Publications by authors named "Tirso Pons"

50Publications

Germline variation in O-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer.

Cancer Lett 2019 04 21;447:86-92. Epub 2019 Jan 21.

Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Program in Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell), IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.01.019DOI Listing
April 2019

Comparison of algorithms for the detection of cancer drivers at subgene resolution.

Nat Methods 2017 Aug 17;14(8):782-788. Epub 2017 Jul 17.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nmeth.4364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935266PMC
August 2017

KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily.

BMC Genomics 2016 06 23;17 Suppl 2:396. Epub 2016 Jun 23.

Center for Biological Sequence Analysis (CBS), Systems Biology Department, Technical University of Denmark (DTU), Kemitorvet, Building 208, 2800 Kgs., Lyngby, Denmark.

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http://dx.doi.org/10.1186/s12864-016-2723-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928150PMC
June 2016

Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?

J Struct Biol 2016 08 18;195(2):259-271. Epub 2016 Jun 18.

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos CP 62210, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2016.06.014DOI Listing
August 2016

Somatic Embryonic FGFR2 Mutations in Keratinocytic Epidermal Nevi.

J Invest Dermatol 2016 08 19;136(8):1718-1721. Epub 2016 Apr 19.

Department of Dermatology, Parc de Salut Mar, Hospital del Mar, Barcelona, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.03.040DOI Listing
August 2016

The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels.

Toxins (Basel) 2016 Apr 13;8(4):110. Epub 2016 Apr 13.

Laboratory of Toxicology and Pharmacology, KU Leuven, Campus Gasthuisberg O&N2, Herestraat 49, P.O. Box 922, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/toxins8040110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848636PMC
April 2016

wKinMut-2: Identification and Interpretation of Pathogenic Variants in Human Protein Kinases.

Hum Mutat 2016 Jan 20;37(1):36-42. Epub 2015 Oct 20.

Center for Biological Sequence Analysis (CBS), Systems Biology Department, Technical University of Denmark (DTU), Kongens Lyngby 2800, Denmark.

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http://dx.doi.org/10.1002/humu.22914DOI Listing
January 2016

Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein-protein interfaces.

Bioinformatics 2015 Jul 11;31(14):2397-9. Epub 2015 Mar 11.

Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btv142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495296PMC
July 2015

NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi.

J Struct Biol 2015 Apr 5;190(1):11-20. Epub 2015 Mar 5.

Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, RJ, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2015.02.007DOI Listing
April 2015

Unraveling the binding mechanism of polyoxyethylene sorbitan esters with bovine serum albumin: a novel theoretical model based on molecular dynamic simulations.

Colloids Surf B Biointerfaces 2014 Apr 19;116:720-6. Epub 2013 Nov 19.

Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, Madrid E-28029, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2013.11.018DOI Listing
April 2014

Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV.

J Biosci 2013 Sep;38(3):461-9

Centro de Estudios de Proteinas (CEP), Facultad de Biologia, Universidad de la Habana, Calle 25 No. 455, Vedado, La Habana 10400, Cuba.

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http://dx.doi.org/10.1007/s12038-013-9333-8DOI Listing
September 2013

A common structural scaffold in CTD phosphatases that supports distinct catalytic mechanisms.

Proteins 2014 Jan 10;82(1):103-18. Epub 2013 Sep 10.

Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/prot.24376DOI Listing
January 2014

Towards a detailed atlas of protein-protein interactions.

Curr Opin Struct Biol 2013 Dec 26;23(6):929-40. Epub 2013 Jul 26.

Joint IRB-BSC Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), c/Baldiri Reixac 10-12, Barcelona 08028, Spain.

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http://dx.doi.org/10.1016/j.sbi.2013.07.005DOI Listing
December 2013

Akirins in sea lice: first steps towards a deeper understanding.

Exp Parasitol 2013 Oct 10;135(2):188-99. Epub 2013 Jul 10.

Animal Biotechnology Division, Center for Genetic Engineering and Biotechnology, Havana, Cuba.

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http://dx.doi.org/10.1016/j.exppara.2013.06.018DOI Listing
October 2013

A novel sea anemone peptide that inhibits acid-sensing ion channels.

Peptides 2014 Mar 10;53:3-12. Epub 2013 Jun 10.

Instituto de Fisiología, Universidad Autónoma de Puebla, 14 sur 6301, CU, San Manuel, Puebla, Puebla CP 72750, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2013.06.003DOI Listing
March 2014

Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Nov 26;68(Pt 11):1289-93. Epub 2012 Oct 26.

Centro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, Calle 25 No. 455, Havana 10400, Cuba.

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http://scripts.iucr.org/cgi-bin/paper?S1744309112039085
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http://dx.doi.org/10.1107/S1744309112039085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515366PMC
November 2012

Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor.

J Struct Biol 2012 Nov 5;180(2):271-9. Epub 2012 Sep 5.

Centro de Estudio de Proteínas, Facultad de Biología, Universidad de la Habana, Calle 25 No 411, Havana, Cuba.

