Todd Brusko

Todd Brusko

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Todd Brusko

Publications by authors named "Todd Brusko"

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Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2019 Aug;26(4):188-194

Department of Pathology, Immunology, and Laboratory Medicine.

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http://dx.doi.org/10.1097/MED.0000000000000484DOI Listing
August 2019

Metformin Inhibits the Type 1 IFN Response in Human CD4 T Cells.

J Immunol 2019 Jul 3;203(2):338-348. Epub 2019 Jun 3.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610;

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http://dx.doi.org/10.4049/jimmunol.1801651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615983PMC
July 2019

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.

J Clin Invest 2019 03 28;129(6):2446-2462. Epub 2019 Mar 28.

Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI124358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546456PMC
March 2019

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Immunity 2019 02 29;50(2):362-377.e6. Epub 2019 Jan 29.

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Sean N. Parker Autoimmune Research Laboratory, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183056
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http://dx.doi.org/10.1016/j.immuni.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476426PMC
February 2019

A checkpoint on innate myeloid cells in pulmonary arterial hypertension.

Pulm Circ 2019 Jan-Mar;9(1):2045894018823528. Epub 2018 Dec 18.

5 Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1177/2045894018823528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329033PMC
December 2018

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells.

Nat Commun 2018 10 22;9(1):4369. Epub 2018 Oct 22.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 1395 Center Drive, Gainesville, FL, 32610, USA.

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http://www.nature.com/articles/s41467-018-06686-0
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http://dx.doi.org/10.1038/s41467-018-06686-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197193PMC
October 2018

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.

Int J Mol Sci 2018 Aug 3;19(8). Epub 2018 Aug 3.

Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.3390/ijms19082277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121540PMC
August 2018

Immune Mechanisms and Pathways Targeted in Type 1 Diabetes.

Curr Diab Rep 2018 08 30;18(10):90. Epub 2018 Aug 30.

Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, 1275 Center Drive, Biomedical Sciences Building J-589, Box 100275, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1007/s11892-018-1066-5DOI Listing
August 2018

Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway.

Diabetes 2017 12 6;66(12):3061-3071. Epub 2017 Sep 6.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL

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http://dx.doi.org/10.2337/db17-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697952PMC
December 2017

T Cell Receptor Profiling in Type 1 Diabetes.

Curr Diab Rep 2017 Oct 11;17(11):118. Epub 2017 Oct 11.

Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA.

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http://dx.doi.org/10.1007/s11892-017-0946-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636870PMC
October 2017

Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes.

Front Endocrinol (Lausanne) 2017 18;8:276. Epub 2017 Oct 18.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, College of Medicine, Gainesville, FL, United States.

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http://dx.doi.org/10.3389/fendo.2017.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651267PMC
October 2017

T cells display mitochondria hyperpolarization in human type 1 diabetes.

Sci Rep 2017 09 7;7(1):10835. Epub 2017 Sep 7.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1038/s41598-017-11056-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589742PMC
September 2017

N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults.

Front Immunol 2017 12;8:655. Epub 2017 Jun 12.

Department of Microbiology and Cell Science, Genetics Institute, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, United States.

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http://dx.doi.org/10.3389/fimmu.2017.00655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466969PMC
June 2017

Serum Trypsinogen Levels in Type 1 Diabetes.

Diabetes Care 2017 Apr 23;40(4):577-582. Epub 2017 Jan 23.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL

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http://dx.doi.org/10.2337/dc16-1774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360284PMC
April 2017

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.

Diabetes 2015 Nov 16;64(11):3873-84. Epub 2015 Jul 16.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL

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http://dx.doi.org/10.2337/db15-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613966PMC
November 2015

Normalization of CD4+ T cell metabolism reverses lupus.

Sci Transl Med 2015 Feb;7(274):274ra18

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa0835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292723PMC
February 2015

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres.

J Mater Chem B 2014 May;2(17):2562-2574

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611.

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http://dx.doi.org/10.1039/C3TB21460EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000038PMC
May 2014

Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.

Immunotherapy 2013 Dec;5(12):1357-66

Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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https://www.futuremedicine.com/doi/10.2217/imt.13.130
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http://dx.doi.org/10.2217/imt.13.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939044PMC
December 2013

The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC.

J Autoimmun 2013 Aug 24;44:8-12. Epub 2013 Jul 24.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.jaut.2013.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775347PMC
August 2013

Immune modulation of effector CD4+ and regulatory T cell function by sorafenib in patients with hepatocellular carcinoma.

Cancer Immunol Immunother 2013 Apr 7;62(4):737-46. Epub 2012 Dec 7.

Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, 1600 SW Archer Rd., P.O. Box 100214, Gainesville, FL 32610-0214, USA.

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http://dx.doi.org/10.1007/s00262-012-1380-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863727PMC
April 2013

Autologous regulatory T cells for the treatment of type 1 diabetes.

Curr Diab Rep 2012 Oct;12(5):623-32

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1007/s11892-012-0304-5DOI Listing
October 2012

Serum levels of soluble CD25 as a marker for hepatocellular carcinoma.

Oncol Lett 2012 Oct 26;4(4):840-846. Epub 2012 Jul 26.

