Publications by authors named "Tingting Song"

117 Publications

A Quantum Dual-Signature Protocol Based on SNOP States without Trusted Participant.

Entropy (Basel) 2021 Sep 30;23(10). Epub 2021 Sep 30.

College of Information Science and Technology, Jinan University, Guangzhou 510632, China.

Quantum dual-signature means that two signed quantum messages are combined and expected to be sent to two different recipients. A quantum signature requires the cooperation of two verifiers to complete the whole verification process. As an important quantum signature aspect, the trusted third party is introduced to the current protocols, which affects the practicability of the quantum signature protocols. In this paper, we propose a quantum dual-signature protocol without arbitrator and entanglement for the first time. In the proposed protocol, two independent verifiers are introduced, here they may be dishonest but not collaborate. Furthermore, strongly nonlocal orthogonal product states are used to preserve the protocol security, i.e., no one can deny or forge a valid signature, even though some of them conspired. Compared with existing quantum signature protocols, this protocol does not require a trusted third party and entanglement resources.
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http://dx.doi.org/10.3390/e23101294DOI Listing
September 2021

Hierarchical nanocomposite of carbon-fiber-supported NiCo-based layered double-hydroxide nanosheets decorated with (NiCo)Se nanoparticles for high performance energy storage.

J Colloid Interface Sci 2021 Oct 1;608(Pt 1):175-185. Epub 2021 Oct 1.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Exploring novel structures consisting of multiple highly active components is a crucial challenge for supercapacitor applications. Using an in-situ self-templated method, we demonstrate the controlled fabrication of a fibrous hierarchical nanocomposite made of carbon microfibers covered with a layer of metal-organic framework (MOF) derived from nickel-cobalt layered double-hydroxide (NiCo-LDH) nanosheets decorated with (NiCo)Se nanoparticles. The (NiCo)Se nanoparticles attached tightly onto the surface of the two-dimensional NiCo-LDH, both of which were generated by the decomposition of the NiCo-based MOF, and exhibited multiple active sites that contributed to improved electrical conductivity, high capacity, and structural stability. Density functional theory calculations revealed that the density of states near the Fermi level was significantly enhanced, favoured OH adsorption, and promoted the kinetics of the electrochemical reaction. Benefiting from the intrinsic synergetic contributions from the hierarchical nanoscale structure, the electrode made from the nanocomposite delivered an impressive capacity of 1394.2 F g (702.7 C g) at 1 A g. Furthermore, a hybrid supercapacitor based on the developed nanocomposite demonstrated an energy density of 50.6 W h kg and a power density of 800 W kg with high cyclic stability. Our results suggest that the hierarchical nanocomposite can be a powerful electrode for advanced next-generation supercapacitors.
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http://dx.doi.org/10.1016/j.jcis.2021.09.181DOI Listing
October 2021

Recurrent neural network FPGA hardware accelerator for delay-tolerant indoor optical wireless communications.

Opt Express 2021 Aug;29(16):26165-26182

The optical wireless communication (OWC) system has been widely studied as a promising solution for high-speed indoor applications. The transmitter diversity scheme has been proposed to improve the performance of high-speed OWC systems. However, the transmitter diversity is vulnerable to the delay of multiple channels. Recently neural networks have been studied to realize delay-tolerant indoor OWC systems, where long-short term memory (LSTM) and attention-augmented LSTM (ALSTM) recurrent neural networks (RNNs) have shown their capabilities. However, they have high computation complexity and long computation latency. In this paper, we propose a low complexity delay-tolerant RNN scheme for indoor OWC systems. In particular, an RNN with parallelized structure is proposed to reduce the computation cost. The proposed RNN schemes show comparable capability to the more complicated ALSTM, where a bit-error-rate (BER) performance within the forward-error-correction (FEC) limit is achieved for up to 5.5 symbol periods delays. In addition, previously studied LSTM/ALSTM schemes are implemented using high-end GPUs, which have high cost, high power consumption, and long processing latency. To solve these practical limitations, in this paper we further propose and demonstrate the FPGA-based RNN hardware accelerator for delay-tolerant indoor OWC systems. To optimize the processing latency and power consumption, we also propose two optimization methods: the parallel implementation with triple-phase clocking and the stream-in based computation with additive input data insertion. Results show that the FPGA-based RNN hardware accelerator with the proposed optimization methods achieves 96.75% effective latency reduction and 90.7% lower energy consumption per symbol compared with the FPGA-based RNN hardware accelerator without optimization. Compared to the GPU implementation, the latency is reduced by about 61% and the power consumption is reduced by about 58.1%.
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http://dx.doi.org/10.1364/OE.427250DOI Listing
August 2021

TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression.

Int J Nanomedicine 2021 14;16:6281-6295. Epub 2021 Sep 14.

Department of Pharmacy, Zunyi Medical University, Zunyi City, People's Republic of China.

Background: Ziyuglycoside I (ZgI), an active ingredient isolated from traditional Chinese medicine L, has been demonstrated to increase the leucocytes and protect hematopoietic stem cells. However, the poor solubility and a short half-life of ZgI limit its bioavailability and efficacy. The D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) has been widely used to increase the solubility, improve the encapsulation rate, and extend the half-life of drugs.

Methods: Here, we formulated the TPGS-modified long-circulating liposomes loading ZgI with a sustained drug release and enhanced therapy for myelosuppression. ZgI-TPGS-liposomes were manufactured using a thin-film hydration technique, followed by characterizations of physicochemical properties, including the particle size, zeta potential, TEM, SEM, FTIR, XRD, stability, drug loading (DL), encapsulation efficiency (EE). The in vitro and in vivo delivery efficiency were further evaluated by cellular uptake, in vitro drug release and in vivo pharmacokinetics. Finally, therapeutic effect on myelosuppression was investigated.

