Publications by authors named "Tingting Zhang"

1,292 Publications

  • Page 1 of 1

Construction lamellar BaFeO/BiMoO photocatalyst for enhanced photocatalytic activity via a photo-Fenton-like Mo/Moredox cycle.

Chemosphere 2022 Aug 5:135909. Epub 2022 Aug 5.

School of Chemistry and Chemical Engineering, School of Pharmacy, School of Agricultural Equipment Engineering Institute of Agricultural Engineering, Jiangsu University, Zhenjiang, 212013, PR China. Electronic address:

The novel BaFeO/BiMoO composite materials were constructed as magnetically recyclable photo-Fenton-like degradation systems. The composite catalyst not only promoted the effective transfer of photo-generated electrons and improved the Mo/Mo cycle consequent, but also activated hydrogen peroxide to generate oxidizing free radicals. BaFeO/BiMoO-0.25 exhibited an outstanding degradation performance for tetracycline hydrochloride it is 1.3 times to BiMoO. The thermal catalytic performance of the BiMoO monomer is similar to that of the BaFeO/BiMoO material without light. However, the removal rate of BaFeO/BiMoO material reaches 84.5% after 60 min with light, far exceeding that of BiMoO material. By way of the contrast experiment with light and without light, it is further demonstrated that interfacial interaction between BaFeO and BiMoO acted a key role in the photocatalytic reaction system. It is also a good advantage that pollutants can be efficiently degraded without adjusting the pH. The characterization of photocurrent and X-ray photoelectron spectroscopy (XPS) also further proved the synergy between the two materials, which is useful to the separation of electrons and holes. The synergy ultimately improves the degradation performance. Besides, BaFeO/BiMoO can be easily separated by an external magnetic field after the photocatalytic activity reaction owing to BaFeO's magnetic properties. It provides a new research idea for the construction and iron-based heterogeneous Fenton-like system for magnetic degradation of antibiotics.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2022.135909DOI Listing
August 2022

Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis.

J Biol Chem 2022 Aug 3:102348. Epub 2022 Aug 3.

Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address:

Progranulin (PGRN) is a glycoprotein implicated in several neurodegenerative diseases. It is highly expressed in microglia and can be secreted or delivered to the lysosome compartment. PGRN comprises 7.5 granulin repeats and is processed into individual granulin peptides within the lysosome, but the functions of these peptides are largely unknown. Here, we identify CD68, a lysosome membrane protein highly expressed in microglia, as a binding partner of PGRN and PGRN-derived granulin E. Deletion analysis of CD68 showed that this interaction is mediated by the mucin-proline-rich domain of CD68. While CD68 deficiency does not affect the lysosomal localization of PGRN, it results in a specific decrease in the levels of granulin E, but no other granulin peptides. On the other hand, the deficiency of PGRN, and its derivative granulin peptides, leads to a significant shift in the molecular weight of CD68, without altering CD68 localization within the cell. Our results support that granulin E and CD68 reciprocally regulate each other's protein homeostasis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbc.2022.102348DOI Listing
August 2022

Correction: Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study.

BMC Pregnancy Childbirth 2022 Aug 6;22(1):622. Epub 2022 Aug 6.

Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-022-04949-9DOI Listing
August 2022

Facile fabrication of [email protected]@C8 nanoparticles as a SERS substrate and their environmental applications.

Analyst 2022 Aug 3. Epub 2022 Aug 3.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, People's Republic of China.

After preparing carbon-coated silver ([email protected]) nanoparticles by a one-step hydrothermal synthesis method, the surface of the nanoparticles was modified with chlorodimethyloctylsilane (C8) to generate C8 functionalized [email protected]@C8 nanoparticles. The [email protected]@C8 nanoparticles were then employed as a substrate for surface enhancement Raman scattering (SERS). The high sensitivity, good uniformity, and long stability Raman signals for both probe dyes (rhodamine 6G and crystal violet) and a real sample (malachite green) in water demonstrated good performance of the as-synthesised [email protected]@C8 nanoparticles. SEM images and TEM images indicate the successful preparation of [email protected] nanoparticles. The results of energy disperse spectroscopy, X-ray photoelectron spectroscopy and contact angle measurements all demonstrate that C8 is successfully functionalized on the surface of [email protected] nanoparticles. The combination of an agglomeration effect and the core-shell structure improves the sensitivity and stability of the substrate. The Raman performance of both [email protected] and [email protected]@C8 nanoparticles was evaluated using representative probe molecules such as rhodamine 6G, crystal violet and malachite green. The sensitivity and enhancement factor of [email protected]@C8 were evaluated using folic acid, a non-dye molecule. Additionally, malachite green in several actual water samples was also measured to evaluate the [email protected]@C8 nanoparticles. Then, using crystal violet as a probe molecule, the long-term stability of the [email protected]@C8 nanoparticles was investigated. The results indicate that for four weeks, the intensity deviations of different characteristic peaks were less than 17.5%, and there was no further downward trend. Our strategy partially overcomes the problem of easy oxidation of Ag nanoparticles by coating them with a thin carbon layer, and subsequent functionalization with C8 can increase the SERS sensitivity for certain pollutants due to a condensation effect.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d2an01073aDOI Listing
August 2022

Identification of the immune subtype of ovarian cancer patients by integrated analyses of transcriptome and single-cell sequencing data.

Sci Rep 2022 Aug 2;12(1):13296. Epub 2022 Aug 2.

Department of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha, China.

