Todd E Golde

Todd E Golde

UNVERIFIED PROFILE

Are you Todd E Golde?   Register this Author

Register author
Todd E Golde

Todd E Golde

Publications by authors named "Todd E Golde"

Are you Todd E Golde?   Register this Author

100Publications

2432Reads

22Profile Views

Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.

Front Immunol 2018 4;9:1288. Epub 2018 Jun 4.

Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.01288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994797PMC
August 2019

MAPT mutations, tauopathy, and mechanisms of neurodegeneration.

Lab Invest 2019 Jul 11;99(7):912-928. Epub 2019 Feb 11.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41374-019-0197-xDOI Listing
July 2019

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

J Biol Chem 2019 Jul 5;294(29):11276-11285. Epub 2019 Jun 5.

Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA119.008041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643044PMC
July 2019

Designing antibodies against LRRK2-targeted tau epitopes.

PLoS One 2018 27;13(9):e0204367. Epub 2018 Sep 27.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204367PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160062PMC
March 2019

Harnessing Immunoproteostasis to Treat Neurodegenerative Disorders.

Authors:
Todd E Golde

Neuron 2019 Mar;101(6):1003-1015

McKnight Brain Institute, Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience and Neurology, University of Florida, Gainesville, FL 32607, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2019.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594693PMC
March 2019

Phosphorylation of serine 305 in tau inhibits aggregation.

Neurosci Lett 2019 01 10;692:187-192. Epub 2018 Nov 10.

Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043940183077
Publisher Site
http://dx.doi.org/10.1016/j.neulet.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351168PMC
January 2019

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration.

Neurobiol Dis 2018 12 6;120:98-106. Epub 2018 Sep 6.

Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190709PMC
December 2018

Alzheimer's disease: The right drug, the right time.

Science 2018 12;362(6420):1250-1251

Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aau0437DOI Listing
December 2018

High-affinity interactions and signal transduction between Aβ oligomers and TREM2.

EMBO Mol Med 2018 11;10(11)

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/emmm.201809027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220267PMC
November 2018

Challenges in Passive Immunization Strategies to Treat Parkinson Disease.

JAMA Neurol 2018 Oct;75(10):1180-1181

McKnight Brain Institute, Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2018.0346DOI Listing
October 2018

Animal models of neurodegenerative diseases.

Nat Neurosci 2018 10 24;21(10):1370-1379. Epub 2018 Sep 24.

Department of Neurology, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41593-018-0236-8
Publisher Site
http://dx.doi.org/10.1038/s41593-018-0236-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615039PMC
October 2018

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.

PLoS One 2018 2;13(4):e0195211. Epub 2018 Apr 2.

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880389PMC
July 2018

Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29.

Mol Immunol 2018 07 26;99:191-198. Epub 2018 May 26.

Graduate Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA, 01003, United States; Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, 01003, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01615890183014
Publisher Site
http://dx.doi.org/10.1016/j.molimm.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281167PMC
July 2018

Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage.

J Cereb Blood Flow Metab 2018 06 19;38(6):1032-1046. Epub 2016 Nov 19.

1 Department of Anesthesiology, University of Florida, Gainesville, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0271678X16679170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999006PMC
June 2018

Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration.

Neurobiol Dis 2018 02 28;110:133-141. Epub 2017 Nov 28.

Center for Translational Research in Neurodegenerative Diseases, University of Florida, Gainesville, FL 32610, United States; Department of Neuroscience, University of Florida, Gainesville, FL 32610, United States; McKnight Brain Institute, University of Florida, Gainesville, FL 32610, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2017.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748010PMC
February 2018

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.

PLoS One 2017 14;12(9):e0184731. Epub 2017 Sep 14.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, Florida, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184731PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599040PMC
October 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

EMBO Mol Med 2017 07;9(7):950-966

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/emmm.201607265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494507PMC
July 2017

Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy?

JAMA Neurol 2017 07;74(7):769-770

Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville3McKnight Brain Institute, University of Florida, Gainesville4Department of Neuroscience, College of Medicine, University of Florida, Gainesville.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2017.0843DOI Listing
July 2017

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau.

Acta Neuropathol Commun 2017 07 31;5(1):58. Epub 2017 Jul 31.

Department of Neuroscience, College of Medicine University of Florida, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-017-0458-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537986PMC
July 2017

Targeting psychologic stress signaling pathways in Alzheimer's disease.

Mol Neurodegener 2017 06 21;12(1):49. Epub 2017 Jun 21.

Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-017-0190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479037PMC
June 2017

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.

Mol Neurodegener 2017 05 29;12(1):40. Epub 2017 May 29.

Department of Neuroscience, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-017-0182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447308PMC
May 2017

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.

J Neurochem 2017 02 19;140(4):662-678. Epub 2016 Aug 19.

Department of Neuroscience, College of Medicine University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452425PMC
February 2017

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.

Mol Neurodegener 2017 01 3;12(1). Epub 2017 Jan 3.

