Tobias E Larsson

Tobias E Larsson

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Tobias E Larsson

Tobias E Larsson

Publications by authors named "Tobias E Larsson"

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Weak acidic stable carbazate modified cellulose membranes target for scavenging carbonylated proteins in hemodialysis.

Carbohydr Polym 2020 Mar 9;231:115727. Epub 2019 Dec 9.

Department of Chemistry, Ångström Laboratory, Uppsala University, Box 538, SE-75121, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.carbpol.2019.115727DOI Listing
March 2020

Carbazate modified dextrans as scavengers for carbonylated proteins.

Carbohydr Polym 2020 Mar 28;232:115802. Epub 2019 Dec 28.

Department of Chemistry - Ångström Laboratory, Uppsala University, Box 538, SE-751 21, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2019.115802DOI Listing
March 2020

Associations of Fibroblast Growth Factor 23 with Markers of Inflammation and Leukocyte Transmigration in Chronic Kidney Disease.

Nephron 2018 4;138(4):287-295. Epub 2018 Jan 4.

Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000485472DOI Listing
September 2019

In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.

Am J Physiol Renal Physiol 2018 11 11;315(5):F1261-F1270. Epub 2018 Jul 11.

Division of Bone and Mineral Research, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine , Boston, Massachusetts.

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http://dx.doi.org/10.1152/ajprenal.00650.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293295PMC
November 2018

Klotho controls the brain-immune system interface in the choroid plexus.

Proc Natl Acad Sci U S A 2018 11 9;115(48):E11388-E11396. Epub 2018 Nov 9.

Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158;

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http://dx.doi.org/10.1073/pnas.1808609115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275534PMC
November 2018

NPT-IIb Inhibition Does Not Improve Hyperphosphatemia in CKD.

Kidney Int Rep 2018 Jan 12;3(1):73-80. Epub 2017 Aug 12.

Astellas Pharma Europe BV, Leiden, Netherlands.

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http://dx.doi.org/10.1016/j.ekir.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762974PMC
January 2018

Klotho expression in osteocytes regulates bone metabolism and controls bone formation.

Kidney Int 2017 09 8;92(3):599-611. Epub 2017 Apr 8.

Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.02.014DOI Listing
September 2017

Tissue expression and source of circulating αKlotho.

Bone 2017 Jul 18;100:19-35. Epub 2017 Mar 18.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bone.2017.03.043DOI Listing
July 2017

Klotho expression in long bones regulates FGF23 production during renal failure.

FASEB J 2017 05 9;31(5):2050-2064. Epub 2017 Feb 9.

Division of Bone and Mineral Research, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA;

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http://dx.doi.org/10.1096/fj.201601036RDOI Listing
May 2017

In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling.

Kidney Int 2016 08 9;90(2):348-362. Epub 2016 Jun 9.

Division of Bone and Mineral Research, Harvard School of Dental Medicine, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.04.009DOI Listing
August 2016

FGF-23 and Osteoprotegerin but not Fetuin-A are associated with death and enhance risk prediction in non-dialysis chronic kidney disease stages 3-5.

Nephrology (Carlton) 2016 Jul;21(7):566-73

Vascular Research Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/nep.12664DOI Listing
July 2016

FGF23, metabolic risk factors, and blood pressure in patients with primary hyperparathyroidism undergoing parathyroid adenomectomy.

Surgery 2016 Jan 2;159(1):211-7. Epub 2015 Oct 2.

Department of Clinical Science, Intervention and Technology, Renal Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.surg.2015.06.057DOI Listing
January 2016

Soluble klotho and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.

Atherosclerosis 2015 Oct 13;242(2):483-9. Epub 2015 Aug 13.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.017DOI Listing
October 2015

Soluble Tumor Necrosis Factor Receptor 1 Is Associated with Glomerular Filtration Rate Progression and Incidence of Chronic Kidney Disease in Two Community-Based Cohorts of Elderly Individuals.

