Publications by authors named "Tobias C Walther"

96Publications

Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.

Dev Cell 2020 Aug 29;54(4):471-487.e7. Epub 2020 Jul 29.

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02124, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.07.001DOI Listing
August 2020

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.

Nature 2020 05 13;581(7808):323-328. Epub 2020 May 13.

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2289-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398557PMC
May 2020

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.

Mol Cell 2020 03 4;77(6):1251-1264.e9. Epub 2020 Feb 4.

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397554PMC
March 2020

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex.

Dev Cell 2019 12 7;51(5):551-563.e7. Epub 2019 Nov 7.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02124, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235935PMC
December 2019

Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics.

Dev Cell 2019 09;50(5):530-532

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397519PMC
September 2019

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.

J Lipid Res 2019 06 1;60(6):1112-1120. Epub 2019 Apr 1.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115

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http://dx.doi.org/10.1194/jlr.M093112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547635PMC
June 2019

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.

Mol Cell 2019 04 4;74(1):32-44.e8. Epub 2019 Mar 4.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.01.036DOI Listing
April 2019

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Atherosclerosis 2018 10 30;277:145-154. Epub 2018 Aug 30.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA; Bluefield Project to Cure FTD, San Francisco, CA, 94107, USA; Broad Institute, Cambridge, MA, 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432779PMC
October 2018

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Mol Biol Cell 2018 08 27;29(17):2045-2054. Epub 2018 Jun 27.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115.

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http://dx.doi.org/10.1091/mbc.E18-05-0282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232964PMC
August 2018

Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.

Mol Cell Proteomics 2018 05 5;17(5):836-849. Epub 2018 Feb 5.

From the ‡Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, 02115.

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http://dx.doi.org/10.1074/mcp.RA117.000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930403PMC
May 2018

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.

Dev Cell 2018 Jan 8;44(1):73-86.e4. Epub 2018 Jan 8.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02124, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764114PMC
January 2018

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

Biochemistry 2018 Feb 26;57(5):827-838. Epub 2017 Dec 26.

Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute , La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b01028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854151PMC
February 2018

Lipid Droplet Biogenesis.

Annu Rev Cell Dev Biol 2017 10 9;33:491-510. Epub 2017 Aug 9.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115; email: ,

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http://dx.doi.org/10.1146/annurev-cellbio-100616-060608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986389PMC
October 2017

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Cell Metab 2017 Aug;26(2):407-418.e3

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195226PMC
August 2017

The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion.

Mol Microbiol 2017 Oct 4;106(1):74-92. Epub 2017 Aug 4.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA.

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http://doi.wiley.com/10.1111/mmi.13754
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http://dx.doi.org/10.1111/mmi.13754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607103PMC
October 2017

Lipid droplets and liver disease: from basic biology to clinical implications.

Nat Rev Gastroenterol Hepatol 2017 Jun 21;14(6):343-355. Epub 2017 Apr 21.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrgastro.2017.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319657PMC
June 2017

Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.

Proteomics 2016 11;16(21):2759-2763

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1002/pmic.201600269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688516PMC
November 2016

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.

Trends Cell Biol 2016 07 16;26(7):535-546. Epub 2016 Mar 16.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute (HHMI), Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976449PMC
July 2016

Lipid droplets go nuclear.

J Cell Biol 2016 Jan;212(1):7-8

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA 02115 Howard Hughes Medical Institute, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115 Broad Institute of MIT and Harvard, Cambridge, MA 02142

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http://dx.doi.org/10.1083/jcb.201512056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700486PMC
January 2016

The GARP complex is required for cellular sphingolipid homeostasis.

Elife 2015 Sep 10;4. Epub 2015 Sep 10.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.

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http://dx.doi.org/10.7554/eLife.08712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600884PMC
September 2015

Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation.

Sci Signal 2015 Aug 18;8(390):ra81. Epub 2015 Aug 18.

Vascular Biology and Therapeutics Program, Department of Pharmacology, Yale University School of Medicine, 10 Amistad Street, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/scisignal.aaa2819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790114PMC
August 2015

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.

Dev Cell 2015 Aug 23;34(3):351-63. Epub 2015 Jul 23.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536137PMC
August 2015

The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins.

J Cell Biol 2015 Jan 12;208(2):197-209. Epub 2015 Jan 12.

Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755

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http://dx.doi.org/10.1083/jcb.201408024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298680PMC
January 2015

Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids.

J Biol Chem 2015 Feb 17;290(7):4238-47. Epub 2014 Dec 17.

From the Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142

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http://www.jbc.org/content/290/7/4238.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.629279
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http://dx.doi.org/10.1074/jbc.M114.629279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326832PMC
February 2015

Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe.

Cell Rep 2014 Dec 26;9(5):1959-1965. Epub 2014 Nov 26.

Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140093
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http://dx.doi.org/10.1016/j.celrep.2014.10.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526151PMC
December 2014

A role for eisosomes in maintenance of plasma membrane phosphoinositide levels.

Mol Biol Cell 2014 Sep 23;25(18):2797-806. Epub 2014 Jul 23.

Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115 Department of Cell Biology, Harvard Medical School, Boston, MA 02115

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http://www.molbiolcell.org/content/25/18/2797.full.pdf
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https://cdn1.sph.harvard.edu/wp-content/uploads/sites/1763/2
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http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E13-11-0639
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http://dx.doi.org/10.1091/mbc.E13-11-0639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161514PMC
September 2014

High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.

J Lipid Res 2014 07 27;55(7):1465-77. Epub 2014 May 27.

Department of Biochemistry and Biophysics University of California, San Francisco, CA 94158 Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158 Department of Medicine, University of California, San Francisco, CA 94158.

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http://dx.doi.org/10.1194/jlr.M050229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076087PMC
July 2014

Lipid droplet biogenesis.

Curr Opin Cell Biol 2014 Aug 14;29:39-45. Epub 2014 Apr 14.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California-San Francisco, CA, USA; Department of Medicine, University of California-San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2014.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526149PMC
August 2014

A mechanism for retromer endosomal coat complex assembly with cargo.

Proc Natl Acad Sci U S A 2014 Jan 16;111(1):267-72. Epub 2013 Dec 16.

Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520.

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http://www.pnas.org/content/111/1/267.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1316482111
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http://dx.doi.org/10.1073/pnas.1316482111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890810PMC
January 2014

The biophysics and cell biology of lipid droplets.

Nat Rev Mol Cell Biol 2013 Dec 13;14(12):775-86. Epub 2013 Nov 13.

1] Yale School of Medicine, Department of Cell Biology, 333 Cedar Street, New Haven, Connecticut 06510, USA. [2] Laboratoire de Physique Statistique, Ecole Normale Supérieure de Paris, Université Pierre et Marie Curie, Université Paris Diderot, Centre National de la Recherche Scientifique, 24 rue Lhomond, 75005 Paris, France.

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http://dx.doi.org/10.1038/nrm3699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526153PMC
December 2013

Cellular fatty acid metabolism and cancer.

Cell Metab 2013 Aug 20;18(2):153-61. Epub 2013 Jun 20.

Department of Biochemistry & Biophysics, University of California, San Francisco, 94158, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742569PMC
August 2013

Balancing the fat: lipid droplets and human disease.

EMBO Mol Med 2013 Jul 6;5(7):973-83. Epub 2013 Jun 6.

Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/emmm.201100671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721468PMC
July 2013

Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation.

Mol Cell Proteomics 2013 Jul 16;12(7):1995-2005. Epub 2013 Apr 16.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1074/mcp.M112.025742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708181PMC
July 2013

Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).

J Biol Chem 2013 Mar 30;288(12):8627-35. Epub 2013 Jan 30.

Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M112.441949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605681PMC
March 2013

Protein correlation profiles identify lipid droplet proteins with high confidence.

Mol Cell Proteomics 2013 May 14;12(5):1115-26. Epub 2013 Jan 14.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1074/mcp.M112.020230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650325PMC
May 2013

Seg1 controls eisosome assembly and shape.

J Cell Biol 2012 Aug;198(3):405-20

Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1083/jcb.201202097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413353PMC
August 2012

Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.

Mol Cell Proteomics 2012 Nov 2;11(11):1510-22. Epub 2012 Aug 2.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/mcp.M112.017251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494197PMC
November 2012

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.

Cell Metab 2012 May;15(5):570-3

Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131120009
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http://dx.doi.org/10.1016/j.cmet.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767424PMC
May 2012

Lipid droplets and cellular lipid metabolism.

Annu Rev Biochem 2012 13;81:687-714. Epub 2012 Apr 13.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1146/annurev-biochem-061009-102430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767414PMC
August 2012

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.

Nat Cell Biol 2012 Apr 15;14(5):542-7. Epub 2012 Apr 15.

Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1038/ncb2480DOI Listing
April 2012

Organized living: formation mechanisms and functions of plasma membrane domains in yeast.

Trends Cell Biol 2012 Mar 12;22(3):151-8. Epub 2012 Jan 12.

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82158 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.tcb.2011.12.002DOI Listing
March 2012

Eisosome proteins assemble into a membrane scaffold.

J Cell Biol 2011 Nov;195(5):889-902

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1083/jcb.201104040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257569PMC
November 2011

Eisosome-driven plasma membrane organization is mediated by BAR domains.

Nat Struct Mol Biol 2011 Jun 19;18(7):854-6. Epub 2011 Jun 19.

Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, Martinsried, Germany.

