Publications by authors named "Tingting Xu"

342 Publications

Cognitive Behavioral Therapy for Prodromal Stage of Psychosis-Outcomes for Transition, Functioning, Distress, and Quality of Life: A Systematic Review and Meta-analysis.

Schizophr Bull 2021 May 4. Epub 2021 May 4.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: This study aimed to provide insight into the efficacy of cognitive-behavioral therapy for psychosis (CBTp) in patients with "clinical high risk of psychosis (CHR-P)".

Methods: Major scientific databases were searched up to April 17, 2020. Randomized controlled trials in CHR-P individuals, comparing CBTp with needs-based interventions (NBI, including treatment as usual or nonspecific control treatment) were included, following PRISMA guidelines. The primary outcome (efficacy) was transition to psychosis by 6 months, 12 months, 24 months, and over 24 months. Secondary outcomes were change in attenuated psychotic symptoms, depression, distress, improvements in functioning, and quality of life.

Results: Ten randomized controlled studies met inclusion criteria. The comparisons included 1128 participants. CBTp was significantly more efficacious in reducing rate of transition to psychosis by 6 months (after post-hoc sensitivity analysis) (relative risk [RR] = 0.44, 95% confidence interval [CI]: 0.26, 0.73), 12 months (RR = 0.44, 95% CI: 0.30, 0.64), 12 months (RR = 0.46, 95%CI: 0.30, 0.69), and over 24 months (RR = 0.58, 95% CI: 0.35, 0.95) after treatment, compared with those receiving NBI. CBTp was also associated with more reduced attenuated psychotic symptoms by 12 months (SMD = -0.17, 95% CI: -0.33, -0.02) and by 24 months (SMD = -0.24, 95% CI: -0.43, -0.06). No beneficial effects on functioning, depression, quality of life, or distress were observed favoring CBTp.

Conclusions: CBTp is effective in reducing both psychosis transition rates and attenuated psychotic symptoms for the prodromal stage of psychosis. It is a promising intervention at the preventative stage.
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http://dx.doi.org/10.1093/schbul/sbab044DOI Listing
May 2021

The relationship of different levels of high iodine and goiter in school children: a meta-analysis.

Nutr Metab (Lond) 2021 May 3;18(1):46. Epub 2021 May 3.

Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Heping District, No. 22, Qixiangtai Road, Tianjin, China.

Background: Over the past decade, the phenomenon of high urine iodine (HUI) and high water iodine (HWI) has become more common. But the risk of goiter caused by different levels of HUI and HWI remains unclear.

Objectives: To explore the risk of goiter development caused by HUI and HWI, and compare the risk of goiter development from different levels of high iodine.

Methods: The Medline, Cochrane library, Embase, China National Knowledge Infrastructure and Wan fang databases were searched for relevant population-based studies investigating the link between high iodine levels and goiter development in mainland China. Three reviewers extracted data from the included studies independently, assessing the prevalence of goiter development due to high iodine.

Results: Taking 100 μg/L ≤ UIC < 300 μg/L (UIC = urinary iodine concentration) as the reference group, the odds ratio (OR) regarding high iodine levels and goiter formation was 1.74 (95% CI 1.50, 2.01, P < 0.001), if the water iodine concentration (WIC) was greater than 100 μg/L, the OR between goiter development and WIC was 4.74 (95% CI 1.15, 19.46, P = 0.001). The Linear trend analysis of HUI and goiter showed that the prevalence of goiter increased with the increase of UIC (χ = 734.605, P < 0.001).

Conclusions: When the UIC ≥ 300 μg/L or the WIC ≥ 100 μg/L, the risk of goiter will increase. The higher the UIC, the greater the risk of goiter development. In order to improve the public thyroid health, we should adhere to the monitoring of urinary iodine and water iodine, and keep them at an appropriate level.

Trial Registration: PROSPEROCR, CRD42020197620. Registered 8 August 2020, https://www.crd.york.ac.uk/PROSPERO/ .
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http://dx.doi.org/10.1186/s12986-021-00563-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094504PMC
May 2021

Electrochemical sensing technology for liquid biopsy of circulating tumor cells-a review.

Bioelectrochemistry 2021 Apr 16;140:107823. Epub 2021 Apr 16.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

In recent years, a lot of new detection techniques for circulating tumor cells (CTCs) have been developed. Among them, electrochemical sensing technology has gradually developed because of its advantages of good selectivity, high sensitivity, low cost and rapid detection. Especially in the latest decade, the field of electrochemical biosensing has witnessed great progress, thanks to the merging of biosensing research area with nanotechnology, immunotechnology, nucleic acid technology, and microfluidic technology. In this review, the recent progress for the detection of CTCs according to the principle of detection was summarized and how they can contribute to the enhanced performance of such biosensors was explained. The latest electrode construction strategies such as rolling circle amplification reaction, DNA walker and microfluidic technology and their advantages were also introduced emphatically. Moreover, the main reasonswhy the existing biosensors have not been widely used clinically and the next research points were clearly put forward.
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http://dx.doi.org/10.1016/j.bioelechem.2021.107823DOI Listing
April 2021

Prevalence of Infection in Military Personnel from Northeast China: A Cross-Sectional Study.

Int J Gen Med 2021 21;14:1499-1505. Epub 2021 Apr 21.

Department of Gastroenterology, General Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area), Shenyang, People's Republic of China.

Purpose: infection is an important cause of peptic ulcer disease and gastric cancer. Current knowledge regarding epidemiology of infection in military personnel has insufficiently been updated. This cross-sectional study aimed to estimate the prevalence of infection in military personnel and to compare the prevalences in military and civilian groups.

Patients And Methods: We retrospectively enrolled the subjects who underwent C-urea breath tests at the Department of Gastroenterology of the General Hospital of Northern Theater Command between January 2017 and July 2020. Subjects were divided into military and civilian groups. infection and major endoscopic findings were reviewed.