Cardiorenal Med 2015 Oct 31;5(4):278-88. Epub 2015 Jul 31.

Department of Medical Cell Biology, Biomedical Center, Uppsala University, Uppsala, Sweden ; School of Health and Social Studies, Dalarna University, Falun, Sweden.

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http://dx.doi.org/10.1159/000435863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662300PMC
October 2015

Endostatin level is associated with kidney injury in the elderly: findings from two community-based cohorts.

Am J Nephrol 2014 14;40(5):417-24. Epub 2014 Nov 14.

Department of Surgery, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1159/000369076DOI Listing
August 2015

Kidney function, β-cell function and glucose tolerance in older men.

J Clin Endocrinol Metab 2015 Feb 27;100(2):587-93. Epub 2014 Nov 27.

Divisions of Renal Medicine and Baxter Novum, Departments of Clinical Science, Intervention and Technology (T.J., H.X., B.L., T.E.L., J.J.C.), Public Health Sciences (T.J.), and Center for Molecular Medicine (J.J.C.), Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Caring Sciences, Section of Geriatrics (J.A.), Clinical Nutrition and Metabolism (U.R., P.S., T.C.), Uppsala University, Uppsala, Sweden; School of Health and Social Studies (J.A.), Dalarna University, Falun, Sweden; and Department of Medicine (T.A.I.), Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1210/jc.2014-3313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318901PMC
February 2015

Soluble tumor necrosis factor receptor 1 (sTNFR1) is associated with increased total mortality due to cancer and cardiovascular causes - findings from two community based cohorts of elderly.

Atherosclerosis 2014 Nov 16;237(1):236-42. Epub 2014 Sep 16.

Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden.

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.09.005DOI Listing
November 2014

The role of klotho on vascular calcification and endothelial function in chronic kidney disease.

Semin Nephrol 2014 Nov;34(6):578-85

Inserm U-1088, University of Picardie Jules verne (UPJV), Amiens, France; Division of Nephrology, Ambroise Paré Hospital, Paris-Ile-de-France-Ouest University (University of Versailles Saint Quentin (UVSQ)), Paris-Boulogne Billancourt, France.

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https://linkinghub.elsevier.com/retrieve/pii/S02709295140014
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http://dx.doi.org/10.1016/j.semnephrol.2014.09.003DOI Listing
November 2014

New insights into the FGF23-Klotho axis.

Semin Nephrol 2014 Nov;34(6):586-97

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Department of Nephrology, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.semnephrol.2014.09.005DOI Listing
November 2014

Calcium-sensing receptor activation in chronic kidney disease: effects beyond parathyroid hormone control.

Semin Nephrol 2014 Nov;34(6):648-59

Department of Nephrology and Institute of Cardiovascular Research VU (Institute for Cardiovascular Research of the Vrije Universiteit of Amsterdam), VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.semnephrol.2014.10.001DOI Listing
November 2014

Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome?

Nephrol Dial Transplant 2014 Oct 9;29(10):1815-20. Epub 2014 Feb 9.

Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1093/ndt/gft514DOI Listing
October 2014

The kidney is the principal organ mediating klotho effects.

J Am Soc Nephrol 2014 Oct 22;25(10):2169-75. Epub 2014 May 22.

Division of Renal Medicine, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm Sweden; Department of Nephrology, Karolinska University Hospital, Stockholm, Sweden

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http://dx.doi.org/10.1681/ASN.2013111209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178446PMC
October 2014

Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.

PLoS Genet 2013 12;9(12):e1003975. Epub 2013 Dec 12.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden ; Department of Nephrology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1371/journal.pgen.1003975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861040PMC
August 2014

Urinary kidney injury molecule-1 and the risk of cardiovascular mortality in elderly men.

Clin J Am Soc Nephrol 2014 Aug 12;9(8):1393-401. Epub 2014 Jun 12.

Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden

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http://dx.doi.org/10.2215/CJN.11901113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123404PMC
August 2014

Soluble TNF receptors and kidney dysfunction in the elderly.

