Publications by authors named "Ting Yang"

1,100 Publications

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Outcome after intubation for septic shock with respiratory distress and hemodynamic compromise: an observational study.

BMC Anesthesiol 2021 Oct 25;21(1):253. Epub 2021 Oct 25.

Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

Background: Acute respiratory failure in septic patients contributes to higher in-hospital mortality. Intubation may improve outcome but there are no specific criteria for intubation. Intubation of septic patients with respiratory distress and hemodynamic compromise may result in clinical deterioration and precipitate cardiovascular failure. The decision to intubate is complex and multifactorial. The purpose of this study was to evaluate the impact of intubation in patients with respiratory distress and predominant hemodynamic instability within 24 h after ICU admission for septic shock.

Methods: We conducted a retrospective analysis of a prospective registry of adult patients with septic shock admitted to the medical ICU at Mayo Clinic, between April 30, 2014 and December 31, 2017. Septic shock was defined by persistent lactate > 4 mmol/L, mean arterial pressure < 65 mmHg, or vasopressor use after 30 mL/kg fluid boluses and suspected or confirmed infection. Patients who remained hospitalized in the ICU at 24 h were separated into intubated while in the ICU and non-intubated groups. The primary outcome was hospital mortality. The first analysis used linear regression models and the second analysis used time-dependent propensity score matching to match intubated to non-intubated patients.

Results: Overall, 358 (33%) ICU patients were eventually intubated after their ICU admission and 738 (67%) were not. Intubated patients were younger, transferred more often from an outside facility, more critically ill, had more lung infection, and achieved blood pressure goals more often, but lactate normalization within 6 h occurred less often. Among those who remained hospitalized in the ICU 24 h after sepsis diagnosis, the crude in-hospital mortality was higher in intubated than non-intubated patients, 89 (26%) vs. 82 (12%), p < 0.001, as was the ICU mortality and ICU and hospital length of stay. After adjustment, intubation showed no effect on hospital mortality but resulted in fewer hospital-free days through day 28. One-to-one propensity resulted in similar conclusion.

Conclusions: Intubation within 24 h of sepsis was not associated with hospital mortality but resulted in fewer 28-day hospital-free days. Although intubation remains a high-risk procedure, we did not identify an increased risk in mortality among septic shock patients with predominant hemodynamic compromise.
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http://dx.doi.org/10.1186/s12871-021-01471-xDOI Listing
October 2021

Can Published Population Pharmacokinetic Models of Busulfan be used for Individualized Dosing in Chinese pediatric patients undergoing Hematopoietic Stem Cell Transplantation: An External Evaluation.

J Clin Pharmacol 2021 Oct 25. Epub 2021 Oct 25.

Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Busulfan (Bu) is a bifunctional alkylating agent that is widely used prior to hematopoietic stem cell transplantation (HSCT), in combination with other chemotherapeutic drugs. As of 2020, there is no population pharmacokinetic (pop PK) model for Bu in Chinese pediatric patients. A systemic external evaluation of eleven published pop PK models was conducted in Chinese HSCT pediatric patients. Forty pediatric patients were enrolled in this study, with a total of 183 blood concentrations. The relative prediction error (PE%), median PE% (MDPE), median absolute PE%, and percentage of PE% within ±20% (F ) and ±30% (F ) were calculated in prediction-based diagnostics. Simulation-based diagnostics were conducted through a prediction- and variability-corrected visual predictive check (pvcVPC) and the normalized prediction distribution error (NPDE). The relative individual prediction error (IPE%) was calculated using Bayesian forecasting with 1-3 concentration points. The one-compartment open linear pop PK model, which was built by Su-jin Rhee et al. (model H), incorporating patient's body surface area, age, dosing day, and aspartate aminotransferase as significant covariates had preferable predictability than other pop PK models. In prediction-based diagnostics, the MDPE, F , and F of model H were 8.48%, 45.35%, and 59.56%, respectively. The NPDE of model H showed that it followed the normal distribution. Based on Bayesian forecasting, model H showed good predictive performance. Thus, model H was the most appropriate model, that can be used clinically for individualized dosage adjustments in Chinese pediatric HSCT patients. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jcph.1992DOI Listing
October 2021

The prevalence of frailty among breast cancer patients: a systematic review and meta-analysis.

Support Care Cancer 2021 Oct 25. Epub 2021 Oct 25.

Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Purpose: Coexistence of frailty and breast cancer (BC) is related to a higher risk of hospitalization, mortality, and falls. Given the potential reversibility of frailty, investigating its epidemiology in BC is of great importance. However, estimates of the prevalence of frailty in BC patients vary considerably. We synthesized the existing body of literature on the prevalence of frailty among BC patients.

Methods: We searched English databases (Cochrane Library, PubMed, Medline, CINAHL, Embase, Scopus, and Web of Science) and Chinese databases (CNKI, WanFang, CBM, and VIP database) from the inception to April 15, 2021, and collected observational studies about the prevalence of frailty among BC patients. The robustness of the pooled estimates was validated by analysis of different subgroups, meta-regression, and sensitivity. All data were analyzed using Stata 15.1.

Results: In total, 4645 articles were screened and data from 24 studies involving 13,510 subjects were used in the meta-analysis. The prevalence of frailty among BC patients in individual studies varied from 5 to 71%. The pooled prevalence of frailty was 43% (95% confidence intervals (CI): 36% to 50%, I = 98.4%, P < 0.05). Subgroup analyses revealed that the therapeutic method, frailty scales, age, frailty stage, regions, publication years, and study quality were associated with the prevalence of frailty among BC patients.