Ovarian cancer (OC) is one the most life-threatening cancers affecting women's health worldwide. Immunotherapy has become a promising treatment for a variety of cancers, but the therapeutic effects in OC remain limited. In this study, we constructed a macrophage risk score (MRS) based on M1 and M2 macrophages and a gene risk score (GRS) based on the prognostic genes associated with MRS. Next, cell-cell communication analysis was performed using single-cell RNA (scRNA) sequencing data. Survival status and immune characteristics were compared between the high- and low-score groups separated by MRS or GRS. Our results suggested that MRS and GRS can identify the immune subtypes of OC patients with better overall survival (OS) and inflammatory immune microenvironment. Moreover, M1 and M2 macrophages may affect the prognosis of OC patients through signal communication with CD8 T cells. Finally, functional differences between the two groups separated by GRS were elucidated. Taken together, this study constructed two useful models for the identification of immune subtypes in OC, which has a better prognosis and may have a sensitive response to immune checkpoint inhibitors (ICIs). The hub genes for the construction of GRS may be potential synergetic targets for immunotherapy in OC patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-022-17645-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346122PMC
August 2022

High-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity.

Cell Death Dis 2022 Aug 1;13(8):669. Epub 2022 Aug 1.

Hepato-pancreato-biliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, 102218, Beijing, China.

Duloxetine (DLX) has been approved for the successful treatment of psychiatric diseases, including major depressive disorder, diabetic neuropathy, fibromyalgia and generalized anxiety disorder. However, since the usage of DLX carries a manufacturer warning of hepatotoxicity given its implication in numerous cases of drug-induced liver injuries (DILI), it is not recommended for patients with chronic liver diseases. In our previous study, we developed an enhanced human-simulated hepatic spheroid (EHS) imaging model system for performing drug hepatotoxicity evaluation using the human hepatoma cell line HepaRG and the support of a pulverized liver biomatrix scaffold, which demonstrated much improved hepatic-specific functions. In the current study, we were able to use this robust model to demonstrate that the DLX-DILI is a human CYP450 specific, metabolism-dependent, oxidative stress triggered complex hepatic injury. High-content imaging analysis (HCA) of organoids exposed to DLX showed that the potential toxicophore, naphthyl ring in DLX initiated oxidative stress which ultimately led to mitochondrial dysfunction in the hepatic organoids, and vice versa. Furthermore, DLX-induced hepatic steatosis and cholestasis was also detected in the exposed EHSs. We also discovered that a novel compound S-071031B, which replaced DLX's naphthyl ring with benzodioxole, showed dramatically lower hepatotoxicities through reducing oxidative stress. Thus, we conclusively present the human-relevant EHS model as an ideal, highly competent system for evaluating DLX induced hepatotoxicity and exploring related mechanisms in vitro. Moreover, HCA use on functional hepatic organoids has promising application prospects for guiding compound structural modifications and optimization in order to improve drug development by reducing hepatotoxicity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-022-05042-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343405PMC
August 2022

Eliciting national and subnational sets of disability weights in mainland China: Findings from the Chinese disability weight measurement study.

Lancet Reg Health West Pac 2022 Sep 26;26:100520. Epub 2022 Jul 26.

Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Street, Changning District, Shanghai City 200051, China.

Background: The disability weight (DW) quantifies the severity of health states from disease sequela and is a pivotal parameter for disease burden calculation. We conducted a national and subnational DW measurement in China.

Methods: In 2020-2021, we conducted a web-based survey to assess DWs for 206 health states in 31 Chinese provinces targeting health workers via professional networks. We fielded questions of paired comparison (PC) and population health equivalence (PHE). The PC data were analysed by probit regression analysis, and the regression results were anchored by results from the PHE responses on the DW scale between 0 (no loss of health) and 1 (health loss equivalent to death).

Findings: We used PC responses from 468,541 respondents to estimate DWs of health states. Eight of 11 domains of health had significantly negative coefficients in the regression of the difference between Chinese and Global Burden of Disease (GBD) DWs, suggesting lower DW values for health states with mention of these domains in their lay description. We noted considerable heterogeneity within domains, however. After applying these Chinese DWs to the 2019 GBD estimates for China, total years lived with disability (YLDs) increased by 14·9% to 177 million despite lower estimates for musculoskeletal disorders, cardiovascular diseases, mental disorders, diabetes and chronic kidney disease. The lower estimates of YLDs for these conditions were more than offset by higher estimates of common, low-severity conditions.

Interpretation: The differences between the GBD and Chinese DWs suggest that there might be some contextual factors influencing the valuation of health states. While the reduced estimates for mental disorders, alcohol use disorder, and dementia could hint at a culturally different valuation of these conditions in China, the much greater shifts in YLDs from low-severity conditions more likely reflects methodological difficulty to distinguish between health states that vary a little in absolute DW value but a lot in relative terms.

Funding: This work was supported by the National Natural Science Foundation of China [grant number 82173626], the National Key Research and Development Program of China [grant numbers 2018YFC1315302], Wuhan Medical Research Program of Joint Fund of Hubei Health Committee [grant number WJ2019H304], and Ningxia Natural Science Foundation Project [grant number 2020AAC03436].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lanwpc.2022.100520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335373PMC
September 2022

Hidden Species Diversity was Explored in Two Genera of Catapyrenioid Lichens (Verrucariaceae, Ascomycota) from the Deserts of China.