Results: Overall, 23,496 subjects were eligible, including 2282 subjects in the military group and 21,214 subjects in the civilian group. In the overall analysis, the prevalence of infection was not significantly different between military and civilian groups (33.9% versus 34.4%, =0.592). In the population aged 17-25 years, the prevalence of infection was significantly higher in the military group than in the civilian group (35.6% versus 25.9%, =0.001). Both C-UBT and endoscopy were performed in 547 inpatients, including 83 military inpatients and 464 civilian inpatients. There was a significantly higher prevalence of in inpatients with peptic ulcer and/or gastric cancer than in those without (65.5% versus 41.4%, =0.001).

Conclusion: Among the adolescent population, infection may be more common in military personnel as compared to the civilians. Well-designed prospective studies should be required to validate such a high prevalence and to explain its potential causes.
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http://dx.doi.org/10.2147/IJGM.S308572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071091PMC
April 2021

The atypical binding mechanism of second calcium on phospholipase A2 group IIE.

Biochem Biophys Res Commun 2021 Jun 21;557:267-272. Epub 2021 Apr 21.

Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. Electronic address:

Secreted phospholipase A2s (sPLA2s) are calcium dependent enzymes involved in various biological events such as lipid metabolism and inflammation. We previously identified the second calcium (Ca2) binding site of human sPLA2 Group IIE (hGIIE) by structural study and suggested that Asn21 act as the switch of Ca2 binding to modulate the enzymatic activity, but the detailed Ca2 binding mechanism is still unclear. Combined with enzymatic assay, model analysis and calcium binding affinity data for mutated hGIIE proteins, we herein further demonstrate that the flexibly bound Ca2 is essential for the catalysis of hGIIE, unlike the stable binding of Ca2 in hGIIA that replenishes the calcium in the typical loop during the reaction. The atypical Ca2 binding feature of hGIIE will provide a better understanding on the catalytic mechanism of hGIIE.
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http://dx.doi.org/10.1016/j.bbrc.2021.04.030DOI Listing
June 2021

Rational construction of KVO nanobelts/CNTs flexible cathode for multi-functional potassium-ion batteries.

Nanoscale 2021 May;13(17):8199-8209

Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450001, China.

Potassium-ion battery (KIB) is one of the emerging electrochemical energy storage technologies due to the abundance, low cost, and low redox potential of K. One of the most promising cathodes of KIBs is a layered vanadium-based compound, but it often suffers from fast capacity decay during repeated cycling. Herein, a K0.5V2O5/CNTs hybrid film composed of K0.5V2O5 nanobelt and carbon nanotube (CNT) network was synthesized by an electrostatic self-assembly and vacuum filtration process, and further used as the cathode in KIBs. The K0.5V2O5/CNTs cathode possessed a flexible and interconnected network structure, which not only offered fast kinetics for electron transfer and ion transportation, but also provided an elastic medium to buffer the large volume change of the K0.5V2O5 nanobelts during cycling. As a cathode for KIBs, the K0.5V2O5/CNTs electrode showed a reversible discharge capacity of ∼90 mA h g-1 at 50 mA g-1 and exhibited good cycling stability (88.8% capacity retention for 100 cycles at 50 mA g-1, 82.2% capacity retention for 300 cycles at 500 mA g-1) and excellent rate performance of ∼62 mA h g-1 at 500 mA g-1. K-Ion full battery testing further confirmed its good electrochemical performance by presenting a high reversible discharge capacity (68 mA h g-1 at 50 mA g-1) and long-term retention (>80% after 80 cycles). Interestingly, a cable-shaped KIB with the flexible K0.5V2O5/CNTs film as the cathode electrode was assembled and showed its further application potential as a power source for wearable electronics.
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http://dx.doi.org/10.1039/d1nr00993aDOI Listing
May 2021

Spatio-temporal evolution and influencing mechanism of the COVID-19 epidemic in Shandong province, China.

Sci Rep 2021 04 9;11(1):7811. Epub 2021 Apr 9.

College of Urban and Environmental Sciences, Northwest University, Xi'an, 710127, China.

The novel coronavirus pneumonia (COVID-19) outbreak that emerged in late 2019 has posed a severe threat to human health and social and economic development, and thus has become a major public health crisis affecting the world. The spread of COVID-19 in population and regions is a typical geographical process, which is worth discussing from the geographical perspective. This paper focuses on Shandong province, which has a high incidence, though the first Chinese confirmed case was reported from Hubei province. Based on the data of reported confirmed cases and the detailed information of cases collected manually, we used text analysis, mathematical statistics and spatial analysis to reveal the demographic characteristics of confirmed cases and the spatio-temporal evolution process of the epidemic, and to explore the comprehensive mechanism of epidemic evolution and prevention and control. The results show that: (1) the incidence rate of COVID-19 in Shandong is 0.76/100,000. The majority of confirmed cases are old and middle-aged people who are infected by the intra-province diffusion, followed by young and middle-aged people who are infected outside the province. (2) Up to February 5, the number of daily confirmed cases shows a trend of "rapid increase before slowing down", among which, the changes of age and gender are closely related to population migration, epidemic characteristics and intervention measures. (3) Affected by the regional economy and population, the spatial distribution of the confirmed cases is obviously unbalanced, with the cluster pattern of "high-low" and "low-high". (4) The evolution of the migration pattern, affected by the geographical location of Wuhan and Chinese traditional culture, is dominated by "cross-provincial" and "intra-provincial" direct flow, and generally shows the trend of "southwest → northeast". Finally, combined with the targeted countermeasures of "source-flow-sink", the comprehensive mechanism of COVID-19 epidemic evolution and prevention and control in Shandong is revealed. External and internal prevention and control measures are also figured out.
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http://dx.doi.org/10.1038/s41598-021-86188-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035406PMC
April 2021

Efficient and Stable Carbon-Based Perovskite Solar Cells via Passivation by a Multifunctional Hydrophobic Molecule with Bidentate Anchors.

ACS Appl Mater Interfaces 2021 Apr 30;13(14):16485-16497. Epub 2021 Mar 30.

Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) & Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), Xi'an, Shaanxi 710072, China.

