Publications by authors named "Tobias Moser"

100Publications

Long-term peripheral immune cell profiling reveals further targets of oral cladribine in MS.

Ann Clin Transl Neurol 2020 11 1;7(11):2199-2212. Epub 2020 Oct 1.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.

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http://dx.doi.org/10.1002/acn3.51206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664268PMC
November 2020

The role of TH17 cells in multiple sclerosis: Therapeutic implications.

Autoimmun Rev 2020 Oct 13;19(10):102647. Epub 2020 Aug 13.

Center of Clinical Neuroscience, University Hospital Carl Gustav Carus, Dresden University of Technical, Fetscherstrasse 74, 01307 Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2020.102647DOI Listing
October 2020

μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve.

EMBO Mol Med 2020 Aug 29;12(8):e12387. Epub 2020 Jun 29.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.15252/emmm.202012387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411546PMC
August 2020

Circumvention of common labelling artefacts using secondary nanobodies.

Nanoscale 2020 May;12(18):10226-10239

Institute of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany.

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http://dx.doi.org/10.1039/d0nr00227eDOI Listing
May 2020

Successful disease control with alemtuzumab in MOG-IgG-associated demyelinating disease with MS-phenotype.

Mult Scler Relat Disord 2020 Jul 15;42:102108. Epub 2020 Apr 15.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany; Department of Neurology, Landesklinikum Mistelbach-Gänserndorf, 2130 Mistelbach, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2020.102108DOI Listing
July 2020

Towards the optical cochlear implant: optogenetic approaches for hearing restoration.

EMBO Mol Med 2020 04 30;12(4):e11618. Epub 2020 Mar 30.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.15252/emmm.201911618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136966PMC
April 2020

Emerging Approaches for Restoration of Hearing and Vision.

Physiol Rev 2020 10 19;100(4):1467-1525. Epub 2020 Mar 19.

Institute for Physiology, University of Bern, Bern, Switzerland; Pre-Synaptogenesis and Intracellular Transport in Hair Cells Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany; Collaborative Research Center 889, University of Göttingen, Göttingen, Germany; Cognitive Hearing in Primates Group, Auditory Neuroscience and Optogenetics Laboratory, Deutsches Primatenzentrum GmbH, Göttingen, Germany; Auditory Neuroscience and Optogenetics Laboratory, Deutsches Primatenzentrum GmbH, Göttingen, Germany; and Multiscale Bioimaging Cluster of Excellence (MBExC), University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1152/physrev.00035.2019DOI Listing
October 2020

Vitamin D Supplementation in Multiple Sclerosis: A Critical Analysis of Potentials and Threats.

Nutrients 2020 Mar 16;12(3). Epub 2020 Mar 16.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.

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http://dx.doi.org/10.3390/nu12030783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146466PMC
March 2020

Clinical Challenges in a 49-Year-Old Patient with Severe Tick-Borne Myeloradiculitis Despite Complete Active Vaccination.

Vaccines (Basel) 2020 Feb 20;8(1). Epub 2020 Feb 20.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.

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http://dx.doi.org/10.3390/vaccines8010093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157544PMC
February 2020

Towards optogenetic approaches for hearing restoration.

Biochem Biophys Res Commun 2020 Jun 4;527(2):337-342. Epub 2020 Feb 4.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075, Göttingen, Germany; Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2019.12.126DOI Listing
June 2020

AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.

J Cell Sci 2020 01 22;133(2). Epub 2020 Jan 22.

Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany

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http://dx.doi.org/10.1242/jcs.236737DOI Listing
January 2020

Sensory Processing at Ribbon Synapses in the Retina and the Cochlea.

Physiol Rev 2020 01 2;100(1):103-144. Epub 2019 Aug 2.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany; Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Göttingen, Germany; Synaptic Nanophysiology Group, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany; and Institute for Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, Homburg, Germany.