J Fungi (Basel) 2022 Jul 13;8(7). Epub 2022 Jul 13.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Verrucariaceae is the third-largest lichen family with high species diversity. However, this diversity has not been well-explored in China. We carried out a wide-scale field investigation in the arid and semi-arid regions of Northwest China from 2017 to 2021. A large number of lichen groups, especially those commonly distributed in deserts, were collected. Based on molecular phylogeny using ITS and nuLSU sequences by Bayesian and maximum likelihood analyses, combining morphological characters, seven taxa of catapyrenioid lichens in Verricariaceae were found in this study, including one genus () and one species () new to China; one genus () new to the mainland of China; and four species (,  ,  , and  ) new to science. It enriched our understanding of the high species diversity in Verrucariaceae and the lichen flora of Chinese arid and semi-arid deserts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof8070729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319096PMC
July 2022

Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study.

BMC Pregnancy Childbirth 2022 Jul 26;22(1):592. Epub 2022 Jul 26.

Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.

Background: Anti-thyroid peroxidase antibody (TPOAb) positivity can contribute to inhibit thyroxine synthesis. Gut microbiota can interact with metabolic or immune diseases. However, dynamics of gut microbiota from the second (T2) to the third trimester (T3) in women with TPOAb-positive/negative subclinical hypothyroidism (TPOAb/TPOAb SCH) have not been reported. Therefore, we aimed to evaluate whether gut microbiota can be potential therapeutic targets for managing TPOAb SCH.

Methods: In this single-center prospective cohort study, we observed gut microbiota dynamics by sequencing 16S rRNA from fecal samples collected in T2 (20-23 weeks) and T3 (28-33 weeks). TPOAb/TPOAb SCH were stratified depending on whether or not they used levothyroxine (LT) during the pregnancy (LT/LT). Microbiome bioinformatics analyses were performed using QIIME2. The linear discriminant analysis effect size (LEfSe) was used for the quantitative analysis of biomarkers. Functional profiling was performed with PICRUSt2.

Results: Distinct gut microbiota dynamics from T2 to T3 were noted in the TPOAb (n = 68) and TPOAb (n = 64) SCH groups. The TPOAb LT group was characterized by enriched bacterial amplicon sequence variants (ASVs) of Prevotella in T2 and Bacteria, Lachnospirales, Lachnospiraceae, Blautia, and Agathobacter in T3 and by depleted ASVs of Gammaproteobacteria, Enterobacterales, and Enterobacteriaceae in T2 and Actinobacteriota, Coriobacteriia, Actinobacteria, Coriobacteriales, Bifidobacteriales, Bifidobacteriaceae, Bifidobacterium, Dorea formicigenerans, and Bifidobacterium longum in T3. The TPOAb LT group was characterized by enriched bacterial ASVs of Blautia, Streptococcus salivarius, and Bifidobacterium longum in T3 and by depleted ASVs of Bacteroidota, Bacteroidia, Bacteroidales, and Prevotella in T2 and Agathobacter in T3. Moreover, we identified 53 kinds of metabolic functions that were mainly involved in sugar, lipid, and amino acid metabolism.

Conclusions: Our results indicated that low dynamics of gut microbiota composition and high dynamics of its metabolic function from T2 to T3 were associated with TPOAb SCH. We concluded that gut microbiota could be new targets for treatment of TPOAb SCH during pregnancy.

Trial Registration: This study was retrospectively registered at the Chinese Clinical Trial Registry (registration number ChiCTR2100047175 ) on June 10, 2021.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-022-04923-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316685PMC
July 2022

Nonvolatile ferroelectric domain wall memory integrated on silicon.

Nat Commun 2022 Jul 26;13(1):4332. Epub 2022 Jul 26.

National Laboratory of Solid State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210093, P. R. China.

Ferroelectric domain wall memories have been proposed as a promising candidate for nonvolatile memories, given their intriguing advantages including low energy consumption and high-density integration. Perovskite oxides possess superior ferroelectric prosperities but perovskite-based domain wall memory integrated on silicon has rarely been reported due to the technical challenges in the sample preparation. Here, we demonstrate a domain wall memory prototype utilizing freestanding BaTiO membranes transferred onto silicon. While as-grown BaTiO films on (001) SrTiO substrate are purely c-axis polarized, we find they exhibit distinct in-plane multidomain structures after released from the substrate and integrated onto silicon due to the collective effects from depolarizing field and strain relaxation. Based on the strong in-plane ferroelectricity, conductive domain walls with reading currents up to nanoampere are observed and can be both created and erased artificially, highlighting the great potential of the integration of perovskite oxides with silicon for ferroelectric domain wall memories.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-022-31763-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325887PMC
July 2022

DeepBindBC: A practical deep learning method for identifying native-like protein-ligand complexes in virtual screening.

Methods 2022 Jul 22;205:247-262. Epub 2022 Jul 22.

Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, PR China. Electronic address:

Identifying native-like protein-ligand complexes (PLCs) from an abundance of docking decoys is critical for large-scale virtual drug screening in early-stage drug discovery lead searching efforts. Providing reliable prediction is still a challenge for most current affinity predicting models because of a lack of non-binding data during model training, lost critical physical-chemical features, and difficulties in learning abstract information with limited neural layers. In this work, we proposed a deep learning model, DeepBindBC, for classifying putative ligands as binding or non-binding. Our model incorporates information on non-binding interactions, making it more suitable for real applications. ResNet model architecture and more detailed atom type representation guarantee implicit features can be learned more accurately. Here, we show that DeepBindBC outperforms Autodock Vina, Pafnucy, and DLSCORE for three DUD.E testing sets. Moreover, DeepBindBC identified a novel human pancreatic α-amylase binder validated by a fluorescence spectral experiment (K = 1.0 × 10 M). Furthermore, DeepBindBC can be used as a core component of a hybrid virtual screening pipeline that incorporating many other complementary methods, such as DFCNN, Autodock Vina docking, and pocket molecular dynamics simulation. Additionally, an online web server based on the model is available at http://cbblab.siat.ac.cn/DeepBindBC/index.php for the user's convenience. Our model and the web server provide alternative tools in the early steps of drug discovery by providing accurate identification of native-like PLCs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2022.07.009DOI Listing
July 2022

Xpert MTB/RIF Ultra outperformed the Xpert assay in tuberculosis lymphadenitis diagnosis: a prospective head-to-head cohort study.