Results: The ZgI-TPGS-liposomes had an particle size of 97.89 ± 1.42 nm and ZP of -28.65 ± 0.16 mV. It exhibited DL of 9.06 ± 0.76% and EE of 92.34 ± 3.83%, along with excellent storage stability, cellular uptake and sustained drug release to free ZgI and liposomes without TPGS. Additionally, the TPGS modified liposomes significantly enhanced the therapeutic effect of ZgI on CTX induced myelosuppression, which can be confirmed in the apoptosis inhibition and cell viability promotion of CTX injured HSPC-1 cells. Also, the mice in vivo pharmacodynamics demonstrated that TPGS liposomes promoted ZgI increasing the numbers of leucocytes and neutrophils in myelosuppression mice induced by CTX.

Conclusion: Our research suggest that TPGS-modified long-circulating liposomes loading ziyuglycoside I has potential application in myelosuppression therapy.
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http://dx.doi.org/10.2147/IJN.S326629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449650PMC
September 2021

Nutrient profiles, functional compositions, and antioxidant activities of seven types of grain fermented with fungus.

J Food Sci Technol 2021 Nov 11;58(11):4091-4101. Epub 2020 Nov 11.

Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021 Zhejiang People's Republic of China.

(SS) is a rare medicinal polypore fungus that grows solely on trees. In this study, seven grains (oats, barley, millet, rice, buckwheat, corn, and coix seed) were used as solid substrates for SS fermentation and characterized in their nutrition, functional composition, and antioxidant activities. After fermentation, the nutrient compositions of crude protein (  = 111.1,  < 0.01), soluble protein (  = 595.7,  < 0.01), soluble sugar (  = 51.4,  < 0.01) and ash (  = 227.3,  < 0.01) increased significantly. Oats were one of the best grains for SS fermentation, SS-Oat produced 6.23 mg QE/g polyphenols, 21.8 mg rutin/g flavonoids, and 2.3% triterpene. In addition, the antioxidant capacities of the seven grains all increased. Principal component analysis analysis shows that the antioxidant properties of the grains were similar after SS fermentation. The changes of antioxidant activity due to SS fermentation were corrected with corresponding grain and remarked as T-AOC/ABTS/DPPH/DNAp, that was correlated to part of changes in polyphenol, carotenoid, triterpenoids, and flavonoid contents. In summary, oats have the greatest potential for use as a fermentation substrate for health food development.
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http://dx.doi.org/10.1007/s13197-020-04868-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405792PMC
November 2021

Overexpression of , and in Alfalfa (a L.) Provides Different Extents of Enhanced Alkali and Salt Tolerance Due to Functional Specialization of .

Front Plant Sci 2021 19;12:702195. Epub 2021 Aug 19.

College of Life Sciences, Northeast Agricultural University, Harbin, China.

Rare cold-inducible 2/plasma membrane protein 3 () genes are ubiquitous in plants and belong to a multigene family whose members respond to a variety of abiotic stresses by regulating ion homeostasis and stabilizing membranes, thus preventing damage. In this study, the expression of , , and under high-salinity, alkali and ABA treatments was analyzed. The results showed that the expression of , , and in alfalfa ( L.) was induced by salt, alkali and ABA treatments, but there were differences between gene expression under different treatments. We investigated the functional differences in the MsRCI2A, MsRCI2B, and MsRCI2C proteins in alfalfa ( L.) by generating transgenic alfalfa plants that ectopically expressed these s under the control of the CaMV35S promoter. The -overexpressing plants exhibited different degrees of improved phenotypes under high-salinity stress (200 mmol.L NaCl) and weak alkali stress (100 mmol.L NaHCO, pH 8.5). Salinity stress had a more significant impact on alfalfa than alkali stress. Overexpression of s in alfalfa caused the same physiological response to salt stress. However, in response to alkali stress, the three proteins encoded by s exhibited functional differences, which were determined not only by their different expression regulation but also by the differences in their regulatory relationship with s or .
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http://dx.doi.org/10.3389/fpls.2021.702195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417119PMC
August 2021

A qualitative and quantitative analysis of the human gingival crevicular fluid proteome and metaproteome.

Proteomics 2021 Oct 12;21(20):e2000321. Epub 2021 Sep 12.

Core Facility of Instrument, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

Gingival crevicular fluid (GCF) is an integral part of oral fluid that plays a special role in maintaining the structure of junctional epithelium and defending against bacterial infection. In this study, we comprehensively analysed the composition of the human GCF proteome and metaproteome simultaneously to obtain multidimensional information about GCF. A total of 3680 human proteins (2540 with at least two unique peptides) were identified in the normal GCF sample, and their functions were mainly associated with immune function and inflammation. Among these proteins, 1874 proteins could be quantified by the iBAQ algorithm, and their abundances spanned a dynamic range of six orders of magnitude. For the GCF metaproteome, a total of 3082 proteins and 69 genera were found. In addition, 16 genera were not identified by GCF metagenomic analysis. Compared to the saliva metaproteome, 32 genera were found to be in common. The protein quantitative analysis showed that the abundance of GCF metaproteome contributed to approximately 4.17% of the total GCF proteome. The top three most abundant genera were Fusobacterium, Corynebacterium, and Leptotrichia. The above data will be useful for future research on GCF-related diseases.
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http://dx.doi.org/10.1002/pmic.202000321DOI Listing
October 2021

Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Mol Cancer 2021 Aug 17;20(1):102. Epub 2021 Aug 17.

Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.

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http://dx.doi.org/10.1186/s12943-021-01391-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369743PMC
August 2021

Teaching NeuroImages: A 41-Year-Old Woman Presented With Excessive Sweating of Contralateral Face and Extremity.

Neurology 2021 Aug 16. Epub 2021 Aug 16.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China

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http://dx.doi.org/10.1212/WNL.0000000000012666DOI Listing
August 2021

Recent progress for silver nanowires conducting film for flexible electronics.