Conclusions: The prevalence of frailty among BC patients was relatively high, and the conditions of BC treatment can increase the risk of frailty. Understanding the effects of frailty on BC, especially in elderly patients, can provide the healthcare personnel with the theoretical basis for patients' management and treatment.
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http://dx.doi.org/10.1007/s00520-021-06641-8DOI Listing
October 2021

Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows.

Natl Sci Rev 2020 Jan 12;7(1):113-127. Epub 2019 Sep 12.

Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Known as the 'third polar region', the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there. Previous studies of birds, animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence. The adaptive processes during the initial phase of highland adaptation remain poorly understood. We studied a human commensal, the Eurasian Tree Sparrow, which has followed human agriculture to the Qinghai-Tibet Plateau. Despite strong phenotypic differentiation at multiple levels, in particular in muscle-related phenotypes, highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years. In a one-month acclimation experiment investigating phenotypic plasticity, we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes. Through population genetic analyses, we identified a signature of polygenic adaptation, whereby shifts in allele frequencies are spread across multiple loci, many of which are associated with muscle-related processes. Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution, shedding light on early stages of adaptive evolution to a novel environment.
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http://dx.doi.org/10.1093/nsr/nwz138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289047PMC
January 2020

Hourly concentrations of fine and coarse particulate matter and dynamic pulmonary function measurements among 4992 adult asthmatic patients in 25 Chinese cities.

Environ Int 2021 Oct 21;158:106942. Epub 2021 Oct 21.

School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; Shanghai Typhoon Institute/CMA, Shanghai Key Laboratory of Meteorology and Health, Shanghai, China. Electronic address:

The short-term associations of fine particulate matter (PM) and coarse particulate matter (PM) with pulmonary function were inconsistent and rarely evaluated by dynamic measurements. Our study aimed to investigate the associations of PM and PM with real-time pulmonary function. We conducted a longitudinal study based on dynamic pulmonary function measurements among adult asthmatic patients in 25 cities of 19 provincial regions of China from 2017 to 2020. Linear mixed-effects models combined with polynomial distributed lag models were used for statistical analysis. A total of 298,396 records among 4,992 asthmatic patients were evaluated. We found generally inverse associations of PM and PM with 16 pulmonary function indicators that were independent of gaseous pollutants. The associations occurred at lag 1 d, became the strongest at lag 4 d, and vanished a week later. PM had stronger associations than PM especially in southern China. Nationally, an interquartile increase in PM (28.0 μg/m) was significantly associated with decreases in forced expiratory volume in 1 s (FEV 41.6 mL), the ratio of FEV in forced vital capacity (1.1%), peak expiratory flow (136.9 mL/s), and forced expiratory flow at 25-75% of forced vital capacity (54.3 mL/s). We observed stronger associations in patients of male, BMI ≥ 25 kg/m, age ≥ 45 years old, and during warm seasons. In conclusion, this study provided robust evidence for impaired pulmonary function by short-term exposure to PM and PM in asthmatic patients using the largest dataset of dynamic monitoring. The associations can last for one week and PM may be more hazardous.
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http://dx.doi.org/10.1016/j.envint.2021.106942DOI Listing
October 2021

Excellent Thermally Conducting Ni Plating Graphite Nanoplatelets/Poly(phenylene sulfone) Composites for High-Performance Electromagnetic Interference Shielding Effectiveness.

Polymers (Basel) 2021 Oct 12;13(20). Epub 2021 Oct 12.

Key Laboratory of High Performance Plastics, Ministry of Education, National & Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, College of Chemistry, Jilin University, Changchun 130012, China.

First, nickel particles were deposited on the surface of graphite nanoplatelets to fabricate highly conductive [email protected] core-shell structure hybrid fillers via electroplating. The modified GnPs were blended with polyphenylene sulfone via the solution blending method, followed by the hot-pressing method to achieve high thermally conducting [email protected]/PPSU composites for high performance electromagnetic interference effectiveness. The results showed that in-plane and through-plane thermal conductivity of the composite at the 40 wt% filler loading could reach 2.6 WmK and 3.7 WmK, respectively, which were 9.4 and 20 times higher than that of pure PPSU resin. The orientation degree of fillers was discussed by XRD and SEM. Then, heat conduction data were fitted and analyzed by the Agari model, and the heat conduction mechanism was further explored. The testing results also demonstrated that the material exhibited good conductivity, electromagnetic shielding effectiveness and superior thermal stability. Overall, the [email protected]/PPSU composites had high thermal conductivity and were effective electromagnetic shielding materials at high temperatures.
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http://dx.doi.org/10.3390/polym13203493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539428PMC
October 2021

Determination of ginsenoside Rh3 in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.

Biomed Chromatogr 2021 Oct 21:e5268. Epub 2021 Oct 21.

North China University of Science and Technology, Hebei, Tangshan, P.R. China.

