Ting-Chao Chou

Ting-Chao Chou

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Ting-Chao Chou

Ting-Chao Chou

Publications by authors named "Ting-Chao Chou"

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75Publications

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Potent effects of roniciclib alone and with sorafenib against well-differentiated thyroid cancer.

Endocr Relat Cancer 2018 Oct 12;25(10):853-864. Epub 2018 Jun 12.

Department of SurgeryMemorial Sloan-Kettering Cancer Center, New York, New York, USA.

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October 2018

Activity of roniciclib in medullary thyroid cancer.

Oncotarget 2018 Jun 15;9(46):28030-28041. Epub 2018 Jun 15.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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June 2018

A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer.

PLoS One 2017 16;12(2):e0172315. Epub 2017 Feb 16.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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September 2017

Effects of roniciclib in preclinical models of anaplastic thyroid cancer.

Oncotarget 2017 Sep 8;8(40):67990-68000. Epub 2017 Jul 8.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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September 2017

Co-exposure to low doses of the food contaminants deoxynivalenol and nivalenol has a synergistic inflammatory effect on intestinal explants.

Arch Toxicol 2017 Jul 3;91(7):2677-2687. Epub 2016 Dec 3.

Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-PURPAN, UPS 180 Chemin de Tournefeuille, BP93173, 31027, Toulouse Cedex 03, France.

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July 2017

Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models.

Oncotarget 2017 Jun;8(25):41294-41304

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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June 2017

Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method.

Am J Cancer Res 2016 15;6(1):97-104. Epub 2015 Dec 15.

Preclinical Pharmacology Core, Molecular Pharmacology & Chemistry Program, Memorial Sloan-Kettering Cancer CenterNew York, NY 10065, USA; Present Address: PD Science LLCParamus, NJ 07652, USA.

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April 2016

Utility of a histone deacetylase inhibitor (PXD101) for thyroid cancer treatment.

PLoS One 2013 14;8(10):e77684. Epub 2013 Oct 14.

Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, ROC.

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June 2014

Utility of a PI3K/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy.

PLoS One 2012 15;7(10):e46726. Epub 2012 Oct 15.

Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China.

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March 2013

The mass-action law based algorithm for cost-effective approach for cancer drug discovery and development.

Authors:
Ting-Chao Chou

Am J Cancer Res 2011 5;1(7):925-54. Epub 2011 Aug 5.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center New York, NY, USA.

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November 2011

Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol.

Proc Natl Acad Sci U S A 2011 Aug 15;108(34):14336-41. Epub 2011 Aug 15.

Preclinical Pharmacology Core Facility and Bio-Organic Laboratory, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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August 2011

The mass-action law based algorithms for quantitative econo-green bio-research.

Authors:
Ting-Chao Chou

Integr Biol (Camb) 2011 May 14;3(5):548-59. Epub 2011 Mar 14.

Preclinical Pharmacology Core Laboratory, Molecular Pharmacology & Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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May 2011

Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates.

Bioorg Med Chem 2011 Mar 2;19(6):1987-98. Epub 2011 Feb 2.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

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March 2011

Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.

J Neurooncol 2011 Feb 25;101(3):379-90. Epub 2010 Jun 25.

Department of Pathology, The Ohio State University, 165 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA.

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February 2011

Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker.

Bioorg Med Chem 2010 Mar 4;18(6):2285-2299. Epub 2010 Feb 4.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan; Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan.

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March 2010

Drug combination studies and their synergy quantification using the Chou-Talalay method.

Authors:
Ting-Chao Chou

Cancer Res 2010 Jan 12;70(2):440-6. Epub 2010 Jan 12.

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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January 2010

Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings.

Eur J Med Chem 2009 Jul 22;44(7):3056-9. Epub 2008 Jul 22.

Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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July 2009

BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors.

Cancer Lett 2009 Apr 23;276(2):204-11. Epub 2008 Dec 23.

Cellular and Molecular Medicine, Genomics Research Center, 128 Academia Sinica, Section 2, Taipei, Taiwan.

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April 2009

Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells.

Basic Clin Pharmacol Toxicol 2009 Mar 21;104(3):241-52. Epub 2009 Jan 21.

Department of Immunology, Harbin Medical University, 150081 Harbin, China.

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March 2009

90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.

Mol Pharmacol 2009 Jan 26;75(1):124-33. Epub 2008 Sep 26.

Laboratory of New Drug Development, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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January 2009

Synthesis of pluraflavin A "aglycone".

J Am Chem Soc 2008 Dec;130(49):16786-90

Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, New York 10027, USA.

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December 2008

Preclinical versus clinical drug combination studies.

Authors:
Ting-Chao Chou

Leuk Lymphoma 2008 Nov;49(11):2059-80

Laboratory of Preclinical Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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November 2008

Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones.

Proc Natl Acad Sci U S A 2008 Sep 28;105(35):13157-62. Epub 2008 Aug 28.

Preclinical Pharmacology Laboratory, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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September 2008

Synergy of a herpes oncolytic virus and paclitaxel for anaplastic thyroid cancer.

Clin Cancer Res 2008 Mar;14(5):1519-28

Department of Surgery and Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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March 2008

Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma.

Ann Surg Oncol 2007 Jan 1;14(1):258-69. Epub 2006 Nov 1.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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January 2007

Reversal of multidrug resistance by two nordihydroguaiaretic acid derivatives, M4N and maltose-M3N, and their use in combination with doxorubicin or paclitaxel.

Cancer Chemother Pharmacol 2006 Nov 17;58(5):640-53. Epub 2006 Mar 17.

Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.

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November 2006

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.

Authors:
Ting-Chao Chou

Pharmacol Rev 2006 Sep;58(3):621-81

Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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September 2006

Cisplatin-induced GADD34 upregulation potentiates oncolytic viral therapy in the treatment of malignant pleural mesothelioma.

