Tom Donnem

Tom Donnem

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Tom Donnem

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Prognostic Value of Macrophage Phenotypes in Resectable Non-Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry.

Neoplasia 2019 03 10;21(3):282-293. Epub 2019 Feb 10.

Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway, 9019; Department of Oncology, University Hospital of North Norway, Tromsø, Norway, 9019. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369140PMC
March 2019

MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer.

Sci Rep 2019 Jan 23;9(1):386. Epub 2019 Jan 23.

Translational Cancer Research Group, Institute of Medical Biology, UiT The Arctic University of Norway, 9037, Tromsø, Norway.

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http://dx.doi.org/10.1038/s41598-018-36854-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344505PMC
January 2019

Evaluation of tumor-infiltrating lymphocytes using routine H&E slides predicts patient survival in resected non-small cell lung cancer.

Hum Pathol 2018 09 6;79:188-198. Epub 2018 Jun 6.

Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway, 9019; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway, 9019. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2018.05.017DOI Listing
September 2018

LAG-3 in Non-Small-cell Lung Cancer: Expression in Primary Tumors and Metastatic Lymph Nodes Is Associated With Improved Survival.

Clin Lung Cancer 2018 05 11;19(3):249-259.e2. Epub 2017 Dec 11.

Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway; Department of Oncology, University Hospital of North Norway, Tromso, Norway.

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http://dx.doi.org/10.1016/j.cllc.2017.12.001DOI Listing
May 2018

Non-angiogenic tumours and their influence on cancer biology.

Nat Rev Cancer 2018 05 9;18(5):323-336. Epub 2018 Mar 9.

Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1038/nrc.2018.14DOI Listing
May 2018

Corrigendum to "Prognostic relevance of estrogen receptor α, β and aromatase expression in non-small cell lung cancer" [Steroids 113 (2016) 5-13].

Steroids 2018 02 19;130:36-37. Epub 2017 Dec 19.

Department of Medical Biology, UiT - The Arctic University of Norway, 9037 Tromso, Norway; Department of Clinical Pathology, University Hospital of North Norway, 9037 Tromso, Norway.

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http://dx.doi.org/10.1016/j.steroids.2017.11.010DOI Listing
February 2018

Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort.

PLoS One 2017 15;12(11):e0186852. Epub 2017 Nov 15.

Translational Cancer Research Group, Department of Medical Biology, UiT The Arctic University of Norway, Tromso, North Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186852PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687762PMC
December 2017

Assessing PDL-1 and PD-1 in Non-Small Cell Lung Cancer: A Novel Immunoscore Approach.

Clin Lung Cancer 2017 03 5;18(2):220-233.e8. Epub 2016 Oct 5.

Department of Oncology, University Hospital of North Norway, Tromso, Norway; Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.

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http://dx.doi.org/10.1016/j.cllc.2016.09.009DOI Listing
March 2017

Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer.

Oncotarget 2016 11;7(44):72184-72196

Department of Clinical Medicine, University of Tromsø, The Arctic University of Norway, N-9037 Tromso, Norway.

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http://dx.doi.org/10.18632/oncotarget.12360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342153PMC
November 2016

Prognostic relevance of estrogen receptor α, β and aromatase expression in non-small cell lung cancer.

Steroids 2016 09 24;113:5-13. Epub 2016 May 24.

Department of Medical Biology, UiT - The Arctic University of Norway, 9037 Tromso, Norway; Department of Clinical Pathology, University Hospital of North Norway, 9037 Tromso, Norway.

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http://dx.doi.org/10.1016/j.steroids.2016.05.008DOI Listing
September 2016

The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non-Small Cell Lung Cancer.

J Thorac Oncol 2016 06 1;11(6):789-800. Epub 2016 Feb 1.

Institute of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway; Department of Oncology, University Hospital of Northern Norway, Tromsø, Norway.

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http://dx.doi.org/10.1016/j.jtho.2016.01.015DOI Listing
June 2016

Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis.

PLoS One 2015 25;10(8):e0132481. Epub 2015 Aug 25.

Department of Oncology, University Hospital of North Norway, Tromso, Norway; Institute of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549062PMC
May 2016

Importance of tumor infiltrating lymphocytes in non-small cell lung cancer?

Ann Transl Med 2016 Apr;4(7):142

1 Institute of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway ; 2 Department of Oncology, University Hospital of Northern Norway, Tromsø, Norway ; 3 Institute of Medical Biology, The Arctic University of Norway, Tromsø, Norway ; 4 Department of Pathology, University Hospital of Northern Norway, Tromsø, Norway.