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http://dx.doi.org/10.1152/physrev.00026.2018DOI Listing
January 2020

Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca Signaling.

J Neurosci 2019 07 13;39(27):5284-5298. Epub 2019 May 13.

Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892,

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http://dx.doi.org/10.1523/JNEUROSCI.2728-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607758PMC
July 2019

Near physiological spectral selectivity of cochlear optogenetics.

Nat Commun 2019 04 29;10(1):1962. Epub 2019 Apr 29.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075, Göttingen, Germany.

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http://www.nature.com/articles/s41467-019-09980-7
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http://dx.doi.org/10.1038/s41467-019-09980-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488702PMC
April 2019

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.

Proc Natl Acad Sci U S A 2019 04 11;116(18):9084-9093. Epub 2019 Apr 11.

Institute for Auditory Neuroscience, University Medical Center Göttingen, 37075 Göttingen, Germany;

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http://dx.doi.org/10.1073/pnas.1818358116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500111PMC
April 2019

Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea.

Proc Natl Acad Sci U S A 2019 03 13;116(13):6415-6424. Epub 2019 Mar 13.

Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany;

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http://dx.doi.org/10.1073/pnas.1812029116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442603PMC
March 2019

Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse.

Front Mol Neurosci 2018 9;11:492. Epub 2019 Jan 9.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.3389/fnmol.2018.00492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338019PMC
January 2019

A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice.

EMBO Mol Med 2019 01;11(1)

Molecular Biology of Cochlear Neurotransmission Group, Department of Otorhinolaryngology, University Medical Center Göttingen, and Collaborative Research Center 889, University of Göttingen, Göttingen, Germany

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201809396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328916PMC
January 2019

Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells.

Proc Natl Acad Sci U S A 2018 12 21;115(50):12811-12816. Epub 2018 Nov 21.

Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1073/pnas.1811814115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294930PMC
December 2018

Ca Regulates the Kinetics of Synaptic Vesicle Fusion at the Afferent Inner Hair Cell Synapse.

Front Cell Neurosci 2018 17;12:364. Epub 2018 Oct 17.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

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https://www.frontiersin.org/article/10.3389/fncel.2018.00364
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http://dx.doi.org/10.3389/fncel.2018.00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199957PMC
October 2018

Toward the Optical Cochlear Implant.

Cold Spring Harb Perspect Med 2019 08 1;9(8). Epub 2019 Aug 1.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1101/cshperspect.a033225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671933PMC
August 2019

Psychophysiological modeling: Current state and future directions.

Psychophysiology 2018 11 2;55(11):e13214. Epub 2018 Sep 2.

Clinical Psychiatry Research, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.

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http://doi.wiley.com/10.1111/psyp.13209
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http://dx.doi.org/10.1111/psyp.13209DOI Listing
November 2018

[Molecular Understanding of Hearing - How Does This Matter to the Hearing Impaired?]

Authors:
Tobias Moser

Laryngorhinootologie 2018 Mar 22;97(S 01):S214-S230. Epub 2018 Mar 22.

Institut für Auditorische Neurowissenschaften, Universitätsmedizin Göttingen.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-121595
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http://dx.doi.org/10.1055/s-0043-121595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541096PMC
March 2018

Quantitative optical nanophysiology of Ca signaling at inner hair cell active zones.

Nat Commun 2018 01 18;9(1):290. Epub 2018 Jan 18.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099, Göttingen, Germany.

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http://dx.doi.org/10.1038/s41467-017-02612-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773603PMC
January 2018

RIM-Binding Protein 2 Promotes a Large Number of Ca1.3 Ca-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.

Front Cell Neurosci 2017 2;11:334. Epub 2017 Nov 2.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.3389/fncel.2017.00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673845PMC
November 2017

Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.

Front Synaptic Neurosci 2017 25;9:14. Epub 2017 Oct 25.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.3389/fnsyn.2017.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660988PMC
October 2017

Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis.

