Tobias M Boeckers

Tobias M Boeckers

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Tobias M Boeckers

Tobias M Boeckers

Publications by authors named "Tobias M Boeckers"

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Altered Intestinal Morphology and Microbiota Composition in the Autism Spectrum Disorders Associated SHANK3 Mouse Model.

Int J Mol Sci 2019 Apr 30;20(9). Epub 2019 Apr 30.

Cellular Neurobiology and Neuro-Nanotechnology lab, Dept. of Biological Sciences, University of Limerick, V94PH61 Limerick, Ireland.

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http://dx.doi.org/10.3390/ijms20092134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540607PMC
April 2019

Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder.

Adv Anat Embryol Cell Biol 2017 ;224:103-119

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1007/978-3-319-52498-6_6DOI Listing
June 2018

Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3.

J Neurochem 2018 06 10;145(6):449-463. Epub 2018 Jun 10.

Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1111/jnc.14322DOI Listing
June 2018

Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain.

Front Mol Neurosci 2017 17;10:456. Epub 2018 Jan 17.

Cellular Neurobiology and Neuro-Nanotechnology Lab, Department of Biological Sciences, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.3389/fnmol.2017.00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776125PMC
January 2018

Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury.

Int Immunopharmacol 2017 Oct 12;51:66-75. Epub 2017 Aug 12.

Dept. of Neurology, University of Ulm, School of Medicine, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2017.08.002DOI Listing
October 2017

Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at ultrahigh resolution.

Biochem Biophys Res Commun 2017 08 21;490(3):806-812. Epub 2017 Jun 21.

Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Finland; Department of Biomedicine, University of Bergen, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.06.121DOI Listing
August 2017

Genetic Animal Models for Autism Spectrum Disorder.

Curr Top Behav Neurosci 2017;30:311-324

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://link.springer.com/content/pdf/10.1007%2F7854_2015_407
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http://link.springer.com/10.1007/7854_2015_407
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http://dx.doi.org/10.1007/7854_2015_407DOI Listing
June 2017

Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2.

Front Mol Neurosci 2017 8;10:180. Epub 2017 Jun 8.

Cellular Neurobiology and Neuro-Nanotechnology Laboratory, Department of Biological Sciences, University of LimerickLimerick, Ireland.

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http://dx.doi.org/10.3389/fnmol.2017.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462907PMC
June 2017

Proteomic Analysis of Post-synaptic Density Fractions from Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder.

Front Mol Neurosci 2017 14;10:26. Epub 2017 Feb 14.

Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany; Division of Neuroanatomy, Institute of Anatomy, Otto-von-Guericke UniversityMagdeburg, Germany; Leibniz Institute for NeurobiologyMagdeburg, Germany.

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00
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http://dx.doi.org/10.3389/fnmol.2017.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306440PMC
February 2017

Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice.

Neuropharmacology 2017 01 17;112(Pt A):104-112. Epub 2016 Aug 17.

Laboratory of Neurobiology, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.08.016DOI Listing
January 2017

Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells.

Neural Plast 2016 9;2016:3760702. Epub 2016 May 9.

Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany; WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2016/3760702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876239PMC
December 2016

Activity and circadian rhythm influence synaptic Shank3 protein levels in mice.

J Neurochem 2016 09 15;138(6):887-95. Epub 2016 Jul 15.

WG Molecular Analysis of Synaptopathies, Department of Neurology, Neurocenter of Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1111/jnc.13709DOI Listing
September 2016

The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons.

Front Synaptic Neurosci 2016 24;8:13. Epub 2016 May 24.

Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany; Department of Neurology, Ulm UniversityUlm, Germany.

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http://dx.doi.org/10.3389/fnsyn.2016.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877498PMC
June 2016

Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models.

Front Neurosci 2016 8;10:133. Epub 2016 Apr 8.

Department of Child and Adolescence Psychiatry/Psychotherapy, University of Ulm Ulm, Germany.

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http://dx.doi.org/10.3389/fnins.2016.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824761PMC
April 2016

Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.

