Tod J Merkel

Tod J Merkel

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Tod J Merkel

Tod J Merkel

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Pertussis Toxin: A Key Component in Pertussis Vaccines?

Toxins (Basel) 2019 Sep 21;11(10). Epub 2019 Sep 21.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.3390/toxins11100557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832755PMC
September 2019

Toward a Controlled Human Infection Model of Pertussis.

Authors:
Tod J Merkel

Clin Infect Dis 2019 Sep 25. Epub 2019 Sep 25.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.

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http://dx.doi.org/10.1093/cid/ciz842DOI Listing
September 2019

Pertussis vaccines and protective immunity.

Curr Opin Immunol 2019 Aug 9;59:72-78. Epub 2019 May 9.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring MD 20993, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774807PMC
August 2019

Histopathology of Bordetella pertussis in the Baboon Model.

Infect Immun 2018 11 25;86(11). Epub 2018 Oct 25.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

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http://dx.doi.org/10.1128/IAI.00511-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204705PMC
November 2018

Maternal Vaccination With a Monocomponent Pertussis Toxoid Vaccine Is Sufficient to Protect Infants in a Baboon Model of Whooping Cough.

J Infect Dis 2018 03;217(8):1231-1236

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.

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http://dx.doi.org/10.1093/infdis/jiy022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018939PMC
March 2018

Activation of Bvg-Repressed Genes in Bordetella pertussis by RisA Requires Cross Talk from Noncooperonic Histidine Kinase RisK.

J Bacteriol 2017 11 17;199(22). Epub 2017 Oct 17.

Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, USA.

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http://jb.asm.org/lookup/doi/10.1128/JB.00475-17
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http://dx.doi.org/10.1128/JB.00475-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648863PMC
November 2017

Pertussis disease and transmission and host responses: insights from the baboon model of pertussis.

J Infect 2017 06;74 Suppl 1:S114-S119

Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/S0163-4453(17)30201-3DOI Listing
June 2017

Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.

Clin Vaccine Immunol 2017 Jan 5;24(1). Epub 2017 Jan 5.

Division of Infectious Diseases, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1128/CVI.00370-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216428PMC
January 2017

The multifaceted RisA regulon of Bordetella pertussis.

Sci Rep 2016 09 13;6:32774. Epub 2016 Sep 13.

Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France.

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http://dx.doi.org/10.1038/srep32774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020355PMC
September 2016

Comparison of Three Whole-Cell Pertussis Vaccines in the Baboon Model of Pertussis.

Clin Vaccine Immunol 2016 01 11;23(1):47-54. Epub 2015 Nov 11.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Silver Spring, Maryland, USA

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http://dx.doi.org/10.1128/CVI.00449-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711092PMC
January 2016

Bordetella pertussis transmission.

Pathog Dis 2015 Nov 14;73(8):ftv068. Epub 2015 Sep 14.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA

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http://dx.doi.org/10.1093/femspd/ftv068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626651PMC
November 2015

Erratum for Boinett et al., Complete Genome Sequence of Bordetella pertussis D420.

Genome Announc 2015 Jul 16;3(4). Epub 2015 Jul 16.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom.

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http://dx.doi.org/10.1128/genomeA.00842-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505139PMC
July 2015

Complete Genome Sequence of Bordetella pertussis D420.

Genome Announc 2015 Jun 11;3(3). Epub 2015 Jun 11.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

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http://dx.doi.org/10.1128/genomeA.00657-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463544PMC
June 2015

The baboon model of pertussis: effective use and lessons for pertussis vaccines.

Expert Rev Vaccines 2014 Oct 3;13(10):1241-52. Epub 2014 Sep 3.

Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Building 72, Room 3308, Silver Spring, MD 20993-0002, USA.

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http://dx.doi.org/10.1586/14760584.2014.946016DOI Listing
October 2014

Maternal and neonatal vaccination protects newborn baboons from pertussis infection.

J Infect Dis 2014 Aug 12;210(4):604-10. Epub 2014 Feb 12.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.

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http://dx.doi.org/10.1093/infdis/jiu090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133576PMC
August 2014

Advax-adjuvanted recombinant protective antigen provides protection against inhalational anthrax that is further enhanced by addition of murabutide adjuvant.

Clin Vaccine Immunol 2014 Apr 19;21(4):580-6. Epub 2014 Feb 19.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA.

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http://cvi.asm.org/lookup/doi/10.1128/CVI.00019-14
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http://dx.doi.org/10.1128/CVI.00019-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993118PMC
April 2014

Pertussis pathogenesis--what we know and what we don't know.

J Infect Dis 2014 Apr;209(7):982-5

Departments of Medicine and Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia.

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http://dx.doi.org/10.1093/infdis/jit639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952676PMC
April 2014

Nonhuman primate and human challenge models of pertussis.

J Infect Dis 2014 Apr;209 Suppl 1:S20-3

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland.

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http://dx.doi.org/10.1093/infdis/jit493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048992PMC
April 2014

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model.

Proc Natl Acad Sci U S A 2014 Jan 25;111(2):787-92. Epub 2013 Nov 25.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, 20892.

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http://dx.doi.org/10.1073/pnas.1314688110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896208PMC
January 2014

Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging.

PLoS One 2013 12;8(3):e59232. Epub 2013 Mar 12.

Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059232PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595258PMC
September 2013

Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection.

Hum Vaccin Immunother 2013 Sep 20;9(9):1841-8. Epub 2013 Jun 20.

Center for Biologics Evaluation and Research; Food and Drug Administration; Bethesda, MD USA.

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http://dx.doi.org/10.4161/hv.25337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906346PMC
September 2013

Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection.

Infect Immun 2013 May 19;81(5):1390-8. Epub 2013 Feb 19.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1128/IAI.00110-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648026PMC
May 2013

Epicutaneous model of community-acquired Staphylococcus aureus skin infections.

Infect Immun 2013 Apr 4;81(4):1306-15. Epub 2013 Feb 4.

Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/IAI.01304-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639601PMC
April 2013

Moraxella catarrhalis activates murine macrophages through multiple toll like receptors and has reduced clearance in lungs from TLR4 mutant mice.

PLoS One 2012 25;7(5):e37610. Epub 2012 May 25.

Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360749PMC
December 2012

Dissemination bottleneck in a murine model of inhalational anthrax.

Infect Immun 2012 Sep 2;80(9):3189-93. Epub 2012 Jul 2.

Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/IAI.00515-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418736PMC
September 2012

Airborne transmission of Bordetella pertussis.

J Infect Dis 2012 Sep 17;206(6):902-6. Epub 2012 Jul 17.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1093/infdis/jis443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501154PMC
September 2012

Nonhuman primate model of pertussis.

Infect Immun 2012 Apr 17;80(4):1530-6. Epub 2012 Jan 17.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/IAI.06310-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318410PMC
April 2012

Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities.

Proc Natl Acad Sci U S A 2010 Oct 4;107(42):18091-6. Epub 2010 Oct 4.

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1013083107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964248PMC
October 2010

Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure.

Infect Immun 2009 Oct 20;77(10):4529-37. Epub 2009 Jul 20.

Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic and Allergenic Products, CBER, FDA, Bethesda, Maryland, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.00563-09
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http://dx.doi.org/10.1128/IAI.00563-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747953PMC
October 2009

Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge.

Infect Immun 2009 Apr 29;77(4):1475-82. Epub 2009 Jan 29.

Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.

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http://iai.asm.org/content/early/2009/01/29/IAI.00828-08.ful
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http://iai.asm.org/cgi/doi/10.1128/IAI.00828-08
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http://dx.doi.org/10.1128/IAI.00828-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663156PMC
April 2009

Role of anthrax toxins in dissemination, disease progression, and induction of protective adaptive immunity in the mouse aerosol challenge model.

Infect Immun 2009 Jan 27;77(1):255-65. Epub 2008 Oct 27.

Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://iai.asm.org/content/early/2008/10/27/IAI.00633-08.ful
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http://iai.asm.org/cgi/doi/10.1128/IAI.00633-08
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http://dx.doi.org/10.1128/IAI.00633-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612249PMC
January 2009

Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors.

Infect Immun 2008 May 3;76(5):2177-82. Epub 2008 Mar 3.

Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802, USA.

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http://dx.doi.org/10.1128/IAI.00647-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346704PMC
May 2008

Spin labelling of Bacillus anthracis endospores: a model for in vivo tracking by EPR imaging.

Free Radic Res 2008 Jan;42(1):49-56

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1080/10715760701787701DOI Listing
January 2008

Murine aerosol challenge model of anthrax.

Infect Immun 2007 Jun 12;75(6):2689-98. Epub 2007 Mar 12.

Laboratory of Respiratory and Special Pathogens, DBPAP/CBER/FDA, Building 29, Room 418, 29 Lincoln Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1128/IAI.01875-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932896PMC
June 2007

MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling.

Infect Immun 2005 Nov;73(11):7535-40

Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, P.O. Box 800513, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1128/IAI.73.11.7535-7540.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273865PMC
November 2005

Complement depletion renders C57BL/6 mice sensitive to the Bacillus anthracis Sterne strain.

Infect Immun 2005 Jul;73(7):4420-2

Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1128/IAI.73.7.4420-4422.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168577PMC
July 2005

Activation of the vrg6 promoter of Bordetella pertussis by RisA.

J Bacteriol 2005 Mar;187(5):1648-58

Laboratory of Respiratory and Special Pathogens, DBPAP/CBER/FDA, Building 29, Rm. 418, 8800 Rockville Pike, Bethesda, MD 20892, USA.

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http://jb.asm.org/cgi/doi/10.1128/JB.187.5.1648-1658.2005
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http://dx.doi.org/10.1128/JB.187.5.1648-1658.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1063992PMC
March 2005

Cytokine response to infection with Bacillus anthracis spores.

Infect Immun 2004 Nov;72(11):6382-9

Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1128/IAI.72.11.6382-6389.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC523056PMC
November 2004

Macrophages release tumor necrosis factor alpha and interleukin-12 in response to intracellular Bacillus anthracis spores.

Infect Immun 2004 May;72(5):3069-72

Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387889PMC
http://dx.doi.org/10.1128/iai.72.5.3069-3072.2004DOI Listing
May 2004

Analysis of bvgR expression in Bordetella pertussis.

J Bacteriol 2003 Dec;185(23):6902-12

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC262712PMC
http://dx.doi.org/10.1128/jb.185.23.6902-6912.2003DOI Listing
December 2003