Ginsenoside Rh3 (GRh3) is a bacterial metabolite of ginsenoside Rg5, which is the main component of hot-processed ginseng. A simple, efficient and sensitive method was developed and validated for the determination of GRh3 in rat plasma by LC-MS/MS. After protein precipitation with methanol/acetonitrile (1:1, V/V) including Propranolol (internal standard), the target analytes were separated on an Agilent XDB C column, methanol containing 0.1% formic acid and water containing 0.1% formic acid were used as mobile phases for gradient elution. Mass spectrometry was detected by electrospray ion source (ESI) positive ion mode and multiple reaction monitoring mode (MRM) , monitoring the transitions m/z 622.5→425.5 for and m/z 260.1→116.1 for GRh3 and IS respectively. The concentration range of GRh3 was 20-20000 ng/mL and the correlation coefficient (r ) was greater than 0.99. The accuracy error (RE%) and relative standard deviation (RSD%) were below 15%. The extraction recovery and matrix effect were 74.2 to 78.7% and 96.9 to 108.4%, respectively. Under different conditions, the GRh3 was stable in the range of 1.8 ~ 8.7%. This method has been successfully applied to study the pharmacokinetics of GRh3 with oral dose of 10.0 mg/kg and intravenous dose of 2.0 mg/kg in rats, respectively. The absolute bioavailability of GRh3 was 37.6%.
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http://dx.doi.org/10.1002/bmc.5268DOI Listing
October 2021

Antibody response elicited by a third boost dose of inactivated SARS-CoV-2 vaccine can neutralize SARS-CoV-2 variants of concern.

Emerg Microbes Infect 2021 Oct 19:1-9. Epub 2021 Oct 19.

The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China 650118.

Neutralizing antibodies waned significantly six months after two-dose procedure of inactivated SARS-CoV-2 vaccine. However, it is not clear whether a third booster dose could quickly activate the body's immune response against the emerging SARS-CoV-2 variants. This study demonstrated that after a third booster dose of inactivated vaccine, immune memory can be quickly awakened, and the antibody response recovered after seven days. Importantly, although the titers decreased, the neutralizing antibodies at 14 days after the third dose can still neutralize alpha, beta, and delta variants.
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http://dx.doi.org/10.1080/22221751.2021.1996210DOI Listing
October 2021

Genetically Encoded CRISPR Components Yield Efficient Gene Editing in the Invasive Pest .

CRISPR J 2021 Oct;4(5):739-751

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California, USA; and North Carolina State University, Raleigh, North Carolina, USA.

Originally from Asia, Matsumura is a global pest of economically important soft-skinned fruits. Also commonly known as spotted wing drosophila, it is largely controlled through repeated applications of broad-spectrum insecticides by which resistance has been observed in the field. There is a pressing need for a better understanding of biology and for developing alternative environmentally friendly methods of control. The RNA-guided Cas9 nuclease has revolutionized functional genomics and is an integral component of several recently developed genetic strategies for population control of insects. Here, we describe genetically modified strains that encode three different terminators and four different promoters to express Cas9 robustly in both the soma and/or germline of . The Cas9 strains were rigorously evaluated through genetic crossing to transgenic strains that encode single-guide RNAs targeting the conserved X-linked body and eye genes. We find that several Cas9/gRNA strains display remarkably high editing capacity. Going forward, these tools will be instrumental for evaluating gene function in and may even provide tools useful for the development of new genetic strategies for control of this invasive species.
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http://dx.doi.org/10.1089/crispr.2021.0032DOI Listing
October 2021

Proliferation characteristics of coxsackievirus A10 in mice and immune protection ability of experimental inactivated vaccine.

Biomed Pharmacother 2021 Nov 27;143:112212. Epub 2021 Sep 27.

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), 935 Jiao Ling Road, Kunming, Yunnan 650118, China; Key Laboratory for Vaccine Research and Development of Major Infectious Diseases in Yunnan Province, Kunming, Yunnan 650118, China. Electronic address:

Coxsackievirus A10 (CVA10) is the main pathogen of hand, foot, and mouth disease in China. However, there are no CVA10-specific drugs and vaccines, and the pathogenesis and effects of this virus in the body are unknown. We investigated the effect of a clinically isolated CVA10 virus strain (CVA10-25) to investigate its effect in suckling mice through different infection routes. We observed the dynamic distribution and proliferation of the virus in mouse tissues by infecting suckling mice with different doses of the virus and mice of different ages with the same dose of the virus. We also analysed the pathological characteristics after infection. A formaldehyde-inactivated experimental vaccine was prepared to immunise 5-week-old BALB/c female mice three times, and newborn suckling mice were tested for the presence of maternally transmitted antibodies. The viral load in each organ after intracerebral administration was higher than that after intraperitoneal administration; the peroral administration route did not cause disease in mice. Mouse paralysis and death after infection were related to age. The skeletal muscles, heart, and lung showed histopathological changes after infection. We established a 2-day-old BALB/c suckling mouse model that could be infected intracranially to study the pathogenesis and pathology of CVA10. Maternally transmitted antibodies protected the mice against the virus. This study provides a reference for CVA10-related pathogenesis and vaccine research.
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http://dx.doi.org/10.1016/j.biopha.2021.112212DOI Listing
November 2021

Suppressors of cytokine signaling 1 protein in a regenerative model of the spinal cord.

J Integr Neurosci 2021 Sep;20(3):585-594

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, 226019 Nantong, Jiangsu, China.