J Nanostructure Chem 2021 Jul 31:1-19. Epub 2021 Jul 31.

Dept Chem Engn, Integrated Composites Lab ICL, University of Tennessee System University of Tennessee Knoxville Univ Tennessee, Knoxville, TN 37996 USA.

Silver nanowires (AgNWs), as one-dimensional nanometallic materials, have attracted wide attention due to the excellent electrical conductivity, transparency and flexibility, especially in flexible and stretchable electronics. However, the microscopic discontinuities require AgNWs be attached to some carrier for practical applications. Relative to the preparation method, how to integrate AgNWs into the flexible matrix is particularly important. In recent years, plenty of papers have been published on the preparation of conductors based on AgNWs, including printing techniques, coating techniques, vacuum filtration techniques, template-assisted assembly techniques, electrospinning techniques and gelating techniques. The aim of this review is to discuss different assembly method of AgNW-based conducting film and their advantages. Conducting films based on silver nanowires (AgNWs) have been reviewed with a focus on their assembly and their advantages.
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http://dx.doi.org/10.1007/s40097-021-00436-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325546PMC
July 2021

The Psychological Impact of COVID-19 Pandemic on Health Care Workers: A Systematic Review and Meta-Analysis.

Front Psychol 2021 8;12:626547. Epub 2021 Jul 8.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.

The COVID-19 epidemic has generated great stress throughout healthcare workers (HCWs). The situation of HCWs should be fully and timely understood. The aim of this meta-analysis is to determine the psychological impact of COVID-19 pandemic on health care workers. We searched the original literatures published from 1 Nov 2019 to 20 Sep 2020 in electronic databases of PUBMED, EMBASE and WEB OF SCIENCE. Forty-seven studies were included in the meta-analysis with a combined total of 81,277 participants. The pooled prevalence of anxiety is 37% (95% CI 0.31-0.42, I = 99.9%) from 44 studies. Depression is estimated in 39 studies, and the pooled prevalence of depression is 36% (95% CI 0.31-0.41, I = 99.6%). There are 10 studies reported the prevalence of insomnia, and the overall prevalence of insomnia is 32% (95% CI 0.23-0.42, I = 99.5%). The subgroup analysis showed a higher incidence of anxiety and depression among women and the frontline HCWs compared to men and non-frontline HCWs respectively. The COVID-19 pandemic has caused heavy psychological impact among healthcare professionals especially women and frontline workers. Timely psychological counseling and intervention ought to be implemented for HCWs in order to alleviate their anxiety and improve their general mental health.
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http://dx.doi.org/10.3389/fpsyg.2021.626547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297953PMC
July 2021

The long noncoding RNA MdLNC499 bridges MdWRKY1 and MdERF109 function to regulate early-stage light-induced anthocyanin accumulation in apple fruit.

Plant Cell 2021 Oct;33(10):3309-3330

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing University of Agriculture, Beijing 102206, China.

Anthocyanin pigments contribute to plant coloration and are valuable sources of antioxidants in the human diet as components of fruits and vegetables. Their production is known to be induced by light in apple fruit (Malus domestica); however, the underlying molecular mechanism responsible for early-stage light-induced anthocyanin biosynthesis remains unclear. Here, we identified an ethylene response factor (ERF) protein, ERF109, involved in light-induced anthocyanin biosynthesis and found that it promotes coloration by directly binding to anthocyanin-related gene promoters. Promoter::β-glucuronidase reporter analysis and Hi-C sequencing showed that a long noncoding RNA, MdLNC499, located nearby MdERF109, induces the expression of MdERF109. A W-box cis-element in the MdLNC499 promoter was found to be regulated by a transcription factor, MdWRKY1. Transient expression in apple fruit and stable transformation of apple calli allowed us to reconstruct a MdWRKY1-MdLNC499-MdERF109 transcriptional cascade in which MdWRKY1 is activated by light to increase the transcription of MdLNC499, which in turn induces MdERF109. The MdERF109 protein induces the expression of anthocyanin-related genes and the accumulation of anthocyanins in the early stages of apple coloration. Our results provide a platform for better understanding the various regulatory mechanisms involved in light-induced apple fruit coloration.
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http://dx.doi.org/10.1093/plcell/koab188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505877PMC
October 2021

Integrated Physiological and Transcriptomic Analyses Responses to Altitude Stress in Oat ( L.).

Front Genet 2021 17;12:638683. Epub 2021 Jun 17.

Department of Grassland Science, College of Animal Science and Technology, Northeast Agricultural University, Harbin, China.

Oat is an annual gramineous forage grass with the remarkable ability to survive under various stressful environments. However, understanding the effects of high altitude stresses on oats is poor. Therefore, the physiological and the transcriptomic changes were analyzed at two sites with different altitudes, low (ca. 2,080 m) or high (ca. 2,918 m), respectively. Higher levels of antioxidant enzyme activity, reactive oxygen and major reductions in photosynthesis-related markers were suggested for oats at high altitudes. Furthermore, oat yields were severely suppressed at the high altitude. RNA-seq results showed that 11,639 differentially expressed genes were detected at both the low and the high altitudes in which 5,203 up-regulated and 6,436 down-regulated. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment tests were conducted and a group of major high altitude-responsive pigment metabolism genes, photosynthesis, hormone signaling, and cutin, suberine and wax biosynthesis were excavated. Using quantitative real-time polymerase chain response, we also confirmed expression levels of 20 DEGs (qRT-PCR). In summary, our study generated genome-wide transcript profile and may be useful for understanding the molecular mechanisms of L. in response to high altitude stress. These new findings contribute to our deeper relevant researches on high altitude stresses and further exploring new candidategenes for adapting plateau environment oat molecular breeding.
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http://dx.doi.org/10.3389/fgene.2021.638683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248544PMC
June 2021

LncRNA Promote Cell Proliferation and Invasion by Sponging miR-125b to Modulate Expression in Laryngocarcinoma.