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http://linkinghub.elsevier.com/retrieve/pii/S104784771200240
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http://dx.doi.org/10.1016/j.jsb.2012.08.009DOI Listing
November 2012

In silico studies of potential phosphoresidues in the human nucleophosmin/B23: its kinases and related biological processes.

J Cell Biochem 2012 Jul;113(7):2364-74

Department of Animal and Human Biology, Faculty of Biology, University of Havana, Havana 10400, Cuba.

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http://dx.doi.org/10.1002/jcb.24108DOI Listing
July 2012

Predicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking.

J Mol Model 2012 Jun 20;18(6):2673-87. Epub 2011 Nov 20.

Centro de Estudio de Proteínas (CEP), Facultad de Biología, Universidad de La Habana, Vedado, La Habana, Cuba.

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http://link.springer.com/10.1007/s00894-011-1290-2
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http://dx.doi.org/10.1007/s00894-011-1290-2DOI Listing
June 2012

Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design.

J Trop Med 2011 3;2011:657483. Epub 2011 Jul 3.

Laboratorio de Biología Computacional y Diseño de Proteínas, Centro de Estudio de Proteínas (CEP), Facultad de Biología, Universidad de La Habana, Cuba.

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http://dx.doi.org/10.1155/2011/657483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134243PMC
November 2011

Functional analysis of archaeal MBF1 by complementation studies in yeast.

Biol Direct 2011 Mar 10;6:18. Epub 2011 Mar 10.

Faculty of Chemistry, Biofilm Centre, Molecular Enzyme Technology and Biochemistry, University of Duisburg-Essen, Universitätsstr. 5, (S05 V03 F41), 45141 Essen, Germany.

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http://dx.doi.org/10.1186/1745-6150-6-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062615PMC
March 2011

Validation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins.

Protein Eng Des Sel 2011 Jun 4;24(6):485-93. Epub 2011 Feb 4.

Faculty of Biology, Center for Protein Studies, University of Havana, Calle 25 #455 e/ J e I, Vedado, Ciudad de La Habana, Cuba.

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http://dx.doi.org/10.1093/protein/gzr002DOI Listing
June 2011

Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV.

Int J Biochem Cell Biol 2011 Mar 17;43(3):363-71. Epub 2010 Nov 17.

Centro de Estudios de Proteínas, Facultad de Biología, Universidad de la Habana, Calle 25 No. 455, Vedado, La Habana 10400, Cuba.

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http://dx.doi.org/10.1016/j.biocel.2010.11.006DOI Listing
March 2011

New parameterization approaches of the LIE method to improve free energy calculations of PlmII-Inhibitors complexes.

J Comput Chem 2010 Nov;31(15):2723-34

Laboratorio de Biología Computacional y Diseño de Proteínas, Centro de Estudios de Proteínas, Facultad de Biología, Universidad de La Habana, Cuba.

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http://dx.doi.org/10.1002/jcc.21566DOI Listing
November 2010

Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin.

Colloids Surf B Biointerfaces 2010 Jan 4;75(1):282-9. Epub 2009 Sep 4.

Departamento de Radioquímica, Instituto Superior de Tecnologías y Ciencias Aplicadas, A.P. 6163, Ciudad de La Habana, Cuba.

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http://dx.doi.org/10.1016/j.colsurfb.2009.08.046DOI Listing
January 2010

Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations.

Proteins 2008 Nov;73(2):440-57

Facultad de Biología, Centro de Estudios de Proteínas (CEP), Universidad de La Habana, Cuba.

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http://dx.doi.org/10.1002/prot.22068DOI Listing
November 2008

Computational biology in Cuba: an opportunity to promote science in a developing country.

PLoS Comput Biol 2007 Nov;3(11):e227

Center for Protein Studies, Faculty of Biology, University of Havana, Havana, Cuba.

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https://dx.plos.org/10.1371/journal.pcbi.0030227
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http://dx.doi.org/10.1371/journal.pcbi.0030227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098855PMC
November 2007

Characterization and comparative 3D modeling of CmPI-II, a novel 'non-classical' Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca).

Biol Chem 2007 Nov;388(11):1183-94

Centro de Estudio de Proteínas (CEP), Facultad de Biología, Universidad de La Habana, Calle 25 No 455, Vedado, Habana, Cuba.

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http://dx.doi.org/10.1515/BC.2007.129DOI Listing
November 2007

Enzymic, spectroscopic and calorimetric studies of a recombinant dextranase expressed in Pichia pastoris.

Biotechnol Appl Biochem 2003 Dec;38(Pt 3):211-21

Departamento de Evaluación de Procesos y Sistemas, Planta de Producción, Centro de Ingeniería Genética y Biotecnología, P.O. Box 6162, Habana 10600, Cuba.

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http://dx.doi.org/10.1042/BA20030063DOI Listing
December 2003

Beta-propellers: associated functions and their role in human diseases.

Curr Med Chem 2003 Mar;10(6):505-24

Centro de Ingenería Genética y Biotecnologia (CIGB), Havana, Cuba.

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http://dx.doi.org/10.2174/0929867033368204DOI Listing
March 2003