Int J Infect Dis 2022 Jul 21. Epub 2022 Jul 21.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research; Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, Beijing, China. Electronic address:

Objectives: Xpert MTB/RIF Ultra (Xpert-Ultra) has shown better sensitivity in comparison with Xpert MTB/RIF (Xpert) in extra-pulmonary tuberculosis, while the head-to-head comparison of these methods in tuberculosis lymphadenitis had barely been performed.

Methods: Patients with undiagnosed lymphadenopathy were recruited prospectively and consecutively, and fine-needle aspirates biopsy (FNA) or lymph node tissue was collected. The specimen was subjected to smear, culture, Xpert and Xpert-Ultra assays. Culture and/or smear for AFB or AFB observed on histopathology were performed as a reference.

Results: 106 participants were recruited, including 41 confirmed TB, 33 probableTB and 32 non-TB lymphadenopathy. The head-to-head comparison for Mtb detection showed that Xpert-Ultra produced the highest sensitivity when compared with smear, culture and Xpert (75.7% vs. 5.4 %, 13.5% and 48.7%).When Xpert-Ultra outcomes were integrated for diagnosis, the percentage of confirmed TB lymphadenitis case increased from 55.4% (41/74) to 85.1% (63/74). The sensitivities of Xpert-Ultra and Xpert on tissue were 73.6% (95%CI,59.4-84.3) and 39.6% (95%CI,26.8-54.0), respectively. The sensitiviyt of Xpert-Ultra on FNA samples (81.0%,95%CI 57.4-93.7) was higher than that of Xpert (71.4%,95% CI 47.7-87.8).

Conclusions: Xpert-Ultra detected significantly more TB lymphadenitis cases than Xpert or culture. This superiority was particularly distinct using lymph node tissue than FNA detection.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2022.07.039DOI Listing
July 2022

Nano-AlO particles affect gut microbiome and resistome in an in vitro simulator of the human colon microbial ecosystem.

J Hazard Mater 2022 Jul 2;439:129513. Epub 2022 Jul 2.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan Tyndall Centre, Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.

Nano-AlO has been widely used in various consumer products and water treatment processes because of its unique physicochemical properties. The probability of human exposure to nano-AlO increases significantly, of which oral ingestion is an important route. However, effects and underlying mechanisms of nano-AlO on gut microbiota and resistome are still not well delineated. Here, we systematically investigated the effects of nano-AlO on the human gut microbiome by an in vitro simulator of human colon microbial ecosystem. Results indicated that nano-AlO interfered with the gut microbiota, and significantly suppressed the short-chain fatty acids metabolism, which might pose adverse effects on the host. More seriously, high level of nano-AlO (50 mg/L) was more destructive to the gut flora, though the damage might be temporary. In addition, sub-inhibitory low-dose of nano-AlO (0.1 mg/L) significantly enhanced the abundance of antibiotic resistance genes (ARGs) after 7-day exposure. This is attributed to that low concentration of nano-AlO can promote horizontal transfer of ARGs by increasing cell membrane permeability and relative abundance of transposase (e.g. tnpA, IS613, and Tp614). Our findings confirmed the adverse effects of nano-AlO on the human gut resistome and emphasized the necessity to assess potential risks of nanomaterials on the human gut health.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2022.129513DOI Listing
July 2022

Combined Effect of Smoking and Fatty Liver Disease on the Progression of Type 2 Diabetes: Insights from a Population-Based Cohort Study.

Comput Math Methods Med 2022 9;2022:1776875. Epub 2022 Jul 9.

Department of Endocrinology, The Fifth Medical Center of Chinese PLA Hospital, Beijing, China.

Objectives: Fatty liver disease (FLD) is strongly linked to the occurrence of type 2 diabetes mellitus (T2DM). Insulin resistance (IR) is linked to smoking. Our study's purpose was to see how smoking and fatty liver accompanied affected the development of T2DM in the past.

Materials And Methods: We collected data from 15,464 Japanese adults aged 18 to 79 years who took part in the NAGALA research, and our team utilized a Cox proportion risk model to look at the combination effect of FLD and smoking status on the incidence of T2DM. Participants were separated into three categories: nonsmokers, ex-smokers, and current smokers. An abdominal ultrasound was used to diagnose FLD.

Results: 384 subjects had T2DM after a median follow-up of 5.4 years. In comparison to the other groups, current FLD smokers had a greater chance of developing T2DM. Ex-smokers and present FLD smokers, on the other hand, had no significant difference in their likelihood of acquiring T2DM. When compared to ex-smokers and nonsmokers without FLD, current smokers with FLD had a considerably greater chance of acquiring T2DM. Furthermore, the risk of T2DM among nonsmokers, ex-smokers with FLD, and current smokers without FLD was not statistically significant.