Demyelination is one of the pathological outcomes that occur immediately following spinal cord injury. Protection of oligodendrocytes against death/apoptosis proves to be beneficial for the preservation of neurological functions. Suppressors of cytokine signaling 1 protein inhibit the harmful effects of several inflammatory cytokines on oligodendrocytes, but its roles in spinal cord injury (SCI) induced apoptosis of oligodendrocytes remain unclear. We cloned suppressors of cytokine signaling 1 cDNA from (Japanese gecko) and analyzed the protein structure revealing the conserved domains contained in other vertebrate suppressors of cytokine signaling 1 proteins. The gecko suppressors of cytokine signaling 1 protein expression were increased in the injured spinal cord following gecko tail amputation and displayed colocalization with oligodendrocytes. The enforced expression of gecko suppressors of cytokine signaling 1 by adenovirus in the Gsn3 gecko oligodendrocyte cell line demonstrated that gecko suppressors of cytokine signaling 1 significantly suppressed cell apoptosis-induced by glucose deprivation. Determination of apoptosis-related proteins revealed that gecko suppressors of cytokine signaling 1 was able to activate extracellular regulated protein kinases (ERK) and serine/threonine protein kinases (Akt). The results presented a distinct protective role of gecko suppressors of cytokine signaling 1 in the regenerative model of the spinal cord, which may provide new cues for central nervous system repair in mammals.
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http://dx.doi.org/10.31083/j.jin2003062DOI Listing
September 2021

Nursing students' attitudes toward mobile learning: An integrative review.

Int J Nurs Sci 2021 Oct 21;8(4):477-485. Epub 2021 Aug 21.

School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China.

Purpose: This study aimed to explore whether the attitudes of nursing students toward the use of mobile learning are positive or negative and to identify the factors influencing their attitudes by reviewing the literature.

Methods: Electronic search of six databases, including PubMed, the Cumulative Index of Nursing and Allied Health Literature, ProQuest, Web of Science, EMBASE, and Cochrane Library, was conducted, and relevant references within articles were manually searched. Retrieval time was from inception to October 21, 2020. The literature review was conducted in accordance with the PRISMA guidelines and the integrative review method. The Mixed Method Appraisal Tool (MMAT) was used for quality assessment.

Results: A total of 316 articles were identified, and 18 English-language studies were finally included by reviewing titles, abstracts, and full text. Six quantitative, five qualitative, and seven mixed-method articles related to nursing students' attitudes toward the use of mobile learning were identified. The results showed that most nursing students had positive attitudes toward mobile learning. Although students expressed strong intentions for mobile learning, the actual usage rate in practical settings was low. Several advantageous factors included usefulness, convenience, and ease of use, whereas disadvantageous factors included hardware facility, updated content, and software stability.

Conclusion: Most nursing students have positive attitudes and willingness to mobile learning, but the actual use rate remains low. Advantageous and disadvantageous factors coexist. Further studies are needed to assess how mobile learning improves nursing students' clinical knowledge and improves patient care.
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http://dx.doi.org/10.1016/j.ijnss.2021.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488805PMC
October 2021

[Advances in the surgical treatment of cholesteatoma of the middle ear].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Oct;35(10):952-956

Middle ear cholesteatoma, as a common ear disease, has been further understood in terms of its molecular mechanism, classification and staging, and it is generally believed that surgical treatment is the first choice, but there is no final conclusion on its surgical choice. Microscopic surgery includes complete or open radical mastoidectomy with or without reconstruction of the middle ear cavity, and their pros and cons have been debated for decades. In the past decade, a variety of surgical methods have been developed, including various improvements and combined operations that combine the advantages of traditional open radical mastoidectomy and complete mastoidectomy. On the other hand, the emergence of ear endoscopic surgery has opened up new surgical methods, as well as the use of laser and other new technologies to improve the surgical effect and prognosis, but also can not avoid their limitations and shortcomings. The purpose of this paper is to summarize the advantages and disadvantages of various surgical treatments for middle ear cholesteatoma in order to provide guidance and help for otologists in the treatment of middle ear cholesteatoma.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.10.020DOI Listing
October 2021

Lymphocyte subsets as a predictor of severity and prognosis in COVID-19 patients.

Int J Immunopathol Pharmacol 2021 Jan-Dec;35:20587384211048567

Department of Infectious Disease, Huoshenshan Hospital, Wuhan, China.

Background: Coronavirus disease 2019 (COVID-19) had become a worldwide health threat. Early prediction of the severity of COVID-19 patients was important for reducing death rate and controlling this disease.

Methods And Materials: A total of 301 patients confirmed with COVID-19 in Wuhan from 8 February to 10 April 2020 were included. Clinical data were collected and analyzed. Diagnostic and prognostic utility of blood cell counts and lymphocyte subsets in COVID-19 patients were investigated. The receiver operator characteristic curve (ROC) was used in discriminating the mild and severe/critical cases.

Results: There were difference in blood cell counts and lymphocyte subsets among mild, severe and critical patients, which were also influenced by comorbidities and duration of disease. The area under the ROC of lymphocyte, CD3 T cells, CD4 T cells, and CD8 T cells were 0.718, 0.721, 0.718, and 0.670, which were higher than that of other hematological parameters. The optimal threshold was 1205, 691, 402, and 177 per μl, respectively. Patients with higher counts of lymphocyte, CD3 T cells, CD4 T cells, or CD8 T cells were correlated with shorter length of stay in hospital ( < 0.05). Multivariable Cox regression analysis showed disease severity, CD3 T cells counts and time when the nucleic acid turned negative were independent risk factors for in-hospital death of COVID-19 patients ( < 0.05).

