Publications by authors named "Ting Zhou"

748 Publications

The complete chloroplast genome sequence of Sims. (Aquifoliaceae), a folk herbal medicine plant in China.

Mitochondrial DNA B Resour 2021 Mar 26;6(3):1241-1242. Epub 2021 Mar 26.

Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, PR China.

The complete chloroplast (cp) genome of , an important economic plant with ornamental and ecological values, was sequenced to investigate its phylogenetic relationship. The entire cp genome of was 157,885 bp in length with 37.61% overall GC content, including a large single-copy (LSC) region of 87,289 bp, and a small single-copy (SSC) region of 18,388 bp, which were separated by a pair of inverted repeats (IRs) of 52,208 bp. The cp genome contained 135 genes, including 90 protein-coding genes, 37 genes, and eight genes. Phylogenetic analysis based on whole cp genome sequences showed that was closely related to and species.
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http://dx.doi.org/10.1080/23802359.2021.1904800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008935PMC
March 2021

Incorporation of Urinary Neutrophil Gelatinase-Associated Lipocalin and Computed Tomography Quantification to Predict Acute Kidney Injury and In-Hospital Death in COVID-19 Patients.

Kidney Dis (Basel) 2021 Mar 15;7(2):120-130. Epub 2020 Sep 15.

Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: The prevalence of acute kidney injury (AKI) in COVID-19 patients is high, with poor prognosis. Early identification of COVID-19 patients who are at risk for AKI and may develop critical illness and death is of great importance.

Objective: The aim of this study was to develop and validate a prognostic model of AKI and in-hospital death in patients with COVID-19, incorporating the new tubular injury biomarker urinary neutrophil gelatinase-associated lipocalin (u-NGAL) and artificial intelligence (AI)-based chest computed tomography (CT) analysis.

Methods: A single-center cohort of patients with COVID-19 from Wuhan Leishenshan Hospital were included in this study. Demographic characteristics, laboratory findings, and AI-assisted chest CT imaging variables identified on hospital admission were screened using least absolute shrinkage and selection operator (LASSO) and logistic regression to develop a model for predicting the AKI risk. The accuracy of the AKI prediction model was measured using the concordance index (C-index), and the internal validity of the model was assessed by bootstrap resampling. A multivariate Cox regression model and Kaplan-Meier curves were analyzed for survival analysis in COVID-19 patients.

Results: One hundred seventy-four patients were included. The median (±SD) age of the patients was 63.59 ± 13.79 years, and 83 (47.7%) were men.u-NGAL, serum creatinine, serum uric acid, and CT ground-glass opacity (GGO) volume were independent predictors of AKI, and all were selected in the nomogram. The prediction model was validated by internal bootstrapping resampling, showing results similar to those obtained from the original samples (i.e., 0.958; 95% CI 0.9097-0.9864). The C-index for predicting AKI was 0.955 (95% CI 0.916-0.995). Multivariate Cox proportional hazards regression confirmed that a high u-NGAL level, an increased GGO volume, and lymphopenia are strong predictors of a poor prognosis and a high risk of in-hospital death.

Conclusions: This model provides a useful individualized risk estimate of AKI in patients with COVID-19. Measurement of u-NGAL and AI-based chest CT quantification are worthy of application and may help clinicians to identify patients with a poor prognosis in COVID-19 at an early stage.
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http://dx.doi.org/10.1159/000511403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573910PMC
March 2021

Using Published Health Utilities in Cost-Utility Analyses: Discrepancies and Issues in Cardiovascular Disease.

Med Decis Making 2021 Apr 3:272989X211004532. Epub 2021 Apr 3.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Background: Health utilities are commonly used as quality weights to calculate quality-adjusted life years in cost-utility analysis (CUA). However, if published health utilities are not properly used, the credibility of CUA could be affected.

Objectives: To identify discrepancies in using published health utilities in CUAs for cardiovascular disease (CVD).

Methods: CVD CUAs in the Tufts Cost-Effectiveness Analysis Registry that reported health utilities were included in the analysis. References cited for health utilities in these CUAs were reviewed to identify the original health utility studies. The description and value of health utilities used in the CUA were compared with those reported in the original utility studies. Logistic regression was used to identify the factors that can predict the discrepancy.

Results: A total of 585 eligible CUAs published between 1977 and 2016 were identified and reviewed. Of these studies, 74.5% were published between 2007 and 2016. 442 CUAs that used a total of 2235 health utilities published in 203 original utility studies were included for the comparison. As compared with those utilities originally reported, only 596 (26.7%) health utilities had the same description and value, whereas 991 health utilities (44.3%) differed in both description and value. Of 1290 health utilities with a different description, 69.1% were due to different severity or disease. No explanation or justification was provided for 1171 (87.4%) of 1340 health utilities with different value.

Conclusions: There are concerning discrepancies in using published health utilities for CVD CUAs. Given the important role health utilities play in CUAs, authors of CUAs should always refer to the original studies for health utilities and be transparent about how published health utilities are selected and incorporated into CUAs.
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http://dx.doi.org/10.1177/0272989X211004532DOI Listing
April 2021

Evolution of Singlet Oxygen by Activating Peroxydisulfate and Peroxymonosulfate: A Review.

Int J Environ Res Public Health 2021 Mar 24;18(7). Epub 2021 Mar 24.

School of Environmental Studies, China University of Geosciences, Wuhan 430074, China.

