Publications by authors named "Tom H Karlsen"

100Publications

Second-line and Third-line therapy for Autoimmune Hepatitis A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group.

J Hepatol 2020 Jul 21. Epub 2020 Jul 21.

Department of Clinical Science, University of Bergen, Bergen, Norway; Norwegian PSC Research Centre, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; European Reference Network on Hepatological Diseases (ERN RARE-LIVER).

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http://dx.doi.org/10.1016/j.jhep.2020.07.023DOI Listing
July 2020

The 6 C's of primary sclerosing cholangitis.

J Hepatol 2020 Jul 7. Epub 2020 Jul 7.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.06.033DOI Listing
July 2020

Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

Authors:
David Ellinghaus Frauke Degenhardt Luis Bujanda Maria Buti Agustín Albillos Pietro Invernizzi Javier Fernández Daniele Prati Guido Baselli Rosanna Asselta Marit M Grimsrud Chiara Milani Fátima Aziz Jan Kässens Sandra May Mareike Wendorff Lars Wienbrandt Florian Uellendahl-Werth Tenghao Zheng Xiaoli Yi Raúl de Pablo Adolfo G Chercoles Adriana Palom Alba-Estela Garcia-Fernandez Francisco Rodriguez-Frias Alberto Zanella Alessandra Bandera Alessandro Protti Alessio Aghemo Ana Lleo Andrea Biondi Andrea Caballero-Garralda Andrea Gori Anja Tanck Anna Carreras Nolla Anna Latiano Anna Ludovica Fracanzani Anna Peschuck Antonio Julià Antonio Pesenti Antonio Voza David Jiménez Beatriz Mateos Beatriz Nafria Jimenez Carmen Quereda Cinzia Paccapelo Christoph Gassner Claudio Angelini Cristina Cea Aurora Solier David Pestaña Eduardo Muñiz-Diaz Elena Sandoval Elvezia M Paraboschi Enrique Navas Félix García Sánchez Ferruccio Ceriotti Filippo Martinelli-Boneschi Flora Peyvandi Francesco Blasi Luis Téllez Albert Blanco-Grau Georg Hemmrich-Stanisak Giacomo Grasselli Giorgio Costantino Giulia Cardamone Giuseppe Foti Serena Aneli Hayato Kurihara Hesham ElAbd Ilaria My Iván Galván-Femenia Javier Martín Jeanette Erdmann Jose Ferrusquía-Acosta Koldo Garcia-Etxebarria Laura Izquierdo-Sanchez Laura R Bettini Lauro Sumoy Leonardo Terranova Leticia Moreira Luigi Santoro Luigia Scudeller Francisco Mesonero Luisa Roade Malte C Rühlemann Marco Schaefer Maria Carrabba Mar Riveiro-Barciela Maria E Figuera Basso Maria G Valsecchi María Hernandez-Tejero Marialbert Acosta-Herrera Mariella D'Angiò Marina Baldini Marina Cazzaniga Martin Schulzky Maurizio Cecconi Michael Wittig Michele Ciccarelli Miguel Rodríguez-Gandía Monica Bocciolone Monica Miozzo Nicola Montano Nicole Braun Nicoletta Sacchi Nilda Martínez Onur Özer Orazio Palmieri Paola Faverio Paoletta Preatoni Paolo Bonfanti Paolo Omodei Paolo Tentorio Pedro Castro Pedro M Rodrigues Aaron Blandino Ortiz Rafael de Cid Ricard Ferrer Roberta Gualtierotti Rosa Nieto Siegfried Goerg Salvatore Badalamenti Sara Marsal Giuseppe Matullo Serena Pelusi Simonas Juzenas Stefano Aliberti Valter Monzani Victor Moreno Tanja Wesse Tobias L Lenz Tomas Pumarola Valeria Rimoldi Silvano Bosari Wolfgang Albrecht Wolfgang Peter Manuel Romero-Gómez Mauro D'Amato Stefano Duga Jesus M Banales Johannes R Hov Trine Folseraas Luca Valenti Andre Franke Tom H Karlsen

N Engl J Med 2020 Jun 17. Epub 2020 Jun 17.