Conclusions: In order to prevent the progression of T2DM, we should recognize that smoking status may vary in FLD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/1776875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288327PMC
July 2022

Synergistic Mechanism of Platinum-GaO Catalysts for Propane Dehydrogenation.

Angew Chem Int Ed Engl 2022 Jul 18:e202201453. Epub 2022 Jul 18.

Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.

The synergy between metals and metal oxides can effectively improve the heterogeneous catalytic process. This paper describes the intrinsic effect of Pt modification over GaO (Pt-GaO ) on propane dehydrogenation. The presence of Pt promotes H dissociation and surface coverage of hydrogen species, which is beneficial for the activation of C-H in propane. With excessive Pt, Ga can be further reduced to form Pt-Ga alloy with less surface hydrogen species. Consequently, the relative propylene formation rate between Pt-GaO and the summed contribution of individual Pt and GaO increases linearly with the content of hydrogen species. Optimally, the relative propylene formation rate of Pt-GaO with 0.03 wt % Pt exceeds 25 % of the summed contribution of individual components.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202201453DOI Listing
July 2022

Characterization of Bacteriophage L5 Which Requires Type IV Pili for Infection.

Front Microbiol 2022 1;13:907958. Epub 2022 Jul 1.

Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

is a common opportunistic human pathogen. With the emergence of multidrug-resistant (MDR) clinical infection of , phage therapy has received renewed attention in treating infections. Moreover, a detailed understanding of the host receptor of lytic phage is crucial for selecting proper phages for therapy. Here, we describe the characterization of the bacteriophage L5 with a double-stranded DNA genome of 42,925 bp. The genomic characteristics indicate that L5 is a lytic bacteriophage belonging to the subfamily In addition, the phage receptors for L5 were also identified as type IV pili, because the mutation of , which is involved in pili synthesis, resists phage infection, while the complementation of restored its phage sensitivity. This research reveals that L5 is a potential phage therapy candidate for the treatment of infection.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2022.907958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284122PMC
July 2022

Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation.

Plant Commun 2022 Jul 14:100412. Epub 2022 Jul 14.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Plant height is an important agronomic trait for lodging resistance and yield. Here we report a new plant height-related gene OsUBR7 in rice (Oryza sativa L.); knockout of OsUBR7 caused fewer cells in internodes, resulting in a semi-dwarf phenotype. OsUBR7 encodes a putative E3 ligase containing a Plant Homeodomain-finger and an Ubiquitin Protein Ligase E3 Component N-Recognin7 (UBR7) domain. OsUBR7 interacts with histones and monoubiquitinates H2B (H2Bub1) at lysine148 with coordination of the E2 conjugase OsUBC18. OsUBR7 mediates H2Bub1 at a number of chromatin loci for the normal expression of target genes, including cell cycle-related and pleiotropic genes, consistent with the observation that the osubr7 mutant had suppression of cell cycle progression due to reductions of H2Bub1 and expression levels at these loci. The genetic divergence of OsUBR7 alleles among japonica and indica cultivars affects their transcriptional activity, and these alleles might have undergone selection during rice domestication. Overall, our results provide a novel mechanism mediating H2Bub1 in plants, and UBR7 orthologs could be utilized as an untapped epigenetic resource for crop improvement.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xplc.2022.100412DOI Listing
July 2022

Neuromodulation in Chronic Pelvic Pain: A Narrative Review.

Pain Ther 2022 Sep 14;11(3):789-816. Epub 2022 Jul 14.

Department of Urology, First Affiliated Hospital of Dalian Medical University, Zhongshan Road No. 222, Dalian, 116021, China.

Chronic primary pelvic pain syndrome (CPPPS) is a heterogeneous disease with unknown pathogenesis and a lack of distinct pathological features, which complicates diagnosis and therapy and has a significant impact on patients' daily life. Because pharmacological management is ineffective and long-term use may result in additional system damage, developing a more effective treatment is critical. Neuromodulation has advanced rapidly over the last few decades, and various types of neuromodulations have demonstrated efficacy in the treatment of CPPPS. In this article we discuss the evolution of neuromodulation technology in the treatment of chronic pelvic pain, its application to various subtypes of chronic pelvic pain, and the comparison of relevant efficacy and parameter differences, as well as assess the relative advantages and disadvantages of sacral neuromodulation, percutaneous tibial nerve stimulation , transcutaneous electrical nerve stimulation, electroacupuncture, and pudendal neuromodulation. Furthermore, it was noted that chronic pelvic pain should be evaluated in terms of pain, associated symptoms, psychological problems, and quality of life. Although neuromodulation approaches have been shown to be effective in treating chronic pelvic pain, more extensive multicenter trials are required to confirm this.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40122-022-00405-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314476PMC
September 2022

Fecal Microbiota Transplantation and Health Outcomes: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials.

Front Cell Infect Microbiol 2022 27;12:899845. Epub 2022 Jun 27.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Meta-analysis of randomized clinical trials (RCT) demonstrated several health benefits of fecal microbiota transplantation (FMT). However, there has been little comprehensive assessment of the strength and quality of evidence. We conducted an umbrella review to summarize the evidence of the association between FMT and health outcomes.

Methods: PubMed, Embase, and Cochrane library databases were searched from inception to August 6, 2021. The random-effects model was applied to recalculate the effect estimates. We used AMSTAR 2 and GRADE to assess the methodological quality and to grade the evidence.