J Am Soc Nephrol 2014 Jun 7;25(6):1313-20. Epub 2014 Feb 7.

Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden

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http://dx.doi.org/10.1681/ASN.2013080860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033380PMC
June 2014

Determinants of fibroblast growth factor-23 and parathyroid hormone variability in dialysis patients.

Am J Nephrol 2013 27;37(5):462-71. Epub 2013 Apr 27.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000350537DOI Listing
February 2014

FGF23 affects the lineage fate determination of mesenchymal stem cells.

Calcif Tissue Int 2013 Dec 26;93(6):556-64. Epub 2013 Sep 26.

Division of Orthopedics and Biotechnology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Huddinge, 14186, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00223-013-9795-6DOI Listing
December 2013

Determinants and survival implications of low bone mineral density in end-stage renal disease patients.

J Nephrol 2013 May-Jun;26(3):485-94. Epub 2012 Sep 13.

Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://www.jnephrol.com/article/determinants-and-survival-im
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http://dx.doi.org/10.5301/jn.5000185DOI Listing
November 2013

Arterial klotho expression and FGF23 effects on vascular calcification and function.

PLoS One 2013 5;8(4):e60658. Epub 2013 Apr 5.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060658PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618102PMC
October 2013

The authors reply:.

Kidney Int 2013 Sep;84(3):621

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http://dx.doi.org/10.1038/ki.2013.240DOI Listing
September 2013

Chronic kidney disease: a clinical model of premature aging.

Am J Kidney Dis 2013 Aug 26;62(2):339-51. Epub 2013 Jan 26.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.ajkd.2012.11.051DOI Listing
August 2013

FGF23 and Klotho in chronic kidney disease.

Curr Opin Nephrol Hypertens 2013 Jul;22(4):397-404

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1097/MNH.0b013e32836213eeDOI Listing
July 2013

Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology.

Clin J Am Soc Nephrol 2013 May 18;8(5):781-6. Epub 2013 Jan 18.

Department of Public Health and Caring Sciences/Section of Geriatrics, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.2215/CJN.09570912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641622PMC
May 2013

Urinary kidney injury molecule 1 and incidence of heart failure in elderly men.

Eur J Heart Fail 2013 Apr 7;15(4):441-6. Epub 2012 Dec 7.

Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

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http://dx.doi.org/10.1093/eurjhf/hfs187DOI Listing
April 2013

Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community.

Kidney Int 2013 Jan 5;83(1):160-6. Epub 2012 Sep 5.

Department of Public Health and Caring Sciences/Section of Geriatrics Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1038/ki.2012.327DOI Listing
January 2013

Circulating fibroblast growth factors as metabolic regulators--a critical appraisal.

Cell Metab 2012 Dec;16(6):693-705

Metabolism Unit, Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences NOVUM, Karolinska Institute at Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2012.11.001DOI Listing
December 2012

Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism.

J Am Soc Nephrol 2012 Oct 9;23(10):1641-51. Epub 2012 Aug 9.

Clinical Research Center, Sixth Floor, Novumhuset, Karolinska University Hospital in Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1681/ASN.2012010048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458458PMC
October 2012

Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men.

J Bone Miner Res 2011 Apr;26(4):857-64

Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.

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http://doi.wiley.com/10.1002/jbmr.263
Publisher Site
http://dx.doi.org/10.1002/jbmr.263DOI Listing
April 2011

Fibroblast growth factor-23 and mineral metabolism after unilateral nephrectomy.

Nephrol Dial Transplant 2010 Dec 4;25(12):4068-71. Epub 2010 Jun 4.

Department of Medical Sciences, Uppsala University Hospital, Ing. 30, 5 tr.; UAS, 75185 Uppsala, Sweden.

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http://dx.doi.org/10.1093/ndt/gfq288DOI Listing
December 2010

Plasma parathyroid hormone and risk of congestive heart failure in the community.