Department of Neuroscience, University of Florida, Gainesville, Florida, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-016-0142-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210310PMC
January 2017

Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies.

Authors:
Todd E Golde

J Neurochem 2016 10 4;139 Suppl 2:224-236. Epub 2016 May 4.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13583DOI Listing
October 2016

Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice.

Biochem Biophys Res Commun 2016 09 15;478(1):286-292. Epub 2016 Jul 15.

Department of Neurosciences, University of California, San Diego, CA 92037, USA; Departments of Medicine and Physiology, National University of Singapore, Yong Loo Lin School of Medicine, Singapore, 117597, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2016.07.015DOI Listing
September 2016

Alzheimer disease: Host immune defence, amyloid-β peptide and Alzheimer disease.

Authors:
Todd E Golde

Nat Rev Neurol 2016 08 15;12(8):433-4. Epub 2016 Jul 15.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brian Institute, College of Medicine, University of Florida, 1275 Center Drive, BMS J-497, Gainesville, Florida 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2016.105DOI Listing
August 2016

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.

Proc Natl Acad Sci U S A 2016 08 16;113(35):E5212-21. Epub 2016 Aug 16.

Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32611; Department of Neuroscience, Center for Translational Research on Neurodegenerative Diseases, University of Florida, Gainesville, FL 32611; Genetics Institute, University of Florida, Gainesville, FL 32611

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1608045113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024614PMC
August 2016

Microglia-specific targeting by novel capsid-modified AAV6 vectors.

Mol Ther Methods Clin Dev 2016 13;3:16026. Epub 2016 Apr 13.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida , Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtm.2016.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909093PMC
June 2016

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans.

Alzheimers Res Ther 2015 5;7(1):55. Epub 2015 Aug 5.

Department of Neurosciences, University of California, La Jolla, San Diego, CA USA ; Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://alzres.com/content/7/1/55
Publisher Site
http://dx.doi.org/10.1186/s13195-015-0137-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523931PMC
May 2016

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.

PLoS One 2015 5;10(6):e0128619. Epub 2015 Jun 5.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, Florida, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457840PMC
March 2016

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

PLoS One 2014 28;9(10):e111553. Epub 2014 Oct 28.

Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, Florida, United States of America; Department of Neuroscience, University of Florida, Gainesville, Florida, United States of America; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211736PMC
January 2016

Re-Opening the Critical Window for Estrogen Therapy.

J Neurosci 2015 Dec;35(49):16077-93

Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1890-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682778PMC
December 2015

Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease.

Hum Mol Genet 2015 Nov 7;24(21):6093-105. Epub 2015 Aug 7.

Department of Neurology, McKnight Brain Institute, Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease and Genetics Institute, University of Florida, Gainesville, FL 32611, USA

View Article

Download full-text PDF

Source
http://hmg.oxfordjournals.org/content/early/2015/08/26/hmg.d
Web Search
http://dx.doi.org/10.1093/hmg/ddv321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599669PMC
November 2015

Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.

Acta Neuropathol Commun 2015 Nov 14;3:72. Epub 2015 Nov 14.

Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-015-0252-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644287PMC
November 2015

IFN-γ promotes τ phosphorylation without affecting mature tangles.

FASEB J 2015 Oct 8;29(10):4384-98. Epub 2015 Jul 8.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.15-275834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137542PMC
October 2015

Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission.

Acta Neuropathol 2015 08 16;130(2):303-5. Epub 2015 May 16.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Diseases, University of Florida, Gainesville, FL, 32610, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-015-1444-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652651PMC
August 2015

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.

Mol Neurodegener 2015 Jul 8;10:25. Epub 2015 Jul 8.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-015-0026-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495639PMC
July 2015

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Mol Neurodegener 2015 Jul 30;10:32. Epub 2015 Jul 30.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Drive, Room BMS J-483, PO Box 100159, Gainesville, FL, 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13024-015-0029-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520273PMC
July 2015

The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.

EMBO J 2015 Jun 11;34(12):1674-86. Epub 2015 May 11.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201488795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475401PMC
June 2015

Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study.

Neurobiol Aging 2015 Feb 31;36(2):1097-104. Epub 2014 Oct 31.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315708PMC
February 2015

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

Mol Ther 2015 Jan 17;23(1):53-62. Epub 2014 Sep 17.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2014.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426802PMC
January 2015

Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein.

J Neurochem 2014 Dec 21;131(6):859-67. Epub 2014 Jul 21.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.12806DOI Listing
December 2014

Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.

J Neurosci 2014 Sep;34(37):12368-78

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, Florida 32610, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2102-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615494PMC
September 2014

Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction.

J Vis Exp 2014 Sep 15(91):51863. Epub 2014 Sep 15.

Department of Neuroscience, Baylor College of Medicine; Department of Neurology and Department of Neurosurgery, Baylor College of Medicine;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/51863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199253PMC
September 2014

Open questions for Alzheimer's disease immunotherapy.