Conclusion: Blood cell counts and lymphocyte subsets correlated with severity of COVID-19.
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http://dx.doi.org/10.1177/20587384211048567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504275PMC
October 2021

Forecast of the Employment Situation of College Graduates Based on the LSTM Neural Network.

Authors:
Xing Li Ting Yang

Comput Intell Neurosci 2021 27;2021:5787355. Epub 2021 Sep 27.

School of Foreign Languages, Jinling Institute of Technology, Nanjing 211169, Jiangsu, China.

Scientific and reasonable forecast model of graduates' employment data can efficaciously embody the complex characteristics of graduates' employment data and embody the nonlinear dynamic interaction of influencing elements of graduates' employment situation. It has a strong and steady characteristic learning capability, thus selecting the main influence data that influence the change of graduates' employment data. In this paper, according to the situation embodied by students' employment, a data mining analysis model is set up by using the statistical method based on the model of cluster analysis technology to forecast the employment situation of graduates. In this paper, a forecast technique of graduates' employment situation based on the long short-term memory (LSTM) recurrent neural network is conceived, including network structure design, network training, and forecast process implementation algorithm. In addition, aiming at minimizing the forecasting error, an LSTM forecasting model parameter optimization algorithm based on multilayer grid search is conceived. It also verifies the applicability and correctness of the LSTM forecasting model and its parameter optimization algorithm in the analysis of graduates' employment situation.
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http://dx.doi.org/10.1155/2021/5787355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490037PMC
October 2021

Ecological wetland paradigm drives water source improvement in the stream network of Yangtze River Delta.

J Environ Sci (China) 2021 Dec 27;110:55-72. Epub 2021 Mar 27.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Jiaxing created a precedent using bypass riparian marshes to purify micro-polluted water sources in China. Pond-wetland complex with constructed root channel technology becomes a paradigm which can be analogized as "human-body wetland model" based on bionics or biomimetics. Heterogeneous plant-bed/ditch system with highly active land/water ecotone interfaces, especially meandering boundaries, breeds many biochemical reactions "living areas". Optimization of hydraulic regulation promotes redox environment alternations and wetland treatment efficiency. Here we reported a series of upgrades and performances in Guanjinggang wetland after the Shijiuyang prototype. Morphological reform of plant-bed/ditch system played a vital role. Spatially root channel zone was main force of wetland purification, and temporally the treatment effect was higher in low-temperature seasons indicating non-temperature dependent mechanisms worked. Water pollution comprehensive index improved steadily from IV to III, and comprehensive pollution load was reduced by ca. 40%-60%. Comprehensive evaluation function value further showed the gradients purification effect of the upgraded wetland. Ecological wetlands ameliorated source water quality, and reduced drinking water treatment reagents, thereby bringing about economic benefits. Through wetlands operation, people can see how the micro-polluted surface water becomes clear and clean, so promoting a significant social benefit. As a viable component of urban green space, wetlands could beautify regional eco-environment, freshen the air, increase urban ecological taste, and enhance the eco-environmental protection publicity. Thus, the multifunctional service values and indirect benefits are substantial. Jiaxing ecological wetlands provide a typical paradigm for water pollution remediation in developing countries and plays a leading role in technology engineering radiation effect.
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http://dx.doi.org/10.1016/j.jes.2021.03.015DOI Listing
December 2021

Skeletal muscle mass indexes and nonalcoholic fatty liver disease in Chinese elders.

Asia Pac J Clin Nutr 2021 Sep;30(3):446-456

Institute of Nutrition & Health, Qingdao University, Qingdao, China. Email:

Background And Objectives: As an endocrine organ, the mass of skeletal muscle is closely related to human health. The present study aimed to investigate the relationship between regional skeletal muscle and nonalcoholic fatty liver disease (NAFLD) in Chinese elders.

Methods And Study Design: A total of 1,328 participants (579 males and 749 females), aged 65 to 96 years were recruited between March to November 2020 in Qingdao, China. Of these, 400 cases and 400 healthy controls, matched by gender and age (±3 years), were included in the study. Skeletal muscle mass was measured by bioelectrical impedance analysis, and body weight was adopted to standardize skeletal muscle mass to obtain skeletal muscle mass indexes.

Results: Inverse associations were observed for trunk muscle mass index (TMI) (OR=0.42; 95% CI: 0.19, 0.93; p for trend=0.083) and leg skeletal muscle mass index (LMI) (OR=0.41; 95% CI: 0.18, 0.97; p for trend=0.012) with NAFLD risk after adjustment for age, body mass index, glucose, total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, dietary intakes of energy, carbohydrate, protein and fat, smoking, alcohol drinking, education and physical activity. Dose-response analysis indicated that per standard deviation increment of LMI was associated with 23% (95%CI: 0.63, 0.95) reduction of NAFLD risk.

Conclusions: The present study demonstrates that higher TMI and LMI are associated with a lower NAFLD risk.
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http://dx.doi.org/10.6133/apjcn.202109_30(3).0011DOI Listing
September 2021

Big data reveals insights for lead importance in ECG interpretation.

J Electrocardiol 2021 Jan 9. Epub 2021 Jan 9.

Advanced Algorithm Research Center, Philips Healthcare, 222 Jacobs St, Cambridge, MA 02141, USA.