Results: A total of 7 meta-analyses comprising 26 RCTs (median [IQR] primary study, 6 [2-7]; median [IQR] sample size, 267 [147-431] participants) were included in the current umbrella review describing 45 unique associations. There were 22 statistically significant associations (49%) demonstrating beneficial outcomes of FMT for antibiotic resistance burden, functional constipation, inflammatory bowel disease, and C. difficile infection. FMT does not appear to be associated with positive outcomes in irritable bowel syndrome and metabolic syndrome. Eight significant associations (36%) were supported by moderate-quality evidence, nine associations (41%) were supported by low-quality evidence, and the remaining associations found to be significant were supported by very low-quality evidence.

Conclusion: Although we found that FMT was positively associated with several outcomes, caution should be exercised in choosing this approach, given the insufficient number of primary studies, low methodological quality, and low quality of evidence. Further high-quality randomized controlled trials with long-term follow-up are needed to improve the strength and credibility of the evidence base.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2022.899845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271871PMC
July 2022

Correction to: M1 macrophage-derived exosomes transfer miR-222 to induce bone marrow mesenchymal stem cell apoptosis.

Lab Invest 2022 Jul 12. Epub 2022 Jul 12.

Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, 7 Weiwu Road, Zhengzhou, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41374-022-00810-xDOI Listing
July 2022

Ocular Inflammatory Reactions following an Inactivated SARS-CoV-2 Vaccine: A Four Case Series.

Ocul Immunol Inflamm 2022 Jul 12:1-6. Epub 2022 Jul 12.

Department of Ophthalmology, Shanghai Tenth People's Hospital affiliated with Tongji University, Shanghai, China.

Purpose: To report a four-case series of ocular adverse events post an inactivated COVID-19 vaccination in China.

Methods: The four patients exhibited ocular inflammatory reactions on the same day after receiving an inactivated SARS-CoV-2 vaccine.

Results: All patients underwent detailed ophthalmic examinations, with the medical diagnosis of Vogt-Koyanagi-Harada, Ponser-Schlossman, secondary post-inflammatory glaucoma, and iridocyclitis, respectively. No patients had any other underlying medical conditions causing the ocular complications. The ocular inflammatory reactions of these four patients were resolved with the administration of oral or topical corticosteroids.

Conclusion: Our cases remind the ophthalmologist that adverse ocular events may happen after the administration of SARS-CoV-2 vaccine. Since the ocular complications could be resolved with the corticosteroid treatment, the events were considered to be inflammatory reactions caused by the SARS-CoV-2 vaccine.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/09273948.2022.2093754DOI Listing
July 2022

Fabrication of nanocomposite [email protected]/CdZnS: promoted electron migration and improved photocatalytic hydrogen evolution.

Dalton Trans 2022 Aug 2;51(30):11397-11403. Epub 2022 Aug 2.

Key Laboratory of Polyoxometalates and Reticular Material Chemistry of Ministry of Education, College of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.

In this work, we successfully prepared composites of carbon-modified in-phase MoC-MoC ([email protected], MMC) nanosheets with CdZnS (ZCS) nanorods. The loading of MMC nanosheets significantly improved the hydrogen production rate of ZCS nanorods. The results showed that the photocatalytic hydrogen production rate of ZCS is the highest when MMC nanosheets are 1 wt% of ZCS nanorods (1-MMC/ZCS), reaching 68.8 mmol h g, which is 7.7 times that of pure ZCS nanorods. The 1-MMC/ZCS photocatalyst was measured with NaS/NaSO as a hole sacrifice reagent under irradiation with 420 nm monochromatic light, and the quantum efficiency of 1-MMC/ZCS was 32.9%. The carbon layer can promote the rapid transfer of photogenerated electrons, and in-phase MoC-MoC as the active site can synergistically improve the photocatalytic hydrogen production rate of ZCS. Most MoC-based materials are still used in the field of electrocatalysis. This study provides a new idea for exploring new molybdenum-based co-catalyst materials in the field of visible light catalytic hydrogen production.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d2dt00825dDOI Listing
August 2022

Correlation Analysis of Japanese Literature and Psychotherapy Effects Based on an Equation Diagnosis Algorithm.

Authors:
Zhang Tingting

Occup Ther Int 2022 11;2022:3032445. Epub 2022 Jun 11.

College of Foreign Languages, Qiqihar University, Qiqihar Heilongjiang 161006, China.

Objective: On the basis of inheriting the classical aesthetic orientation of Japanese literature, contemporary Japanese literature changes the creative methods of traditional Japanese writers, strives to transcend the national limitations of Japanese literature, and strives to capture literary materials with a "modern feel." Combined with modern western literary techniques to express the "modern self," and integrating popular literature with pure literature, Japanese writers created a "healing" literature that is popular all over the world. There is some value in exploring the correlation between Japanese literature and the influence of psychotherapy.

Method: In this paper, an equation diagnosis algorithm based on iterative learning for a class of linear discrete systems is studied, and the existing discrete iterative learning diagnostics are improved. We exchange the order of time domain and iterative domain to achieve the purpose of point-by-point equation diagnosis. On this basis, a virtual influence initial value estimation algorithm with a sliding window is proposed. The impact that has not been diagnosed is estimated and used as the initial value of the impact, so as to reduce the number of iterations and improve the efficiency of equation diagnosis. This paper takes the public and readers as different perspectives, based on the use and satisfaction theory and prospect theory, and uses interviews and questionnaires to study the communication effect of Japanese literature from the three dimensions of cognition, emotion, and behavior. The cognitive part includes the public's understanding and readers' understanding and reading; the emotional part includes the public's and readers' impressions and emotional attitudes; the behavioral part includes the public's reading situation and readers' behavior changes. . In the survey of loyal readers, although readers' understanding of Japanese literature has improved compared with the general public, it is not high, and their liking and influence on behavior are slightly lower than the preset level. This paper believes that the existing problems of Japanese literature dissemination are mainly concentrated in three aspects: the market is somewhat biased, which narrows the cognitive scope of users; as a cross-cultural literary work, Japanese literature still makes readers feel that it exists; there is some sense of estrangement, which will affect their enjoyment in reading; as a niche interest, readers lack timely communication and sharing objects after reading, so it is difficult to enhance their sense of identity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/3032445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206568PMC
July 2022

Synergistic and capacitance effects in nanocarbon based capacitor batteries designed for superior rate capability and long-cycle stability.