Surface passivation has demonstrated to be an effective strategy to improve the power conversion efficiency (PCE) and long-term stability of perovskite solar cells (PSCs). Passivation treatment can effectively reduce the density of defect states at the surface and grain boundaries of perovskite films. Herein, a passivation agent of 2-amino-5-(trifluoromethyl)pyridine (5-TFMAP) with bidentate groups is applied to passivate perovskite CHNHPbI films for the first time. Two types of electron-rich nitrogen atoms from both the pyridine ring and the amino group provide strong interaction with the under-coordinated Pb. Additionally, the trifluoromethyl group offers a hydrophobic property and improves moisture stability of the as-fabricated PSCs. It is found that the 5-TFMAP passivation layer can effectively reduce the defect states, promote better carrier transport, and suppress non-radiation recombination of the perovskite films. The best PCE of carbon-based PSCs passivated by the 5-TFMAP agent achieves a high efficiency of 14.96% compared with that of 11.90% for the control PSCs. Moreover, the long-term stability of PSCs with the 5-TFMAP passivation treatment is greatly improved, and its PCE can maintain 80% of its original PCE after being stored for 1200 h with a relative humidity of around 35% at room temperature.
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http://dx.doi.org/10.1021/acsami.1c02218DOI Listing
April 2021

Explore the effects of Shidan granules on chronic atrophic gastritis by LC-MS-based plasma metabolomics study.

Biomed Chromatogr 2021 Mar 29:e5129. Epub 2021 Mar 29.

Department of Gastroenterology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Shidan granule (SDG), a traditional Chinese medicine (TCM) in-hospital preparation, has been demonstrated to exert good effects on chronic atrophic gastritis (CAG) in clinic. However, the underlying mechanism of SDG against CAG was still unclear. In this study, an untargeted plasma metabolomics approach was utilized to explore the potential mechanism of SDG in the CAG rats using LC-MS and pattern recognition analysis. The results indicated that SDG could effectively improve the biochemical indexes and pathology features of CAG rats. Nineteen potential biomarkers (VIP > 1 and P < 0.05) contributing to CAG progress were identified. After SDG intervention, seventeen biomarkers were obviously restored back to the normal levels. Further metabolic pathway analysis showed that aspartate and glutamate metabolism, arachidonic acid metabolism, arginine and proline metabolism, and TCA cycle were the most related pathways for SDG treatment. Based on the above findings, the main mechanisms of SDG against CAG might be ascribed to the regulatory effects of energy balance, inflammatory suppression, and improvement of disturbed amino acids and lipids metabolism. This study provided available information for the mechanism research of SDG against CAG, and would promote its clinical application.
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http://dx.doi.org/10.1002/bmc.5129DOI Listing
March 2021

Learning parametric policies and transition probability models of markov decision processes from data.

Eur J Control 2021 Jan 26;57:68-75. Epub 2020 May 26.

Department of Electrical and Computer Engineering, Division of Systems Engineering, and Department of Biomedical Engineering, Boston University, 8 St. Mary's St., Boston, MA 02215.

We consider the problem of estimating the policy and transition probability model of a Markov Decision Process from data (state, action, next state tuples). The transition probability and policy are assumed to be parametric functions of a sparse set of features associated with the tuples. We propose two regularized maximum likelihood estimation algorithms for learning the transition probability model and policy, respectively. An upper bound is established on the regret, which is the difference between the average reward of the estimated policy under the estimated transition probabilities and that of the original unknown policy under the true (unknown) transition probabilities. We provide a sample complexity result showing that we can achieve a low regret with a relatively small amount of training samples. We illustrate the theoretical results with a healthcare example and a robot navigation experiment.
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http://dx.doi.org/10.1016/j.ejcon.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944408PMC
January 2021

Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3/miR-214 signaling pathway.

J Ethnopharmacol 2021 Jun 8;274:113997. Epub 2021 Mar 8.

The Affiliated Hospital of Nanjing University of Chinese Medicine, #155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu, 210029, China. Electronic address:

Ethnopharmacological Relevance: Ginseng is a valuable medicinal herb used in China for the prevention and treatment of cancer, diabetes, cardiovascular diseases and other diseases. As the main active ingredient of ginseng, ginsenoside has a wide range of pharmacological effects. Ginsenoside Rh2, a protopanaxadiol saponin from ginseng, exhibits anti-inflammatory and anticancer effects.

Aim Of The Study: The potential biological mechanism of Rh2 in the treatment of ulcerative colitis (UC) has not been clarified clearly. In our research, we aimed to explore the therapeutic effects of Rh2 on dextran sodium sulfate (DSS)-induced colitis and elucidate the mechanism of Rh2 in treating UC.

Methods: DSS-induced UC mice were established and randomly divided into the following four groups: control group, DSS group, Rh2 (50 mg/kg) group and sulfasalazine (SASP, 200 mg/kg) group. Except for the control group, 3% DSS drinking water was given to each group for 7 days, and the other two groups were intragastrically administered with Rh2 and SASP for 10 days. At the end of the experiment, colon samples were collected, and phenotypic and pathological analyses were performed in UC mice. Then, Western blot, immunohistochemistry and quantitative real-time PCR analyses were performed to determine the expression of signaling pathway-related factors.

Results: Rh2 markedly alleviated DSS-induced body weight loss, intestinal damage, colon length shortening and disease activity index (DAI) scores. Furthermore, proinflammatory cytokines, such as TNF-α, IL-6 and IL-1β, were reduced by Rh2. Additionally, STAT3/miR-214 activation was also suppressed by Rh2 administration. In vitro, we demonstrated that Rh2 effectively inhibited IL-6-induced STAT3 phosphorylation and miR-214 expression in cultured normal colonic epithelial cells.

Conclusion: Our results suggested that Rh2 exhibits potential application value in the treatment of UC, and its mechanism is related to the downregulation of STAT3/miR-214 levels, which is expected to be applicable in the treatment of clinical UC.
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http://dx.doi.org/10.1016/j.jep.2021.113997DOI Listing
June 2021

The prevalence of antibodies to SARS-CoV-2 among blood donors in China.