Front Immunol 2017 28;8:835. Epub 2017 Jul 28.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.

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http://dx.doi.org/10.3389/fimmu.2017.00835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532517PMC
July 2017

Resection of Navigated Transcranial Magnetic Stimulation-Positive Prerolandic Motor Areas Causes Permanent Impairment of Motor Function.

Neurosurgery 2017 Jul;81(1):99-110

Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1093/neuros/nyw169DOI Listing
July 2017

Ca-binding protein 2 inhibits Ca-channel inactivation in mouse inner hair cells.

Proc Natl Acad Sci U S A 2017 02 9;114(9):E1717-E1726. Epub 2017 Feb 9.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;

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http://dx.doi.org/10.1073/pnas.1617533114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338518PMC
February 2017

Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice.

Neuroscience 2017 03 9;344:380-393. Epub 2017 Jan 9.

Department of Cell Biology and Neuroscience, Rutgers the State University of New Jersey, Piscataway, NJ 08854, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.12.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303641PMC
March 2017

New insights into cochlear sound encoding.

F1000Res 2016 26;5. Epub 2016 Aug 26.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany; Auditory Neuroscience Group, Max-Planck-Institute for Experimental Medicine, Göttingen, Germany.

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http://dx.doi.org/10.12688/f1000research.8924.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007750PMC
September 2016

Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.

Proc Natl Acad Sci U S A 2016 08 26;113(32):E4716-25. Epub 2016 Jul 26.

Institute for Auditory Neuroscience & InnerEarLab, University Medical Center Göttingen, 37099 Goettingen, Germany; Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, 37073 Goettingen, Germany; Bernstein Focus for Neurotechnology, University of Göttingen, 37073 Goettingen, Germany; Collaborative Research Center 889, University of Göttingen, 37099 Goettingen, Germany; Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37073 Goettingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, 37073 Goettingen, Germany

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http://dx.doi.org/10.1073/pnas.1605737113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987782PMC
August 2016

Farmers' Preferences for Future Agricultural Land Use Under the Consideration of Climate Change.

Environ Manage 2016 Sep 2;58(3):446-64. Epub 2016 Jul 2.

School of Resource and Environmental Management (REM), Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.

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http://dx.doi.org/10.1007/s00267-016-0720-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969349PMC
September 2016

Eyes without a ribbon.

Authors:
Tobias Moser

EMBO J 2016 05 22;35(10):1018-20. Epub 2016 Mar 22.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Göttingen, Germany.

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http://dx.doi.org/10.15252/embj.201694205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868952PMC
May 2016

Auditory neuropathy--neural and synaptic mechanisms.

Nat Rev Neurol 2016 Mar 19;12(3):135-49. Epub 2016 Feb 19.

Center for Hearing Research, University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1038/nrneurol.2016.10DOI Listing
March 2016

Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

EMBO J 2015 Nov 7;34(21):2686-702. Epub 2015 Oct 7.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany Collaborative Research Center 889, University of Göttingen, Göttingen, Germany Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, Göttingen, Germany

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http://dx.doi.org/10.15252/embj.201591885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641533PMC
November 2015

Gene therapy for deafness: How close are we?

Authors:
Tobias Moser

Sci Transl Med 2015 Jul;7(295):295fs28

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany. Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. Auditory Neuroscience Group, German Primate Center, Göttingen, Germany. Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Göttingen, Germany. Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1126/scitranslmed.aac7545DOI Listing
July 2015

Synaptic encoding and processing of auditory information in physiology and disease.

Hear Res 2015 Dec 26;330(Pt B):155-6. Epub 2015 Jun 26.

Collaborative Research Center 889, University of Göttingen, Göttingen, Germany; Auditory Systems Physiology Group, InnerEarLab, Department of Otolaryngology, University of Göttingen Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.heares.2015.06.015DOI Listing
December 2015

Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.