J Colloid Interface Sci 2022 Jun 30;626:395-404. Epub 2022 Jun 30.

State Key Laboratory of NBC Protection for Civilian, Research Institute of Chemical Defense, Beijing 102205, China. Electronic address:

Existing lithium-ion batteries struggle to achieve high-rate discharge stability. To address this problem, this study combines resin-based carbon nanospheres with a double electric layer effect and cathode materials with lithium-ion intercalation/delithiation behavior to form a LiNiCoMnO/resin-based carbon-sphere hybrid electrode. For further improvement in electron contact and tap density, the size of the carbon nanospheres was controlled by changing the synthetic parameters, and a size-matched spatial structure model of each component within the hybrid electrode was constructed. Considering the excellent rate capability of small-sized hard carbon, hard-carbon nanospheres derived from glucose were employed as the anode active material to assemble a capacitor battery. With the integration of characteristics of both lithium-ion batteries and supercapacitors, the as-prepared new capacitor battery exhibited a specific capacity of 146.1 mAh/g at 0.1C and an energy density of 474.5 Wh/kg on the cathode active material mass, a reversible capacity of 113.2 mAh/g at 1C after 200 cycles with retention of 85.3%, and the capacity remained at 82 mAh/g even at a high current rate of 10C. These results offer insights into the design of energy storage devices with excellent cycling stability and rate capability.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2022.06.111DOI Listing
June 2022

Genetic Diversity Analysis of the Chinese Daur Ethnic Group in Heilongjiang Province by Complete Mitochondrial Genome Sequencing.

Front Genet 2022 21;13:919063. Epub 2022 Jun 21.

Scientific Research Centre, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Mitochondrial DNA (mtDNA) has the characteristics of maternal inheritance, high mutation rate, high copy number, and no recombination As the most powerful tool for studying the origin and evolution of modern humans, mtDNA has great significance in the research of population genetics and evolutionary genetics. Here, we provide new insights into the maternal genetic history of the Daur ethnic group by generating complete mitochondrial genomes from a total of 146 Daur individuals in China. We also collected the published complete mitochondrial genome sequences of 5,094 individuals from 56 worldwide populations as reference data to further explore the matrilineal genetic landscape of the Daur ethnic group. First, the haplotype diversity was 0.9943 ± 0.0019 and nucleotide diversity was 0.0428 ± 0.0210. The neutrality tests of the Daur group showed significant negative values and the mismatch distribution curve was obviously distributed in a unimodal pattern. The results showed that the Daur ethnic group has high genetic diversity and may have experienced recent population expansion. In addition, the main haplogroups of the Daur population were haplogroup D (31.51%), M* (20.55%), C (10.28%), F (7.53%), and B (6.85%), all of which were prevalent in northern China. It probably implies the northern Chinese origin of the Daur population. The PCA, , and phylogenetic analysis results indicated that the Daur group formed a cluster with East Asian populations, and had few genetic differences with the populations in northern China. More importantly, we found that disease-related mutation sites of the mitochondrial genome may be related to ethnic groups, which may have important implications for the prevention and occurrence of specific diseases. Overall, this study revealed the complexity and diversity of the matrilineal genetic background of the Daur ethnic group. Meanwhile, it provided meaningful data for the research on the diversity of the human genome.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2022.919063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253502PMC
June 2022

Duck LGP2 Downregulates RIG-I Signaling Pathway-Mediated Innate Immunity Against Tembusu Virus.

Front Immunol 2022 15;13:916350. Epub 2022 Jun 15.

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin of Shandong Province, Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, Tai'an City, China.

In mammals, the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) has been demonstrated to play a critical role in activating downstream signaling in response to viral RNA. However, its role in ducks' antiviral innate immunity is less well understood, and how gene-mediated signaling is regulated is unknown. The regulatory role of the duck laboratory of genetics and physiology 2 (duLGP2) in the duck RIG-I (duRIG-I)-mediated antiviral innate immune signaling system was investigated in this study. In duck embryo fibroblast (DEF) cells, overexpression of duLGP2 dramatically reduced duRIG-I-mediated IFN-promotor activity and cytokine expression. In contrast, the knockdown of duLGP2 led to an opposite effect on the duRIG-I-mediated signaling pathway. We demonstrated that duLGP2 suppressed the duRIG-I activation induced by duck Tembusu virus (DTMUV) infection. Intriguingly, when duRIG-I signaling was triggered, duLGP2 enhanced the production of inflammatory cytokines. We further showed that duLGP2 interacts with duRIG-I, and this interaction was intensified during DTMUV infection. In summary, our data suggest that duLGP2 downregulated duRIG-I mediated innate immunity against the Tembusu virus. The findings of this study will help researchers better understand the antiviral innate immune system's regulatory networks in ducks.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2022.916350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241487PMC
June 2022

The impact of insurance institutional investors on corporate value from selection and creation perspective.

