Tobias Neff

Tobias Neff

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Tobias Neff

Tobias Neff

Publications by authors named "Tobias Neff"

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27Publications

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Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations.

PLoS Genet 2018 Sep 14;14(9):e1007642. Epub 2018 Sep 14.

Allen Discovery Center and Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of America.

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September 2018

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Cancer Cell 2017 06;31(6):755-770.e6

Department of Pediatrics, Section of Hematology/Oncology/BMT, University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pharmacology, University of Colorado, Denver/Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

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June 2017

The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities.

Front Pediatr 2016 18;4:49. Epub 2016 May 18.

Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado Denver , Aurora, CO , USA.

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May 2016

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia.

Cell Rep 2016 Mar 18;14(8):1953-65. Epub 2016 Feb 18.

Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, Aurora, CO 80045, USA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA. Electronic address:

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March 2016

Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

Exp Hematol 2015 Nov 26;43(11):930-935.e6. Epub 2015 Jun 26.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, University of Colorado Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA.

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November 2015

Histone profiles in cancer.

Pharmacol Ther 2015 Oct 22;154:87-109. Epub 2015 Jul 22.

Division of Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045 Aurora, CO, 80045, USA. Electronic address:

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October 2015

Epigenetic modifiers in normal and malignant hematopoiesis.

Epigenomics 2015 ;7(2):301-20

Division of Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine & Children's Hospital Colorado, Aurora, CO 80045, USA.

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September 2015

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.

Nat Chem Biol 2013 Oct 25;9(10):643-50. Epub 2013 Aug 25.

1] Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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October 2013

Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire.

Cell Stem Cell 2013 Oct 12;13(4):492-505. Epub 2013 Sep 12.

Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

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October 2013

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia.

Blood 2013 Jun 6;121(24):4847-53. Epub 2013 May 6.

Center for Cancer and Blood Disorders, Children's Hospital Colorado, and Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA.

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June 2013

Extended survival of glioblastoma patients after chemoprotective HSC gene therapy.

Sci Transl Med 2012 May;4(133):133ra57

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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May 2012

An unusual case of congenital primitive neuroectodermal tumor with ocular metastasis.

J Pediatr Hematol Oncol 2012 Mar;34(2):e69-71

Pontificia Universidad Católica, Ophtalmology, Santiago, Chile.

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March 2012

Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

Proc Natl Acad Sci U S A 2012 Mar 6;109(13):5028-33. Epub 2012 Mar 6.

Dana-Farber/Children's Hospital Cancer Center, Boston, MA 02115, USA.

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March 2012

Hematopoietic stem cell engraftment: a direct comparison between intramarrow and intravenous injection in nonhuman primates.

Exp Hematol 2007 Jul;35(7):1132-9

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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July 2007

Improved short-term engraftment of lentivirally versus gammaretrovirally transduced allogeneic canine repopulating cells.

J Gene Med 2007 May;9(5):357-61

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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May 2007

In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs.

Hum Gene Ther 2007 May;18(5):451-6

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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May 2007

Survival of the fittest: in vivo selection and stem cell gene therapy.

Blood 2006 Mar 3;107(5):1751-60. Epub 2005 Nov 3.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.

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March 2006

Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy.

Blood 2005 Feb 19;105(3):997-1002. Epub 2004 Oct 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1-100, Seattle, WA 98109, USA.

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February 2005

Stem cell gene transfer--efficacy and safety in large animal studies.

Mol Ther 2004 Sep;10(3):417-31

Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, 98109, USA.

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September 2004

Efficient lentiviral gene transfer to canine repopulating cells using an overnight transduction protocol.

Blood 2004 May 22;103(10):3710-6. Epub 2004 Jan 22.

Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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May 2004

Pharmacologically regulated in vivo selection in a large animal.

Blood 2002 Sep;100(6):2026-31

Divisions of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA 89195, USA.

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September 2002