Tobias Schmelzle

Tobias Schmelzle

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Tobias Schmelzle

Tobias Schmelzle

Publications by authors named "Tobias Schmelzle"

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25Publications

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Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.

Bioorg Med Chem Lett 2019 Aug 18;29(16):2316-2319. Epub 2019 Jun 18.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2019.06.022DOI Listing
August 2019

Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy.

FEBS J 2019 Jun 11;286(12):2381-2398. Epub 2019 Apr 11.

Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1111/febs.14817DOI Listing
June 2019

Correction of copy number induced false positives in CRISPR screens.

PLoS Comput Biol 2018 07 19;14(7):e1006279. Epub 2018 Jul 19.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pcbi.1006279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067744PMC
July 2018

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

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http://dx.doi.org/10.1016/j.cell.2017.07.005DOI Listing
July 2017

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers.

PLoS Genet 2015 Aug 21;11(8):e1005465. Epub 2015 Aug 21.

Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1005465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546604PMC
August 2015

The surprising features of the TEAD4-Vgll1 protein-protein interaction.

Chembiochem 2014 Mar 6;15(4):537-42. Epub 2014 Feb 6.

Disease Area Oncology, Novartis Institutes for Biomedical Research, 141 Klybeckstrasse, 4057 Basel (Switzerland).

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http://dx.doi.org/10.1002/cbic.201300715DOI Listing
March 2014

The path to oncology drug target validation: an industry perspective.

Methods Mol Biol 2013 ;986:3-13

Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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http://link.springer.com/content/pdf/10.1007%2F978-1-62703-3
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http://link.springer.com/10.1007/978-1-62703-311-4_1
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http://dx.doi.org/10.1007/978-1-62703-311-4_1DOI Listing
August 2013

The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences.

Chembiochem 2013 Jul 18;14(10):1218-25. Epub 2013 Jun 18.

Disease Area Oncology, Novartis Institutes for Biomedical Research, 141 Klybeckstrasse, 4057 Basel, Switzerland.

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http://dx.doi.org/10.1002/cbic.201300163DOI Listing
July 2013

Engineering tumors with 3D scaffolds.

Nat Methods 2007 Oct 2;4(10):855-60. Epub 2007 Sep 2.

School of Engineering and Applied Sciences, Harvard University, 40 Oxford Street; Cambridge, Massachusetts 02138, USA.

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http://search.proquest.com/openview/c176069f593242b2bf749605
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http://dx.doi.org/10.1038/nmeth1085DOI Listing
October 2007

Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast.

Mol Cell Biol 2004 Jan;24(1):338-51

Division of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC303340PMC
http://dx.doi.org/10.1128/mcb.24.1.338-351.2004DOI Listing
January 2004

Quantitation of changes in protein phosphorylation: a simple method based on stable isotope labeling and mass spectrometry.

Proc Natl Acad Sci U S A 2003 Feb 22;100(3):880-5. Epub 2003 Jan 22.

Department of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.232735599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298695PMC
February 2003

The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae.

Mol Microbiol 2002 Sep;45(5):1433-41

Department of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03110.xDOI Listing
September 2002

Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast.

Mol Cell Biol 2002 Mar;22(5):1329-39

Department of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134704PMC
http://dx.doi.org/10.1128/mcb.22.5.1329-1339.2002DOI Listing
March 2002