Nat Commun 2021 03 2;12(1):1383. Epub 2021 Mar 2.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.

In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18-60 year-old adults (18-65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%-3.07%) in Wuhan, 0.033% (95% CI: 0.0029%-0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%-0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.
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http://dx.doi.org/10.1038/s41467-021-21503-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925561PMC
March 2021

A novel host of MCR-5 belonging to Enterobacter spp. isolated from hospital sewage water.

Environ Microbiol Rep 2021 Apr 17;13(2):234-237. Epub 2021 Feb 17.

Shenzhen Institute of Respiratory Diseases, Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, the First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, China.

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http://dx.doi.org/10.1111/1758-2229.12937DOI Listing
April 2021

Dynamic change of MMP-9 in diabetic stroke visualized by optical imaging and treated with CD28 superagonist.

Biomater Sci 2021 Apr 15;9(7):2562-2570. Epub 2021 Feb 15.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.

Type 2 diabetes mellitus is associated with an increased risk for stroke and unfavorable outcomes following stroke. Matrix metalloproteinase-9 (MMP-9) is a potential contributor to the poor prognosis of diabetic ischemic stroke. Investigations on diabetic stroke are limited by the lack of non-invasive imaging techniques. In this study, we report a fast and ultra-sensitive MMP-activatable optical imaging probe (MMP-P12) to achieve non-invasive and real-time visualization of the dynamic expression of MMP-9 in diabetic stroke. Moreover, by using this probe, we aim to detect the therapeutic efficacy of CD28 SA in diabetic stroke. Serial near-infrared fluorescence (NIRF) imaging was performed on wild-type and STZ-induced diabetic mice after MMP-P12 probe injection on days 1, 3, and 7 post ischemic stroke. The dynamic change in MMP-9 expression after CD28 SA treatment was also imaged on days 1, 3, and 7 post stroke and confirmed by immunohistochemistry staining and western blotting. NIRF imaging showed that diabetic stroke mice presented a trend of higher levels of MMP-9. CD28 SA treatment significantly downregulated the expression of MMP-9 on day 7 post stroke. Glucose also had a downward trend in CD28 SA treated diabetic stroke mice. In conclusion, our data suggest that MMP-P12 probe successfully detect the dynamic change of MMP-9 in diabetic stroke by utilizing optical imaging. CD28 SA treatment decreased the expression of MMP-9 and could be a promising therapeutic strategy for the treatment of diabetic stroke.
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http://dx.doi.org/10.1039/d0bm02014aDOI Listing
April 2021

Comprehensive analysis of prognostic value of lymph node staging classifications in patients with head and neck squamous cell carcinoma after cervical lymph node dissection.

Eur J Surg Oncol 2021 Jan 30. Epub 2021 Jan 30.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Purpose: To determine the optimal threshold of examined lymph node (ELN) number from cervical lymph node dissection for head and neck squamous cell carcinoma (HNSCC). Further to compare the prognostic value of multiple lymph node classification systems and to determine the most suitable scheme to predict survival.

Methods: A total of 20991 HNSCC patients were included. Odds ratios (ORs) for negative-to-positive node stage migration and hazard ratios (HRs) for survival were fitted using the LOWESS smoother. Structural breakpoints were determined by the Chow test. The R square, C-index, likelihood ratio, and Akaike information criterion (AIC) were used to compare the prognostic abilities among AJCC N stage, number of positive lymph nodes (pN), positive lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) stages.

Results: A minimal threshold ELN number of fifteen had the discriminatory capacities for both stage migration and survival. LODDS stages had the highest R square value (0.208), C-index (0.736) and likelihood ratio (2467) and the smallest AIC value (65874). LODDS stages also showed prognostic value in estimating patients with AJCC N0 stage. A novel staging system was proposed and showed good prognostic performance when stratified by different primary sites.

Conclusion: Fifteen lymph nodes should be examined for HNSCC patients. LODDS stage allows better prognostic stratification, especially in N0 stage. The proposed staging system may serve as precise evaluation tools to estimate postoperative prognoses.
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http://dx.doi.org/10.1016/j.ejso.2021.01.020DOI Listing
January 2021

A Series of Metal-Organic Framework Isomers Based on Pyridinedicarboxylate Ligands: Diversified Selective Gas Adsorption and the Positional Effect of Methyl Functionality.

Inorg Chem 2021 Feb 29;60(4):2704-2715. Epub 2021 Jan 29.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, Zhejiang 321004, China.

Solvothermal assembly of copper(II) cations and 5-(pyridine-3-yl)isophthalate linkers bearing different position-substituted methyl groups afforded four ligand-induced metal-organic framework (MOF) isomers as a platform for investigating diverse selective gas adsorption properties and understanding the positional effect of methyl functionality. Single-crystal X-ray diffraction (SCXRD) analyses showed that, when the methyl substituent is at the position with respect to the pyridinic N atom, the resultant framework compound features an -type topology, while the other three solids possess an isoreticular structure with an -type topology when the methyl group is situated at the other positions. As revealed by N physi-adsorption measurements at 77 K, they exhibit moderate specific surface areas ranging from 584 to 1182 m g and distinct degrees of framework flexibility, which are heavily dependent on the methyl position. Comprehensive gas adsorption studies show that they are capable of effectively separating three pairs of binary gas mixtures including CH-CH, CO-CH, and CO-N couples. Moreover, their uptake capacities and adsorption selectivities can be tailored by altering the methyl position. In addition, their framework hydro-stability is also influenced by the methyl position. Compared to and , and exhibit poorer stability against HO, although the methyl group is more close to inorganic secondary building units (SBUs), which are believed to originate from the steric effect of the methyl group. Overall, the four MOFs display the methyl position-dependent network architectures, framework flexibilities, and selective gas adsorption properties as well as hydrostabilities. The findings observed in this work not only demonstrate the importance of the positional effect of the functional group but also highlight that engineering the substituent position is a potential strategy for achieving the modulation of MOF structures and properties.
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http://dx.doi.org/10.1021/acs.inorgchem.0c03583DOI Listing
February 2021

Transplantation of Human Neural Precursor Cells Reverses Syrinx Growth in a Rat Model of Post-Traumatic Syringomyelia.