Advanced oxidation processes (AOPs) based on peroxydisulfate (PDS) or peroxymonosulfate (PMS) activation have attracted much research attention in the last decade for the degradation of recalcitrant organic contaminants. Sulfate (SO) and hydroxyl (OH) radicals are most frequently generated from catalytic PDS/PMS decomposition by thermal, base, irradiation, transition metals and carbon materials. In addition, increasingly more recent studies have reported the involvement of singlet oxygen (O) during PDS/PMS-based AOPs. Typically, O can be produced either along with SO and OH or discovered as the dominant reactive oxygen species (ROSs) for pollutants degradation. This paper reviews recent advances in O generation during PDS/PMS activation. First, it introduces the basic chemistry of O, its oxidation properties and detection methodologies. Furthermore, it elaborates different activation strategies/techniques, including homogeneous and heterogeneous systems, and discusses the possible reaction mechanisms to give an overview of the principle of O production by activating PDS/PMS. Moreover, although O has shown promising features such as high degradation selectivity and anti-interference capability, its production pathways and mechanisms remain controversial in the present literatures. Therefore, this study identifies the research gaps and proposes future perspectives in the aspects of novel catalysts and related mechanisms.
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http://dx.doi.org/10.3390/ijerph18073344DOI Listing
March 2021

Comparison of the Anterior Tooth and Lip Esthetic Characteristics of Hani and Han Youth in China When Speaking.

Clin Cosmet Investig Dermatol 2021 23;14:285-290. Epub 2021 Mar 23.

Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan, 650100, People's Republic of China.

Objective: This study aims to measure and analyze the lip and tooth dynamic esthetic characteristics at rest and during speech in order to provide a reference for its esthetic design and restoration among the Hani and Han populations in Yunnan Province, China.

Methods: Subjects of Hani and Han ethnicity in Yunnan were selected using multistage stratified sampling and inclusive criteria. The lip and tooth dynamic esthetic characteristics of the subjects at rest and during the pinyin pronunciation of "me", "yi", "fu", and "si" were recorded using digital photography and analyzed with computer software.

Results: No statistical difference was detected between the Hani and Han groups in the upper central-incisor display, when pronouncing the pinyin "yi". Furthermore, there were no statistical differences in lip dynamic esthetic parameters between the Hani and Han groups, except for the distance between the upper and lower lips when pronouncing "si". There were three kinds of correlation between the upper central-incisor edge and lower lip: separation, contact, and overlap.

Conclusion: The display of upper central incisors and the mouth width of Hani people are larger than those of Han people when at rest. When the pinyin "si" is pronounced, the display of upper central incisors and the upper-lower lip distance of Hani people is less than that of Han people due to labial muscle movement.
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http://dx.doi.org/10.2147/CCID.S295149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001037PMC
March 2021

Perceived organizational support and PTSD symptoms of frontline healthcare workers in the outbreak of COVID-19 in Wuhan: The mediating effects of self-efficacy and coping strategies.

Appl Psychol Health Well Being 2021 Mar 20. Epub 2021 Mar 20.

Intensive Care Unit, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

The present study aimed to examine the effect of perceived organizational support on the PTSD symptoms of frontline healthcare workers, and to examine the mediating effects of coping self-efficacy and coping strategies in this relationship. A short-term longitudinal study design was used to conduct two waves of online surveys in March and April 2020. Participants comprised 107 medical staff in both waves of investigation. Self-efficacy, coping strategies, and perceived organizational support were reported at Wave 1, and PTSD symptoms were reported at Wave 2. Results indicated that (1) The prevalence of probable PTSD was 9.3% and 4.7% on the Chinese version of the Impact of Events Scale-Revised of 33 and 35, respectively. Local healthcare workers had greater risks of PTSD than the members of medical rescue teams. Doctors reported higher PTSD symptoms than nurses. (2) Perceived organizational support had a significant indirect effect on PTSD symptoms through the mediation of problem-focused coping strategies and the sequential mediating effect of coping self-efficacy and problem-focused coping strategies. The findings highlight the importance of providing adequate organizational support to reduce PTSD symptoms in frontline medical staff during the COVID-19 pandemic.
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http://dx.doi.org/10.1111/aphw.12267DOI Listing
March 2021

LncRNA XIST Promoted OGD-Induced Neuronal Injury Through Modulating/miR-455-3p/TIPARP Axis.

Neurochem Res 2021 Mar 18. Epub 2021 Mar 18.

Department of Rehabilitation Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Street, Wuhan, 430014, Hubei, China.

In recent years, the incidence of ischemic stroke has gradually increased, but its pathogenesis has not been fully elucidated. lncRNAs played an important role in the occurrence and regulation of disease, but the research on ischemic stroke is very limited. Therefore, the role of lncRNA in ischemic stroke needs further exploration. The mice model was built to obtain OGD-induced neuronal cells for the following experiments. The protein expression of TCDD inducible poly [ADP-ribose] polymerase (TIPARP), B-cell lymphoma-2 (Bcl-2) and Cleaved Caspase-3 (Cleaved-cas3) were detected with western blot. qRT-PCR was used to analyze expression of XIST, miR-455-3p and TIPARP. CCK-8 assay indicated the capacity of cell proliferation. Flow cytometry was applied to assess cell apoptosis rate. Moreover, dual-luciferase reporter assay and RIP assay were used to determine that the relationship among XIST, miR-455-3p and TIPARP. In this study, we found that oxygen-glucose deprivation (OGD) induced XIST expression, inhibited miR-455-3p expression and promoted TIPARP mRNA and protein expression in neurons. Furthermore, XIST could affect cell growth of OGD-induced neuronal cells. Further analysis showed that XIST could regulate TIPARP by binding to miR-455-3p, and overexpression of miR-455-3p or inhibition of TIPARP could reverse the effects of high XIST expression on OGD-induced neuronal cells. On the contrary, suppression of miR-455-3p or promotion of TIPARP could reverse the effects of low XIST expression on OGD-induced neuronal cells. XIST could affect cell proliferation and apoptosis through miR-455-3p/TIPARP axis in OGD-induced neuronal cells, providing a new regulatory network to understand the pathogenesis of hypoxia-induced neuronal injury.
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http://dx.doi.org/10.1007/s11064-021-03286-1DOI Listing
March 2021

Toxicological and physiological effects of successive exposure to ochratoxin A at food regulatory limits.