Background: Not every lead contributes equally in the interpretation of an ECG. There are some abnormalities in which the lead importance is not clear either from cardiac electrophysiology or experience. Therefore, it is beneficial to develop an algorithm to quantify the lead importance in the reading of ECGs, namely to determine how much to weigh the evidence from each individual lead when interpreting ECG.

Methods: One representative beat per ECG lead was constructed for each ECG in a database. An algorithm was developed to find the top K (K = 1, 5, 10, 20, 50, 100) ECGs in the database that had the most similar morphology to the query ECG, independently for each lead. For each lead, the query ECG was interpreted based on the weighted average voting on the most similar ECGs by applying a variety of thresholds. For each category of abnormality, we found the threshold that maximized the median F1 score of sensitivity and positive predictive value among all ECG leads. Finally, the F1 score of each lead at this chosen threshold was defined as the importance value for that lead.

Results: Eighteen morphology-based categories of abnormality were investigated for two databases. For most, the lead importance confirmed what expert ECG readers already know. However, it also revealed new insights. For example, lead aVR appeared in the top 6 most important leads in 11 and 12 categories of abnormality in two databases respectively, and ranked first among 12 leads if summarizing all categories.

Conclusions: Lead importance information may be useful in selecting only the most important leads to screen for a specific abnormality, for example using wearable patches.
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http://dx.doi.org/10.1016/j.jelectrocard.2021.01.002DOI Listing
January 2021

Reconstruction of an Extensive Maxillofacial Avulsion Injury Caused by Bear Attack With a Double-Island Anterolateral Thigh Free Flap.

J Craniofac Surg 2021 Sep 22. Epub 2021 Sep 22.

The State Key Laboratory of Oral Diseases Department of Oral and Maxillofacial Surgery, West China College of Stomatology National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Abstract: Bear attack, a relatively rare cause of maxillofacial trauma, could lead to severe facial deformity as well as functional impairment. A 45-year-old male ranger was attacked by a bear and suffered an extensive maxillofacial avulsion injury, resulting in massive soft tissue loss (17.5 × 10 cm2) on his left temporal-facial region with an intraoral defect (3 × 2 cm2), surrounded by pus and necrotic tissue. Computed tomography revealed a comminuted fracture of the mandible, as well as bone defects in the left zygomatic bone, zygomatic arch, and part of the lateral orbital wall. In contrast with tumor resection, this large defect wound resulting from trauma was an infected wound with extensive loss of soft tissue and bone, which presented many operational challenges. The initial goal was to control local infection and then repair the maxillofacial and intraoral defects simultaneously. The left oral mucosal lining and maxillofacial skin after infection control were repaired by transposition of a double-island anterolateral thigh flap, and the fractured mandible was fixed, achieving primary closure for the reconstruction of large soft and hard tissue injuries in the oral and maxillofacial region. Five months postoperatively, the flap had healed and the patient was satisfied with the profile. This patient demonstrated how a rare severe injury caused by a bear attack was treated by preliminary closure of an extremely large post-traumatic oral and maxillofacial defect. The authors recommend the 1 pedicled double-island free anterolateral thigh flap as a worthwhile choice for the reconstruction of complicated oral and maxillofacial tissue defects combined with an intraoral defect. To our knowledge, this is the largest clinical application reported to date of an anterolateral thigh flap (approximately 200 cm2) for a post-traumatic oral and maxillofacial defect.
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http://dx.doi.org/10.1097/SCS.0000000000008213DOI Listing
September 2021

Vitamin A Levels Among Pre-School Children of Central and Western China.

Front Public Health 2021 6;9:694106. Epub 2021 Sep 6.

Department of Child Health Care, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China.

To investigate vitamin A deficiency of pre-school children in central and western China for developing strategies to prevent and control vitamin A deficiency (VAD) among children. From November 2018 to September 2019, a total of 2,194 healthy children aged 2-6 years were enrolled. Serum retinol levels in the children were detected by liquid-phase tandem mass spectrometry. In addition, social demographic and dietary questionnaires were collected through interviews with children's caregivers. The participants were enrolled in 12 cities or their subordinate jurisdictions in the central and western regions of China. Two thousand one hundred and ninety four healthy children aged 2-6 years old. Overall, 35.51% (779/2,194) of the children were found to be vitamin A insufficient (VAI, serum retinol < 1.05 μmol/L). Elder children had a higher risk to suffer from VAI, with proportions of 25.00% (87/348), 28.92% (142/491), 38.38% (256/667), and 42.73% (294/688) among children aged 2, 3, 4, and 5 years, respectively. Vitamin A levels were also positively correlated with per capita income (AOR = 1.18) and regional economic level (0.71), and the frequency of milk intake (0.91). The incidence of VAI was higher among children aged 2-6 years, and the incidence of VAI increases with age. VA levels were positively correlated with levels of economic development in the family and region. So prevention strategies for VAD need to focus on pre-school children, especially dairy intake and developing regions.
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http://dx.doi.org/10.3389/fpubh.2021.694106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450327PMC
October 2021

Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration.