PLoS One 2022 1;17(7):e0269520. Epub 2022 Jul 1.

School of Mathematical and Computational Sciences, University of Prince Edward Island, Charlottetown, Canada.

The majority of insurance investment funds are derived from policy liability debt funds. It differs from other institutional investors in a number of ways, including investment size, horizon, duration, risk, and so on. However, only a small portion of the extant literature focuses on in-depth and extensive analysis of Insurance Institutional Investors' holdings (IIIs). This study analyses the impact of shareholding by insurance institutions on the value of Shanghai and Shenzhen A-share listed companies in China's capital market. The paper offers three major contributions. First, we discovered that long-term equity-holding IIIs have both value selection and value creation functions. Second, the value creation function becomes more significant among long-term stock-holding IIIs with an increase in the period during which they retain the company's shares; Third, fast-in and fast-out (FIFO) IIIs have a value-inhibiting effect on the held company and serve a value selection role, rather than a value creation function. This study provides more insight on the lack of academic interest in insurance institutions and serves as a foundation and reference for the design of regulatory policies for insurance institutions' involvement in stock markets. It also gives empirical evidence for corporations to accurately analyze shareholding by insurance institutions. Furthermore, since this study concentrates on China's capital market, it can serve as a benchmark for other nations, particularly, those designated as developing market economies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249200PMC
July 2022

Effect of different cadmium levels in Boletus griseus on bioaccessibility, bioavailability, and intestinal flora by establishing a complete bionic digestion system in vitro.

J Food Sci 2022 Jun 28. Epub 2022 Jun 28.

Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China.

The bioaccessibility and bioavailability of different cadmium (Cd) levels (low: 7.31 mg/kg, medium: 24.20 mg/kg, high: 41.64 mg/kg) in Boletus griseus were evaluated by establishing a bionic digestive system in vitro. The results showed that the bioaccessibility of high Cd level by gastrointestinal digestion was significantly higher than other two levels. Further, colonic digestion significantly increased the bioaccessibilities of low Cd level (p < 0.05). After intestinal flora fermentation, the bioaccessibilities of different Cd levels significantly decreased (p < 0.05), and high and medium Cd levels had no significant difference (p > 0.05). A Caco-2 monolayer cell model was established to evaluate the bioavailability of Cd. The bioavailabilities of low and high Cd levels by gastrointestinal digestion were 8.75 and 10.58%, and the bioavailabilities increased by 38.17% and 5.20% after colonic digestion, respectively. Furthermore, Cd could affect diversity, composition, and balance of intestinal flora, and the relative abundances of several genera were correlation with Cd levels in B. griseus.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1750-3841.16231DOI Listing
June 2022

Adipose Mesenchymal Stromal Cell-Derived Exosomes Prevent Testicular Torsion Injury Activating PI3K/AKT and MAPK/ERK1/2 Pathways.

Oxid Med Cell Longev 2022 16;2022:8065771. Epub 2022 Jun 16.

Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150001, China.

Adipose mesenchymal stromal cell-derived exosomes (ADSC-Exos) have shown great potential in the treatment of oxidative stress induced by ischemia-reperfusion injury. However, alleviation of testicular torsion injury by ADSC-Exos has not been reported. Therefore, we investigated the protective effect of ADSC-Exos against testicular torsion-detorsion injury. ADSC-Exos were isolated by ultracentrifugation and injected into torsion-detorsion-affected testes of rats. H&E staining and sperm quality were used to evaluate the therapeutic effects of ADSC-Exos, and tissue oxidative stress was measured by determining MDA and SOD levels. In addition, TUNEL staining and immunohistological analysis (Ki67, Cleaved Caspase-3, IL-6, IL-10, CCR7, and CD163) were used to clarify the effects of ADSC-Exos on spermatogenic cell proliferation, apoptosis, and the inflammatory microenvironment . Possible signaling pathways were predicted using sequencing technology and bioinformatics analysis. The predicted signaling pathways were validated by assessing the proliferation (EdU assay), migration (transwell assay and scratch test), and apoptosis (flow cytometry, TUNEL staining, and western blotting) of spermatogenic cells. The results showed that ADSC-Exos alleviated testicular torsion-detorsion injury by attenuating oxidative stress and the inflammatory response. In addition, ADSC-Exos promoted the proliferation and migration of spermatogenic cells and inhibited their apoptosis by activating the PI3K/AKT and MAPK/ERK1/2 signaling pathways.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2022/8065771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225846PMC
June 2022

YOLO-SASE: An Improved YOLO Algorithm for the Small Targets Detection in Complex Backgrounds.

Sensors (Basel) 2022 Jun 18;22(12). Epub 2022 Jun 18.

School of Mechanical and Electronic Engineering, Wuhan University of Technology, Wuhan 430070, China.

To improve the detection ability of infrared small targets in complex backgrounds, an improved detection algorithm YOLO-SASE is proposed in this paper. The algorithm is based on the YOLO detection framework and SRGAN network, taking super-resolution reconstructed images as input, combined with the SASE module, SPP module, and multi-level receptive field structure while adjusting the number of detection output layers through exploring feature weight to improve feature utilization efficiency. Compared with the original model, the accuracy and recall rate of the algorithm proposed in this paper were improved by 2% and 3%, respectively, in the experiment, and the stability of the results was significantly improved in the training process.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/s22124600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228422PMC
June 2022
-->