Publications by authors named "Tom G Richardson"

36Publications

Common mechanisms for type 2 diabetes and psychosis: Findings from a prospective birth cohort.

Schizophr Res 2020 Aug 19. Epub 2020 Aug 19.

Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, England, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, England, UK.

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http://dx.doi.org/10.1016/j.schres.2020.08.006DOI Listing
August 2020

Characterizing the Causal Pathway for Genetic Variants Associated with Neurological Phenotypes Using Human Brain-Derived Proteome Data.

Am J Hum Genet 2020 06 14;106(6):885-892. Epub 2020 May 14.

Medical Research Council (MRC) Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273531PMC
June 2020

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.

BMJ 2020 May 6;369:m1203. Epub 2020 May 6.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1136/bmj.m1203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201936PMC
May 2020

The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study.

J Bone Miner Res 2020 Jul 12;35(7):1224-1235. Epub 2020 Mar 12.

Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.3989DOI Listing
July 2020

Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways.

Am J Hum Genet 2020 03 20;106(3):315-326. Epub 2020 Feb 20.

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058834PMC
March 2020

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.

Nat Commun 2020 01 10;11(1):185. Epub 2020 Jan 10.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-019-13921-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954187PMC
January 2020

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease.

Hum Mol Genet 2019 10;28(19):3293-3300

MRC Integrative Epidemiology Unit, Population Health Sciences Institute, University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1093/hmg/ddz155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859431PMC
October 2019

An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility.

Int J Epidemiol 2019 06;48(3):887-898

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyz119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659375PMC
June 2019

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 04 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478731PMC
April 2019

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome.

Elife 2019 03 5;8. Epub 2019 Mar 5.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.7554/eLife.43657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400585PMC
March 2019

Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of complex traits and disease.

Transl Psychiatry 2019 02 28;9(1):105. Epub 2019 Feb 28.

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41398-019-0437-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395652PMC
February 2019

Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization.

Genome Med 2019 01 31;11(1). Epub 2019 Jan 31.

MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1186/s13073-019-0613-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354354PMC
January 2019

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Authors:
Aldi T Kraja Chunyu Liu Jessica L Fetterman Mariaelisa Graff Christian Theil Have Charles Gu Lisa R Yanek Mary F Feitosa Dan E Arking Daniel I Chasman Kristin Young Symen Ligthart W David Hill Stefan Weiss Jian'an Luan Franco Giulianini Ruifang Li-Gao Fernando P Hartwig Shiow J Lin Lihua Wang Tom G Richardson Jie Yao Eliana P Fernandez Mohsen Ghanbari Mary K Wojczynski Wen-Jane Lee Maria Argos Sebastian M Armasu Ruteja A Barve Kathleen A Ryan Ping An Thomas J Baranski Suzette J Bielinski Donald W Bowden Ulrich Broeckel Kaare Christensen Audrey Y Chu Janie Corley Simon R Cox Andre G Uitterlinden Fernando Rivadeneira Cheryl D Cropp E Warwick Daw Diana van Heemst Lisa de Las Fuentes He Gao Ioanna Tzoulaki Tarunveer S Ahluwalia Renée de Mutsert Leslie S Emery A Mesut Erzurumluoglu James A Perry Mao Fu Nita G Forouhi Zhenglong Gu Yang Hai Sarah E Harris Gibran Hemani Steven C Hunt Marguerite R Irvin Anna E Jonsson Anne E Justice Nicola D Kerrison Nicholas B Larson Keng-Hung Lin Latisha D Love-Gregory Rasika A Mathias Joseph H Lee Matthias Nauck Raymond Noordam Ken K Ong James Pankow Amit Patki Alison Pattie Astrid Petersmann Qibin Qi Rasmus Ribel-Madsen Rebecca Rohde Kevin Sandow Theresia M Schnurr Tamar Sofer John M Starr Adele M Taylor Alexander Teumer Nicholas J Timpson Hugoline G de Haan Yujie Wang Peter E Weeke Christine Williams Hongsheng Wu Wei Yang Donglin Zeng Daniel R Witte Bruce S Weir Nicholas J Wareham Henrik Vestergaard Stephen T Turner Christian Torp-Pedersen Evie Stergiakouli Wayne Huey-Herng Sheu Frits R Rosendaal M Arfan Ikram Oscar H Franco Paul M Ridker Thomas T Perls Oluf Pedersen Ellen A Nohr Anne B Newman Allan Linneberg Claudia Langenberg Tuomas O Kilpeläinen Sharon L R Kardia Marit E Jørgensen Torben Jørgensen Thorkild I A Sørensen Georg Homuth Torben Hansen Mark O Goodarzi Ian J Deary Cramer Christensen Yii-Der Ida Chen Aravinda Chakravarti Ivan Brandslund Klaus Bonnelykke Kent D Taylor James G Wilson Santiago Rodriguez Gail Davies Bernardo L Horta Bharat Thyagarajan D C Rao Niels Grarup Victor G Davila-Roman Gavin Hudson Xiuqing Guo Donna K Arnett Caroline Hayward Dhananjay Vaidya Dennis O Mook-Kanamori Hemant K Tiwari Daniel Levy Ruth J F Loos Abbas Dehghan Paul Elliott Afshan N Malik Robert A Scott Diane M Becker Mariza de Andrade Michael A Province James B Meigs Jerome I Rotter Kari E North

