Publications by authors named "Tingwei Li"

8 Publications

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Contributions of park constructions to residents' demands of ecosystem services consumption: A case study of urban public parks in Beijing.

PLoS One 2021 15;16(12):e0259661. Epub 2021 Dec 15.

Department of data research, Beijing E-Hualu Information Technology Co., Ltd., Beijing, 100430, China.

Urban public parks can provide convenience for residents to get close to nature and provide places for daily ecosystem services. It is of practical and theoretical significance to choose urban public parks as the entry point to explore the changing trends and supply paths of urban residents' daily ecosystem service consumption. Based on the government 's research? of urban public parks in Beijing from 1993 to 2018, this study explores the residents' ecosystem services consumption demands and the contributions of park constructions to these demands. The results show that: (1) in the past 25 years, the frequency, duration, participation rate, and evaluation of people's daily ecosystem service consumption have increased significantly. In other words, the ecosystem services demands are increasing. (2) different constructions of a park have distinct contributions to the increasing demands of ecosystem service consumption. The contributions from constructions of the natural landscape and the infrastructure have been in decline since 1993, yet they contribute the most to the demands of residents' ecosystem services consumption until 2018. The contributions made by constructions of management and maintenance, and transportation around urban public parks have been on the rise and the significant points occurring after the 2008 Olympic Games. Our research proposes a method to determine the relation between the demands of residents' ecosystem services consumption and the contributions of park constructions to these demands, which has significant implications for optimizing the constructions of urban public parks to better meet the demands of ecosystem services consumption.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0259661PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8673618PMC
January 2022

No obvious association exists between mean platelet volume and hypertension subtypes.

Biomark Med 2021 06 14;15(8):577-584. Epub 2021 May 14.

Tianjin Key Laboratory of Lung Cancer Metastasis & Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, 300052, PR China.

To determine the association between mean platelet volume (MPV) and hypertension subtypes. 44,281 Chinese individuals were enrolled in this cross-sectional study. The mean blood pressure decreased with increasing MPV in females (p = 0.001) and increased MPV seemed to be a potential protective factor for isolated diastolic hypertension in models 1 and 2. The OR (CI) was 0.878 (0.789-0.976) for model 1 and 0.880 (0.789-0.981) for model 2 in males and 0.646 (0.495-0.841) for model 1 and 0.657 (0.503-0.858) for model 2 in females, when MPV was analyzed as a categorical variable. The OR (CI) was 0.947 (0.911-0.985) for Model 1 and 0.947 (0.910-0.985) for Model 2 in males, and 0.886 (0.807-0.973) for Model 1 and 0.892 (0.813-0.978) for Model 2 in females when MPV was analyzed as a continuous variable. However, the statistical difference of OR disappeared when we added blood-related covariates in Model 3. No obvious association exists between MPV and hypertension subtypes. Other blood parameters might have a greater impact on hypertension subtypes.
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http://dx.doi.org/10.2217/bmm-2020-0305DOI Listing
June 2021

The different associations between platelet distribution width and hypertension subtypes in males and females.

Biosci Rep 2020 11;40(11)

Tianjin University of Traditional Chinese Medicine, Jian Kang Chan Ye Yuan, Jinghai District, Tianjin, PR China.

The prevalence of hypertension has increased rapidly in recent years. Currently, increasing attention has been paid to the relationship between hypertension and platelet abnormalities. As a simple and available platelet parameter, platelet distribution width (PDW) can reflect platelet abnormalities and further reflect the risk of thrombotic diseases. However, the views on PDW and hypertension are controversial at present studies. Hence, we aimed to find the associations between PDW and hypertension subtypes in the present study. A total of 73,469 participants (44,665 males and 28,804 females) were enrolled. We found that PDW was a risk factor for isolated systolic hypertension (ISH), and the risk of ISH increased with PDW quartiles among women. In men, high PDW might be a risk factor for isolated diastolic hypertension and systolic-diastolic hypertension.
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http://dx.doi.org/10.1042/BSR20201747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677823PMC
November 2020

Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy.

Int J Nanomedicine 2020 15;15:7967-7977. Epub 2020 Oct 15.

Department of Stomatology Medical Center, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People's Republic of China.

