Todd C Skaar

Todd C Skaar

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Todd C Skaar

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Influence of Uridine Diphosphate Glucuronosyltransferase Family 1 Member A1 and Solute Carrier Organic Anion Transporter Family 1 Member B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers.

Drug Metab Dispos 2020 Mar 30;48(3):169-175. Epub 2019 Dec 30.

Department of Medicine, Division of Clinical Pharmacology (K.S.C., I.F.M., B.T.G., J.L., T.C.S., Z.D.), and Department of Medical and Molecular Genetics (E.B.M., V.M.P.), Indiana University School of Medicine, Indianapolis, Indiana

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http://dx.doi.org/10.1124/dmd.119.089052DOI Listing
March 2020

Nephrotoxicity in a Patient With Inadequate Pain Control: Potential Role of Pharmacogenetic Testing for Cytochrome P450 2D6 and Apolipoprotein L1.

Front Pharmacol 2019 8;10:1511. Epub 2020 Jan 8.

Indiana University Department of Medicine, Indianapolis, IN, United States.

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http://dx.doi.org/10.3389/fphar.2019.01511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960206PMC
January 2020

MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation.

Cancer Genomics Proteomics 2019 Nov-Dec;16(6):433-442

Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, IN, U.S.A.

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http://dx.doi.org/10.21873/cgp.20147DOI Listing
August 2019

Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.

J Mol Diagn 2019 May 20;21(3):491-502. Epub 2019 Feb 20.

Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504676PMC
May 2019

Next generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction.

Atherosclerosis 2018 11 3;278:232-239. Epub 2018 Oct 3.

Department of Clinical Pharmacology, Indiana University School of Medicine, United States; Krannert Institute of Cardiology, Indiana University School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350783PMC
November 2018

Report of Confirmation of the rs7853758 and rs885004 Haplotype in SLC28A3.

Genet Test Mol Biomarkers 2018 Nov 23;22(11):652-655. Epub 2018 Oct 23.

1 Department of Medical and Molecular Genetics and Indiana University School of Medicine , Indianapolis, Indiana.

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http://dx.doi.org/10.1089/gtmb.2018.0194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249667PMC
November 2018

Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.

Clin Pharmacol Ther 2018 07 25;104(1):130-138. Epub 2017 Oct 25.

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/cpt.892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871545PMC
July 2018

PASSPORT-seq: A Novel High-Throughput Bioassay to Functionally Test Polymorphisms in Micro-RNA Target Sites.

Front Genet 2018 15;9:219. Epub 2018 Jun 15.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.

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http://dx.doi.org/10.3389/fgene.2018.00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013768PMC
June 2018

CYP2D6 and Endoxifen in Tamoxifen Therapy: A Tribute to David A. Flockhart.

Clin Pharmacol Ther 2018 05 23;103(5):755-757. Epub 2018 Feb 23.

Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/cpt.1039DOI Listing
May 2018

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes.

Pharmacol Res Perspect 2018 04 26;6(2):e00386. Epub 2018 Mar 26.

Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis IN.

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http://doi.wiley.com/10.1002/prp2.386
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http://dx.doi.org/10.1002/prp2.386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869567PMC
April 2018

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2018 01 1;11(2):181-191. Epub 2017 Nov 1.

Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida; Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jcin.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775044PMC
January 2018

siRNA Delivery and Rebound of Renal in Mice.

J Drug Deliv 2017 20;2017:4070793. Epub 2017 Dec 20.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1155/2017/4070793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750491PMC
December 2017

Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson.

Pharmacogenomics 2017 Apr 30;18(6):523-529. Epub 2017 Mar 30.

Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.2217/pgs-2016-0178DOI Listing
April 2017

Population Pharmacokinetic Modeling To Estimate the Contributions of Genetic and Nongenetic Factors to Efavirenz Disposition.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Indiana University School of Medicine, Division of Clinical Pharmacology, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1128/AAC.01813-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192152PMC
January 2017

Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers.

Antimicrob Agents Chemother 2016 11 21;60(11):6813-6822. Epub 2016 Oct 21.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1128/AAC.01000-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075090PMC
November 2016

A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β.

Bioorg Med Chem 2016 11 31;24(21):5400-5409. Epub 2016 Aug 31.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065788PMC
http://dx.doi.org/10.1016/j.bmc.2016.08.064DOI Listing
November 2016

Sleep disorders in breast cancer survivors.

Support Care Cancer 2016 10 4;24(10):4197-205. Epub 2016 May 4.