Iran J Public Health 2021 May;50(5):959-969

No 2 Department of Oncology, Qingdao Tumor Hospital, Qingdao 266042, China.

Background: Laryngocarcinoma is the most frequent head and neck malignant tumor. MALAT1 have a role in promoting cell proliferation and metastasis in several tumors. This research aimed to investigate the great roles of MALAT1in laryngocarcinoma.

Methods: Overall, 54 cases of laryngocarcinoma tissues pathological specimens and paracancerous tissues were collected by surgical resection from the Department of Otolaryngology-Head and Neck Surgery at the Shandong Provincial Hospital affiliated to Shandong University, China from Jan 2012 to Oct 2015. The microRNA and protein levels of genes were evaluated by RT-qPCR and western blot. The proliferative and invasive ability were calculated usingCCK8 and transwell assays. Kaplan-Meier method was used to assess the survival of laryngocarcinoma patients.

Results: In laryngocarcinoma tissues and cells, lncRNA MALAT1 expression was significantly increased compared to normal tissues and cells. LncRNA MALAT1 promotes proliferation and migration of laryngocarcinoma cells. LncRNA MALAT1 upregulates expression by acting as a competitive endogenous RNA (ceRNA) for miR-125b. Rescue experiments showed that microRNA-125b inhibitor reversed the change in cell viability and invasion induced by sh-MALAT1. Down regulation of lncRNA MALAT1 inhibits laryngocarcinoma proliferation and invasion by modulating miR-125b/.

Conclusion: LncRNA MALAT1 promotes the development of laryngocarcinoma by regulating the expression level of by acting as a miR-125b ceRNA and may be considered as a new strategy for the development of laryngocarcinoma.
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http://dx.doi.org/10.18502/ijph.v50i5.6113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223581PMC
May 2021

Rectosigmoid-Junction Squamous Cell Carcinoma With pMMR/MSS Achieved a Partial Response Following PD-1 Blockade Combined With Chemotherapy: A Case Report.

Front Oncol 2021 25;11:596342. Epub 2021 May 25.

Department of Internal Medicine-Oncology, Qingdao Tumor Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, China.

Colorectal squamous cell carcinoma (SCC) is extremely rare and associated with a poor prognosis. And the pMMR/MSS colorectal cancer is related to a limited response to programmed death ligand-1 (PD-1) blockade monotherapy. However, the clinical activity of PD-1 blockade monotherapy or combination therapy in colorectal SCC is unknown. One patient with rectosigmoid-junction SCC was treated with PD-1 blockade combined with chemotherapy. After 3 months of PD-1 blockade and chemotherapy, the computed tomography imaging showed that this patient achieved a partial response. The next generation sequencing and immunohistochemistry analysis showed that the patient had tumors with proficient mismatch repair (pMMR) and microsatellite stability (MSS), strong PD-L1 expression, and tumor mutational burden-high (TMB-High), respectively. This case suggests that PD-1 blockade combined with chemotherapy might be an effective therapy for colorectal SCC with pMMR/MSS status. Moreover, the PD-L1 expression and TMB might be the potential predictors of PD-1 blockade response for colorectal SCC patients.
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http://dx.doi.org/10.3389/fonc.2021.596342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185331PMC
May 2021

Urinary Proteomic Characteristics of Hyperuricemia and Their Possible Links with the Occurrence of Its Concomitant Diseases.

ACS Omega 2021 Apr 29;6(14):9500-9508. Epub 2021 Mar 29.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

Hyperuricemia (HUA), a chronic disease caused by metabolic disorders of purine, is often accompanied by other diseases such as gout, type 2 diabetes mellitus (T2DM), and hyperlipidemia. However, little is known about the relationship between HUA and these diseases on the protein level. We performed label-free liquid chromatography MS/MS spectrometry analysis of urine samples from 26 HUA patients and 25 healthy controls, attempting to establish the possible protein links between HUA and these diseases by profiling urine proteome. A total of 2119 proteins were characterized in sample proteomes. Among them, 11 were found decreased and 2 were found increased in HUA samples. Plausible pathways found by enrichment analysis of these differentially expressed proteins (DEPs) include the processes for insulin receptor recycling and lipid metabolism, suggesting potential links between HUA and T2DM and hyperlipidemia. The abundance changes of three key proteins (VATB1, CFAD, and APOC3) involved in these processes were validated by enzyme-linked immunosorbent assay (ELISA). In conclusion, our result provides proteomic evidence, for the first time, that the aberrant pathways enriched by described key DEPs are closely related to the incidence of HUA and its concomitant diseases.
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http://dx.doi.org/10.1021/acsomega.0c06229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047722PMC
April 2021

Apple MPK4 mediates phosphorylation of MYB1 to enhance light-induced anthocyanin accumulation.

Plant J 2021 Jun 7;106(6):1728-1745. Epub 2021 May 7.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing University of Agriculture, Beijing, China.