Section of Hepatobiliary Diseases, Department of Medicine;

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http://dx.doi.org/10.3892/ol.2012.826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506698PMC
October 2012

Central role for interleukin-2 in type 1 diabetes.

Diabetes 2012 Jan;61(1):14-22

Department of Pathology, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.2337/db11-1213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237657PMC
January 2012

Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.

Arthritis Res Ther 2011 Jun 27;13(3):R106. Epub 2011 Jun 27.

Department of Medicine, Division of Rheumatology and Clinical Medicine, University of Florida, 1600 Archer Road, Gainesville, FL 32610-0275, USA.

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http://dx.doi.org/10.1186/ar3387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218921PMC
June 2011

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells.

PLoS One 2011 Jan 6;6(1):e15868. Epub 2011 Jan 6.

Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015868PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017077PMC
January 2011

Regulatory T cells directed to the site of the action.

Proc Natl Acad Sci U S A 2009 Dec 1;106(49):20553-4. Epub 2009 Dec 1.

The Diabetes Center at the University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1073/pnas.0911848107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791590PMC
December 2009

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.

PLoS One 2009 Nov 24;4(11):e7980. Epub 2009 Nov 24.

Department of Pathology, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007980PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775921PMC
November 2009

Mesenchymal stem cells: a potential border patrol for transplanted islets?

Authors:
Todd M Brusko

Diabetes 2009 Aug;58(8):1728-9

Diabetes Center, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.2337/db09-0749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712779PMC
August 2009

Expansion of human regulatory T-cells from patients with type 1 diabetes.

Diabetes 2009 Mar 15;58(3):652-62. Epub 2008 Dec 15.

Diabetes Center at the University of California, San Francisco (UCSF), San Francisco, California, USA.

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http://dx.doi.org/10.2337/db08-1168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646064PMC
March 2009

CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes.

Cytokine 2008 Oct 7;44(1):154-9. Epub 2008 Sep 7.

Department of Pediatrics, University of Florida, College of Medicine, P.O. Box 100296, Gainesville, FL 32610, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104346660800220
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http://dx.doi.org/10.1016/j.cyto.2008.07.468DOI Listing
October 2008

Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.

Am J Pathol 2008 Jul 29;173(1):154-60. Epub 2008 May 29.

Departments of Surgery, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.2353/ajpath.2008.070963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438293PMC
July 2008

Autologous umbilical cord blood infusion for type 1 diabetes.

Exp Hematol 2008 Jun 20;36(6):710-5. Epub 2008 Mar 20.

Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1016/j.exphem.2008.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2444031PMC
June 2008

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.

Immunol Rev 2008 Jun;223:371-90

Diabetes Center, University of California, San Francisco, CA 94143-0540, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00637.xDOI Listing
June 2008

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation.

Eur J Immunol 2008 Apr;38(4):931-4

UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 941430540, USA.

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http://dx.doi.org/10.1002/eji.200738108DOI Listing
April 2008

Assessing the in vitro suppressive capacity of regulatory T cells.

Immunol Invest 2007 ;36(5-6):607-28

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1080/08820130701790368DOI Listing
March 2008

Treg in type 1 diabetes.

Cell Biochem Biophys 2007 ;48(2-3):165-75

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.

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November 2007

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Nat Genet 2007 Sep 5;39(9):1074-82. Epub 2007 Aug 5.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, UK.

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http://www.nature.com/doifinder/10.1038/ng2102
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http://dx.doi.org/10.1038/ng2102DOI Listing
September 2007

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes.

Diabetes 2007 Mar;56(3):604-12

Department of Pathology, College of Medicine, University of Florida, 1600 SW Archer Rd., Gainesville, FL 32610-0275, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-12
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http://dx.doi.org/10.2337/db06-1248DOI Listing
March 2007

A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.

Pediatr Nephrol 2006 May 7;21(5):603-10. Epub 2006 Mar 7.

Department of Pediatrics, College of Medicine, University of Florida, 100296 Gainesville, Florida 32610-0296, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00467-006-00
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http://link.springer.com/10.1007/s00467-006-0026-5
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http://dx.doi.org/10.1007/s00467-006-0026-5DOI Listing
May 2006

PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).

Gene 2006 Mar 18;369:134-41. Epub 2006 Jan 18.

Department of Pathology and Laboratory Medicine, 803D Abramson Research Center 3516 Civic Center Blvd., Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S037811190500695
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http://dx.doi.org/10.1016/j.gene.2005.10.040DOI Listing
March 2006

An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells.

J Immunol 2005 May;174(9):5181-6

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.4049/jimmunol.174.9.5181DOI Listing
May 2005

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes.

Diabetes 2005 May;54(5):1407-14

Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, ARB-R3-128, 1600 SW Archer Rd., Gainesville, FL 32610-0275, USA.

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http://diabetes.diabetesjournals.org/content/54/5/1407.full.
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http://dx.doi.org/10.2337/diabetes.54.5.1407DOI Listing
May 2005

Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice.

J Immunol 2004 Dec;173(11):6777-85

Division of Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.4049/jimmunol.173.11.6777DOI Listing
December 2004