Proc Natl Acad Sci U S A 2015 Jun 1;112(24):E3141-9. Epub 2015 Jun 1.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37099 Göttingen, Germany; Collaborative Sensory Research Center 889, University of Göttingen, 37099 Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, 37073 Göttingen, Germany;

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http://dx.doi.org/10.1073/pnas.1417207112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475996PMC
June 2015

EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.

Proc Natl Acad Sci U S A 2015 Mar 17;112(9):E1028-37. Epub 2015 Feb 17.

Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany; Collaborative Research Center 889, University of Göttingen, 37099 Göttingen, Germany; Bernstein Center for Computational Neuroscience, Göttingen University, 37077 Göttingen, Germany;

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http://dx.doi.org/10.1073/pnas.1416424112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352837PMC
March 2015

Optogenetic stimulation of the auditory pathway for research and future prosthetics.

Authors:
Tobias Moser

Curr Opin Neurobiol 2015 Oct 28;34:29-36. Epub 2015 Jan 28.

Institute for Auditory Neuroscience and Collaborative Research Center 889, University Medical Center Göttingen, Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Göttingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2015.01.004DOI Listing
October 2015

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

J Cell Sci 2015 Feb 20;128(4):638-44. Epub 2015 Jan 20.

Institute for Auditory Neuroscience and InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, 37099 Göttingen, Germany Collaborative Research Center 889, University of Göttingen, 37099 Göttingen, Germany Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany

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http://dx.doi.org/10.1242/jcs.162099DOI Listing
February 2015

Considering optogenetic stimulation for cochlear implants.

Hear Res 2015 Apr 16;322:224-34. Epub 2015 Jan 16.

Institute for Auditory Neuroscience, University Medical Center Goettingen, Goettingen, Germany; Auditory Neuroscience Group, German Primate Center, Goettingen, Germany; Bernstein Focus for Neurotechnology, University of Göttingen, Goettingen, Germany; Collaborative Research Center 889, University of Goettingen Medical Center, Goettingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Goettingen, Goettingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2015.01.005DOI Listing
April 2015

Optogenetic stimulation of the auditory nerve.

J Vis Exp 2014 Oct 8(92):e52069. Epub 2014 Oct 8.

InnerEarLab, Department of Otolaryngology, University Medical Center Goettingen; Bernstein Focus for Neurotechnology, University of Goettingen; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Goettingen;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841303PMC
http://dx.doi.org/10.3791/52069DOI Listing
October 2014

Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis.

Neuron 2014 Sep 4;83(6):1389-403. Epub 2014 Sep 4.

InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, 37075 Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, 37073 Göttingen, Germany; Collaborative Research Center 889 Cellular Mechanisms of Sensory Processing, 37099 Göttingen, Germany; Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37073 Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.08.003DOI Listing
September 2014

A new probe for super-resolution imaging of membranes elucidates trafficking pathways.

J Cell Biol 2014 May;205(4):591-606

Department of Neuro- and Sensory Physiology; European Neuroscience Institute; and InnerEarLab and Molecular Biology of Cochlear Neurotransmission Group, Department of Otolaryngology; University Medical Center Göttingen, 37099 Göttingen, GermanyDepartment of Neuro- and Sensory Physiology; European Neuroscience Institute; and InnerEarLab and Molecular Biology of Cochlear Neurotransmission Group, Department of Otolaryngology; University Medical Center Göttingen, 37099 Göttingen, Germany Collaborative Research Center 889 and Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37099 Göttingen, Germany Collaborative Research Center 889 and Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, University of Göttingen, 37099 Göttingen, Germany

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http://dx.doi.org/10.1083/jcb.201402066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033769PMC
May 2014

ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.

J Neurosci 2014 May;34(20):6843-8

InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, 37099 Göttingen, Germany, Collaborative Research Center 889, University of Göttingen, 37099 Göttingen, Germany

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http://dx.doi.org/10.1523/JNEUROSCI.4990-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608114PMC
May 2014

Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.