Anthocyanins are plant pigments with diverse biological functions that contribute to fruit quality and are beneficial to human health. Anthocyanin accumulation can be influenced by environmental signals, such as light, and plants have developed sophisticated systems to receive and transduce these signals. However, the associated molecular mechanisms are not well understood. In this study, we investigated the potential function of mitogen-activated protein kinases, which are members of the light signaling pathway, during light-induced anthocyanin accumulation in apple (Malus domestica) fruit peels. An antibody array and yeast two-hybrid screen indicated that proteins encoded by two MdMPK4 genes are light-activated and interact with the transcription factor and anthocyanin biosynthesis regulator MdMYB1. A phosphorylation assay showed that the MdMPK4 proteins phosphorylate MdMYB1, thereby increasing its stability under light conditions. Transient MdMPK4 and MdMYB1 overexpression assays further revealed that light-induced anthocyanin accumulation relies on MdMPK4 kinase activity, which is required for maximum MdMYB1 activity. Based on the expression of the chromosome 6 allele MdMPK4-06G under light conditions and the presence of light response elements in the MdMPK4-06G promoter, we concluded that it is more responsive to light than the chromosome 14 allele MdMPK4-14G. These results suggest a potential biotechnological strategy for increasing fruit anthocyanin content via light induction.
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http://dx.doi.org/10.1111/tpj.15267DOI Listing
June 2021

The complete mitochondrial genome of Zhehuang-1 (Hymenochaetales, Basidiomycota).

Mitochondrial DNA B Resour 2021 Mar 19;6(3):1096-1097. Epub 2021 Mar 19.

Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, People's Republic of China.

In this study, the complete mitochondrial genome of Zhehuang-1 was determined. Genomic DNA samples individually collected from a population in southeastern China (Qiandaohu, Zhejiang Province, N29°44'24'', E118°52'48'') were sequenced with an Illumina NovaSeq 6000. The complete mitochondrial genome was 97,345 bp in length and consisted of 22 protein-coding genes (PCGs), 29 tRNAs, 3 ribosomal RNAs, and a control region. has a mitochondrial gene arrangement that is similar to that of . Phylogenetic analysis performed using ML methods based on the complete mitogenome sequence showed that is a member of the Polyporaceae. The complete mitogenome sequence provides important data for further study of the complex.
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http://dx.doi.org/10.1080/23802359.2020.1832592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995906PMC
March 2021

Growth differentiation factor-15 promotes immune escape of ovarian cancer via targeting CD44 in dendritic cells.

Exp Cell Res 2021 05 23;402(1):112522. Epub 2021 Mar 23.

Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, No.127 Changle Road (West), Xi'an City, Shannxi Province, 710032, China. Electronic address:

Immune escape is the main cause of the low response rate to immunotherapy for cancer, including ovarian cancer. Growth differentiation factor-15 (GDF-15) inhibits immune cell function. However, only few reports described the mechanism. Therefore, the aim of this study was to investigate the mechanism of immune escape regulated by GDF-15 in ovarian cancer. Ovarian cancer patients and healthy women were enrolled in this study. Immunohistochemistry and ELISA were performed to measure GDF-15 expression. Immunoprecipitation combined with mass spectrometry, surface plasmon resonance, and co-immunoprecipitation assay were used to evaluate the interaction between GDF-15 and the surface molecules of DCs. Immunofluorescence analysis, flow cytometry and transwell assay were used to evaluate additional effects of GDF-15 on DCs. The results showed that GDF-15 expression was higher in the ovarian cancer patients compared to that in the healthy women. The TIMER algorithm revealed that highly GDF-15 expression is associated with immune DC infiltration in immunoreactive high-grade serous carcinoma. A further study showed that GDF-15 suppressed DCs maturation, as well as IL-12p40 and TNF-α secretion, the length and number of protrusions and the migration. More importantly, CD44 in the surface of DCs interacted with GDF-15. The overexpression of CD44 in DCs resulted in the suppression of the inhibitory effect of GDF-15 on the length and number of DC synapses. In DCs overexpressing CD44 the inhibition of GDF-15 on the expression of CD11c, CD83 and CD86 was decreased, while in DCs with a knockdown of CD44 the inhibition was further enhanced. Knockdown of CD44 in DCs enhanced the inhibitory effect of GDF-15 on DC migration, while the overexpression of CD44 inhibited the inhibitory effect of GDF-15 on DC migration. In conclusion, the present study suggested that GDF-15 might facilitate ovarian cancer immune escape by interacting with CD44 in DCs to inhibit their function.
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http://dx.doi.org/10.1016/j.yexcr.2021.112522DOI Listing
May 2021

Indoor optical wireless communication system with continuous and simultaneous positioning.

Opt Express 2021 Feb;29(3):4582-4595

The optical wireless communication (OWC) technology has been widely studied to provide high-speed communications in indoor environments. The indoor OWC-based positioning function is also highly demanded and the received signal strength (RSS) method has attracted intensive interests, where multiple transmitters are used and the positioning information is provided by estimating the channel gain from each transmitter with known location. However, this process normally requires dedicated positioning time slots, RF carriers or codewords, which limit the system data rate and throughput. To solve this limitation, in this paper we propose a filter-enhanced indoor OWC positioning scheme, where spatial waveform shaping filters are applied to the transmitters, thus enabling the signals from different transmitters to be separated via matched filters at the receiver side. Hence, this approach allows the RSS information to be obtained from the wireless communication signal directly and the positioning function realized without affecting the wireless communication data rate or throughput. In addition, since positioning is realized using the communication signal, continuous positioning can be achieved for real-time tracking. The proposed filter-enhanced positioning scheme is experimentally demonstrated in a near-infrared indoor OWC system with laser transmitters. Results show that an average positioning accuracy of 5.41 cm and 2.5 Gb/s wireless communication are achieved simultaneously. The proposed filter-enhanced positioning scheme can also be applied in visible light communication (VLC) systems with LED transmitters, and the feasibility is verified via simulations. The proposed filter-enhanced scheme provides a promising positioning method in indoor OWC systems without affecting the wireless data communication.
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http://dx.doi.org/10.1364/OE.409395DOI Listing
February 2021

Nitrogen availability improves the physiological resilience of coral endosymbiont Cladocopium goreaui to high temperature.

J Phycol 2021 08 8;57(4):1187-1198. Epub 2021 May 8.

Department of Marine Sciences, University of Connecticut, Groton, Connecticut, 06340, USA.