Neurotherapeutics 2021 Jan 19. Epub 2021 Jan 19.

Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Posttraumatic syringomyelia (PTS) is a serious condition of progressive expansion of spinal cord cysts, affecting patients with spinal cord injury years after injury. To evaluate neural cell therapy to prevent cyst expansion and potentially replace lost neurons, we developed a rat model of PTS. We combined contusive trauma with subarachnoid injections of blood, causing tethering of the spinal cord to the surrounding vertebrae, resulting in chronically expanding cysts. The cysts were usually located rostral to the injury, extracanalicular, lined by astrocytes. T2*-weighted magnetic resonance imaging (MRI) showed hyperintense fluid-filled cysts but also hypointense signals from debris and iron-laden macrophages/microglia. Two types of human neural stem/progenitor cells-fetal neural precursor cells (hNPCs) and neuroepithelial-like stem cells (hNESCs) derived from induced pluripotent stem cells-were transplanted to PTS cysts. Cells transplanted into cysts 10 weeks after injury survived at least 10 weeks, migrated into the surrounding parenchyma, but did not differentiate during this period. The cysts were partially obliterated by the cells, and cyst walls often merged with thin layers of cells in between. Cyst volume measurements with MRI showed that the volumes continued to expand in sham-transplanted rats by 102%, while the cyst expansion was effectively prevented by hNPCs and hNESCs transplantation, reducing the cyst volumes by 18.8% and 46.8%, respectively. The volume reductions far exceeded the volume of the added human cells. Thus, in an animal model closely mimicking the clinical situation, we provide proof-of-principle that transplantation of human neural stem/progenitor cells can be used as treatment for PTS.
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http://dx.doi.org/10.1007/s13311-020-00987-3DOI Listing
January 2021

Analysis of Root Canal Curvature and Root Canal Morphology of Maxillary Posterior Teeth in Guizhou, China.

Med Sci Monit 2021 Jan 13;27:e928758. Epub 2021 Jan 13.

Department of Endodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, China (mainland).

BACKGROUND We investigated the root canal curvature and morphology of maxillary posterior teeth in Guizhou, China, to provide references for clinical practice. MATERIAL AND METHODS We collected 274 maxillary posterior teeth in Guizhou Province, China. The root canal curvature was observed by X-ray film measurement. Two hundred teeth were selected to make transparent tooth models, and root canal configuration was recorded according to Vertucci classification criteria. The position of the MB2 root canal orifice and the mesiobuccal root canal configuration were observed by micro-computed tomographic (micro-CT) scanning. The t test and the chi-square test were used for statistical analysis. RESULTS The root canals of the maxillary posterior teeth showed more significant curvature in the mesiodistal direction than in the buccolingual direction (P<0.05). The MB2 root canal of maxillary molars showed severe bending in the mesiodistal direction: 25.16±6.6 degrees and 28.05±8.65 degrees in first and second molars, respectively. The detection rate of MB2 was 48% in maxillary first molars and 32% in maxillary second molars. The results of micro-CT showed that the vertical distances between the MB2 and MB-P line were 0.64±0.34 mm and 0.57±0.28 mm in first and second molars, respectively. CONCLUSIONS The root canal morphology and curvature of maxillary posterior teeth varied greatly in the Guizhou population, which increases the difficulty of treatment. It is necessary for clinicians to gain understanding of the root canal and to improve the success rate of root canal therapy.
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http://dx.doi.org/10.12659/MSM.928758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812699PMC
January 2021

Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome.

Mol Cancer 2021 01 4;20(1). Epub 2021 Jan 4.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Background: Cytokine release syndrome (CRS) is a systemic inflammatory response characterized by the overexpression of inflammatory genes. Controlling CRS is essential for improving the therapeutic effects of chimeric antigen receptor (CAR) engineered T cells. However, current treatment options are limited given the complexity of cytokine interactions so it is important to seek a mild strategy with broad-spectrum inhibition to overcome this challenge.

Methods: Using THZ1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7), we demonstrated the transcriptional suppression of inflammatory genes in activated macrophages. RNA sequencing and ChIP sequencing were conducted to identify the key target genes of the inflammatory response. Pathogen- and CAR T cell-induced CRS models were also established to assess the efficacy and safety of targeting CDK7.

Results: CDK7 blockade attenuated cytokine release, mitigated hyperinflammatory states and rescued mice from lethal CRS. Targeting CDK7 preferentially suppressed a set of inflammatory genes, of which STAT1 and IL1 were the key targets associated with super enhancers. Furthermore, we confirmed the potent efficacy of THZ1 in alleviating the CRS induced by CAR T cell infusion without causing tissue injury or impairing antitumor effects.

Conclusions: Our work indicates the CDK7-dependent transcription addiction of inflammatory genes. Targeting CDK7 is a promising strategy for treating CRS by inhibiting multiple cytokines.
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http://dx.doi.org/10.1186/s12943-020-01301-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780220PMC
January 2021

Engineering ligand conformation by substituent manipulation towards diverse copper-tricarboxylate frameworks with tuned gas adsorption properties.

Dalton Trans 2021 Jan;50(2):638-646

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China.