From the Institute of Clinical Molecular Biology, Christian-Albrechts-University (D.E., F.D., J.K., S. May, M. Wendorff, L.W., F.U.-W., X.Y., A.T., A. Peschuck, C.G., G.H.-S., H.E.A., M.C.R., M.E.F.B., M. Schulzky, M. Wittig, N.B., S.J., T.W., W.A., M. D'Amato, A.F.), and University Hospital Schleswig-Holstein, Campus Kiel (N.B., A.F.), Kiel, the Institute for Cardiogenetics, University of Lübeck, Lübeck (J.E.), the German Research Center for Cardiovascular Research, partner site Hamburg-Lübeck-Kiel (J.E.), the University Heart Center Lübeck (J.E.), and the Institute of Transfusion Medicine, University Hospital Schleswig-Holstein (S.G.), Lübeck, Stefan-Morsch-Stiftung, Birkenfeld (M. Schaefer, W.P.), and the Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön (O.O., T.L.L.) - all in Germany; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (D.E.); the Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute-Donostia University Hospital-University of the Basque Country (L.B., K.G.-E., L.I.-S., P.M.R., J.M.B.), Osakidetza Basque Health Service, Donostialdea Integrated Health Organization, Clinical Biochemistry Department (A.G.C., B.N.J.), and the Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute (M. D'Amato), San Sebastian, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III (L.B., M. Buti, A. Albillos, A. Palom, F.R.-F., B.M., L. Téllez, K.G.-E., L.I.-S., F.M., L.R., M.R.-B., M. Rodríguez-Gandía, P.M.R., M. Romero-Gómez, J.M.B.), the Departments of Gastroenterology (A. Albillos, B.M., L. Téllez, F.M., M. Rodríguez-Gandía), Intensive Care (R.P., A.B.O.), Respiratory Diseases (D.J., A.S., R.N.), Infectious Diseases (C.Q., E.N.), and Anesthesiology (D. Pestaña, N. Martínez), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria, University of Alcalá, and Histocompatibilidad y Biologia Molecular, Centro de Transfusion de Madrid (F.G.S.), Madrid, the Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus (M. Buti, A. Palom, L.R., M.R.-B.), Hospital Clinic, University of Barcelona, and the August Pi i Sunyer Biomedical Research Institute (J.F., F.A., E.S., J.F.-A., L.M., M.H.-T., P.C.), the European Foundation for the Study of Chronic Liver Failure (J.F.), Vall d'Hebron Institut de Recerca (A. Palom, F.R.-F., A.J., S. Marsal), and the Departments of Biochemistry (A.-E.G.-F., F.R.-F., A.C.-G., C.C., A.B.-G.), Intensive Care (R.F.), and Microbiology (T.P.), University Hospital Vall d'Hebron, the Immunohematology Department, Banc de Sang i Teixits, Autonomous University of Barcelona (E.M.-D.), Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Consortium for Biomedical Research in Epidemiology and Public Health and University of Barcelona, l'Hospitalet (V. Moreno), and Autonoma University of Barcelona (T.P.), Barcelona, Universitat Autònoma de Barcelona, Bellatera (M. Buti, F.R.-F., M.R.-B.), GenomesForLife-GCAT Lab Group, Germans Trias i Pujol Research Institute (A.C.N., I.G.-F., R.C.), and High Content Genomics and Bioinformatics Unit, Germans Trias i Pujol Research Institute (L. Sumoy), Badalona, Institute of Parasitology and Biomedicine Lopez-Neyra, Granada (J.M., M.A.-H.), the Digestive Diseases Unit, Virgen del Rocio University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville (M. Romero-Gómez), and Ikerbasque, Basque Foundation for Science, Bilbao (M. D'Amato, J.M.B.) - all in Spain; the Division of Gastroenterology, Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milan Bicocca (P.I., C.M.), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (D. Prati, G.B., A.Z., A. Bandera, A.G., A.L.F., A. Pesenti, C.P., F.C., F.M.-B., F.P., F.B., G.G., G. Costantino, L. Terranova, L. Santoro, L. Scudeller, M. Carrabba, M. Baldini, M.M., N. Montano, R.G., S.P., S. Aliberti, V. Monzani, S. Bosari, L.V.), the Department of Biomedical Sciences, Humanitas University (R.A., A. Protti, A. Aghemo, A. Lleo, E.M.P., G. Cardamone, M. Cecconi, V.R., S.D.), Humanitas Clinical and Research Center, IRCCS (R.A., A. Protti, A. Aghemo, A. Lleo, A.V., C.A., E.M.P., H.K., I.M., M. Cecconi, M. Ciccarelli, M. Bocciolone, P.P., P.O., P.T., S. Badalamenti, S.D.), University of Milan (A.Z., A. Bandera, A.G., A.L.F., A. Pesenti, F.M.-B., F.P., F.B., G.G., G. Costantino, M.M., N. Montano, R.G., S.P., S. Aliberti, S. Bosari, L.V.), and the Center of Bioinformatics, Biostatistics, and Bioimaging (M.G.V.) and the Phase 1 Research Center (M. Cazzaniga), School of Medicine and Surgery, and the Departments of Emergency, Anesthesia, and Intensive Care (G.F.), Pneumologia (P.F.), and Infectious Diseases (P.B.); University of Milano-Bicocca, Milan, the European Reference Network on Hepatological Diseases (P.I., C.M.) and the Infectious Diseases Unit (P.B.), San Gerardo Hospital, Monza, the Pediatric Departement and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo (A. Biondi, L.R.B., M. D'Angiò), the Gastroenterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (A. Latiano, O.P.), the Department of Medical Sciences, Università degli Studi di Torino, Turin (S. Aneli, G.M.), and the Italian Bone Marrow Donor Registry, E.O. Ospedali Galliera, Genoa (N.S.) - all in Italy; the Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases, and Transplantation, and the Research Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases, and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo (M.M.G., J.R.H., T.F., T.H.K.), and the Section for Gastroenterology, Department of Transplantation Medicine, Division for Cancer Medicine, Surgery, and Transplantation, Oslo University Hospital Rikshospitalet (J.R.H., T.F., T.H.K.), Oslo; the School of Biological Sciences, Monash University, Clayton, VIC, Australia (T.Z., M. D'Amato); Private University in the Principality of Liechtenstein (C.G.); the Institute of Biotechnology, Vilnius University, Vilnius, Lithuania (S.J.); and the Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm (M. D'Amato).