Food Chem Toxicol 2021 Mar 13;151:112128. Epub 2021 Mar 13.

State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science Technology, Anhui Agricultural University, Heifei 230036, China. Electronic address:

Ochratoxin A (OTA), a potent mycotoxin, is a common contaminant of agro-products, which seriously threatens food safety. The OTA regulatory limits vary from different countries/regions. However, little is known about the toxicological effects of successive exposure to regulatory levels of OTA. In this study, feedstuffs contaminated with 0.5-20 μg kg OTA were evaluated in Sprague-Dawley (SD) rats. During the study, poisoning-associated behaviors, and significant differences of body weight and food intake, were not observed between OTA-treated rats and control group. However, the renal function indexes of blood urea nitrogen (BUN) and creatinine (CR) increased, and architecture destruction of glomeruli and tubuli was observed from the OTA-treated groups. The apoptosis study indicated that at a concentration of 20 μg kg, OTA modulated apoptosis in renal tissues via the Bcl-2/Bax pathway. The results of this study suggest that exposure to low doses of OTA successively at levels lower than the regulatory limits of certain countries could induce nephrotoxicity, and modulate apoptosis. Therefore, agencies pertaining to food safety should establish strict OTA regulatory limits for food and feedstuff.
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http://dx.doi.org/10.1016/j.fct.2021.112128DOI Listing
March 2021

Toxic Metabolic Encephalopathy in Hospitalized Patients with COVID-19.

Neurocrit Care 2021 Mar 16. Epub 2021 Mar 16.

Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA.

Background: Toxic metabolic encephalopathy (TME) has been reported in 7-31% of hospitalized patients with coronavirus disease 2019 (COVID-19); however, some reports include sedation-related delirium and few data exist on the etiology of TME. We aimed to identify the prevalence, etiologies, and mortality rates associated with TME in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients.

Methods: We conducted a retrospective, multicenter, observational cohort study among patients with reverse transcriptase-polymerase chain reaction-confirmed SARS-CoV-2 infection hospitalized at four New York City hospitals in the same health network between March 1, 2020, and May 20, 2020. TME was diagnosed in patients with altered mental status off sedation or after an adequate sedation washout. Patients with structural brain disease, seizures, or primary neurological diagnoses were excluded. The coprimary outcomes were the prevalence of TME stratified by etiology and in-hospital mortality (excluding comfort care only patients) assessed by using a multivariable time-dependent Cox proportional hazards models with adjustment for age, race, sex, intubation, intensive care unit requirement, Sequential Organ Failure Assessment scores, hospital location, and date of admission.

Results: Among 4491 patients with COVID-19, 559 (12%) were diagnosed with TME, of whom 435 of 559 (78%) developed encephalopathy immediately prior to hospital admission. The most common etiologies were septic encephalopathy (n = 247 of 559 [62%]), hypoxic-ischemic encephalopathy (HIE) (n = 331 of 559 [59%]), and uremia (n = 156 of 559 [28%]). Multiple etiologies were present in 435 (78%) patients. Compared with those without TME (n = 3932), patients with TME were older (76 vs. 62 years), had dementia (27% vs. 3%) or psychiatric history (20% vs. 10%), were more often intubated (37% vs. 20%), had a longer hospital length of stay (7.9 vs. 6.0 days), and were less often discharged home (25% vs. 66% [all P < 0.001]). Excluding comfort care patients (n = 267 of 4491 [6%]) and after adjustment for confounders, TME remained associated with increased risk of in-hospital death (n = 128 of 425 [30%] patients with TME died, compared with n = 600 of 3799 [16%] patients without TME; adjusted hazard ratio [aHR] 1.24, 95% confidence interval [CI] 1.02-1.52, P = 0.031), and TME due to hypoxemia conferred the highest risk (n = 97 of 233 [42%] patients with HIE died, compared with n = 631 of 3991 [16%] patients without HIE; aHR 1.56, 95% CI 1.21-2.00, P = 0.001).

Conclusions: TME occurred in one in eight hospitalized patients with COVID-19, was typically multifactorial, and was most often due to hypoxemia, sepsis, and uremia. After we adjustment for confounding factors, TME was associated with a 24% increased risk of in-hospital mortality.
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http://dx.doi.org/10.1007/s12028-021-01220-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962078PMC
March 2021

Turn-on fluorescence measurement of acid phosphatase activity through an aggregation-induced emission of thiolate-protected gold nanoclusters.

Talanta 2021 May 9;227:122197. Epub 2021 Feb 9.

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Industrial Park, Suzhou, 215123, China. Electronic address:

A fluorescence method was developed for a turn-on measurement of acid phosphatase (ACP) activity. It was found that cerous ion (Ce) could lead to an enhancement of glutathione protected gold nanocluster fluorescence through an aggregation-induced-emission (AIE) process, while its higher valent counterpart ceric ion (Ce) could not. In a weakly acidic environment, ACP catalyzed the dephosphorylation of a phosphate ester of ascorbic acid, with a generation of ascorbic acid (AA). AA reduced Ce into Ce, which subsequently enhanced the nanocluster fluorescence. This kind of turn-on fluorescence linearly related to the ACP activity in the range of 0.005-2.4 U/L, with a limit of detection as 0.001 U/L. Human serum samples were measured after a trichloroacetic acid treatment and a simple dilution. The whole analyses were accomplished in 1.5 h with results in good accordance with a reference method.
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http://dx.doi.org/10.1016/j.talanta.2021.122197DOI Listing
May 2021

SNX10 gene mutation in infantile malignant osteopetrosis: A case report and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Jan;46(1):108-112

Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.