Am J Hum Genet 2019 01 27;104(1):112-138. Epub 2018 Dec 27.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27516, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323610PMC
January 2019

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:
Ayush Giri Jacklyn N Hellwege Jacob M Keaton Jihwan Park Chengxiang Qiu Helen R Warren Eric S Torstenson Csaba P Kovesdy Yan V Sun Otis D Wilson Cassianne Robinson-Cohen Christianne L Roumie Cecilia P Chung Kelly A Birdwell Scott M Damrauer Scott L DuVall Derek Klarin Kelly Cho Yu Wang Evangelos Evangelou Claudia P Cabrera Louise V Wain Rojesh Shrestha Brian S Mautz Elvis A Akwo Muralidharan Sargurupremraj Stéphanie Debette Michael Boehnke Laura J Scott Jian'an Luan Jing-Hua Zhao Sara M Willems Sébastien Thériault Nabi Shah Christopher Oldmeadow Peter Almgren Ruifang Li-Gao Niek Verweij Thibaud S Boutin Massimo Mangino Ioanna Ntalla Elena Feofanova Praveen Surendran James P Cook Savita Karthikeyan Najim Lahrouchi Chunyu Liu Nuno Sepúlveda Tom G Richardson Aldi Kraja Philippe Amouyel Martin Farrall Neil R Poulter Markku Laakso Eleftheria Zeggini Peter Sever Robert A Scott Claudia Langenberg Nicholas J Wareham David Conen Colin Neil Alexander Palmer John Attia Daniel I Chasman Paul M Ridker Olle Melander Dennis Owen Mook-Kanamori Pim van der Harst Francesco Cucca David Schlessinger Caroline Hayward Tim D Spector Marjo-Riitta Jarvelin Branwen J Hennig Nicholas J Timpson Wei-Qi Wei Joshua C Smith Yaomin Xu Michael E Matheny Edward E Siew Cecilia Lindgren Karl-Heinz Herzig George Dedoussis Joshua C Denny Bruce M Psaty Joanna M M Howson Patricia B Munroe Christopher Newton-Cheh Mark J Caulfield Paul Elliott J Michael Gaziano John Concato Peter W F Wilson Philip S Tsao Digna R Velez Edwards Katalin Susztak Christopher J O'Donnell Adriana M Hung Todd L Edwards

Nat Genet 2019 01 21;51(1):51-62. Epub 2018 Dec 21.

Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.

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http://www.nature.com/articles/s41588-018-0303-9
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0303-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102PMC
January 2019

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.

J Autoimmun 2018 09 29;93:66-75. Epub 2018 Jun 29.

MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183020
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.06.005DOI Listing
September 2018

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

Hum Mol Genet 2018 09;27(18):3293-3304

MRC Integrative Epidemiology Unit (IEU), Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.

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http://dx.doi.org/10.1093/hmg/ddy210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121186PMC
September 2018

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.

Genes (Basel) 2018 Jan 22;9(1). Epub 2018 Jan 22.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.3390/genes9010045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793196PMC
January 2018

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk.

Am J Hum Genet 2017 Oct;101(4):590-602

MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1016/j.ajhg.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630190PMC
October 2017

A pathway-centric approach to rare variant association analysis.

Eur J Hum Genet 2016 01 31;25(1):123-129. Epub 2016 Aug 31.

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/ejhg.2016.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136291PMC
January 2016

Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.

Hum Mol Genet 2016 10 24;25(19):4339-4349. Epub 2016 Aug 24.

MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK

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http://dx.doi.org/10.1093/hmg/ddw283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291201PMC
October 2016

Incorporating Non-Coding Annotations into Rare Variant Analysis.

PLoS One 2016 29;11(4):e0154181. Epub 2016 Apr 29.

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851421PMC
March 2017

A Protein Domain and Family Based Approach to Rare Variant Association Analysis.

PLoS One 2016 29;11(4):e0153803. Epub 2016 Apr 29.

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153803PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851355PMC
February 2017

Identifying Highly Penetrant Disease Causal Mutations Using Next Generation Sequencing: Guide to Whole Process.

Biomed Res Int 2015 6;2015:923491. Epub 2015 Apr 6.

Bristol Genetic Epidemiology Laboratories (BGEL), School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK ; MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1155/2015/923491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461748PMC
March 2016

Structural and population-based evaluations of TBC1D1 p.Arg125Trp.

PLoS One 2013 7;8(5):e63897. Epub 2013 May 7.

Bristol Genetic Epidemiology Laboratories, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646766PMC
December 2013