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http://dx.doi.org/10.1056/NEJMoa2020283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315890PMC
June 2020

Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis.

Sci Rep 2019 06 11;9(1):8450. Epub 2019 Jun 11.

Norwegian PSC Research Center, Department of transplantation medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1038/s41598-019-44762-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559994PMC
June 2019

The dawn of a new EASL - A new chapter in the history of the European Association for the Study of the liver.

J Hepatol 2019 07 2;71(1):5-8. Epub 2019 May 2.

Centre for Liver Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; National Institute for Health Research, Liver Biomedical Research Unit at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham, Birmingham, United Kingdom; Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

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http://dx.doi.org/10.1016/j.jhep.2019.03.010DOI Listing
July 2019

Clinical Practice Guidelines of the European Association for the study of the Liver - Advancing methodology but preserving practicability.

J Hepatol 2019 01 9;70(1):5-7. Epub 2018 Nov 9.

Department of Gastroenterology, Metabolic Diseases and Intensive Care Medicine, University Hospital Aachen, Germany.

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http://dx.doi.org/10.1016/j.jhep.2018.10.011DOI Listing
January 2019

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis.

Liver Int 2019 02 24;39(2):371-381. Epub 2018 Oct 24.

Norwegian PSC Center, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://doi.wiley.com/10.1111/liv.13979
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http://dx.doi.org/10.1111/liv.13979DOI Listing
February 2019

Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease.

Hepatol Commun 2018 Aug 6;2(8):956-967. Epub 2018 Aug 6.

Centre for Liver Research and National Institute for Health Research Birmingham Biomedical Research Centre, Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom.

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http://dx.doi.org/10.1002/hep4.1200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078219PMC
August 2018

The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities.

Lancet 2018 08 27;392(10148):621-622. Epub 2018 Jul 27.

European Association for the Study of the Liver, Geneva, Switzerland.

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http://dx.doi.org/10.1016/S0140-6736(18)31734-3DOI Listing
August 2018

Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.

J Hepatol 2018 08 28;69(2):368-377. Epub 2018 Apr 28.

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria; Department of Internal Medicine, Medical University of Graz, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183201
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http://dx.doi.org/10.1016/j.jhep.2018.04.009DOI Listing
August 2018

«The times they are a'changin'» - Positioning the European Association for the Study of the Liver in the changing landscape of hepatology.

J Hepatol 2018 05 2;68(5):873-875. Epub 2018 Mar 2.