Background: Current drugs used for osteoporosis therapy show strong adverse effects. Stem cell-derived extracellular vesicles (EVs) provide another choice for osteoporosis therapy. Mouse mesenchymal stem cells (mMSCs)-derived EVs promote bone regeneration; however, their clinical application is limited due to non-specific tissue targeting. Alendronate specifically targets bone tissue via hydroxyapatite. Therefore, EVs were combined with alendronate to generate Ale-EVs by "click chemistry" to facilitate EVs targeting bone via alendronate/hydroxyapatite binding.

Methods: Ale-EVs were characterized based on size using dynamic light scattering analysis and morphology was visualized by transmission electron microscopy. Hydroxyapatite affinity of Ale-EVs was detected by flow cytometry. Bone targeting of Ale-EVs was tested by ex vivo fluorescent imaging. Cell viability was assessed by using WST-8 reduction assay kit for testing the ability of Ale-EVs to promote mMSCs proliferation. Alkaline phosphatase experiment was used to detect ability of Ale-EVs to promote differentiation of mouse mesenchymal stem cells in vitro. Western blotting and Q-PCR assay were used to detect the early marker of osteogenic differentiation. Antiosteoporotic effects of Ale-EVs were detected in ovariectomy (OVX)-induced osteoporosis rat model. The safety of the Ale-EVs in vivo was measured by H&E staining and serum markers assay.

Results: In vitro, Ale-EVs had high affinity with hydroxyapatite. Also, ex vivo data indicated that Ale-EVs-DiD treatment of mice induced strong fluorescece in bone tissues compared with EVs-DiD group. Furthermore, results suggested that Ale-EVs promoted the growth and differentiation of mouse MSCs. They also protected against osteoporosis in ovariectomy (OVX)-induced osteoporotic rats. Ale-EVs were well tolerated and no side effects were found, indicating that Ale-EVs specifically target bone and can be used as a new therapeutic in osteoporosis treatment.

Conclusion: We used the Ale-N3 to modify mouse mesenchymal stem cells-derived extracellular vesicles by copper-free "click chemistry" to generate a Ale-EVs system. The Ale-EVs had a high affinity for bone and have great potential for clinical applications in osteoporosis therapy with low systemic toxicity.
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http://dx.doi.org/10.2147/IJN.S263756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573321PMC
November 2020

Fast estimation of optical properties of pear using a single snapshot technique combined with a least-squares support vector regression model based on spatial frequency domain imaging.

Appl Opt 2019 May;58(15):4075-4084

Spatial frequency domain imaging has great potential in agricultural produce quality control due to its advantage of wide-field mapping of absorption (μ) and reduced scattering (μs') parameters. However, it is not widely adopted in real applications due to the large time cost during image acquisition and inversion calculation processes. In this study, a single snapshot technique was used to obtain ac and dc components (R_ac, R_dc) of diffuse reflectance of turbid media (phantoms and pears). The validation results for the snapshot method indicate that at the spatial frequency of 1000/3  m, it achieved the optimal demodulation, by comparison with the results obtained by the commonly used time-domain amplitude demodulation method. Diffusion approximation, artificial neural network, least-squares support vector machine regression (LSSVR), and LSSVR combined with a genetic algorithm (LSSVR+GA) were then used to predict μ and μs' from the obtained R_ac, R_dc at the f of 1000/3  m. Validation results indicated that the LSSVR method took the least time to calculate μ and μs' with high performance. The proposed imaging system and algorithm were implemented for the inspection of a pear bruise. Results indicated that the bruise, which is not obviously distinguishable in original gray maps, can show obvious contrast in calculated μ and μs' maps, especially in μ maps. Further, the contrast becomes more obvious with the passage of time. In summary, this study developed a low-cost spatial frequency imaging system and matching software that could realize fast detection of optical properties for a pear with the proposed snapshot and LSSVR algorithms.
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http://dx.doi.org/10.1364/AO.58.004075DOI Listing
May 2019

Ultralow lattice thermal conductivity induced high thermoelectric performance in the δ-CuS monolayer.

Nanoscale 2019 May;11(21):10306-10313

Department of Materials Science and Engineering, Peking University, Beijing 100871, China.