To expand the structural diversity and optimize the material performance, it is essential but challenging to regulate MOF structures in a predictable and controllable manner. In this work, by manipulating the substituents to engineer the ligand conformations, we designed and synthesized two asymmetric tricarboxylate ligands, and used them to successfully target two copper-tricarboxylate frameworks with diversified topologies depending on the ligand conformations. Besides, the ligand asymmetry induced the formation of two uncommon kinds of copper-carboxylate clusters, thus greatly expanding the library of copper-carboxylate secondary building units. Furthermore, the two compounds also displayed tunable gas adsorption properties pertinent to C2H2 separation and purification. At 298 K and 1 atm, the uptake capacity of C2H2 varies from 79.5 to 104.6 cm3 (STP) g-1, while the adsorption selectivities of C2H2 with respect to CO2 and CH4 are in the range of 2.3-3.8 and 15.3-21.6 for the equimolar components, respectively. Compared to the nitro counterpart, the methoxy MOF features higher C2H2 uptake capacity, larger C2H2/CO2 and C2H2/CH4 adsorption selectivities, and lower regeneration energy. This work demonstrates that simple ligand modification can be used to engineer the structures and tune gas adsorption properties of the resulting MOFs.
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http://dx.doi.org/10.1039/d0dt03410jDOI Listing
January 2021

Endogenous mRNA Triggered DNA-Au Nanomachine for In Situ Imaging and Targeted Multimodal Synergistic Cancer Therapy.

Angew Chem Int Ed Engl 2021 03 28;60(11):5948-5958. Epub 2021 Jan 28.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.

The development of versatile nanotheranostic platforms that integrate both diagnostic and therapeutic functions have always been an intractable challenge in precise cancer treatment. Herein, an aptamer-tethered deoxyribonucleic acids-gold particle (Apt-DNA-Au) nanomachine has been developed for in situ imaging and targeted multimodal synergistic therapy of mammary carcinoma. Upon specifically internalized into MCF-7 cells, the tumor-related TK1 mRNA activates the Apt-DNA-Au nanomachine by DNA strand displacement cascades, resulting in the release of the fluorophore and antisense DNA as well as the aggregation of AuNPs for in situ imaging, suppression of survivin expression and photothermal therapy, respectively. Meanwhile, the controlled released drugs are used for chemotherapy, while under the laser irradiation the loaded photosensitizer produces reactive oxygen species (ROS) for photodynamic therapy. The results confirm that the proposed Apt-DNA-Au nanomachine provides a powerful nanotheranostic platform for in situ imaging-guided combinatorial anticancer therapy.
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http://dx.doi.org/10.1002/anie.202012801DOI Listing
March 2021

Consumers' attention on identification, nutritional compounds, and safety in heavy metals of Canadian sea cucumber in Chinese food market.

Food Sci Nutr 2020 Nov 13;8(11):5962-5975. Epub 2020 Sep 13.

Clinical Medical College of Acupuncture Moxibustion and Rehabilitation School of Pharmaceutical Science Guangzhou University of Chinese Medicine Guangzhou China.

Background: Based on the consumers' attention issues of sea cucumbers, we aimed to complete comprehensive information of commercial Canadian sea cucumbers (CCSC), which sprang up extensively in Chinese food market.

Results: CCSC were identified as and characterized based on the characteristics, nutritional compositions, and heavy metals. The abdomen and five internal tendons of were special orange. The average of soaking degree and water content, which consumers paid great attention to, was 2.8 ± 0.3 and 0.46 ± 0.09%, respectively. Proteins (56.4 ± 9.1%) and polysaccharides (12.2 ± 14.7%) were the principal nutrient component. In addition, there was a variety of free amino acids, in which arginine (70.1 ± 50.0 mg/100 g), glutamate (42.6 ± 23.9 mg/100 g), and alanine (32.2 ± 21.0 mg/100 g) were the main components. Phosphorus (P, 0.26 ± 0.05%), magnesium (Mg, 0.19 ± 0.07%), and kalium (K, 0.17 ± 0.08%) were the major mineral elements. Amount of heavy metal was within the safety limitation (5.5 ± 1.4 mg/kg). Furthermore, the active ingredients were positively correlated with size.

Conclusion: The overall findings enriched the information of for consumers and suggested that the quality of was varied following commercial classification and size.
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http://dx.doi.org/10.1002/fsn3.1882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684582PMC
November 2020

Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s.

ACS Cent Sci 2020 Nov 15;6(11):1977-1986. Epub 2020 Oct 15.

Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.

Transcatheter arterial embolization (TAE) has been widely applied in treatments of unresectable or hypervascular tumors, but the procedure of TAE is complicated possibly brings inherent risks. Here, inspired by pH-responsive drug delivery systems, a new method of noninvasive and target embolization therapy by intravenous injection was developed. This method is based on a type of acidic microenvironment-responsive hyperbranched poly(amino acid) (HPTTG) to avoid using catheterization and real-time image guidance angiography, simplifying the procedure, elevating compliance and general applicability of embolization therapy. The pH value of the sol-to-gel phase transition with decreasing pH of HPTTG was controlled by adjusting the ratio of acidic amino acids in copolymers. The results of the tumor-bearing animal experiment indicate that the HPTTG have an excellent target and embolic ability; they accumulate the most at the tumor site in 8 h postinjection. Blood vessels of the tumors were occluded, and the tumors were inhibited and necrotized in about 20 days. Therefore, it is expected that HPTTG not only can be used as novel embolic materials for efficient noninvasive embolization therapy of many solid tumors but also can be used as a multifunctional platform for combined theranostics, for example, combination with controlled release, thermal ablation, multimodal imaging, synergistic therapy, etc.
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http://dx.doi.org/10.1021/acscentsci.0c00506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706070PMC
November 2020

Transcriptomic Analyses and Potential Therapeutic Targets of Pancreatic Cancer With Concomitant Diabetes.

Front Oncol 2020 4;10:563527. Epub 2020 Nov 4.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.

Background: Type 2 diabetes mellitus (T2DM) known as non-insulin-dependent diabetes mellitus, which is increasingly acknowledged as being associated with an increased risk for a series of cancers. Pancreatic cancer is currently the fourth most common cause of cancer-related mortality, which has been proved to be worsened by internal diabetic condition. However, the underlying molecular mechanisms are less addressed. Furthermore, current knowledge revealed that therapeutic strategy by anti-diabetes for pancreatic cancer under diabetes condition have no satisfactory efficacy, and nor by chemotherapy in our study.