A case of SNX10 gene mutation in a patient with infantile malignant osteopetrosis (IMO) was admitted to Department of Pediatrics, Third Xiangya Hospital, Central South University. The patient had the symptom of anemia, hepatosplenomegaly and growth retardation. The X-ray examination suggested extensive increase of bone density throughout the body, which was clinically diagnosed as IMO. The homozygous mutation of SNX10 gene c.61C>T was found via gene sequencing. We reviewed the relevant literatures and found that anemia, visual and hearing impairment, hepatosplenomegaly are the main clinical symptoms of IMO, SNX10 gene mutation is a rare cause of IMO, and hematopoietic stem cell transplantation is an effective treatment.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2021.190322DOI Listing
January 2021

A rare case of uniparental isodisomy of chromosome 19 with no phenotypic abnormalities.

Taiwan J Obstet Gynecol 2021 03;60(2):376-377

Department of Clinical Laboratory, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.tjog.2021.01.023DOI Listing
March 2021

Copper-Catalyzed Tandem Cross-Coupling/Thermally Promoted [2 + 2] Cycloaddition of 1,6-Enynes and Diazo Compounds To Assemble Methylenecyclobutane-Fused Ring System.

J Org Chem 2021 Mar 5;86(6):4714-4732. Epub 2021 Mar 5.

School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, People's Republic of China.

An unprecedented copper-catalyzed tandem reaction of 1,6-enynes with diazo compounds via a cross-coupling/[2 + 2] cycloaddition sequence was reported. A library of methylenecyclobutane-fused ring systems including cyclobuta[]indolines, cyclobuta[]benzofuran, benzo[]cyclobuta[]thiophene, and bicyclo[3.2.0] structures were obtained in moderate to excellent yields under very mild reaction conditions. The reaction exhibited high proximal-regioselectivity and diastereoselectivity. Moreover, 1,6-allenene has proven to be the key intermediate and proceeds via a thermally promoted [2 + 2] cycloaddition in the absence of copper catalyst.
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http://dx.doi.org/10.1021/acs.joc.1c00104DOI Listing
March 2021

Challenges Associated With the Formation of Recombinant Protein Inclusion Bodies in and Strategies to Address Them for Industrial Applications.

Front Bioeng Biotechnol 2021 10;9:630551. Epub 2021 Feb 10.

Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON, Canada.

Recombinant proteins are becoming increasingly important for industrial applications, where is the most widely used bacterial host for their production. However, the formation of inclusion bodies is a frequently encountered challenge for producing soluble and functional recombinant proteins. To overcome this hurdle, different strategies have been developed through adjusting growth conditions, engineering host strains of , altering expression vectors, and modifying the proteins of interest. These approaches will be comprehensively highlighted with some of the new developments in this review. Additionally, the unique features of protein inclusion bodies, the mechanism and influencing factors of their formation, and their potential advantages will also be discussed.
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http://dx.doi.org/10.3389/fbioe.2021.630551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902521PMC
February 2021

Partial splenic embolization combined with endoscopic therapies and NSBB decreases the variceal rebleeding rate in cirrhosis patients with hypersplenism: a multicenter randomized controlled trial.

Hepatol Int 2021 Feb 27. Epub 2021 Feb 27.

Department of Gastroenterology, Qilu Hospital of Shandong University, Wenhua Xi Road, 107, Jinan City, 250012, Shandong Province, People's Republic of China.

Background: Global research on endoscopic therapies in combination with partial splenic embolization (PSE) for variceal hemorrhage (VH) is limited. Therefore, we aimed to evaluate the efficacy and safety of endoscopy plus PSE (EP) treatment in comparison to endoscopic (E) treatment for the secondary prophylaxis of VH in cirrhosis patients with hypersplenism.

Methods: Cirrhosis patients with hypersplenism (platelet count < 100, 000/µL) and those who had recovered from an episode of VH were enrolled in a multicenter randomized controlled trial. The participants were randomly assigned into EP and E groups in a 1:1 ratio. The primary endpoint was variceal rebleeding, and the secondary endpoints were severe variceal recurrence and mortality during the 2-year follow-up. Hematological indices, serum biochemical parameters, and the Child-Pugh score were measured at each time point.

Results: From June 2016 to December 2019, 108 patients were enrolled in the study, among which 102 patients completed the protocol (51 in EP and 51 in E group). The rebleeding rate of the varices was significantly reduced in the EP group compared to that in the E group during the 2 years (16% vs. 31%, p < 0.001). The EP group showed a significantly lower variceal recurrence rate than the E group (22% vs. 67%, p < 0.001). The COX proportional hazard models revealed that grouping was an independent predictor for variceal rebleeding (H = 0.122, 95% CI 0.055-0.270, p < 0.001) and variceal recurrence (hazard ratio, H = 0.160, 95% CI 0.077-0.332, p < 0.001). The peripheral blood cell count, Child-Pugh class/score, albumin concentration, and coagulation function in the EP group improved significantly compared to the values observed in the E group at any time point (p < 0.05).

Conclusions: The EP treatment was more effective in preventing variceal rebleeding and variceal recurrence than the conventional E treatment during the secondary prophylaxis of VH in cirrhosis patients with hypersplenism. Furthermore, the EP treatment could significantly increase the peripheral blood cell count and albumin concentration and also improved the coagulation function and the Child-Pugh score.

Clinical Trials Registration: Trial registration number ClincialTrials.gov: NCT02778425. The URL of the clinical trial: https://clinicaltrials.gov/.
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http://dx.doi.org/10.1007/s12072-021-10155-0DOI Listing
February 2021

Serum Progranulin As a Risk Predictor in Patients with Acute Myocardial Infarction.

Med Sci Monit 2021 Feb 26;27:e928864. Epub 2021 Feb 26.

Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China (mainland).