Indiana University School of Medicine, 714 N. Senate Ave Suite 120, Indianapolis, IN, 46202, USA.

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http://dx.doi.org/10.1007/s00520-016-3247-6DOI Listing
October 2016

ESR1 and PGR polymorphisms are associated with estrogen and progesterone receptor expression in breast tumors.

Physiol Genomics 2016 09 19;48(9):688-98. Epub 2016 Aug 19.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1152/physiolgenomics.00065.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111879PMC
September 2016

Identification of rifampin-regulated functional modules and related microRNAs in human hepatocytes based on the protein interaction network.

BMC Genomics 2016 08 22;17 Suppl 7:517. Epub 2016 Aug 22.

College of Automation, Harbin Engineering University, 145 Nantong Street, Nangang District, Harbin, Heilongjiang, 150001, China.

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http://dx.doi.org/10.1186/s12864-016-2909-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001204PMC
August 2016

Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study.

PLoS One 2015 20;10(10):e0141279. Epub 2015 Oct 20.

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; VA Roudebush Hospital, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Department of Obstetrics and Gynecology Medical Sciences Program Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States of America; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141279PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612782PMC
June 2016

Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes.

Front Pharmacol 2016 26;7:111. Epub 2016 Apr 26.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine Indianapolis, IN, USA.

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http://dx.doi.org/10.3389/fphar.2016.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845040PMC
May 2016

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Drug Metab Pharmacokinet 2016 Apr 29;31(2):107-16. Epub 2015 Jul 29.

Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974081PMC
April 2016

Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.

J Med Chem 2016 Jan 24;59(1):157-70. Epub 2015 Dec 24.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126733PMC
January 2016

Genotyping concordance in DNA extracted from formalin-fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses.

Mol Oncol 2015 Nov 29;9(9):1868-76. Epub 2015 Jul 29.

Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Health System, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624024PMC
November 2015

AMPD1 polymorphism and response to regadenoson.

Pharmacogenomics 2015 Nov 10;16(16):1807-15. Epub 2015 Nov 10.

Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N. Capitol Ave, MPC2, ME-400, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.2217/pgs.15.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826562PMC
November 2015

Characterization of hepatic enzyme activity in older adults with dementia: potential impact on personalizing pharmacotherapy.

Clin Interv Aging 2015 14;10:269-75. Epub 2015 Jan 14.

Indiana University Center for Aging Research, Indiana University School of Medicine, Indianapolis, IN, USA ; Regenstrief Institute, Indiana University School of Medicine, Indianapolis, IN, USA ; Center for Innovation and Implementation Science, Indiana University, Indianapolis, IN, USA.

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http://www.dovepress.com/characterization-of-hepatic-enzyme-
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http://dx.doi.org/10.2147/CIA.S65980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298284PMC
September 2015

Pooled Analysis of Six Pharmacologic and Nonpharmacologic Interventions for Vasomotor Symptoms.

Obstet Gynecol 2015 Aug;126(2):413-22

MsFLASH Data Coordinating Center, Fred Hutchinson Cancer Research Center, the Group Health Research Institute, and the University of Washington School of Medicine, Seattle, Washington; the Department of Family and Preventive Medicine, University of California, San Diego, San Diego, and the Division of Research, Kaiser Permanente, Oakland, California; the VA Medical Center/University of Minnesota, Minneapolis, Minnesota; Brigham and Women's Hospital, Dana Farber Cancer Institute, and Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; the School of Nursing and the Department of Medicine, Division of Clinical Pharmacology, Indiana University, Indianapolis, Indiana; and the Departments of Obstetrics and Gynecology and Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1097/AOG.0000000000000927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526122PMC
August 2015

FDA's draft guidance on laboratory-developed tests increases clinical and economic risk to adoption of pharmacogenetic testing.

J Clin Pharmacol 2015 Jul;55(7):725-7

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1002/jcph.492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719776PMC
July 2015

Cypiripi: exact genotyping of CYP2D6 using high-throughput sequencing data.

Bioinformatics 2015 Jun;31(12):i27-34

School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA and School of Informatics and Computing, Indiana University, Bloomington, IN 47401, USA School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA and School of Informatics and Computing, Indiana University, Bloomington, IN 47401, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btv232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542776PMC
June 2015

Considerations for the Utility of the CPIC Guideline for CYP2D6 Genotype and Codeine Therapy.

Clin Chem 2015 May 13;61(5):775-6. Epub 2015 Mar 13.