Eur J Heart Fail 2010 Nov 26;12(11):1186-92. Epub 2010 Aug 26.

Uppsala Clinical Research Center, Uppsala University, 751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1093/eurjhf/hfq134DOI Listing
November 2010

Relation between serum fibroblast growth factor-23 level and mortality in incident dialysis patients: are gender and cardiovascular disease confounding the relationship?

Nephrol Dial Transplant 2010 Sep 5;25(9):3033-8. Epub 2010 Apr 5.

Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/ndt/gfq191DOI Listing
September 2010

The role of FGF-23 in CKD-MBD and cardiovascular disease: friend or foe?

Authors:
Tobias E Larsson

Nephrol Dial Transplant 2010 May 2;25(5):1376-81. Epub 2010 Feb 2.

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http://dx.doi.org/10.1093/ndt/gfp784DOI Listing
May 2010

Mutation analysis and serum FGF23 level in a patient with pulmonary alveolar microlithiasis.

Endocrine 2010 Apr 5;37(2):244-8. Epub 2010 Jan 5.

Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s12020-009-9299-3DOI Listing
April 2010

Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncardiovascular mortality in the community.

Arterioscler Thromb Vasc Biol 2010 Feb 30;30(2):333-9. Epub 2009 Nov 30.

Department of Nephrology, Karolinska University Hospital, Stockholm, Sweden.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.196675
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.109.196675DOI Listing
February 2010

Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population.

Atherosclerosis 2009 Dec 21;207(2):546-51. Epub 2009 May 21.

Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.05.013DOI Listing
December 2009

Relationship between circulating FGF23 and total body atherosclerosis in the community.

Nephrol Dial Transplant 2009 Oct 9;24(10):3125-31. Epub 2009 May 9.

Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1093/ndt/gfp205DOI Listing
October 2009

Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community.

Atherosclerosis 2009 Aug 9;205(2):385-90. Epub 2009 Jan 9.

Department of Medical Sciences, Uppsala University Hospital, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150090000
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http://dx.doi.org/10.1016/j.atherosclerosis.2009.01.001DOI Listing
August 2009

Type I membrane klotho expression is decreased and inversely correlated to serum calcium in primary hyperparathyroidism.

J Clin Endocrinol Metab 2008 Oct 5;93(10):4152-7. Epub 2008 Aug 5.

Department of Medical Sciences, Uppsala University Hospital, Ing.70, 3 tr, UAS, 75185 Uppsala, Sweden.

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http://dx.doi.org/10.1210/jc.2008-0564DOI Listing
October 2008

A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome.

Eur J Endocrinol 2008 Jun 5;158(6):929-34. Epub 2008 Mar 5.

Department of Medical Sciences, Uppsala University Hospital, Ing.70, 3 tr, 75185 Uppsala, Sweden.

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http://dx.doi.org/10.1530/EJE-08-0011DOI Listing
June 2008

Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23.

Nephrol Dial Transplant 2008 Mar 2;23(3):827-33. Epub 2007 Oct 2.

Department of Surgical Sciences, Uppsala University Hospital, Uppsala 751 85, Sweden.

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http://dx.doi.org/10.1093/ndt/gfm672DOI Listing
March 2008

Regulation of fibroblast growth factor-23 in chronic kidney disease.

Nephrol Dial Transplant 2007 Nov 13;22(11):3202-7. Epub 2007 Jun 13.

Department of Medical Sciences, Uppsala University Hospital, Ing. 70, 3 tr., UAS, 75185 Uppsala, Sweden.

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http://dx.doi.org/10.1093/ndt/gfm347DOI Listing
November 2007

The roles of specific genes implicated as circulating factors involved in normal and disordered phosphate homeostasis: frizzled related protein-4, matrix extracellular phosphoglycoprotein, and fibroblast growth factor 23.

Endocr Rev 2006 May 7;27(3):221-41. Epub 2006 Feb 7.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1210/er.2005-0019DOI Listing
May 2006