Acta Biomater 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Chengdu Shiliankangjian Biotechnology Co., Ltd.. Electronic address:

Rapid angiogenesis is one of the challenges in endodontic regeneration. Recently, tailored polymeric microsphere system that loaded pro-angiogenic growth factors (GFs) is promising in facilitating vascularization in dental pulp regeneration. In addition, the synergistic effect of multiple GFs is considered more beneficial, but combination usage of them is rather complex and costly. Herein, we aimed to incorporate human platelet lysate (PL), a natural-derived pool of multiple GFs, into gelatin methacrylate (GelMA) microsphere system (GP), which was further modified by Laponite (GPL), a nanoclay with efficient drug delivery ability. These hybrid microspheres were successfully fabricated by electrostatic microdroplet technique with suitable size range (180∼380 µm). After incorporation of the PL and Laponite with GelMA, the Young's modulus of the hybrid hydrogel increased up to about 3-fold and the swelling and degradation rate decreased simultaneously. The PL-derived GFs continued to release up to 28 days from both the GP and GPL microspheres, while the latter released relatively more slowly. What's more, the released GFs could effectively induce tubule formation of human umbilical endothelial cells (HUVECs) and also promote human dental pulp stem cells (hDPSCs) migration. Additionally, the PL component in the GelMA microspheres significantly improved the proliferation, spreading, and odontogenic differentiation of the encapsulated hDPSCs. As further verified by the subcutaneous implantation results, both of the GP and GPL groups enhanced microvascular formation and pulp-like tissue regeneration. This work demonstrated that PL-incorporating GelMA microsphere system was a promising functional vehicle for promoting vascularized endodontic regeneration. STATEMENT OF SIGNIFICANCE: Polymeric microsphere system loaded with pro-angiogenic growth factors (GFs) shows great promise for regeneration of vascularized dental pulp. Herein, we prepared a functional GelMA microsphere system incorporated with human platelet lysates (PL) and nanoclay Laponite by the electrostatic microdroplet method. The results demonstrated that the GelMA/PL/Laponite microspheres significantly improved the spreading, proliferation, and odontogenic differentiation of the encapsulated hDPSCs compared with pure GelMA microspheres. Moreover, they also enhanced microvascular formation and pulp-like tissue regeneration in vivo. This hybrid microsphere system has great potential to accelerate microvessel formation in regenerated dental pulp and other tissues.
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http://dx.doi.org/10.1016/j.actbio.2021.09.024DOI Listing
September 2021

ECG reading differences demonstrated on two databases.

J Electrocardiol 2021 Sep 10. Epub 2021 Sep 10.

Advanced Algorithm Research Center, Philips Healthcare, Andover, MA, USA.

Many studies that rely on manual ECG interpretation as a reference use multiple ECG expert interpreters and a method to resolve differences between interpreters, reflecting the fact that experts sometimes use different criteria. The aim of this study was to show the effect of manual ECG interpretation style on training automated ECG interpretation.

Methods: The effect of ECG interpretation style or differing ECG criteria on algorithm training was shown in this study by careful analysis of the changes in algorithm performance when the algorithm was trained on one database and tested on a different database. Morphology related ECG interpretation was summarized in eleven abnormalities such as left bundle branch block (LBBB) and old anterior myocardial infarction (MI). Each of the two databases used in the study had a reference interpretation mapped to those eleven abnormalities. F1 algorithm performance scores across abnormalities were compared for four cases. First, the algorithm was trained and tested on randomly split database A and then trained on the training set of database A and tested on randomly chosen test set of database B. The previous two test cases were repeated for opposite databases, train and test on database B and then train on database B and test on the test set of database A.

Results: F1 scores across abnormalities were generally higher when training and testing on the same database. F1 scores were high for bundle branch blocks (BBB) no matter the training and testing database combination. Old anterior MI F1 score dropped for one cross-database comparison and not the other suggesting a difference in manual interpretation.

Conclusion: For some abnormalities, human experts appear to have used different criteria for ECG interpretation, as evident by the difference between cross-database and within-database performance. Bundle branch blocks appear to be interpreted in a consistent manner.
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http://dx.doi.org/10.1016/j.jelectrocard.2021.09.005DOI Listing
September 2021

Dosage-dependent antimicrobial activity of DNA-histone microwebs against .

Adv Mater Interfaces 2021 Sep 18;8(17). Epub 2021 Aug 18.

State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Neutrophil extracellular traps (NETs) is an antimicrobial cobweb-structured material produced by immune cells for clearance of pathogens in the body, but paradoxically associated with biofilm formation and exacerbated lung infections. To provide a better materials perspective on the pleiotropic roles played by NETs at diverse compositions/concentrations, a NETs-like material (called 'microwebs', abbreviated as μwebs) is synthesized for decoding the antimicrobial activity of NETs against in infection-relevant conditions. We show that μwebs composed of low-to-intermediate concentrations of DNA-histone complexes successfully trap and inhibit growth and biofilm formation. However, with growing concentrations and histone proportions, the resulting microwebs appear gel-like structures accompanied by reduced antimicrobial activity that can even promote formation of biofilms. Our simplified model of NETs provides a materials-based evidence on NETs-relevant pathology in the development of biofilms.
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http://dx.doi.org/10.1002/admi.202100717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447838PMC
September 2021

TREM2: A Novel Potential Biomarker of Alzheimer's Disease.

Biomed Environ Sci 2021 Sep;34(9):719-724

Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

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http://dx.doi.org/10.3967/bes2021.099DOI Listing
September 2021

HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats.

J Neuroinflammation 2021 Sep 16;18(1):205. Epub 2021 Sep 16.

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, 226001, People's Republic of China.