Methods: To clarify these mysteries and widen our knowledge, both obesity-associated and non-obese-associated T2DM mouse models were generated by chemical induction with streptozotocin (STZ) and leptin receptor knockout () in mice. Then, the process of tumor progression was researched, and the gene expression profiling of pancreatic cancer in mice was performed using RNA-seq.

Results: Our results showed that pancreatic cancer malignancy was increased with notable proliferation and metastatic potential in two diabetic mice model. Totally, 136 and 64 significantly differentially expressed genes (DEGs) were identified in STZ and / mice by transcriptomic analysis. The results also suggested that different carcinogenesis-related genes and potential molecular mechanisms contribute to the malignancy of pancreatic cancer in obesity-associated and non-obesity-associated T2DM. In obesity-associated / mice, the GO subcategories associated with most of the genes with downregulated expression are involved in the immune response. However, in non-obesity-associated STZ mice, in addition to the immune response category, the enriched subcategories also included angiogenesis and the extracellular matrix. While, two genes respectively encoding MMP-2 and MMP-9 were simultaneously abnormal up-regulated in pancreatic cancer tissue from diabetic mice of both STZ and /, that could act as potential therapeutic targets for significantly suppressing the malignant progression. Furthermore, an optimizing therapeutic strategy was further proposed that combining MMP-2/9 inhibitor with gemcitabine significantly enhanced anti-tumor effects on pancreatic cancer under diabetic condition, providing a theoretical basis for clinical applications.

Conclusions: Generally, this study provides a comprehensive insight into diabetes as a risk factor for pancreatic cancer and has the potential to guide the development of enhanced treatment strategies.
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http://dx.doi.org/10.3389/fonc.2020.563527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672183PMC
November 2020

M2 Macrophage-Derived Exosomal lncRNA AFAP1-AS1 and MicroRNA-26a Affect Cell Migration and Metastasis in Esophageal Cancer.

Mol Ther Nucleic Acids 2020 Dec 4;22:779-790. Epub 2020 Oct 4.

Digestive Endoscopy Center of the First Affiliated Hospital of Xiamen University, Xiamen, 361000 Fujian, China.

Exosomes from cancer cells or immune cells, carrying bio-macromolecules or long non-coding RNAs (lncRNAs), participate in tumor pathogenesis and progression by modulating the microenvironment. This study aims to explore the function of M2 macrophage-derived exosomes on the invasion and metastasis of esophageal cancer (EC) with the involvement of the lncRNA AFAP1-AS1/microRNA-26a (miR-26a)/activating transcription factor 2 (ATF2) axis. We found that lncRNA AFAP1-AS1 could specifically bind to miR-26a, thus affecting the expression of miR-26a, and ATF2 was the direct target of miR-26a. Compared with M1 macrophage-derived exosomes, M2 macrophage-derived exosomes exhibited higher AFAP1-AS1 and ATF2 expression and lower miR-26a expression. Moreover, extracellular AFAP1-AS1 could be moved to KYSE410 cells via being incorporated into M2 macrophage-derived exosomes. M2 macrophage-derived exosomes could downregulate miR-26a and promote the expression of ATF2 through high expression of AFAP1-AS1, thus promoting the migration, invasion, and lung metastasis of EC cells; M2-exosomes upregulating AFAP1-AS1 or downregulating miR-26a ameliorated this effect. In summary, M2 macrophage-derived exosomes transferred lncRNA AFAP1-AS1 to downregulate miR-26a and upregulate ATF2, thus promoting the invasion and metastasis of EC. Targeting M2 macrophages and the lncRNA AFAP1-AS1/miR-26a/ATF2 signaling axis represents a potential therapeutic strategy for EC.
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http://dx.doi.org/10.1016/j.omtn.2020.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595846PMC
December 2020

Impaired cortico-striatal functional connectivity is related to trait impulsivity in unmedicated patients with obsessive-compulsive disorder.

J Affect Disord 2021 02 13;281:899-907. Epub 2020 Nov 13.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, PR China; Shanghai Key Laboratory of Psychotic Disorders, PR China. Electronic address:

Objectives: Convergent evidence has demonstrated that trait impulsivity, a key feature in obsessive-compulsive disorder (OCD), involves dysregulated frontal-striatal circuits. The present study aims to explore relationships between frontal-striatal circuits, trait impulsivity, and obsessive-compulsive symptoms.

Methods: Thirty-six unmedicated patients with OCD and 50 healthy controls (HCs) matched for age, sex, and years of education underwent a magnetic resonance imaging (MRI) procedure. Voxel-wise statistical parametric analysis was used to investigate the differences in resting-state functional connectivity between brain regions functionally connected to six pairs of a-priori defined striatal seed regions, between patients with OCD and HCs. Associations between frontal-striatal connectivity and both trait impulsivity and symptom severity of OCD were analyzed.

Results: The results showed altered striatal functional connectivity in OCD group compared to HCs, including increased connectivity of dorsal caudate (DC)-orbitofrontal cortex (OFC), ventral striatum (VS)-OFC, VS-medial prefrontal cortex, and putamen-sensorimotor area, and decreased functional connectivity of DC-anterior cingulate cortex (ACC), putamen-ACC, and putamen-dorsolateral prefrontal cortex (DLPFC). Furthermore, the putamen-DLPFC connectivity was negatively correlated with attentional impulsivity in the OCD group, but showed a positive correlation in HCs.

Conclusions: The present findings suggested that dorsal cognitive circuits could reflect the level of inhibitory control, which is balanced with the impulsive drive in healthy controls, but breakdown in OCD. Our findings supported that DLPFC-putamen connectivity underlying trait impulsivity, which were involved in the pathophysiology of OCD. The findings have provided new insights into the neurobiological mechanisms of OCD.
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http://dx.doi.org/10.1016/j.jad.2020.11.037DOI Listing
February 2021

Primary Drug-Resistance Pattern and Trend in Elderly Tuberculosis Patients in Shandong, China, from 2004 to 2019.

Infect Drug Resist 2020 13;13:4133-4145. Epub 2020 Nov 13.

Department of Respiratory Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People's Republic of China.