BACKGROUND Although progranulin was recently proposed as an adipokine that may be involved in glucose metabolic and inflammatory diseases, the role of serum progranulin in cardiovascular disease is elusive and remains disputed. The aim of our research was to determine the concentration of serum progranulin in Chinese patients with cardiovascular disease, notably in acute myocardial infarction (AMI), and its relationship to other cardiometabolic risk factors. MATERIAL AND METHODS This prospective observational study included 342 Chinese AMI patients and 255 healthy control subjects. Serum progranulin concentrations and various cardiometabolic risk factor levels were investigated. We assessed the relationship between progranulin and other cardiometabolic risk factors. Logistic regression analysis was applied to evaluate risk factors in patients with AMI. RESULTS Progranulin levels were obviously elevated in AMI patients compared to control subjects (P=0.0001). Correlation analysis showed that progranulin levels were positively associated with coronary artery disease severity (r=0.380, P=0.0001), glucose (r=0.195, P=0.015), and myeloperoxidase (r=0.198, P=0.014). In logistic regression analysis, serum progranulin (Exp(B)=1.104, 95% CI=1.043-1.168, P=0.001), myeloperoxidase (Exp(B)=1.006, 95% CI=1.003-1.008, P=0.0001), and uric acid (Exp(B)=1.020, 95% CI=1.009-1.032, P=0.0001) were independent risk factors in AMI patients. CONCLUSIONS Patients with AMI had significantly higher serum progranulin concentrations than control subjects. This study suggests that serum progranulin is an independent risk predictor in Chinese patients with AMI.
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http://dx.doi.org/10.12659/MSM.928864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923397PMC
February 2021

Lifetime Division Multiplexing by Multilevel Encryption Algorithm.

ACS Nano 2021 Feb 24. Epub 2021 Feb 24.

Center for Biomedical Photonics, College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen 518060, P. R. China.

Asymmetric, multilevel, switchable, and reversible encryption is realized by algorithm encryption, which plays an important role in encryption technology. Fluorescence lifetime encryption is currently not executed by an algorithm. It is well-known that the short fluorescence lifetime (τ1), long fluorescence lifetime (τ2), amplitude-weighted average fluorescence lifetime (τm), and intensity-weighted average fluorescence lifetime (τi) can be obtained using a double exponential fitting, and then these four lifetime parameters can be considered as four lifetime algorithms. Therefore, we propose that the acquisition of these four fluorescence lifetimes can be regarded as further dividing the lifetime by different algorithms and optimizing lifetime multiplexing. Moreover, the four lifetime algorithms of τ1, τm, τ2, and τi can be switched between each other and can be used to perform asymmetric, multilevel, and reversible lifetime encryption to effectively increase the difficulties of anticounterfeiting.
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http://dx.doi.org/10.1021/acsnano.0c09177DOI Listing
February 2021

Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.

Biochem Biophys Res Commun 2021 Apr 18;547:139-147. Epub 2021 Feb 18.

Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Fibrotic scarring is tightly linked to the development of heart failure in patients with post-myocardial infarction (MI). Atypical chemokine receptor 4 (ACKR4) can eliminate chemokines, such as C-C chemokine ligand 21 (CCL21), which is independently associated with heart failure mortality. However, the role of ACKR4 in the heart during MI is unrevealed. This study aimed to determine whether ACKR4 modulates cardiac remodeling following MI and to illuminate the potential molecular mechanisms. The expression of ACKR4 was upregulated in the border/infarct area, and ACKR4 was predominantly expressed in cardiac fibroblasts (CFs). Knockout of ACKR4 protected against adverse ventricular remodeling in mice post-MI. These protective effects of ACKR4 deficiency were independent of dendritic cell immune response but could be attributed to downregulated CF-derived IL-6, affecting CF proliferation and endothelial cell (EC) functions, which consequently inhibited cardiac fibrosis. ACKR4 promoted IL-6 generation and proliferation of CFs. Besides, ACKR4 induced endothelial-to-mesenchymal transition (EndMT) in ECs through IL-6 paracrine effect. The p38 MAPK/NF-κB signaling pathway was involved in ACKR4 facilitated IL-6 generation. Moreover, ACKR4 overexpression in vivo via AAV9 carrying a periostin promoter aggravated heart functional impairment post-MI, which was abolished by IL-6 neutralizing antibody. Therefore, our study established a novel link between ACKR4 and IL-6 post-MI, indicating that ACKR4 may be a novel therapeutic target to ameliorate cardiac remodeling.
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http://dx.doi.org/10.1016/j.bbrc.2021.02.013DOI Listing
April 2021

Air quality characteristics in Wuhan (China) during the 2020 COVID-19 pandemic.

Environ Res 2021 04 17;195:110879. Epub 2021 Feb 17.

School of Environmental Science & Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, PR China.

Understanding the relationship between air quality, pollution emission control measures, and meteorological conditions is important for developing effective air quality improvement policies. In this study, we used pollution monitoring and meteorological data from January to May 2020 to analyze the air quality characteristics during the COVID-19 lockdown in Wuhan, which lasted from January 23 to April 8, 2020. Compared with the same period in 2019, the air quality in 2020 was significantly better. The total excellent and good air quality rates increased by 17.58%-90.08% in 2020; concentrations of NO, particulate matter with a diameter <10 μm (PM) and <2.5 μm (PM), and total volatile organic compounds (TVOCs) also decreased by 38.23%, 30.25%, 32.92%, and 39.80%, respectively. Moreover, the number of days with NO, PM, and PM as the primary pollutants decreased by approximately 10%, 9%, and 15%, respectively. We compared the wind direction, wind speed, temperature, and relative humidity in January-April 2020, 2019, 2018, and 2017 and found no obvious correlation between meteorological factors and improved air quality during the 2020 lockdown. The implementation of strict lockdown measures, such as home quarantining, traffic restrictions, and non-essential enterprise shutdowns, was the dominant cause for the substantial air quality improvement during the 2020 COVID-19 lockdown in Wuhan.
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http://dx.doi.org/10.1016/j.envres.2021.110879DOI Listing
April 2021

Effect of chlortetracycline on the growth and intracellular components of Spirulina platensis and its biodegradation pathway.

J Hazard Mater 2021 Feb 4;413:125310. Epub 2021 Feb 4.

Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, 1390 Eckles Ave., St. Paul, MN 55108, USA.

Chlortetracycline (CTC) usually presents in livestock wastewater with oxytetracycline (OTC), causing damage to human health and ecosystems. It's urgent to seek low-cost and ecofriendly technology for antibiotics removal. In this study, effects of CTC and CTC + OTC (CTC:OTC= 1:1, g/g) on Spirulina platensis have been investigated. EC value of CTC for S. platensis was 8.76 mg/L at 96 h and risk quotient value in wastewater was 15.85. Inhibition of CTC on S. platensis gradually enhanced with increase of CTC, but CTC + OTC below 1.0 mg/L didn't harm the growth of microalgae. Chlorophyll-a (Chl-a) and carotenoid content showed a parabolic trend with extension of time at CTC group. Chl-a synthesis gradually decreased with increase of CTC + OTC stress. High concentrations of CTC and CTC + OTC showed obvious inhibition on phycocyanin production. Polyunsaturated fatty acids (PUFA) and saturated fatty acids (SFA) contents peaked at 1.0 mg/L CTC, corresponding to the minimum of superoxide dismutase (SOD) activity in S. platensis. SFA and PUFA contents decreased when CTC + OTC content was above 2.0 mg/L. CTC and CTC + OTC (both over 2.0 mg/L) stimulated production of dissolved extracellular organic matters in S. platensis. Removal efficiency of CTC by S. platensis was about 98.63-99.95% and its biodegradation pathways were hydroxylation and side-chain breakdown.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125310DOI Listing
February 2021

Determination of dopamine based on its enhancement of gold-silver nanocluster fluorescence.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 1;252:119519. Epub 2021 Feb 1.

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Industrial Park, Suzhou 215123, China. Electronic address:

Dopamine (DA) is one of the most important neurotransmitters in human bodies and its sensitive detection remains a challenge. Herein, protein stabilized gold-silver nanoclusters (Au-AgNCs) were synthesized at first. It was found that the introduction of dopamine lead to a significant enhancement of the fluorescence from the nanoclusters, together with a red-shift of the peak. Through related spectroscopic and electrochemical studies, the fluorescence enhancement was attributed to the reduction of the nanoclusters by dopamine. This enhancement was then adopted for quantitative measurements, and linear responses toward dopamine in the ranges 0.01-1.7 μM and 1.7-10 μM were constructed. A limit of detection was obtained at 6.9 nM. The present study provided a facile and efficient method for the determination of dopamine, and the method was successfully applied for related measurements in serum samples.
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http://dx.doi.org/10.1016/j.saa.2021.119519DOI Listing
May 2021

Cinnamon Oil Inhibits Growth by Disturbing the Carbohydrate Metabolic Process.

J Fungi (Basel) 2021 Feb 9;7(2). Epub 2021 Feb 9.

Research Centre for Plant RNA Signaling, College of Life and Environmental Science, Hangzhou Normal University, Hangzhou 310036, China.

is a major postharvest pathogen that mainly threatens the global pome fruit industry and causes great economic losses annually. In the present study, the antifungal effects and potential mechanism of cinnamon oil against were investigated. Results indicated that 0.25 mg L cinnamon oil could efficiently inhibit the spore germination, conidial production, mycelial accumulation, and expansion of . In addition, it could effectively control blue mold rots induced by in apples. Cinnamon oil could also reduce the expression of genes involved in patulin biosynthesis. Through a proteomic quantitative analysis, a total of 146 differentially expressed proteins (DEPs) involved in the carbohydrate metabolic process, most of which were down-regulated, were noticed for their large number and functional significance. Meanwhile, the expressions of 14 candidate genes corresponding to DEPs and the activities of six key regulatory enzymes (involving in cellulose hydrolyzation, Krebs circle, glycolysis, and pentose phosphate pathway) showed a similar trend in protein levels. In addition, extracellular carbohydrate consumption, intracellular carbohydrate accumulation, and ATP production of under cinnamon oil stress were significantly decreased. Basing on the correlated and mutually authenticated results, we speculated that disturbing the fungal carbohydrate metabolic process would be partly responsible for the inhibitory effects of cinnamon oil on growth. The findings would provide new insights into the antimicrobial mode of cinnamon oil.
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http://dx.doi.org/10.3390/jof7020123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915993PMC
February 2021

GSK2593074A blocks progression of existing abdominal aortic dilation.

JVS Vasc Sci 2020 28;1:123-135. Epub 2020 Jul 28.

Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison.

Objective: Receptor interacting proteins kinase 1 and 3 (RIPK1 and RIPK3) have been shown to play essential roles in the pathogenesis of abdominal aortic aneurysms (AAAs) by mediating necroptosis and inflammation. We previously discovered a small molecular inhibitor GSK2593074A (GSK'074) that binds to both RIPK1 and RIPK3 with high affinity and prevents AAA formation in mice. In this study, we evaluated whether GSK'074 can attenuate progression of existing AAA in the calcium phosphate model.

Methods: C57BL6/J mice were subjected to the calcium phosphate model of aortic aneurysm generation. Mice were treated with either GSK'074 (4.65 mg/kg/day) or dimethylsulfoxide (DMSO) controls starting 7 days after aneurysm induction. Aneurysm growth was monitored via ultrasound imaging every 7 days until harvest on day 28. Harvested aortas were examined via immunohistochemistry. The impact of GSK'074 on vascular smooth muscle cells and macrophages were evaluated via flow cytometry and transwell migration assay.