Motivated by the recent experimental exfoliation of β-Cu2S thin films and the theoretical finding of a new phase labeled the δ-Cu2S monolayer, we carried out extensive studies on thermal conductivity and thermoelectric properties of the new phase using first principles combined with Boltzmann transport theory, focusing on the analysis of group velocities, Gruneisen parameters, three-phonon scattering rates, and the scattering phase space. Our results show that the δ-Cu2S monolayer exhibits an intrinsically ultralow lattice thermal conductivity of 0.10 W m-1 K-1 at 800 K. Such an ultralow lattice thermal conductivity leads to a high thermoelectric figure of merit ZT = 1.33 at 800 K in an optimum p-type doping concentration, which is not only larger than the value of 1.23 in In2S3 doped Cu2S at 850 K but also comparable with the value of 1.7 in Cu1.97S at 1000 K, exhibiting good potential in thermoelectric applications.
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http://dx.doi.org/10.1039/c9nr01501aDOI Listing
May 2019

Impact of Serum Apolipoprotein A-I on Prognosis and Bevacizumab Efficacy in Patients with Metastatic Colorectal Cancer: a Propensity Score-Matched Analysis.

Transl Oncol 2017 Apr 2;10(2):288-294. Epub 2017 Mar 2.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China; VIP Region, Sun Yat-Sen University Cancer Center, Guangzhou, China. Electronic address:

Purpose: We aimed to investigate the role of apolipoprotein A-I (ApoA-I) as a predictor of prognosis and treatment efficacy of bevacizumab in patients with metastatic colorectal cancer (mCRC) treated with first-line chemotherapy with or without bevacizumab.

Methods: We conducted a retrospective study on consecutive patients who were diagnosed with mCRC at Sun Yat-sen University Cancer Center. According to their pretreatment ApoA-I level, patients were divided into low- and high-ApoA-I groups. Propensity score-matched method was performed to balance baseline characteristics between two groups. Based on whether they accepted bevacizumab as a first-line therapy, patients were further divided into the chemo + bevacizumab group and the chemo group. Overall survival (OS) and progression-free survival (PFS) were assessed with Kaplan-Meier method, log-rank test, and Cox regression.

Results: The optimal cutoff value for the ApoA-I level was determined to be 1.105 g/l. In the propensity-matched cohort of 508 patients, low ApoA-I was significantly associated with inferior OS (P<.001) and PFS (P<.001) than high ApoA-I. Multivariate analysis showed that ApoA-I level was an independent prognostic maker of OS (P<.001) and PFS (P=.001). PFS (P<.001) in either the high- or low-ApoA-I groups could be extended significantly after the administration of bevacizumab, and patients with a high ApoA-I level also had a better OS in the chemo + bevacizumab group than the chemo group (P=.049).

Conclusions: Patients with a low ApoA-I level have poor prognoses, and they did not display an OS benefit from bevacizumab.
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http://dx.doi.org/10.1016/j.tranon.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334545PMC
April 2017

Decreased apolipoprotein A-I level indicates poor prognosis in extranodal natural killer/T-cell lymphoma, nasal type.

Onco Targets Ther 2016 14;9:1281-90. Epub 2016 Mar 14.

State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China, Guangzhou, China; VIP Region, Sun Yat-Sen University Cancer Center, Sun Yat-Sen University Cancer Center, Guangzhou, China; Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.

Background: Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an invasive lymphoid malignancy with unfavorable survival, for which a prognostic model has not yet been validated. We hypothesized that serum apolipoprotein A-I (ApoA-I) may serve as a novel prognostic marker for ENKTL.

Patients And Methods: A total of 236 newly diagnosed cases of ENKTL were analyzed retrospectively.

Results: The optimal cutoff value for the serum ApoA-I level was determined to be 0.95 g/L. A total of 154 and 82 cases were assigned to the high and low ApoA-I groups, respectively. Patients in the low ApoA-I group tended to present with poorer clinical features, a lower complete remission rate (P=0.001), and poor median progression-free survival (P<0.001) and overall survival (P<0.001). Multivariate analysis using Cox model showed that the serum ApoA-I level was an independent prognostic marker of overall survival (P<0.001) and progression-free survival (P<0.001) for ENKTL patients. For cases in the low-risk group, as assessed by International Prognostic Index, Prognosis Index for peripheral T-cell lymphoma, unspecified, and Korean Prognostic Index, the serum ApoA-I level was able to differentiate cases with poor outcomes from cases with good outcomes.

Conclusion: Our results showed that the baseline serum ApoA-I level was helpful for predicting ENKTL prognosis.
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http://dx.doi.org/10.2147/OTT.S96549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803244PMC
April 2016
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