Department of Gastroenterology, Metabolic Diseases and Intensive Care Medicine, University Hospital Aachen, Germany.

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http://dx.doi.org/10.1016/j.jhep.2018.02.001DOI Listing
May 2018

The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts.

Semin Liver Dis 2017 11 22;37(4):314-331. Epub 2017 Dec 22.

Division of Surgery, Inflammatory Diseases and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center and Section of Gastroenterology, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1055/s-0037-1608801DOI Listing
November 2017

Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis.

Am J Pathol 2018 03 15;188(3):627-639. Epub 2017 Dec 15.

Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.ajpath.2017.11.010DOI Listing
March 2018

Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.

Inflamm Bowel Dis 2017 10;23(10):1752-1761

1Department of Clinical Science, University of Bergen, Bergen, Norway; 2Department of Pediatrics, Haukeland University Hospital, Bergen, Norway; 3Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway; 4K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 5Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; 6Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 7Department of Clinical Medicine, University of Bergen, Bergen, Norway; 8Department of Medicine, Haukeland University Hospital, Bergen, Norway; 9National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway; 10Department of Gastroenterology, Oslo University Hospital, Ullevål, Oslo, Norway; 11Max Planck Institute for Evolutionary Biology, Plön, Germany; 12Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Kiel, Germany; 13Department of Transplantation Medicine, Section of Gastroenterology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; and 14Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1097/MIB.0000000000001264DOI Listing
October 2017

Primary sclerosing cholangitis - a comprehensive review.

J Hepatol 2017 12 10;67(6):1298-1323. Epub 2017 Aug 10.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1016/j.jhep.2017.07.022DOI Listing
December 2017

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?

Gut 2017 11 21;66(11):1873-1877. Epub 2017 Jul 21.

Division of Gastroenterology and Hepatology and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1136/gutjnl-2017-314249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739855PMC
November 2017

Overview of methodologies for T-cell receptor repertoire analysis.

BMC Biotechnol 2017 07 10;17(1):61. Epub 2017 Jul 10.

Institute of Clinical Molecular Biology, Kiel University, Rosalind-Franklin-Str. 12, 24105, Kiel, Germany.

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http://dx.doi.org/10.1186/s12896-017-0379-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504616PMC
July 2017

Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome.

PLoS Comput Biol 2017 Jun 22;13(6):e1005361. Epub 2017 Jun 22.

Computational Systems Biology, Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1005361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480827PMC
June 2017

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

JAMA Neurol 2017 07;74(7):780-792

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany30Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1001/jamaneurol.2017.0469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710535PMC
July 2017

Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease.

Dig Dis 2017 3;35(4):323-333. Epub 2017 May 3.

Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, College of Medical and Dental Sciences, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1159/000456583DOI Listing
October 2017

Genetics of primary sclerosing cholangitis and pathophysiological implications.

Nat Rev Gastroenterol Hepatol 2017 05 15;14(5):279-295. Epub 2017 Mar 15.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Postbox 4950Nydalen, 0424 Oslo, Norway.

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http://dx.doi.org/10.1038/nrgastro.2016.154DOI Listing
May 2017

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Gastroenterology 2017 06 6;152(8):1975-1984.e8. Epub 2017 Mar 6.

Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546611PMC
June 2017

The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.

Physiol Rep 2017 Feb;5(4)

Norwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway

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http://dx.doi.org/10.14814/phy2.13117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328767PMC
February 2017

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice.

Hepatology 2017 08 19;66(2):542-554. Epub 2017 Jun 19.

Department of Gastroenterology & Hepatology and Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/hep.29029
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http://dx.doi.org/10.1002/hep.29029DOI Listing
August 2017

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Nat Genet 2017 Feb 19;49(2):269-273. Epub 2016 Dec 19.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540332PMC
February 2017

Liver transplantation in patients with primary antibody deficiency.

J Allergy Clin Immunol 2017 05 6;139(5):1708-1710.e2. Epub 2016 Dec 6.

Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.jaci.2016.10.025DOI Listing
May 2017

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease.

J Hepatol 2017 01 17;66(1):116-122. Epub 2016 Sep 17.

Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.09.002DOI Listing
January 2017

The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation.

J Hepatol 2017 02 5;66(2):382-389. Epub 2016 Oct 5.

Norwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Centre and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Division of Surgery, Inflammatory Medicine and Transplantation, Surgery, and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250551PMC
February 2017

Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis.