Mol Brain 2016 Mar 11;9:28. Epub 2016 Mar 11.

WG Molecular Analysis of Synaptopathies, Neurology Department, Ulm University, Albert-Einstein-Allee 11, D-89081, Ulm, Germany.

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http://dx.doi.org/10.1186/s13041-016-0206-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788860PMC
March 2016

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency.

Front Behav Neurosci 2016 3;10:37. Epub 2016 Mar 3.

Institute for Anatomy and Cell Biology, Ulm UniversityUlm, Germany; WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm UniversityUlm, Germany.

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http://dx.doi.org/10.3389/fnbeh.2016.00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776245PMC
March 2016

Effects of trace metal profiles characteristic for autism on synapses in cultured neurons.

Neural Plast 2015 23;2015:985083. Epub 2015 Feb 23.

WG Molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, 89081 Ulm, Germany ; Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2015/985083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352758PMC
November 2015

Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging.

Neurobiol Dis 2015 Oct 4;82:420-429. Epub 2015 Aug 4.

Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, 01307 Dresden, Germany; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.07.017DOI Listing
October 2015

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.

Proteomics 2014 Nov 18;14(21-22):2607-13. Epub 2014 Oct 18.

Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes-Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1002/pmic.201300520DOI Listing
November 2014

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments.

PLoS Genet 2014 Sep 4;10(9):e1004580. Epub 2014 Sep 4.

Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France; CNRS UMR 3571 Genes, Synapses and Cognition, Institut Pasteur, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France; FondaMental Foundation, Créteil, France.

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http://dx.doi.org/10.1371/journal.pgen.1004580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154644PMC
September 2014

Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain--an in vivo study.

Drug Des Devel Ther 2013 4;7:1433-46. Epub 2013 Dec 4.

Department of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.2147/DDDT.S50448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857115PMC
August 2014

Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release.

Int J Pharm 2014 Aug 2;471(1-2):349-57. Epub 2014 Jun 2.

Pharmaceutical Technology, Te.Far.T.I. group, Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.05.054DOI Listing
August 2014

Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses.

Biometals 2014 Aug 10;27(4):715-30. Epub 2014 Jul 10.

WG molecular Analysis of Synaptopathies, Neurology Department, Neurocenter of Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.

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http://link.springer.com/10.1007/s10534-014-9764-1
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http://dx.doi.org/10.1007/s10534-014-9764-1DOI Listing
August 2014

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation.

Exp Neurol 2014 Mar 29;253:126-37. Epub 2013 Dec 29.

WG Molecular Analysis of Synaptopathies, Neurology Dept., Neurocenter of Ulm University, Albert-Einstein Allee 11, 89081 Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, Albert-Einstein Allee 11, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2013.12.015DOI Listing
March 2014

Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport.

J Control Release 2014 Mar 11;177:96-107. Epub 2014 Jan 11.

WG Molecular Analysis of Synaptopathies, Neurology Dept., Neurocenter of Ulm University, Ulm, Germany; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.01.004DOI Listing
March 2014

Neurobiology of autism gene products: towards pathogenesis and drug targets.

Psychopharmacology (Berl) 2014 Mar 14;231(6):1037-62. Epub 2014 Jan 14.

Department Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3984 CG, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00213-013-3403-3DOI Listing
March 2014

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution.

J Control Release 2014 Jan 5;174:195-201. Epub 2013 Dec 5.

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2013.11.023DOI Listing
January 2014

The Autism ProSAP1/Shank2 mouse model displays quantitative and structural abnormalities in ultrasonic vocalisations.

Behav Brain Res 2013 Nov 28;256:677-89. Epub 2013 Aug 28.

Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France; CNRS URA 2182 'Genes, synapses and cognition', Institut Pasteur, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Human Genetics and Cognitive Functions, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2013.08.031DOI Listing
November 2013

Calcium activated potassium channel expression during human iPS cell-derived neurogenesis.

Ann Anat 2013 Jul 28;195(4):303-11. Epub 2013 Mar 28.