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http://dx.doi.org/10.21037/atm.2016.03.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842396PMC
April 2016

Stromal expression of MiR-21 predicts biochemical failure in prostate cancer patients with Gleason score 6.

PLoS One 2014 17;9(11):e113039. Epub 2014 Nov 17.

Department of Medical Biology, UIT The Arctic University of Norway, Tromsø, Norway; Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113039PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234532PMC
January 2016

High progesterone receptor expression in prostate cancer is associated with clinical failure.

PLoS One 2015 27;10(2):e0116691. Epub 2015 Feb 27.

Dept. of Medical Biology, UiT - The Arctic University of Norway, Tromso, Norway; Dept. of Clinical Pathology, University Hospital of North Norway, Tromso, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344236PMC
November 2015

CD45RO(+) Memory T Lymphocytes--a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer.

Neoplasia 2015 Nov;17(11):839-48

Department of Oncology, University Hospital of North Norway, Mailbox 100, N-9038 Tromso, Norway; Department of Clinical Medicine, UiT The Arctic University of Norway, Mailbox 6050 Langnes, N-9037 Tromso, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681889PMC
November 2015

The prognostic significance of CXCL16 and its receptor C-X-C chemokine receptor 6 in prostate cancer.

Am J Pathol 2015 Oct 10;185(10):2722-30. Epub 2015 Aug 10.

Department of Medical Biology, UiT The Arctic University of Norway, Tromsø, Norway; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway.

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http://dx.doi.org/10.1016/j.ajpath.2015.06.013DOI Listing
October 2015

Organized metabolic crime in prostate cancer: The coexpression of MCT1 in tumor and MCT4 in stroma is an independent prognosticator for biochemical failure.

Urol Oncol 2015 Aug 8;33(8):338.e9-17. Epub 2015 Jun 8.

Department of Clinical Medicine, Translational Cancer Research Group, The Arctic University of Norway, Tromso, Norway; Department of Oncology, University Hospital of North Norway, Tromso.

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http://dx.doi.org/10.1016/j.urolonc.2015.05.013DOI Listing
August 2015

The prognostic role of progesterone receptor expression in non-small cell lung cancer patients: Gender-related impacts and correlation with disease-specific survival.

Steroids 2015 Jun 7;98:29-36. Epub 2015 Feb 7.

Department of Medical Biology, University of Tromso, 9037 Tromso, Norway; Department of Clinical Pathology, University Hospital of North Norway, 9037 Tromso, Norway.

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http://dx.doi.org/10.1016/j.steroids.2015.01.020DOI Listing
June 2015

Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer.

Clin Cancer Res 2015 Jun 13;21(11):2635-43. Epub 2015 Feb 13.

Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway. Institute of Medical Biology, The Arctic University of Norway, Tromso, Norway.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1905DOI Listing
June 2015

Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival.

PLoS One 2014 16;9(9):e105038. Epub 2014 Sep 16.

Department of Clinical Medicine, University of Tromso, Tromso, Norway; Department of Oncology, University Hospital of North Norway, Tromso, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105038PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165596PMC
May 2015

Infiltration of CD8+ lymphocytes is an independent prognostic factor of biochemical failure-free survival in prostate cancer.

Prostate 2014 Oct 11;74(14):1452-61. Epub 2014 Aug 11.

Institute of Medical Biology, UiT The Arctic University of Norway, Tromso.

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http://dx.doi.org/10.1002/pros.22862DOI Listing
October 2014

Positive prognostic impact of miR-210 in non-small cell lung cancer.

Lung Cancer 2014 Feb 14;83(2):272-8. Epub 2013 Nov 14.

Department of Clinical Medicine, University of Tromso, Norway; Department of Oncology, University Hospital of North Norway, Tromso, Norway.

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http://dx.doi.org/10.1016/j.lungcan.2013.11.005DOI Listing
February 2014

Stage and tissue-specific prognostic impact of miR-182 in NSCLC.

BMC Cancer 2014 Feb 27;14:138. Epub 2014 Feb 27.

Institute of Clinical Medicine, University of Tromso, Tromso, Norway.

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http://dx.doi.org/10.1186/1471-2407-14-138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996062PMC
February 2014

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

Cancer Med 2013 Aug 8;2(4):427-36. Epub 2013 Jul 8.

Department of Oncology, University Hospital of North Norway Tromso, Norway ; Institute of Clinical Medicine, University of Tromso Tromso, Norway.