Results: At the onset of treatment, mice in both the control (DMSO) and GSK'074 groups showed similar degree of aneurysmal expansion. The weekly ultrasound imaging showed a steady aneurysm growth in DMSO-treated mice. The aneurysm growth was attenuated by GSK'074 treatment. At humane killing, GSK'074-treated mice had significantly reduced progression in aortic diameter from baseline as compared with the DMSO-treated mice (83.2% ± 13.1% [standard error of the mean] vs 157.2% ± 32.0% [standard error of the mean]; < .01). In addition, the GSK'074-treated group demonstrated reduced macrophages (F4/80, CD206, MHCII), less gelatinase activity, a higher level of smooth muscle cell-specific myosin heavy chain, and better organized elastin fibers within the aortic walls compared with DMSO controls. In vitro, GSK'074 inhibited necroptosis in mouse aortic smooth muscle cells; whereas, it was able to prevent macrophage migration without affecting and expression.

Conclusions: GSK'074 is able to attenuate aneurysm progression in the calcium phosphate model. The ability to inhibit both vascular smooth muscle cell necroptosis and macrophage migration makes GSK'074 an attractive drug candidate for pharmaceutical treatment of aortic aneurysms.

Clinical Relevance: Previous clinical trials evaluating pharmaceutical treatments in blocking aneurysm progression have failed. However, most agents used in those trials focused on inhibiting only one mechanism that contributes to aneurysm pathogenesis. In this study, we found GSK'074 is able to attenuate aneurysm progression in the calcium phosphate model by inhibiting both vascular smooth muscle cell necroptosis and macrophage migration, which are both key processes in the pathogenesis of aneurysm progression. The ability of GSK'0474 to inhibit multiple key pathologic mechanisms makes it an attractive therapeutic candidate for aneurysm progression.
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http://dx.doi.org/10.1016/j.jvssci.2020.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872141PMC
July 2020

The Ribosome-Binding Mode of Trichothecene Mycotoxins Rationalizes Their Structure-Activity Relationships.

Int J Mol Sci 2021 Feb 5;22(4). Epub 2021 Feb 5.

Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.

Trichothecenes are the most prevalent mycotoxins contaminating cereal grains. Some of them are also considered as the virulence factors of head blight disease. However, the mechanism behind the structure-activity relationship for trichothecenes remains unexplained. Filling this information gap is a crucial step for developing strategies to manage this large family of mycotoxins in food and feed. Here, we perform an in-depth re-examination of the existing structures of ribosome complexed with three different trichothecenes. Multiple binding interactions between trichothecenes and 25S rRNA, including hydrogen bonds, nonpolar pi stacking interactions and metal ion coordination interactions, are identified as important binding determinants. These interactions are mainly contributed by the key structural elements to the toxicity of trichothecenes, including the oxygen in the 12,13-epoxide ring and a double bond between C and C. In addition, the C-OH group also participates in binding. The comparison of three trichothecenes binding to the ribosome, along with their binding pocket architecture, suggests that the substitutions at different positions impact trichothecenes binding in two different patterns. Moreover, the binding of trichothecenes induced conformation changes of several nucleotide bases in 25S rRNA. This then provides a structural framework for understanding the structure-activity relationships apparent in trichothecenes. This study will facilitate the development of strategies aimed at detoxifying mycotoxins in food and feed and at improving the resistance of cereal crops to fungal diseases.
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http://dx.doi.org/10.3390/ijms22041604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914836PMC
February 2021

Prenylated flavonoids in foods and their applications on cancer prevention.

Crit Rev Food Sci Nutr 2021 Feb 5:1-14. Epub 2021 Feb 5.

Department of Horticulture, Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Key Laboratory of Post-Harvest Handling of Fruits, Ministry of Agriculture, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.

Functional foods play an important role in health care and chronic diseases prevention, particularly cancer. Prenylated flavonoids are presented in many food resources. They are recognized as neutraceuticals due to their diverse health benefits. Up to now, more than 1000 prenylated flavonoids have been identified in plants. Their food resources are reviewed in this paper. Due to the good safety and cancer prevention effect of prenylated flavonoids, this paper reviews the cancer prevention activities and mechanisms reported in last decade. The structure-activity relationship is discussed. Due to the limited availability in nature, the heterologously biosynthetic technique of prenylated flavonoids is discussed in this review. Inclusion of dietary prenylated flavonoids into human diet is highly desirable. This paper combines the up-to-date information and give a clear image regarding prenylated flavonoids as neutraceuticals.
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http://dx.doi.org/10.1080/10408398.2021.1881437DOI Listing
February 2021

General Liquid-Driven Coaxial Flow Focusing Preparation of Novel Microcapsules for Rechargeable Magnesium Batteries.

Adv Sci (Weinh) 2021 Jan 27;8(2):2002298. Epub 2020 Nov 27.

National Key Laboratory of Science and Technology on Micro/Nano Fabrication Key Laboratory for Thin Film and Microfabrication of Ministry of Education Department of Micro/Nano-electronics Shanghai Jiao Tong University Shanghai 200240 P. R. China.

Magnesium batteries have been considered promising candidates for next-generation energy storage systems owing to their high energy density, good safety without dendrite formation, and low cost of magnesium resources. However, high-performance cathodes with stable capacity, good conductivity, and fast ions transport are needed, since many conventional cathodes possess a low performance and poor preparation controllability. Herein, a liquid-driven coaxial flow focusing (LDCFF) approach for preparing a novel microcapsule system with controllable size, high loading, and stable magnesium-storage performance is presented. Taking the MoS-infilled microcapsule as a case study, the magnesium battery cathode based on the microcapsules displays a capacity of 100 mAh g after 100 cycles. High capacity retention is achieved at both low and high temperatures of -10, ‒5, and 45 °C, and a stable rate-performance is also obtained. The influences of the liquid flow rates on the size and shell thickness of the microcapsules are investigated; and electron and ion diffusion properties are also studied by first-principle calculations. The presented LDCFF method is quite general, and the high performance of the microcapsules enables them to find broad applications for making emerging energy-storage materials and secondary battery systems.
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http://dx.doi.org/10.1002/advs.202002298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816708PMC
January 2021