Liver Int 2017 03 13;37(3):458-465. Epub 2016 Sep 13.

Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1111/liv.13238DOI Listing
March 2017

Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway.

Transplant Direct 2015 Oct 19;1(9):e39. Epub 2015 Oct 19.

Division of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Section of Gastroenterology, Division of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1097/TXD.0000000000000548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946487PMC
October 2015

Primary sclerosing cholangitis: 50 years of a gut-liver relationship and still no love?

Authors:
Tom H Karlsen

Gut 2016 10 11;65(10):1579-81. Epub 2016 Jul 11.

Division of Surgery, Inflammatory Medicine and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway Faculty of Medicine, University of Oslo, Institute of Clinical Medicine, Norway Division of Surgery, Inflammatory Medicine and Transplantation, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1136/gutjnl-2016-312137DOI Listing
October 2016

Genetic Risk and the Development of Autoimmune Liver Disease.

Dig Dis 2015 7;33 Suppl 2:13-24. Epub 2015 Dec 7.

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http://dx.doi.org/10.1159/000440706DOI Listing
July 2016

Imputation of KIR Types from SNP Variation Data.

Am J Hum Genet 2015 Oct;97(4):593-607

Statistical Genetics, Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596914PMC
October 2015

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires.

Hepatology 2016 May 30;63(5):1608-19. Epub 2015 Sep 30.

Centre for Liver Research, National Institute for Health Research Birmingham Liver Biomedical Research Unit, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1002/hep.28116DOI Listing
May 2016

The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study.

PLoS One 2015 24;10(7):e0133804. Epub 2015 Jul 24.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine and K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514645PMC
May 2016

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis.

J Hepatol 2015 Nov 25;63(5):1220-8. Epub 2015 Jun 25.

Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.06.018DOI Listing
November 2015

Genetics of liver disease: From pathophysiology to clinical practice.

J Hepatol 2015 Apr;62(1 Suppl):S6-S14

Institute of Liver Studies, Division of Transplantation Immunology and Mucosal Biology, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jhep.2015.02.025DOI Listing
April 2015

Transplantation With Livers From Deceased Donors Older Than 75 Years.

Transplantation 2015 Dec;99(12):2534-42

1 Department of Transplantation Medicine, Section for Transplant Surgery, Oslo University Hospital, Oslo, Norway. 2 Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway. 3 Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Oslo, Norway. 4 Department of Transplantation, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden. 5 Division of Transplantation Surgery, Karolinska University Hospital Huddinge, Solna, Sweden. 6 Department of Surgical Sciences, Upper Abdominal Surgery, Uppsala Academic Hospital, Uppsala, Sweden. 7 Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland. 8 Department of Surgical Gastroenterology and Transplantation, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark. 9 Division of Cancer medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 10 Institute for Clinical Medicine, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1097/TP.0000000000000728DOI Listing
December 2015

Primary sclerosing cholangitis - the Norwegian experience.

Scand J Gastroenterol 2015 Jun 12;50(6):781-96. Epub 2015 Apr 12.

Norwegian PSC research center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet , Oslo , Norway.

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http://dx.doi.org/10.3109/00365521.2015.1028996DOI Listing
June 2015

The biliary epithelium presents antigens to and activates natural killer T cells.

Hepatology 2015 Oct 20;62(4):1249-59. Epub 2015 May 20.

Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1002/hep.27840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589438PMC
October 2015

Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.

PLoS One 2015 8;10(4):e0123057. Epub 2015 Apr 8.

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, United States of America; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA 92093, United States of America; Department of Radiology, University of California San Diego, La Jolla, CA 92093, United States of America; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390360PMC
March 2016

Rare variants at 16p11.2 are associated with common variable immunodeficiency.

J Allergy Clin Immunol 2015 Jun 10;135(6):1569-77. Epub 2015 Feb 10.

Center for Applied Genomics, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, Pa; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine Philadelphia, University of Pennsylvania, Philadelphia, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461447PMC
June 2015

Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis.

Gastroenterology 2015 May 2;148(5):924-927.e2. Epub 2015 Feb 2.

Norwegian Primary Sclerosing Cholangitis Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammation Research Centre, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.01.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409500PMC
May 2015

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.

PLoS One 2014 18;9(12):e114486. Epub 2014 Dec 18.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K.G Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Section for Gastroenterology, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270690PMC
December 2015

Differences in long-term survival among liver transplant recipients and the general population: a population-based Nordic study.