Cancer Biol Ther 2006 Jan 12;5(1):48-53. Epub 2006 Jan 12.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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January 2006

Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives.

Bioorg Med Chem 2005 Dec 1;13(23):6513-20. Epub 2005 Sep 1.

Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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December 2005

Total synthesis as a resource in drug discovery: the first in vivo evaluation of panaxytriol and its derivatives.

J Org Chem 2005 Dec;70(25):10375-80

Department of Chemistry, Columbia University, 3000 Broadway, New York, New York, 10027, USA.

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December 2005

5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer.

J Gastrointest Surg 2005 Nov;9(8):1068-77; discussion 1077-9

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.

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November 2005

Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice.

Cancer Chemother Pharmacol 2005 Oct 4;56(4):379-90. Epub 2005 May 4.

Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

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October 2005

Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route.

Cancer Res 2005 Oct;65(20):9445-54

Preclinical Pharmacology and Analytical Chemistry Core Laboratories, and Bio-Organic Chemistry Laboratory, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center.

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October 2005

Quantitation of synergism of arabinosylcytosine and cladribine against the growth of arabinosylcytosine-resistant human lymphoid cells.

J Cancer Res Clin Oncol 2005 Sep 20;131(9):609-16. Epub 2005 Oct 20.

Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33101, USA.

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September 2005

Radiation therapy potentiates effective oncolytic viral therapy in the treatment of lung cancer.

Ann Thorac Surg 2005 Aug;80(2):409-16; discussion 416-7

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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August 2005

On the remarkable antitumor properties of fludelone: how we got there.

Angew Chem Int Ed Engl 2005 May;44(19):2838-50

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

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May 2005

Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation.

Bioorg Med Chem Lett 2004 Sep;14(18):4719-22

Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

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September 2004

Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate.

J Am Chem Soc 2004 Sep;126(35):10913-22

Contribution from the Laboratory for Bioorganic Chemistry, Preclinical Pharmacology Core Facility, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

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September 2004

2-Chloro-2'-deoxyadenosine synergistically enhances azidothymidine cytotoxicity in azidothymidine resistant T-lymphoid cells.

Biochem Biophys Res Commun 2004 Apr;316(2):518-22

Division of Hematology-Oncology, Department of Medicine (M862), P.O. Box 019132, University of Miami School of Medicine, Miami, FL 33101, USA.

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April 2004

Analysis of protease inhibitor combinations in vitro: activity of lopinavir, amprenavir and tipranavir against HIV type 1 wild-type and drug-resistant isolates.

J Antimicrob Chemother 2004 Mar 12;53(3):464-8. Epub 2004 Feb 12.

Istituto di Malattie Infettive e Tropicali, Università degli Studi, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milano, Italy.

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March 2004

Enhanced hydrolytic stability and water solubility of an aromatic nitrogen mustard by conjugation with molecular umbrellas.

Bioconjug Chem 2003 May-Jun;14(3):667-71

Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA.

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January 2004

Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine.

J Infect Dis 2004 Jan 31;189(1):71-4. Epub 2003 Dec 31.

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

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January 2004

Favorable interactions between enfuvirtide and 1-beta-D-2,6-diaminopurine dioxolane in vitro.

Antimicrob Agents Chemother 2003 Nov;47(11):3644-6

Massachusetts General Hospital, Infectious Diseases Unit, Harvard Medical School, Boston, Massachusetts, USA.

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November 2003

Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.

Angew Chem Int Ed Engl 2003 Oct;42(39):4762-7

Preclinical Pharmacology Core Facility, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

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October 2003

Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells.

Int J Oncol 2003 Jul;23(1):151-8

Department of Medicine, Hematology/Oncology, University of Münster, Albert-Schweitzer-Strasse 33, D-48129 Münster, Germany.

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July 2003

Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones.

Angew Chem Int Ed Engl 2003 Jun;42(22):2518-21

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

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June 2003

Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

J Am Chem Soc 2003 Mar;125(10):2899-901

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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March 2003

Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo.

Cancer Res 2002 Dec;62(23):6909-15

Program of Molecular Pharmacology and Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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December 2002

Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B.

J Org Chem 2002 Nov;67(22):7730-6

Laboratories for Bioorganic Chemistry and Laboratories for Preclinical Pharmacology, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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November 2002

Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series.

J Org Chem 2002 Nov;67(22):7737-40

Laboratory for Bioorganic Chemistry, Preclinical Pharmacology Core Facility and Analytical Pharmacology Core Facility, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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November 2002

On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings.

Org Lett 2002 Nov;4(23):4081-4

Laboratories for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.

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November 2002

Synergy determination issues.

Authors:
Ting-Chao Chou

J Virol 2002 Oct;76(20):10577; author reply 10578

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October 2002

Antitumor AHMA linked to DNA minor groove binding agents: synthesis and biological evaluation.

J Med Chem 2002 Sep;45(20):4485-93

Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

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September 2002

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

J Am Chem Soc 2002 Aug;124(33):9825-32

Bioorganic Chemistry, Preclinical Pharmacology Core Facility and Analytical Pharmacology Core Facility, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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August 2002

Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro.

Antimicrob Agents Chemother 2002 May;46(5):1336-9

Massachusetts General Hospital, Infectious Diseases Unit, Harvard Medical School, Boston, Massachusetts 02114, USA.

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May 2002

p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.

Genes Dev 2002 Apr;16(8):984-93

Laboratory of Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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April 2002

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B.

Angew Chem Int Ed Engl 1998 Oct;37(19):2675-2678

[+] Further address: Havemeyer Hall, Department of Chemistry, Columbia University, New York, NY 10027 (USA).

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October 1998