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http://dx.doi.org/10.1002/cam4.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799277PMC
August 2013

Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas.

BMC Clin Pathol 2013 Mar 15;13. Epub 2013 Mar 15.

Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway.

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http://dx.doi.org/10.1186/1472-6890-13-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602168PMC
March 2013

Sudden death by an atrial-esophageal fistulae.

J Thorac Oncol 2013 Feb;8(2):254

Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.

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http://dx.doi.org/10.1097/JTO.0b013e31827ce3a9DOI Listing
February 2013

In NSCLC, VEGF-A response to hypoxia may differ between squamous cell and adenocarcinoma histology.

Anticancer Res 2012 Nov;32(11):4729-36

Department of Clinical Medicine, University of Tromso, Norway.

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November 2012

Prognostic impacts of hypoxic markers in soft tissue sarcoma.

Sarcoma 2012 20;2012:541650. Epub 2012 Feb 20.

Institute of Clinical Medicine, University of Tromso, 9037 Tromso, Norway.

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http://dx.doi.org/10.1155/2012/541650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289941PMC
August 2012

High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator.

Oncoimmunology 2012 Jan;1(1):75-77

Dept. of Clinical Pathology, University Hospital of North Norway; Tromso, Norway ; Institute of Medical Biology, University of Tromso; Tromso, Norway.

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http://dx.doi.org/10.4161/onci.1.1.17825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376973PMC
January 2012

Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients.

J Transl Med 2011 Jul 6;9:104. Epub 2011 Jul 6.

Institute of Medical Biology, University of Tromso, PB 9037, Tromso, Norway.

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http://dx.doi.org/10.1186/1479-5876-9-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141498PMC
July 2011

Diverging prognostic impacts of hypoxic markers according to NSCLC histology.

Lung Cancer 2011 Jun 13;72(3):294-302. Epub 2010 Nov 13.

Institute of Clinical Medicine, University of Tromso, Norway.

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http://dx.doi.org/10.1016/j.lungcan.2010.10.006DOI Listing
June 2011

Correlation and coexpression of HIFs and NOTCH markers in NSCLC.

Anticancer Res 2011 May;31(5):1603-6

Institute of Clinical Medicine, University of Tromso, Norway.

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May 2011

Estrogen receptor and progesterone receptor are prognostic factors in soft tissue sarcomas.

Int J Oncol 2011 Apr 24;38(4):1031-40. Epub 2011 Jan 24.

Department of Clinical Pathology, University Hospital of Northern Norway, 9038 Tromsø, Norway.

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http://dx.doi.org/10.3892/ijo.2011.920DOI Listing
April 2011

Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size.

Clin Lung Cancer 2011 Mar 11;12(2):106-15. Epub 2011 Apr 11.

Department of Oncology, University Hospital of North Norway, Tromso.

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http://dx.doi.org/10.1016/j.cllc.2011.03.005DOI Listing
March 2011

Prognostic impact of lymphocytes in soft tissue sarcomas.

PLoS One 2011 Jan 27;6(1):e14611. Epub 2011 Jan 27.

Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014611PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029277PMC
January 2011

Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis.

PLoS One 2010 Dec 14;5(12):e15368. Epub 2010 Dec 14.

Institute of Medical Biology, University of Tromso, and Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001883PMC
December 2010

Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer.

Anticancer Res 2009 Oct;29(10):4175-83

Institute of Medical Biology, University of Tromso, Norway.

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October 2009

The prognostic value of intraepithelial and stromal innate immune system cells in non-small cell lung carcinoma.

Histopathology 2009 Sep;55(3):301-12

Department of Pathology, Nordland Central Hospital, Bodo 8092, Norway.

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http://dx.doi.org/10.1111/j.1365-2559.2009.03379.xDOI Listing
September 2009

Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells.

J Thorac Oncol 2008 Sep;3(9):963-70

Institute of Clinical Medicine, University of Tromso, Norway.

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http://dx.doi.org/10.1097/JTO.0b013e3181834f52DOI Listing
September 2008

Prognostic effect of epithelial and stromal lymphocyte infiltration in non-small cell lung cancer.

Clin Cancer Res 2008 Aug;14(16):5220-7

Department of Pathology, Nordland Central Hospital, Bodø, Norway.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0133DOI Listing
August 2008

Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer.

Clin Cancer Res 2007 Nov;13(22 Pt 1):6649-57

Institute of Clinical Medicine, University of Tromsö, University Hospital of Northern Norway, Tromsö, Norway.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-0414DOI Listing
November 2007