Authors:
Todd E Golde

Alzheimers Res Ther 2014 7;6(1). Epub 2014 Jan 7.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056616PMC
August 2014

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

Proc Natl Acad Sci U S A 2014 Jul 7;111(29):10732-7. Epub 2014 Jul 7.

Department of Neuroscience,Center for Translational Research in Neurodegenerative Disease, andMcKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1321785111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115570PMC
July 2014

Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems.

Alzheimers Res Ther 2013 7;5(2):10. Epub 2013 Mar 7.

Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive, BMS J-497, P.O. Box 100159, Gainesville, FL32610-0159, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706797PMC
June 2014

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease.

Alzheimers Res Ther 2013 21;5(3):24. Epub 2013 May 21.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706774PMC
June 2014

NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome.

Front Immunol 2014 26;5:249. Epub 2014 May 26.

Program in Molecular and Cellular Biology, University of Massachusetts/Amherst , Amherst, MA , USA ; Department of Veterinary and Animal Sciences, University of Massachusetts/Amherst , Amherst, MA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2014.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033603PMC
June 2014

Progress in Alzheimer's disease research circa 2013: Is the glass half empty or half full?

Alzheimers Res Ther 2013 29;5(3):26. Epub 2013 May 29.

Department of Neurology and Alzheimer Center, VU University Medical Center and Neuroscience Campus Amsterdam, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706787PMC
May 2014

Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.

Biochemistry 2014 Apr 20;53(12):1947-57. Epub 2014 Mar 20.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, and McKnight Brain Institute, College of Medicine, University of Florida , Gainesville, Florida 32603, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi401521tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985764PMC
April 2014

Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.

Front Immunol 2014 12;5:54. Epub 2014 Feb 12.

Program in Molecular and Cellular Biology, University of Massachusetts Amherst , Amherst, MA , USA ; Department of Veterinary and Animal Sciences, University of Massachusetts Amherst , Amherst, MA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2014.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921607PMC
March 2014

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

J Neurosci 2014 Mar;34(11):3826-40

Department of Neuroscience, Department of Neurology, Department of Molecular and Cellular Biology, Department of Human and Molecular Genetics, Department of Neurosurgery, the Jan and Dan Duncan Neurological Research Institute, and the Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 77030, Texas A&M Health Science Center, College Station, Texas 77843, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, Department of Computational and Applied Mathematics, Rice University, Houston, Texas 77251, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, and Department of Neuroscience, University of Florida, Gainesville, Florida 32610.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.5171-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951689PMC
March 2014

Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain.

PLoS One 2013 25;8(6):e67680. Epub 2013 Jun 25.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067680PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692458PMC
February 2014

γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.

J Biol Chem 2014 Feb 18;289(6):3276-87. Epub 2013 Dec 18.

From the Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, Florida 32610 and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.512921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916530PMC
February 2014

γ-Secretase inhibitors and modulators.

Biochim Biophys Acta 2013 Dec 17;1828(12):2898-907. Epub 2013 Jun 17.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857966PMC
December 2013

Anti-tau antibodies: hitting the target.

Neuron 2013 Oct;80(2):254-6

Departments of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease and McKnight Brain Institute, College of Medicine University of Florida, Gainesville, FL 32610, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2013.10.009DOI Listing
October 2013

Steroids as γ-secretase modulators.

FASEB J 2013 Sep 28;27(9):3775-85. Epub 2013 May 28.

Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.12-225649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752532PMC
September 2013

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.

Brain Res 2013 Aug 15;1524:62-73. Epub 2013 Jun 15.

Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2013.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914001PMC
August 2013

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.

Acta Neuropathol 2013 Jul 11;126(1):39-50. Epub 2013 May 11.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, 1275 Center Drive, BMS Building J-483, PO Box 100159, Gainesville, FL 32610-0244, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-013-1123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690181PMC
July 2013

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein.

Acta Neuropathol Commun 2013 Jul 17;1:38. Epub 2013 Jul 17.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, BMS Building J-483, University of Florida College of Medicine, 1275 Center Drive, PO Box 100159, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://actaneurocomms.biomedcentral.com/articles/10.1186/205
Publisher Site
http://dx.doi.org/10.1186/2051-5960-1-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893388PMC
July 2013

Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model.

PLoS One 2012 7;7(12):e50750. Epub 2012 Dec 7.

Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050750PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517621PMC
May 2013

Thinking laterally about neurodegenerative proteinopathies.

J Clin Invest 2013 May 1;123(5):1847-55. Epub 2013 May 1.

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI66029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635732PMC
May 2013

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

Science 2013 May;340(6135):924-d

Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, 1275 Center Drive, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1234089DOI Listing
May 2013

Conformational templating of α-synuclein aggregates in neuronal-glial cultures.

Mol Neurodegener 2013 May 28;8:17. Epub 2013 May 28.

Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-1326-8-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671973PMC
May 2013