The physiological response of symbiotic Symbiodiniaceae to high temperature is believed to result in coral bleaching. However, the potential effect of nitrogen availability on heat acclimatization of symbiotic Symbiodiniaceae is still unclear. In this study, physiological responses of Symbiodiniaceae Cladocopium goreaui to temperature and nitrogen nutrient stress conditions were investigated. Nitrogen deficiency caused significant declines in cell concentration and chlorophyll content per cell, but significant increases in nitric oxide synthase activity, caspase3 activation level, and cellular carbon content of C. goreaui at normal temperature. Algal cells under high temperature and nitrogen deficiency showed significant rises in Fv/Fm, catalase activity, and caspase3 activation level, but no significant changes in cell yield, cell size, chlorophyll content, superoxide dismutase, nitric oxide synthase activity, and cellular contents of nitrogen and carbon, in comparison with those under normal temperature and nitrogen deficiency. Growth, chlorophyll, and nitrogen contents of algal cells under the high temperature and nitrogen-replete conditions were significantly higher than those under high temperature or nitrogen deficiency alone, whereas nitric oxide synthase activity, superoxide dismutase activity, catalase activity, carbon content, and caspase3 activation level exhibited opposite trends of variation. Transcriptomic and network analyses revealed ion transport and metabolic processes mainly involved in regulating these physiological activities under different temperature and nitrogen nutrient. The totality of results shows that high temperature activates stress responses, induces antioxidant capacity of apoptosis, and limits the growth rate of C. goreaui. Adequate nitrogen nutrient can improve the resilience of this Symbiodiniaceae against heat stress through repressed apoptosis, promoted ion transport, and optimized metabolism.
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http://dx.doi.org/10.1111/jpy.13156DOI Listing
August 2021

Dose-Effect of Zearalenone on the Localization and Expression of Growth Hormone, Growth Hormone Receptor, and Heat Shock Protein 70 in the Ovaries of Post-weaning Gilts.

Front Vet Sci 2021 4;8:629006. Epub 2021 Feb 4.

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an, China.

Zearalenone (ZEA) has an estrogen-like effect, which can injure the reproductive system of animals, causing infertility, and abortion in sows. However, the underlying mechanisms are still not clear. The objective of this study was to assess the effects of ZEA on the localization and expression of growth hormone (GH), growth hormone receptor (GHR), and heat shock protein 70 (Hsp70) in the ovaries of post-weaning gilts. Forty healthy post-weaning gilts were randomly provided one of four diets: normal basal diet supplemented with 0 (control), 0.5 (ZEA0.5), 1.0 (ZEA1.0), and 1.5 (ZEA1.5) mg ZEA/kg. Gilts were housed and fed individually for 35 days; the ovaries were collected after euthanasia for antioxidant index, relative mRNA and protein expression, and immunohistochemical analyses of GH, GHR, and Hsp70. The results revealed that the glutathione peroxidase and total superoxide dismutase levels decreased ( < 0.05), whereas the malondialdehyde level increased ( < 0.05) with increasing ZEA content. The localization pattern of GH, GHR, and Hsp70 in ZEA-treated gilts was the same as that in the control; however, the localization of yellow and brown immunoreactive substances of GH, GHR, and Hsp70 was stronger in the ZEA groups than in the control. The relative mRNA and protein expression of GHR and Hsp70 was the highest in the ZEA1.0 group ( < 0.05), whereas that of GH was the highest in the ZEA0.5 group ( < 0.05). The mRNA and protein expression of GH was lower in the ZEA1.5 group than in the control ( < 0.05). Hsp70 results showed adverse responses to increasing ZEA levels in gilt ovaries, suggesting that Hsp70 played an important role in alleviating ZEA-induced oxidative stress.
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http://dx.doi.org/10.3389/fvets.2021.629006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889998PMC
February 2021

Bacterial community diversity, lignocellulose components, and histological changes in composting using agricultural straws for production.

PeerJ 2021 9;9:e10452. Epub 2021 Feb 9.

Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hanzghou, Zhejiang, China.

Agricultural straws (AS) may serve as potential base-substances in the production of . Six AS that occur across China were investigated in a two-stage composting experiment; lignocellulose components, AS morphology, and the effects of different AS on mushroom yields from 2015-2017 were examined. In addition, microbial biodiversity and their impact on substrate degradation were studied using 16S gene sequenc based on six different AS on the 3rd (I.F), 6th (I.S), and 10th (I.T) day of Phase I, and Phase II (II). Results showed that the six different AS exhibited differences in the progression of degradation under the same compost condition; the wheat straw, rice straw, and cotton straw induced a significantly higher mushroom yield than did the others ( < 0.05); , and genera may play an important role in the different AS degradations. According to our experiments, we can adjust formulations and compost methods to obtain high-yield mushroom compost based on different AS in the future.
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http://dx.doi.org/10.7717/peerj.10452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879949PMC
February 2021

Effects of end-tidal carbon dioxide levels in patients undergoing direct revascularization for Moyamoya disease and risk factors associated with postoperative complications.

Medicine (Baltimore) 2021 Feb;100(7):e24527

The First Hospital of Jilin University, Changchun, Jilin.

