Apr 11.

Department of Biochemistry, University of Cambridge , Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom.

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May 2016

Structure-activity relationship of the peptide binding-motif mediating the BRCA2:RAD51 protein-protein interaction.

Authors:
Duncan E Scott May Marsh Tom L Blundell Chris Abell Marko Hyvönen

FEBS Lett 2016 04 6;590(8):1094-102. Epub 2016 Apr 6.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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April 2016

A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.

Authors:
Petar O Nikiforov Sachin Surade Michal Blaszczyk Vincent Delorme Priscille Brodin Alain R Baulard Tom L Blundell Chris Abell

Org Biomol Chem 2016 Feb 25;14(7):2318-26. Epub 2016 Jan 25.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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February 2016

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity.

Authors:
Douglas E V Pires Jing Chen Tom L Blundell David B Ascher

Sci Rep 2016 Jan 22;6:19848. Epub 2016 Jan 22.

Department of Biochemistry, Sanger Building, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK.

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January 2016

Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.

Authors:
Qian Wu Atanu Paul Dan Su Shahid Mehmood Tzeh Keong Foo Takashi Ochi Emma L Bunting Bing Xia Carol V Robinson Bin Wang Tom L Blundell

Mol Cell 2016 Feb 14;61(3):434-448. Epub 2016 Jan 14.

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK. Electronic address:

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February 2016

Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.

Authors:
Anja Winter Anna G Sigurdardottir Danielle DiCara Giovanni Valenti Tom L Blundell Ermanno Gherardi

Mol Cancer Ther 2016 Jan 28;15(1):3-14. Epub 2015 Dec 28.

MRC Centre, Cambridge, United Kingdom.

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January 2016

Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.

Authors:
Angela Pacitto David B Ascher Louise H Wong Beata K Blaszczyk Ravi K Nookala Nianshu Zhang Svetlana Dokudovskaya Tim P Levine Tom L Blundell

Open Biol 2015 Dec;5(12):150174

Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK

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December 2015

Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism.

Authors:
Vitor Mendes Michal Blaszczyk Ana Maranha Nuno Empadinhas Tom L Blundell

Sci Rep 2015 Nov 30;5:17144. Epub 2015 Nov 30.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

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November 2015

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis.

Authors:
Alvin W Hung H Leonardo Silvestre Shijun Wen Guillaume P C George Jennifer Boland Tom L Blundell Alessio Ciulli Chris Abell

ChemMedChem 2016 Jan 21;11(1):38-42. Epub 2015 Oct 21.

Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge, CB2 1EW, UK.

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January 2016

SInCRe-structural interactome computational resource for Mycobacterium tuberculosis.

Authors:
Rahul Metri Sridhar Hariharaputran Gayatri Ramakrishnan Praveen Anand Upadhyayula S Raghavender Bernardo Ochoa-Montaño Alicia P Higueruelo Ramanathan Sowdhamini Nagasuma R Chandra Tom L Blundell Narayanaswamy Srinivasan

Database (Oxford) 2015 30;2015:bav060. Epub 2015 Jun 30.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, and

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March 2016

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.

Authors:
Michal Blaszczyk Nicholas J Harmer Dimitri Y Chirgadze David B Ascher Tom L Blundell

Prog Biophys Mol Biol 2015 Sep 5;118(3):103-11. Epub 2015 May 5.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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September 2015

Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma.

Authors:
Mariam Jafri Naomi C Wake David B Ascher Douglas E V Pires Dean Gentle Mark R Morris Eleanor Rattenberry Michael A Simpson Richard C Trembath Astrid Weber Emma R Woodward Alan Donaldson Tom L Blundell Farida Latif Eamonn R Maher

Cancer Discov 2015 Jul 14;5(7):723-9. Epub 2015 Apr 14.

Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom.

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July 2015

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures.

Authors:
Douglas E V Pires Tom L Blundell David B Ascher

J Med Chem 2015 May 22;58(9):4066-72. Epub 2015 Apr 22.

†Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Sanger Building, Cambridge, Cambridgshire CB2 1GA, U.K.

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May 2015

CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis.

Authors:
Bernardo Ochoa-Montaño Nishita Mohan Tom L Blundell

Database (Oxford) 2015 31;2015. Epub 2015 Mar 31.

Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK and Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600036, India.

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September 2015

Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.

Authors:
Martina Nemethova Jan Radvanszky Ludevit Kadasi David B Ascher Douglas E V Pires Tom L Blundell Berardino Porfirio Alessandro Mannoni Annalisa Santucci Lia Milucci Silvia Sestini Gianfranco Biolcati Fiammetta Sorge Caterina Aurizi Robert Aquaron Mohammed Alsbou Charles Marques Lourenço Kanakasabapathi Ramadevi Lakshminarayan R Ranganath James A Gallagher Christa van Kan Anthony K Hall Birgitta Olsson Nicolas Sireau Hana Ayoob Oliver G Timmis Kim-Hanh Le Quan Sang Federica Genovese Richard Imrich Jozef Rovensky Rangan Srinivasaraghavan Shruthi K Bharadwaj Ronen Spiegel Andrea Zatkova

Eur J Hum Genet 2016 Jan 25;24(1):66-72. Epub 2015 Mar 25.

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.

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January 2016

Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

Authors:
Jennie E Murray Mirjam van der Burg Hanna IJspeert Paula Carroll Qian Wu Takashi Ochi Andrea Leitch Edward S Miller Boris Kysela Alireza Jawad Armand Bottani Francesco Brancati Marco Cappa Valerie Cormier-Daire Charu Deshpande Eissa A Faqeih Gail E Graham Emmanuelle Ranza Tom L Blundell Andrew P Jackson Grant S Stewart Louise S Bicknell

Am J Hum Genet 2015 Mar 26;96(3):412-24. Epub 2015 Feb 26.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.

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March 2015

Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif.

Authors:
Qian Wu Harry Jubb Tom L Blundell

Prog Biophys Mol Biol 2015 Mar 17;117(2-3):143-148. Epub 2015 Feb 17.

Department of Biochemistry, 80 Tennis Court Road, University of Cambridge, CB2 1GA, Cambridge, United Kingdom.

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March 2015

Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations.

Authors:
Jeannette L Usher David B Ascher Douglas E V Pires Anna M Milan Tom L Blundell Lakshminarayan R Ranganath

JIMD Rep 2015 15;24:3-11. Epub 2015 Feb 15.

Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool and Broadgreen University Hospital Trust, Duncan Building, Liverpool, L7 8XP, UK.

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September 2015

Flexibility and small pockets at protein-protein interfaces: New insights into druggability.

Authors:
Harry Jubb Tom L Blundell David B Ascher

Prog Biophys Mol Biol 2015 Oct 7;119(1):2-9. Epub 2015 Feb 7.

Department of Biochemistry, Sanger Building, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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October 2015