Institute for Anatomy & Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1016/j.aanat.2013.02.009DOI Listing
July 2013

Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation.

J Neurosci 2013 Jun;33(23):9699-715

Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR)-5203, Institut de Génomique Fonctionnelle, Montpellier, F-34094, France.

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http://dx.doi.org/10.1523/JNEUROSCI.2725-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619703PMC
June 2013

Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).

Cell Tissue Res 2012 Oct 10;350(1):13-26. Epub 2012 Jul 10.

Institute for Anatomy & Cell Biology, Ulm University, Albert-Einstein Allee 11, 89081 Ulm, Germany.

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http://link.springer.com/10.1007/s00441-012-1463-z
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http://dx.doi.org/10.1007/s00441-012-1463-zDOI Listing
October 2012

The potential of iPS cells in synucleinopathy research.

Stem Cells Int 2012 18;2012:629230. Epub 2012 Mar 18.

Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1155/2012/629230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329650PMC
July 2012

Scaffold proteins at the postsynaptic density.

Adv Exp Med Biol 2012 ;970:29-61

CNR Institute of Neuroscience, Department of Pharmacology, University of Milan and Neuromuscular Diseases and Neuroimmunology, Neurological Institute Foundation Carlo Besta, Via Vanvitelli 32, 20129 Milan, Italy.

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http://dx.doi.org/10.1007/978-3-7091-0932-8_2DOI Listing
June 2012

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies.

Trends Cell Biol 2011 Oct 15;21(10):594-603. Epub 2011 Aug 15.

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1016/j.tcb.2011.07.003DOI Listing
October 2011

The spatio-temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development.

Dev Dyn 2011 Jun 28;240(6):1528-36. Epub 2011 Mar 28.

Institute for Biochemistry and Molecular Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1002/dvdy.22613DOI Listing
June 2011

Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: an in vitro study.

World J Biol Psychiatry 2011 Mar 24;12(2):89-98. Epub 2010 Aug 24.

Institute of Anatomy and Cell Biology, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.3109/15622975.2010.506927DOI Listing
March 2011

Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences.

PLoS One 2011 Mar 23;6(3):e17851. Epub 2011 Mar 23.

Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017851PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063171PMC
March 2011

How can we deal with mental distress in the dissection room?-An evaluation of the need for psychological support.

Ann Anat 2010 Dec 19;192(6):366-72. Epub 2010 Aug 19.

Ulm University, Faculty of Medicine, Institute of Anatomy and Cell Biology, Albert-Einstein-Allee 11, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.aanat.2010.08.002DOI Listing
December 2010

Synaptogenesis of hippocampal neurons in primary cell culture.

Cell Tissue Res 2009 Dec 3;338(3):333-41. Epub 2009 Nov 3.

Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany.

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http://dx.doi.org/10.1007/s00441-009-0881-zDOI Listing
December 2009

Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.

J Biol Chem 2009 Oct 24;284(42):29146-57. Epub 2009 Aug 24.

Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.

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http://dx.doi.org/10.1074/jbc.M109.020628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781459PMC
October 2009

Efficient targeting of proteins to post-synaptic densities of excitatory synapses using a novel pSDTarget vector system.

J Neurosci Methods 2009 Jul 22;181(2):227-34. Epub 2009 May 22.

Institute for Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2009.05.008DOI Listing
July 2009

ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3.

Biochem Biophys Res Commun 2009 Jul 27;385(3):460-5. Epub 2009 May 27.

Institute of Anatomy and Cell Biology, Albert Einstein Allee 11, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2009.05.098DOI Listing
July 2009

"Theatrum anatomicum" -- a revived teaching facility in gross anatomy.

Ann Anat 2008 Dec 17;190(6):495-501. Epub 2008 Oct 17.

Institute of Anatomy and Cell Biology, Ulm University, Ulm, Baden-Wuerttemberg, Germany.

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http://dx.doi.org/10.1016/j.aanat.2008.08.004DOI Listing
December 2008