Abstract: A history of transient ischemic attack, severity of disease, urinary output, hematocrit, hypocapnia, and hypotension during direct revascularization (superficial temporal artery to middle cerebral artery [STA-MCA]) in patients with Moyamoya disease (MMD) may lead to a poor prognosis, however, to our knowledge evidence for end-tidal carbon dioxide (ETCO2) targets is lacking. Within the ranges of standardized treatment, the article was primarily designed to study the risk factors associated with the neurologic outcomes during STA-MCA for MMD especially including ETCO2 ranges and the duration in different groups. The primary goals of this study were to investigate the risk factors for neurologic deterioration and explore the association between ETCO2 ranges and neurologic outcome during general anesthesia for STA-MCA.This retrospective observational study included 56 consecutively adult Moyamoya patients who underwent STA-MCA under general anesthesia between January 2015 and August 2019. ETCO2 was summarized per patient every 5 minutes. Clinical outcome was assessed with clinical presentation, computed tomography findings, magnetic resonance imaging findings, cerebral angiography, and the modified Rankin Scale scores at discharge as main outcome measure. The outcomes were also compared for the duration of surgery, anesthesia, and the length of stay.A total of 56 patients were studied, all patients had comprehensive ETCO2 measurements. The incidence of postoperative complications was 44.6% (25/56). There was no association between age, sex, hypertension, diabetes, smoking history, drinking history, sevoflurane use, invasive arterial blood pressure monitoring, combined encephalomyosynangiosis and postoperative complications. Duration of surgery (P = .04), anesthesia (P = .036), hospital stay (P = .023) were significant correlates of postoperative complications. In the multiple logistic regression model, they were not the significant predictors. The ETCO2 ranges and the length of time in different groups within the current clinical setting was not associated with postoperative complications (P > .05).Within a standardized intraoperative treatment strategy, we found that postoperative complications had no significant correlation with sex, age, hypertension, diabetes, smoking history, drinking history, invasive arterial blood pressure monitoring, combined encephalomyosynangiosis, or sevoflurane use. Further, hypocapnia and hypercapnia during STA-MCA were not found to be associated with postoperative complications in patients with MMD.
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http://dx.doi.org/10.1097/MD.0000000000024527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899818PMC
February 2021

Effects of thermostable phytase supplemented in diets on growth performance and nutrient utilization of broilers.

Anim Sci J 2021 Jan;92(1):e13513

College of Animal Sciences and Technology, Shandong Agricultural University, Tai'an, P. R. China.

Phytase is an enzyme that has the ability to release phosphorous (P) from phytate by hydrolyzing inositol-phosphate linkages. Recently, thermostable phytases have gained great consideration because the reduction in phytase activity was found when exposed to heat during feed pelleting. In this study, the effects of the granular thermostable phytase (Aspergillus niger) on growth performance and nutrient utilization of broilers were investigated. A total of 96 21-day-old Arbor Acres broilers were randomly distributed into six treatments including basal diet (control) and basal diet supplemented with 500, 1,000, 2,000, 4,000, 8,000 U of phytase/kg. In general, the metabolizable energy (ME) and the apparent and true availability of dry matter (DM), organic matter (OM), ether extract (EE), crude protein (CP), and amino acids (AA) showed both linearly (p < .01) and quadratically (p < .01) increase with increasing levels of phytase in the diet. Additionally, diet supplementation with phytase could improve (p < .05) body weight (BW), average daily gain (ADG), and feed/gain (F/G) on day 42 compared with the control. The results suggested that diet supplementation of the granular thermostable phytase in the crumbled pellets could improve chicken growth performance and nutrient utilization.
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http://dx.doi.org/10.1111/asj.13513DOI Listing
January 2021

Enhanced control of sulfonamide resistance genes and host bacteria during thermophilic aerobic composting of cow manure.

Environ Pollut 2021 Apr 1;275:116587. Epub 2021 Feb 1.

Agricultural Clean Watershed Research Group, Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, PR China. Electronic address:

Traditional composting has already shown a certain effect in eliminating antibiotic residues, antibiotic-resistant bacteria (ARBs), and antibiotic resistance genes (ARGs). It is worth noting that the rebounding of ARGs and the succession of the bacterial community during conventional aerobic composting are still serious threats. Considering the probable risk, improved and adaptable technologies are urgently needed to control antibiotic resistance efficiently. This study monitored how thermophilic aerobic composting affected the ARGs, as well as the bacterial diversity during the composting of cow manure spiked with sulfamethoxazole (SMX) at different concentrations. Results showed that the degradation of SMX was enhanced during thermophilic aerobic composting (control > SMX25 > SMX50 > SMX100) and was no longer detected after 20 days of composting. High temperature or heat significantly stimulated the rebounding of certain genes. After 35 days, the abundance of detected genes (sul2, sulA, dfrA7, and dfrA1) significantly decreased (p < 0.05) in control and antibiotic-spiked treatments, except for sul1. The addition of three concentrations of SMX elicited a sharp effect on bacterial diversity, and microbial structure in SMX25 led to significant differences with others (p < 0.05). The network analysis revealed more rigorous interactions among ARGs and abundant genera, suggesting that the host of ARGs potentially increased at low concentrations of SMX. Especially, genera g_norank_f__Beggiatoaceae, Ruminiclostridium, Caldicoprobacter, g_norank_o_MBA03, Hydrogenispora, and Ruminiclostridium_1 were major potential hosts for sul1. In conclusion, the rebounding of ARGs could be intermitted partially, and more efficient control of antibiotic resistance could be achieved in the thermophilic composting compared to conventional methods.
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http://dx.doi.org/10.1016/j.envpol.2021.116587DOI Listing
April 2021

Effect of Cultured Substrates on the Chemical Composition and Biological Activities of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes).

Int J Med Mushrooms 2020 ;22(12):1183-1190

Institute of Horticulture, Zhejiang Academy of Agricultural Science, Hangzhou 310021, People's Republic of China.

A systematic study was carried out to compare the chemical composition and biological activities of wood-cultured and sack-cultured Ganoderma lucidum (WG and SG, respectively). The proximate composition, microelement content, and functional compounds of the two different cultivated mushrooms were investigated. Antioxidant and hypoglycemic activities of polysaccharide and phenolic extracts of WG and SG were also investigated. The phenolic extracts exhibited higher antioxidant and hypoglycemic activity than the polysaccharidic extracts, and activities of the WG extracts were better than those of the SG extracts. Therefore, wood culture is a superior method of artificial cultivation for the production of such antioxidant and hypoglycemic activities.
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http://dx.doi.org/10.1615/IntJMedMushrooms.2020037133DOI Listing
July 2021

Anxiety levels during a second local COVID-19 pandemic breakout among quarantined people: A cross sectional survey in China.