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http://dx.doi.org/10.1038/nsmb.2080DOI Listing
June 2011

A new way to look at fat.

Nat Methods 2011 Feb;8(2):132-3

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http://dx.doi.org/10.1038/nmeth0211-132DOI Listing
February 2011

Yeast expression proteomics by high-resolution mass spectrometry.

Methods Enzymol 2010 1;470:259-80. Epub 2010 Mar 1.

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1016/S0076-6879(10)70011-2DOI Listing
January 2011

Mass spectrometry-based proteomics in cell biology.

J Cell Biol 2010 Aug;190(4):491-500

Organelle Architecture and Dynamics and 2 Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1083/jcb.201004052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928005PMC
August 2010

Keeping sphingolipid levels nORMal.

Authors:
Tobias C Walther

Proc Natl Acad Sci U S A 2010 Mar 16;107(13):5701-2. Epub 2010 Mar 16.

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1073/pnas.1001503107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851878PMC
March 2010

Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating.

Proc Natl Acad Sci U S A 2010 Mar 11;107(9):4170-5. Epub 2010 Feb 11.

Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1073/pnas.0914094107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840153PMC
March 2010

SnapShot: Lipid Droplets.

Cell 2009 Nov;139(5):1024-1024.e1

Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

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http://dx.doi.org/10.1016/j.cell.2009.11.023DOI Listing
November 2009

Lipid droplets finally get a little R-E-S-P-E-C-T.

Cell 2009 Nov;139(5):855-60

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.cell.2009.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097139PMC
November 2009

Comparing cellular proteomes by mass spectrometry.

Genome Biol 2009 28;10(10):240. Epub 2009 Oct 28.

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried/Munich, Germany.

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http://dx.doi.org/10.1186/gb-2009-10-10-240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784314PMC
January 2010

Global analysis of the yeast osmotic stress response by quantitative proteomics.

Mol Biosyst 2009 Nov 10;5(11):1337-46. Epub 2009 Sep 10.

The Novo Nordisk Foundation Center for Protein Research, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1039/b902256bDOI Listing
November 2009

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Science 2009 Aug 16;325(5942):834-40. Epub 2009 Jul 16.

Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1126/science.1175371DOI Listing
August 2009

A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling.

J Cell Biol 2009 Jun;185(7):1227-42

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712959PMC
June 2009

Lipid droplets at a glance.

J Cell Sci 2009 Mar;122(Pt 6):749-52

Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1242/jcs.037630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714424PMC
March 2009

TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain.

Mol Biol Cell 2009 Mar 14;20(5):1565-75. Epub 2009 Jan 14.

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, 82152 Martinsried/Munich, Germany.

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http://www.molbiolcell.org/doi/10.1091/mbc.e08-10-1001
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649262PMC
March 2009

The life of lipid droplets.

Biochim Biophys Acta 2009 Jun 7;1791(6):459-66. Epub 2008 Nov 7.

Organelle Architecture and Dynamics, Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://dx.doi.org/10.1016/j.bbalip.2008.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782899PMC
June 2009

Pil1 controls eisosome biogenesis.

Mol Biol Cell 2009 Feb 26;20(3):809-18. Epub 2008 Nov 26.

Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1091/mbc.e08-03-0313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633383PMC
February 2009

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast.

Nature 2008 Oct 28;455(7217):1251-4. Epub 2008 Sep 28.

Proteomics and Signal Transduction, Max-Planck-Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

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http://www.nature.com/articles/nature07341
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October 2008

Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution.

J Proteome Res 2008 Sep 16;7(9):4050-7. Epub 2008 Aug 16.

Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1021/pr800368mDOI Listing
September 2008

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.

Nature 2008 May 13;453(7195):657-61. Epub 2008 Apr 13.

Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734507PMC
May 2008

Pkh-kinases control eisosome assembly and organization.

EMBO J 2007 Dec 22;26(24):4946-55. Epub 2007 Nov 22.

Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094096PMC
December 2007

Eisosomes mark static sites of endocytosis.

Nature 2006 Feb;439(7079):998-1003

Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, 600-16th Street, San Francisco, California 94143-2200, USA.

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http://www.nature.com/articles/nature04472
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February 2006

Pushing the envelope: structure, function, and dynamics of the nuclear periphery.

Annu Rev Cell Dev Biol 2005 ;21:347-80

Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1146/annurev.cellbio.21.090704.151152DOI Listing
January 2006

RanGTP mediates nuclear pore complex assembly.

Nature 2003 Aug 30;424(6949):689-94. Epub 2003 Jul 30.

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature01898DOI Listing
August 2003

Chromosomal association of Ran during meiotic and mitotic divisions.

J Cell Sci 2002 Dec;115(Pt 23):4685-93

Department of Physiology, University of Connecticut Health Center, Farmington, CT 06032, USA.

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December 2002