Division of Clinical Pharmacology Department of Medicine Indiana University School of Medicine Indianapolis, IN.

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http://dx.doi.org/10.1373/clinchem.2014.237412DOI Listing
May 2015

A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice.

Antivir Chem Chemother 2015 Apr 30;24(2):72-6. Epub 2015 Jul 30.

Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, USA.

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http://journals.sagepub.com/doi/10.1177/2040206615595318
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http://dx.doi.org/10.1177/2040206615595318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890517PMC
April 2015

Report of new haplotype for ABCC2 gene: rs17222723 and rs8187718 in cis.

J Mol Diagn 2015 Mar 29;17(2):201-5. Epub 2014 Dec 29.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.jmoldx.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348475PMC
March 2015

Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.

J Med Chem 2015 Mar 9;58(6):2623-48. Epub 2015 Mar 9.

†Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm501218eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687028PMC
March 2015

Genome-wide discovery of drug-dependent human liver regulatory elements.

PLoS Genet 2014 Oct 2;10(10):e1004648. Epub 2014 Oct 2.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America; Institute for Human Genetics, University of California, San Francisco, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183418PMC
October 2014

Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223.

Drug Metab Dispos 2013 Oct 25;41(10):1778-81. Epub 2013 Jul 25.

Indiana University School of Medicine, Division of Clinical Pharmacology, Indianapolis, Indiana.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.052357
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http://dx.doi.org/10.1124/dmd.113.052357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781369PMC
October 2013

Regulation of microRNA expression by rifampin in human hepatocytes.

Drug Metab Dispos 2013 Oct 9;41(10):1763-8. Epub 2013 Aug 9.

Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children's Mercy Hospital and Clinics, Kansas City, Missouri (A.G.).

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http://dx.doi.org/10.1124/dmd.113.052886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781376PMC
October 2013

Medication use in breast cancer survivors compared to midlife women.

Support Care Cancer 2013 Jul 10;21(7):1827-33. Epub 2013 Feb 10.

Indiana University School of Nursing, 1111 Middle Drive NU W401, Indianapolis, IN 46202, USA.

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http://link.springer.com/10.1007/s00520-013-1727-5
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http://dx.doi.org/10.1007/s00520-013-1727-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669653PMC
July 2013

Alt Event Finder: a tool for extracting alternative splicing events from RNA-seq data.

BMC Genomics 2012 17;13 Suppl 8:S10. Epub 2012 Dec 17.

Bioinformatics Program, School of Informatics, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1186/1471-2164-13-S8-S10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535697PMC
June 2013

Histoplasma capsulatum preferentially induces IDO in the lung.

Med Mycol 2013 Apr 27;51(3):270-9. Epub 2012 Nov 27.

Indiana University School of Medicine and Roudebush Veterans' Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.3109/13693786.2012.710857DOI Listing
April 2013

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer.

Breast Cancer Res Treat 2013 Apr 2;138(3):807-16. Epub 2013 Apr 2.

Breast Oncology Program, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Med Inn Bldg C450, Ann Arbor, MI 48109-5843, USA.

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http://dx.doi.org/10.1007/s10549-013-2504-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646626PMC
April 2013

Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.

Front Pharmacol 2012 30;3:54. Epub 2012 Mar 30.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine Indianapolis, IN, USA.

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http://journal.frontiersin.org/article/10.3389/fphar.2012.00
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http://dx.doi.org/10.3389/fphar.2012.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315790PMC
October 2012

Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET study.

J Clin Endocrinol Metab 2012 Sep 20;97(9):3207-15. Epub 2012 Jun 20.

Center for Women's Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts 02114, USA.

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http://dx.doi.org/10.1210/jc.2012-1413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791433PMC
September 2012

Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene.

Horm Cancer 2012 Apr;3(1-2):37-43

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, 46202, USA.

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http://link.springer.com/10.1007/s12672-011-0086-2
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http://dx.doi.org/10.1007/s12672-011-0086-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402208PMC
April 2012

In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.

Drug Metab Dispos 2012 Apr 9;40(4):726-33. Epub 2012 Jan 9.

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.111.040329
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http://dx.doi.org/10.1124/dmd.111.040329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310421PMC
April 2012

Collection of human genomic DNA from neonates: a comparison between umbilical cord blood and buccal swabs.

Am J Obstet Gynecol 2011 Apr 16;204(4):362.e1-6. Epub 2011 Feb 16.

Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1016/j.ajog.2010.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073721PMC
April 2011

In silico identification of microRNAs predicted to regulate the drug metabolizing cytochrome P450 genes.

Drug Metab Lett 2011 Apr;5(2):126-31

Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis, IN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308728PMC
http://dx.doi.org/10.2174/187231211795305258DOI Listing
April 2011

Resequencing of the vascular endothelial growth factor promoter reveals haplotype structure and functional diversity.

Angiogenesis 2010 Sep 16;13(3):211-8. Epub 2010 Jun 16.

Department of Medicine, Division of Hematology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/s10456-010-9173-1DOI Listing
September 2010

Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays.

Pharmacogenet Genomics 2010 Jul;20(7):451-4

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32833a1083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411953PMC
July 2010

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

J Clin Pharmacol 2010 Apr 15;50(4):450-8. Epub 2010 Jan 15.

Division of Biostatistics/Clinical Pharmacology, Indiana University, School of Medicine, 410 W. 10th St., HITS 3000, Indianapolis, IN 46202; e-mail:

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http://dx.doi.org/10.1177/0091270009359182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816977PMC
April 2010

Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes.

Breast Cancer Res Treat 2009 Aug 11;116(3):543-9. Epub 2008 Sep 11.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/s10549-008-0178-zDOI Listing
August 2009

Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy.

Breast Cancer Res Treat 2009 Jun 12;115(3):643-50. Epub 2008 Dec 12.

Department of Hematology/Oncology, Marshfield Clinic Weston Center, 3501 Cranberry Boulevard, Weston, WI 54476, USA.

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http://dx.doi.org/10.1007/s10549-008-0264-2DOI Listing
June 2009

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity.

Pharmacogenet Genomics 2009 Jun;19(6):464-76

Department of medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1097/fpc.0b013e32832c005aDOI Listing
June 2009

The role of single nucleotide polymorphisms in breast cancer metastasis.

Breast Cancer Res 2008 18;10(1):301. Epub 2008 Jan 18.

Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1186/bcr1842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374952PMC
June 2008

The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.

Cancer Genet Cytogenet 2007 May;175(1):61-4

Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080700029
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http://dx.doi.org/10.1016/j.cancergencyto.2006.12.008DOI Listing
May 2007

Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.

J Pharmacol Exp Ther 2006 Aug 11;318(2):503-12. Epub 2006 May 11.

Division of Clinical Pharmacology, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg., W7123, Indianapolis, IN 46202, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.10051
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http://dx.doi.org/10.1124/jpet.105.100511DOI Listing
August 2006

Analysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodes.

Breast Cancer Res Treat 2006 Apr 28;96(3):209-15. Epub 2006 Feb 28.

Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

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http://link.springer.com/10.1007/s10549-005-9003-0
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http://dx.doi.org/10.1007/s10549-005-9003-0DOI Listing
April 2006

Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.

Carcinogenesis 2005 Sep 5;26(9):1527-35. Epub 2005 May 5.

Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1093/carcin/bgi113DOI Listing
September 2005

Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen.

Cancer Chemother Pharmacol 2005 May 1;55(5):471-8. Epub 2005 Feb 1.

Division of Clinical Pharmacology, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg., W7123, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1007/s00280-004-0926-7DOI Listing
May 2005

Association between the CYP3A5 genotype and blood pressure.

Hypertension 2005 Feb 13;45(2):294-8. Epub 2004 Dec 13.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 1001 W Tenth St, WD Myers Room W7123, Indianapolis, IN 46202, USA.

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https://www.ahajournals.org/doi/10.1161/01.HYP.0000151361.31
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http://dx.doi.org/10.1161/01.HYP.0000151361.31736.96DOI Listing
February 2005

interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).

Cancer Res 2004 Jun;64(11):4030-9

Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20007, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-3602DOI Listing
June 2004

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen.

Breast Cancer Res Treat 2004 May;85(2):151-9

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA.

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http://dx.doi.org/10.1023/B:BREA.0000025406.31193.e8DOI Listing
May 2004

Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.

Oncogene 2003 Oct;22(47):7316-39

Department of Oncology and Vincent T. Lombardi Cancer Center, Georgetown University School of Medicine, 3970 Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1038/sj.onc.1206937DOI Listing
October 2003

Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.

Pharmacogenetics 2003 Apr;13(4):199-206

Department of Medicine Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1097/00008571-200304000-00004DOI Listing
April 2003

Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).

Cancer Res 2002 Jun;62(12):3428-37

Vincent T. Lombardi Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20007, USA.

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June 2002