J Psychiatr Res 2021 03 5;135:37-46. Epub 2021 Jan 5.

Center for Reproductive Medicine, the Eighth People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. Electronic address:

Only a few studies investigated the impact of quarantine on anxiety of general population during a second wave of COVID-19 breakout. We aimed to compare anxiety levels of quarantined and non-quarantined people and investigate factors affecting anxiety during the second COVID-19 pandemic. A total of 1837 participants were included in this cross-sectional study. Anxiety was measured by the State-Trait Anxiety Inventory (STAI). Participants were divided into the quarantined group (QG) and non-quarantined group (Non-QG). The mean STAI-S score in the QG was significantly higher than Non-QG (41.8 ± 11.2 vs 40.01 ± 9.9), so was the proportion of severe state anxiety (11.6% vs 5.5%). Males in the QG were significantly more anxious than females evaluated by both STAI-S and STAI-T. High income was independent protective factors while moderate or bad health status and high trait anxiety level were independent risk factors for severe state anxiety. In conclusion, the COVID-19 confinement could significantly increase anxiety of quarantined people. Males were more vulnerable to the quarantine of COVID-19 with significantly increased anxiety level than females. The results suggest that attention should be paid to anxiety during a second round of quarantine due to COVID-19 and are of help in planning psychological interventions.
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http://dx.doi.org/10.1016/j.jpsychires.2020.12.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783475PMC
March 2021

Enhanced alkali tolerance of rhizobia-inoculated alfalfa correlates with altered proteins and metabolic processes as well as decreased oxidative damage.

Plant Physiol Biochem 2021 Feb 6;159:301-311. Epub 2021 Jan 6.

College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China. Electronic address:

Aims: Alkaline salt is one of the most devastating environmental factors limiting alfalfa productivity, however, the mechanisms underlying adaptation of alfalfa to alkaline remain unclear. Our aim is to investigate proteomic and metabolomic differences in growth and root of alfalfa under alkaline salt in Rhizobium-alfalfa symbiotic relationships.

Methods: Rhizobium-inoculated and non-inoculated alfalfa plants were treated with 200 mmol/L NaHCO to investigate physiological, metabolic, and proteomic responses of root-nodule symbiosis under alkaline-induced stress, using an integrated approach combining metabolome and proteome analysis with measurements of physiological parameters.

Results: The improved tolerance to alkalinity was observed in RI-plants compared with NI-plants. RI-plants accumulated more proline and MDH, and had higher antioxidant activity and relatively high RWC but low MDA content and low Na/K ratio. The stress-related genes (P5CS, GST13, H-Ppase, NADP-Me, SDH, and CS) were actively upregulated in RI plants under alkaline stress. In RI-plants, damage caused by alkaline stress was mainly alleviated by decreasing oxidative damage, enhancing the organic acid and amino acid metabolic processes, and scavenging harmful ROS by activating the phenylpropanoid biosynthetic pathway.

Conclusions: We revealed distinct proteins and metabolites related to alkali tolerance in RI-plants compared to NI-plants. Alkali tolerance of rhizobia-inoculated alfalfa was enhanced by altered proteins and metabolic processes as well as decreased oxidative damage.
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http://dx.doi.org/10.1016/j.plaphy.2020.12.021DOI Listing
February 2021

FGF-23 correlates with endocrine and metabolism dysregulation, worse cardiac and renal function, inflammation level, stenosis degree, and independently predicts in-stent restenosis risk in coronary heart disease patients underwent drug-eluting-stent PCI.

BMC Cardiovasc Disord 2021 01 7;21(1):24. Epub 2021 Jan 7.

Department of Cardiology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, 050000, China.

Background: The present study aimed to assess the correlation of fibroblast growth factor (FGF)-23 expression with clinical characteristics, then further explore its value in predicting 2-year in-stent restenosis (ISR) risk in coronary heart disease (CHD) patients underwent percutaneous coronary intervention (PCI) with drug-eluting stent (DES).

Methods: In this prospective, single-center, observational study, totally 214 CHD patients treated by PCI with DES were consecutively recruited, and peripheral blood samples were collected prior to PCI with DES for serum samples isolation. Following, FGF-23 level in the serum samples was detected via enzyme linked-immuno-sorbent Assay. The follow-up coronary angiography was performed at 1 year and 2 years after PCI or if suspected ISR symptoms occurred.

Results: FGF-23 was positively correlated with fasting blood-glucose, insulin resistance, serum creatinine, serum uric acid, LDL-C, high-sensitivity C-reactive protein, cardiac troponin I and N-terminal-proB-type natriuretic peptide, while was negatively associated with HDL-C and left ventricular ejection fraction (all P < 0.01). Furthermore, FGF-23 was positively correlated with hypercholesteremia, hyperuricemia and family history of CAD (all P < 0.05). However, it did not correlate with other chronic complications, biochemical indexes, lesion features or PCI parameters (all P > 0.05). Moreover, FGF-23 level was higher in 2-year ISR patients (n = 38) compared to 2-year non-ISR patients (n = 176) (P < 0.001), and receiver operating characteristic curve indicated that FGF-23 was of good value in predicting 2-year ISR risk (AUC 0.828, 95% CI 0.761-0.896).

Conclusion: FGF-23 correlates with endocrine and metabolism dysregulation, worse cardiac and renal function, inflammation level, stenosis degree of target lesion, and serves as an independent risk factor for 2-year ISR risk in CHD patients underwent PCI with DES.
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http://dx.doi.org/10.1186/s12872-020-01839-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791850PMC
January 2021
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