Background: With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become a significant obstacle for the global TB control. There is still little study on DR-TB in the elderly in China so far. Thus, more research on the epidemiological characteristics and trend of primary DR-TB among the elderly will be necessary.

Methods: A retrospective study was conducted in Shandong, China from 2004 to 2019. We collected 12,661 primary TB cases, of which 4368 elderly (≥60 years) primary TB cases were involved. Clinical characteristics including age, sex, cavity, smoking, drinking, comorbidity and drug susceptibility data were collected from 36 TB prevention and control institutions of Shandong Province. Sputum samples were collected by each surveillance site, and examined in the TB Reference Laboratory of SPCH. Descriptive statistical analysis, chi-square and linear regression were used for analyzing.

Results: Among 4368 elderly patients with primary TB, the DR-TB and multi-resistant tuberculosis (MDR-TB) accounted for 17.19% and 2.29%, respectively. During 2004-2019, the proportions of MDR-TB, polydrug resistant tuberculosis (PDR-TB), rifampin (RFP)-resistance increased by 160.00%, 18.18%, 231.82%, respectively and the rate of DR-TB among elderly patients with primary cavitary TB increased by 255%. Among the elderly with primary DR-TB during 2004-2019, the proportion of male (from 85.19 to 89.06), cavity (from 7.41 to 46.88), RFP-resistance (from 3.70 to 21.88), and streptomycin (SM)-resistance (from 37.04 to 62.5) increased significantly (P<0.05). And the proportion of female (from 14.81 to 10.94), non-cavity (from 92.59 to 32.81), INH-resistance (from 66.67 to 57.81) decreased significantly (P<0.05).

Conclusion: Among the elderly, the proportions of MDR-TB, PDR-TB, RFP-resistance and cavitary DR-TB increased significantly. The pattern of DR-TB changed from female, non-cavity and INH-resistant groups to male, cavity, RFP or SM-resistant groups. For a better control on the elderly DR-TB in the future, we should pay more attention to male, smoking, drinking, chronic obstructive pulmonary disease (COPD) and diabetes subgroups and take targeted measures to control these subgroups.
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http://dx.doi.org/10.2147/IDR.S277203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671465PMC
November 2020

Successful deliveries of uterine prolapse in two primigravid women after obstetric management and perinatal care: case reports and literature review.

Ann Palliat Med 2020 Nov 17. Epub 2020 Nov 17.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Uterine prolapse as a common form of pelvic organ prolapse (POP) is very rare during pregnancy. The literature was extremely limited concerning the management and causation of uterine prolapse during pregnancy women, especially in nulliparous women. We reported two cases of uterine prolapse in two primigravid female. Analysis and recommendations regarding the reasons and management of this condition was provided with past 20-year literature review. In our report, two patients noticed a lump protruding from vagina in the third and second trimester of pregnancy and were found uterine prolapse (28+3 weeks and 24 weeks of gestation respectively). One patient' prolapsed uterus cannot be returned spontaneously, vaginal packing with sterilized oil gauze and indwelling catheter were executed. She was hospitalized and with careful antenatal care. Corticosteroids were administered for fetal lung maturation. But the patient underwent emergency cesarean section because of obstetric factors two days later and two healthy twins were born. Another one treated with conservative antenatal management for a month, and with cesarean delivery at 33+6 weeks of pregnancy. After the delivery, patients were found no uterine prolapse at one-month post-partum examination. Successful pregnancy outcome of uterine prolapse depending on symptomatology, severity of the prolapse, obstructed status and the preference of patients; based on these facts require individualized management and treatment.
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http://dx.doi.org/10.21037/apm-20-1322DOI Listing
November 2020

The impact of childhood trauma on thalamic functional connectivity in patients with obsessive-compulsive disorder.

Psychol Med 2020 Nov 20:1-10. Epub 2020 Nov 20.

Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Childhood trauma is a vulnerability factor for the development of obsessive-compulsive disorder (OCD). Empirical findings suggest that trauma-related alterations in brain networks, especially in thalamus-related regions, have been observed in OCD patients. However, the relationship between childhood trauma and thalamic connectivity in patients with OCD remains unclear. The present study aimed to examine the impact of childhood trauma on thalamic functional connectivity in OCD patients.

Methods: Magnetic resonance imaging resting-state scans were acquired in 79 patients with OCD, including 22 patients with a high level of childhood trauma (OCD_HCT), 57 patients with a low level of childhood trauma (OCD_LCT) and 47 healthy controls. Seven thalamic subdivisions were chosen as regions of interest (ROIs) to examine the group difference in thalamic ROIs and whole-brain resting-state functional connectivity (rsFC).

Results: We found significantly decreased caudate-thalamic rsFC in OCD patients as a whole group and also in OCD_LCT patients, compared with healthy controls. However, OCD_HCT patients exhibited increased thalamic rsFC with the prefrontal cortex when compared with both OCD_LCT patients and healthy controls.

Conclusions: Taken together, OCD patients with high and low levels of childhood trauma exhibit different pathological alterations in thalamic rsFC, suggesting that childhood trauma may be a predisposing factor for some OCD patients.
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http://dx.doi.org/10.1017/S0033291720004328DOI Listing
November 2020

Marine Alkaloid Pityriacitrin and Its Analogues: Discovery, Structures, Synthetic Methods and Biological Properties.

Mini Rev Med Chem 2021 ;21(2):233-244

National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

Pityriacitrin is a natural marine alkaloid with a typical β-carboline scaffold, and which has been demonstrated to exhibit diverse biological functions. The special structural features for pityriacitrin lead to the increasing research interest and the emergence of versatile derivatives, and many pityriacitrin analogues have been isolated or synthesized over the past decades. The structural diversity and evolved biological activity of these natural alkaloids can offer opportunities for the development of highly potential novel drugs with a new mechanism of action, and therefore, the aim of this brief review is to describe the discovery, synthesis, and biological properties of natural pityriacitrin and its derivatives, as well as the isolation source.
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http://dx.doi.org/10.2174/1389557520666201116144156DOI Listing
January 2021