[Progranulin (PGRN) promotes invasion and migration of mouse breast cancer 4T1 cells by promoting epithelial-mesenchymal transition of cancer cells and activating ERK1/2 pathway].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Feb;37(2):125-131

Ministry-of-Education Key Laboratory of Laboratory Medical Diagnostics, Chongqing Medical University, Chongqing 400016, China. *Corresponding author, E-mail:

Objective To investigate the effect of progranulin (PGRN) on the invasion and migration of mouse breast cancer 4T1 cells and its mechanism. Methods After treated with PGRN (1 μg/mL) for 24 hours, the invasion ability of breast cancer 4T1 cells was detected by Transwell invasion assay, the migration ability was detected by scratch test, and the epithelial cadherin (E-cadherin), vimentin mRNA expression was detected by real-time fluorescent quantitative PCR. Western blot assay was used to detect the expression of E-cadherin, vimentin, extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphorylated ERK1/2 (p-ERK1/2). After treated with 1 μg/mL PGRN and ERK1/2 signaling pathway inhibitor U0126 (10 μmol/L) simultaneously, the migration and invasion ability of 4T1 cells and the changes in the expression of E-cadherin, vimentin and p-ERK proteins were detected again. Results After treated with PGRN, the migration and invasion capabilities of breast cancer 4T1 cells were significantly enhanced; E-cadherin expression decreased; vimentin and p-ERK1/2 expression increased. After treated with ERK1/2 signaling pathway inhibitor, the ability of PGRN to promote breast cancer 4T1 cell migration, invasion and epithelial-mesenchymal transition (EMT) was significantly inhibited. Conclusion PGRN can promote the migration and invasion of breast cancer 4T1 cells by promoting EMT and activating the ERK1/2 pathway.
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February 2021

UV treatment for degradation of chemical contaminants in food: A review.

Compr Rev Food Sci Food Saf 2021 Mar 23;20(2):1857-1886. Epub 2021 Jan 23.

Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, Ontario, Canada.

Application of ultraviolet (UV) irradiation for the degradation of chemical contaminants in food products has gained more and more interest in the past two decades. The majority of the research in this field was on mycotoxins, especially aflatoxins and patulin, with limited studies on pesticide residues and other chemical contaminants in food. These studies have been focused on identifying the structure and toxicity of degradation products, investigating the influence of UV treatment factors on the degradation efficiency, determining the impact of UV treatment on the quality of food products, and developing updated UV treatment methods such as TiO induced photocatalytic degradation. The summary of published literatures provided insights into future research opportunities in this area, which include determining a standard for the UV treatment description, working with naturally contaminated samples rather than artificially spiked samples, conducting pilot plant or industrial scale studies, examining more targets and conducting multi-targets studies, and developing more innovative methods for UV treatment.
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http://dx.doi.org/10.1111/1541-4337.12698DOI Listing
March 2021

Covalent Organic Frameworks Enabling Site Isolation of Viologen-Derived Electron-Transfer Mediators for Stable Photocatalytic Hydrogen Evolution.

Angew Chem Int Ed Engl 2021 Jan 22. Epub 2021 Jan 22.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, 2005 Songhu Road, Shanghai, 200438, China.

Electron transfer is the rate-limiting step in photocatalytic water splitting. Viologen and its derivatives are able to act as electron-transfer mediators (ETMs) to facilitate the rapid electron transfer from photosensitizers to active sites. Nevertheless, the electron-transfer ability often suffers from the formation of a stable dipole structure through the coupling between cationic-radical-containing viologen-derived ETMs, by which the electron-transfer process becomes restricted. Herein, cyclic diquats, a kind of viologen-derived ETM, are integrated into a 2,2'-bipyridine-based covalent organic framework (COF) through a post-quaternization reaction. The content and distribution of embedded diquat-ETMs are elaborately controlled, leading to the favorable site-isolated arrangement. The resulting materials integrate the photosensitizing units and ETMs into one system, exhibiting the enhanced hydrogen evolution rate (34600 μmol h  g ) and sustained performances when compared to a single-module COF and a COF/ETM mixture. The integration strategy applied in a 2D COF platform promotes the consecutive electron transfer in photochemical processes through the multi-component cooperation.
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http://dx.doi.org/10.1002/anie.202016618DOI Listing
January 2021

The relationship between different C-peptide level and insulin dose of insulin pump.

Nutr Diabetes 2021 01 22;11(1). Epub 2021 Jan 22.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia; Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830017, China.

Background: This study aims to explore the insulin requirement profiles, and analyze the related factors of type-2 diabetes mellitus (T2DM) with different C-peptide levels on insulin pump therapy.

Methods: A retrospective study was conducted on 271 T2DM patients treated with insulin pumps from 2016 to 2018. These patients were divided into groups according to the ratio of C-peptide at 2 h after meals to fasting C-peptide (Ch/C), and the dosage of insulin and influencing factors were analyzed.

Results: In comparing group A (C/C < 2.5) with group B (C/C ≥ 2.5), the percentage of the base amount in total (%TBa, 0.50 ± 0.06) in group A was higher than that in group B (0.48 ± 0.05) (P < 0.05). Furthermore, there was a correlation between C/C and waist circumference, HbA1c, Fasting Plasma Glucose (FPG) and Blood glucose 2 h after meal (2hPG) (r = -0.137, -0.154, -0.471, and -0.172; all, P < 0.05). The multiple linear regression analysis revealed that BMI and FPG were independent factors of %TBa (β' = 0.124 and 0.144; all, P < 0.05), and BMI and FPG were independent factors of C/C (β' = -0.134 and -0.502; all, P < 0.05).

Conclusions: The basal premeal dose ratio of T2DM with different C-peptide levels differs during intensive insulin pump therapy. Parameters that indicate the glycemic control and β-cell function should be taken into consideration for total insulin requirements.
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http://dx.doi.org/10.1038/s41387-020-00148-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822886PMC
January 2021