EMBO J 2014 Mar 17;33(5):512-27. Epub 2014 Jan 17.

InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1002/embj.201385887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989631PMC
March 2014

Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.

J Neurosci 2014 Jan;34(3):705-16

InnerEarLab, Department of Otolaryngology, Molecular Architecture of Synapses Group, InnerEarLab, Department of Otolaryngology, and Department of Neurology, University Medical Center Göttingen, D-37099 Göttingen, Germany, Collaborative Research Center 889, International Max Planck Research Schools, Neuroscience, Göttingen Graduate School for Neuroscience, Biophysics, and Molecular Biosciences, Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain, and Bernstein Focus for Neurotechnology, University of Göttingen, D-37073 Göttingen, Germany, and The Jackson Laboratory, Bar Harbor, Maine 04609.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3313-13.2
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891952PMC
January 2014

Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.

J Neurosci 2013 Jun;33(26):10661-6

InnerEarLab, Auditory Systems Physiology Group, Department of Otolaryngology, and Collaborative Research Center 889, University Medical Center Göttingen, D-37099 Göttingen, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1215-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618488PMC
June 2013

Review of hair cell synapse defects in sensorineural hearing impairment.

Otol Neurotol 2013 Aug;34(6):995-1004

InnerEarLab, Department of Otolaryngology, University of Göttingen Medical School, Göttingen, Germany.

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August 2013

Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells.

J Physiol 2013 Jul 22;591(13):3253-69. Epub 2013 Apr 22.

Department of Molecular Physiology and Biophysics, University of Iowa, 5-610 Bowen Science Building, 51 Newton Rd, Iowa City, IA 52242, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717226PMC
July 2013

Otoferlin: a multi-C2 domain protein essential for hearing.

Trends Neurosci 2012 Nov 7;35(11):671-80. Epub 2012 Sep 7.

InnerEarLab, Department of Otolaryngology and Collaborative Research Center 889, University Medical Center Göttingen, Göttingen, Germany.

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November 2012

Spike encoding of neurotransmitter release timing by spiral ganglion neurons of the cochlea.

J Neurosci 2012 Apr;32(14):4773-89

InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Goettingen Medical School, D-37075 Goettingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620899PMC
April 2012

Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.

Nat Neurosci 2011 Aug 7;14(9):1109-11. Epub 2011 Aug 7.

Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164920PMC
August 2011

Connexin32 can restore hearing in connexin26 deficient mice.

Eur J Cell Biol 2011 Oct 2;90(10):817-24. Epub 2011 Aug 2.

Institute of Genetics, University of Bonn, 53117 Bonn, Germany.

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October 2011

Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins.

Nat Neurosci 2011 Apr 6;14(4):411-3. Epub 2011 Mar 6.

InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen Medical Center, Göttingen, Germany.

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April 2011

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.

Proc Natl Acad Sci U S A 2011 Feb 31;108(7):3053-8. Epub 2011 Jan 31.

Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D-37075 Göttingen, Germany.

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February 2011

The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region.

J Mol Biol 2011 Feb 7;406(3):479-90. Epub 2011 Jan 7.

Molecular Biology of Cochlear Neurotransmission Junior Research Group, University Medical Center Göttingen, Robert-Koch-Str. 40, 37099 Göttingen, Germany.

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February 2011

The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome.

Hum Mol Genet 2011 Jan 6;20(1):28-39. Epub 2010 Oct 6.

Institut for Genetik, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://dx.doi.org/10.1093/hmg/ddq429DOI Listing
January 2011

Structure and function of cochlear afferent innervation.

Curr Opin Otolaryngol Head Neck Surg 2010 Oct;18(5):441-6

Department of Otorhinolaryngology, University of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1097/MOO.0b013e32833e0586DOI Listing
October 2010

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells.

Nat Neurosci 2010 Jul 20;13(7):869-76. Epub 2010 Jun 20.

InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.

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July 2010