Publications by authors named "Todd M Pitts"

59Publications

Bitter melon juice intake with gemcitabine intervention circumvents resistance to gemcitabine in pancreatic patient-derived xenograft tumors.

Mol Carcinog 2020 10 20;59(10):1227-1240. Epub 2020 Aug 20.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1002/mc.23251DOI Listing
October 2020

First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.

Mol Cancer Ther 2020 08 4;19(8):1598-1612. Epub 2020 Jun 4.

The Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1158/1535-7163.MCT-20-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665848PMC
August 2020

Structure, dynamics and function of the evolutionarily changing biliverdin reductase B family.

J Biochem 2020 Aug;168(2):191-202

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, 12801 E 17th Ave., Aurora, CO 80045, USA.

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http://dx.doi.org/10.1093/jb/mvaa039DOI Listing
August 2020

Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer.

Cancers (Basel) 2020 Mar 19;12(3). Epub 2020 Mar 19.

Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO 80045, USA.

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http://dx.doi.org/10.3390/cancers12030719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140086PMC
March 2020

Targeting PDZ-binding kinase is anti-tumorigenic in novel preclinical models of ACC.

Endocr Relat Cancer 2019 10;26(10):765-778

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1530/ERC-19-0262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938568PMC
October 2019

Biliverdin Reductase B Dynamics Are Coupled to Coenzyme Binding.

J Mol Biol 2018 09 20;430(18 Pt B):3234-3250. Epub 2018 Jun 20.

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431292PMC
September 2018

Procedure for Horizontal Transfer of Patient-Derived Xenograft Tumors to Eliminate .

J Am Assoc Lab Anim Sci 2017 Mar;56(2):166-172

Office of Laboratory Animal Resources, Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361042PMC
March 2017

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.

Front Pharmacol 2015 16;6:120. Epub 2015 Jun 16.

Division of Medical Oncology, Department of Internal Medicine, University of Colorado Anschutz Medical Campus Aurora, CO, USA ; University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus Aurora, CO, USA.

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http://dx.doi.org/10.3389/fphar.2015.00120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468631PMC
July 2015

Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.

PLoS One 2014 17;9(11):e113037. Epub 2014 Nov 17.

Division of Medical Oncology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States of America; University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113037PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234626PMC
January 2016

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.

Int J Cancer 2015 Apr 29;136(8):1967-75. Epub 2014 Sep 29.

Division of Medical Oncology, University of Colorado Denver and University of Colorado Cancer Center, Aurora, CO; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea.

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http://dx.doi.org/10.1002/ijc.29225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323738PMC
April 2015

Targeting nuclear kinases in cancer: development of cell cycle kinase inhibitors.

Pharmacol Ther 2014 May 19;142(2):258-69. Epub 2013 Dec 19.

Department of Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, United States; University of Colorado Cancer Center, University of Colorado Denver, Anschutz Medical Campus, United States.

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http://dx.doi.org/10.1016/j.pharmthera.2013.12.010DOI Listing
May 2014

Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.

Clin Cancer Res 2013 Nov 17;19(22):6219-29. Epub 2013 Sep 17.

Authors' Affiliations: Division of Medical Oncology and Department of Pathology, University of Colorado at Denver, Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843359PMC
November 2013

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer.

Front Pharmacol 2013 22;4:22. Epub 2013 Mar 22.

Pfizer Global Research and Development La Jolla, CA, USA ; Department of Pharmaceutical Sciences, University of Colorado Denver Aurora, CO, USA ; University of Colorado Cancer Center, University of Colorado Denver Aurora, CO, USA.

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http://dx.doi.org/10.3389/fphar.2013.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605511PMC
March 2013

Patient-derived tumour xenografts as models for oncology drug development.

Nat Rev Clin Oncol 2012 Apr 17;9(6):338-50. Epub 2012 Apr 17.

Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrclinonc.2012.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928688PMC
April 2012

Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.

Clin Cancer Res 2012 Feb 15;18(4):1051-62. Epub 2011 Dec 15.

Division of Medical Oncology, Department of Anesthesiology and Radiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876277PMC
February 2012

Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models.

Mol Cancer Ther 2009 Feb 27;8(2):342-9. Epub 2009 Jan 27.

Division of Medical Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813767PMC
February 2009

Activation of gene expression in human neutrophils by high mobility group box 1 protein.

Am J Physiol Cell Physiol 2003 Apr;284(4):C870-9

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1152/ajpcell.00322.2002DOI Listing
April 2003

Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis.

Cell Signal 2003 Feb;15(2):225-33

Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/s0898-6568(02)00063-3DOI Listing
February 2003

Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia.

J Leukoc Biol 2002 Sep;72(3):571-9

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA.

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September 2002