Hepatology 2015 Feb 5;61(2):668-77. Epub 2015 Jan 5.

Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland; Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/hep.27538DOI Listing
February 2015

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation.

World J Gastroenterol 2014 Apr;20(14):3986-4000

Bjarte Fosby, Sigrid Næss, Johannes R Hov, Kirsten M Boberg, Espen Melum, Tom H Karlsen, Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, N-0424 Oslo, Norway.

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http://dx.doi.org/10.3748/wjg.v20.i14.3986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983454PMC
April 2014

Genetics in PSC: what do the "risk genes" teach us?

Clin Rev Allergy Immunol 2015 Jun;48(2-3):154-64

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, 4950 Nydalen, 0424, Oslo, Norway.

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http://dx.doi.org/10.1007/s12016-014-8417-zDOI Listing
June 2015

Update on primary sclerosing cholangitis genetics.

Curr Opin Gastroenterol 2014 May;30(3):310-9

aDivision of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet bDivision of Cancer Medicine, Surgery and Transplantation, K.G. Jebsen Inflammation Research Centre, Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo cDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.

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http://dx.doi.org/10.1097/MOG.0000000000000052DOI Listing
May 2014

Characterization of animal models for primary sclerosing cholangitis (PSC).

J Hepatol 2014 Jun 19;60(6):1290-303. Epub 2014 Feb 19.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517670PMC
June 2014

Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease.

Liver Int 2014 Nov 7;34(10):1488-95. Epub 2014 Mar 7.

Division of Cancer Medicine, Surgery and Transplantation, Department of Transplantation Medicine, Norwegian PSC Research Center, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1111/liv.12492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128902PMC
November 2014

Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.

Hypertension 2014 Apr 6;63(4):819-26. Epub 2014 Jan 6.

Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Dr, Suite C101, La Jolla, CA 92037-0841. and Ole A. Andreassen, NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Ullevål, PO Box 4956 Nydalen, 0424 Oslo, Norway. Email

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.113.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984909PMC
April 2014

Novel insights into autoimmune liver diseases provided by genome-wide association studies.

J Autoimmun 2013 Oct 7;46:41-54. Epub 2013 Aug 7.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Cambridge, UK; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.jaut.2013.07.004DOI Listing
October 2013

Primary sclerosing cholangitis.

Lancet 2013 Nov 28;382(9904):1587-99. Epub 2013 Jun 28.

Centre for Liver Research, National Institute for Health Research Biomedical Research Unit, University of Birmingham, Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(13)60096-3DOI Listing
November 2013

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Nat Genet 2013 Jun 21;45(6):670-5. Epub 2013 Apr 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://petercroucher.com/wp-content/uploads/2013/10/51_Natur
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http://www.nature.com/doifinder/10.1038/ng.2616
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http://dx.doi.org/10.1038/ng.2616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667736PMC
June 2013

Update on primary sclerosing cholangitis.

J Hepatol 2013 Sep 18;59(3):571-82. Epub 2013 Apr 18.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278130019
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http://dx.doi.org/10.1016/j.jhep.2013.03.015DOI Listing
September 2013

The genetics of complex cholestatic disorders.

Gastroenterology 2013 Jun 10;144(7):1357-74. Epub 2013 Apr 10.

Centre for Liver Research, National Institute for Health Research Biomedical Research Unit, University of Birmingham, Birmingham, England.

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http://dx.doi.org/10.1053/j.gastro.2013.03.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705954PMC
June 2013

Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease.

Clin Gastroenterol Hepatol 2013 May 16;11(5):517-23. Epub 2013 Jan 16.

Section for Gastroenterology, Department of Transplantation Medicine, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1016/j.cgh.2012.12.027DOI Listing
May 2013

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

A lecture on the genetics of primary sclerosing cholangitis.

Authors:
Tom H Karlsen

Dig Dis 2012 11;30 Suppl 1:32-8. Epub 2012 Oct 11.

Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway. t.h.karlsen @ medisin.uio.no

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http://dx.doi.org/10.1159/000341122DOI Listing
May 2013

Genetics in primary sclerosing cholangitis.

Clin Res Hepatol Gastroenterol 2012 Aug 1;36(4):325-33. Epub 2012 May 1.

Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway.

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http://dx.doi.org/10.1016/j.clinre.2012.02.003DOI Listing
August 2012