Background: Two activation states of reactive astrocytes termed A1 and A2 subtypes emerge at the lesion sites following spinal cord injury (SCI). A1 astrocytes are known to be neurotoxic that participate in neuropathogenesis, whereas A2 astrocytes have been assigned the neuroprotective activity. Heat shock transcription factor 1 (HSF1) plays roles in protecting cells from stress-induced apoptosis and in controlling inflammatory activation. It is unknown whether HSF1 is involved in suppressing the conversion of A1 astrocytes following SCI.

Methods: A contusion model of the rat spinal cord was established, and the correlations between HSF1 expression and onset of A1 and A2 astrocytes were assayed by Western blot and immunohistochemistry. 17-AAG, the agonist of HSF1, was employed to treat the primary cultured astrocytes following a challenge by an A1-astrocyte-conditioned medium (ACM) containing 3 ng/ml of IL-1α, 30 ng/ml of TNF-α, and 400 ng/ml of C1q for induction of the A1 subtype. The effects of 17-AAG on the phenotype conversion of astrocytes, as well as underlying signal pathways, were examined by Western blot or immunohistochemistry.

Results: The protein levels of HSF1 were significantly increased at 4 days and 7 days following rat SCI, showing colocalization with astrocytes. Meanwhile, C3-positive A1 astrocytes were observed to accumulate at lesion sites with a peak at 1 day and 4 days. Distinctively, the S100A10-positive A2 subtype reached its peak at 4 days and 7 days. Incubation of the primary astrocytes with ACM markedly induced the conversion of the A1 phenotype, whereas an addition of 17-AAG significantly suppressed such inducible effects without conversion of the A2 subtype. Activation of HSF1 remarkably inhibited the activities of MAPKs and NFκB, which was responsible for the regulation of C3 expression. Administration of 17-AAG at the lesion sites of rats was able to reduce the accumulation of A1 astrocytes.

Conclusion: Collectively, these data reveal a novel mechanism of astrocyte phenotype conversion following SCI, and HSF1 plays key roles in suppressing excessive increase of neurotoxic A1 astrocytes.
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http://dx.doi.org/10.1186/s12974-021-02271-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444373PMC
September 2021

The Clausena lansium (Wampee) genome reveal new insights into the carbazole alkaloids biosynthesis pathway.

Genomics 2021 Sep 11;113(6):3696-3704. Epub 2021 Sep 11.

State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen 518120, China; Department of Biology, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Clausena lansium (Lour.) Skeels (Rutaceae), recognized as wampee, is a widely distributed fruit tree which is utilized as a folk-medicine for treatment of several common diseases. However, the genomic information about this medicinally important species is still lacking. Therefore, we assembled the first genome of Clausena genus with a total length of 310.51 Mb and scaffold N50 of 2.24 Mb by using 10× Genomics technology. Further annotation revealed a total of 34,419 protein-coding genes, while repetitive elements covered 39.08% (121.36 Mb) of the genome. The Clausena and Citrus genus were found to diverge around 22 MYA, and also shared an ancient whole-genome triplication event with Vitis. Furthermore, multi-tissue transcriptomic analysis enabled the identification of genes involved in the synthesis of carbazole alkaloids. Altogether, these findings provided new insights into the genome evolution of Wampee species and highlighted the possible role of key genes involved in the carbazole alkaloids biosynthetic pathway.
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http://dx.doi.org/10.1016/j.ygeno.2021.09.007DOI Listing
September 2021

A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS-CoV-2 vaccine.

J Med Virol 2021 Sep 13. Epub 2021 Sep 13.

Department of Vaccine and Diagnostics, The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China.

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http://dx.doi.org/10.1002/jmv.27334DOI Listing
September 2021

Predictive Value of Metabolic Parameters Derived From F-FDG PET/CT for Microsatellite Instability in Patients With Colorectal Carcinoma.

Front Immunol 2021 26;12:724464. Epub 2021 Aug 26.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Microsatellite instability (MSI) is one of the important factors that determine the effectiveness of immunotherapy in colorectal cancer (CRC) and serves as a prognostic biomarker for its clinical outcomes.

Purpose: To investigate whether the metabolic parameters derived fromF-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) can predict MSI status in patients with CRC.

Materials And Methods: A retrospective analysis was performed on CRC patients who underwent F-FDG PET/CT examination before surgery between January 2015 and April 2021. The metabolic F-FDG PET/CT parameters of the primary CRC lesion were calculated and recorded with different thresholds, including the maximum, peak, and mean standardized uptake value (SUV, SUV, and SUV), as well as the metabolic tumor volume (MTV) and the total lesion glycolysis (TLG). The status of MSI was determined by immunohistochemical assessment. The difference of quantitative parameters between MSI and microsatellite stability (MSS) groups was assessed, and the receiver operating characteristic (ROC) analyses with area under ROC curves (AUC) was used to evaluate the predictive performance of metabolic parameters.

Results: A total of 44 patients (24 men and 20 women; mean ± standard deviation age: 71.1 ± 14.2 years) were included. There were 14 patients in the MSI group while there were 30 in the MSS group. MTV, MTV, MTV, and MTV, as well as TLG and TLG showed significant difference between two groups (all -values <0.05), among which MTV demonstrated the highest performance in the prediction of MSI, with an AUC of 0.805 [95% confidence interval (CI): 0.657-0.909], a sensitivity of 92.9% (95% CI: 0.661-0.998), and a specificity of 66.7% (95% CI: 0.472-0.827). Patients' age and MTV were significant predictive indicators of MSI in multivariate logistic regression.

Conclusion: The metabolic parameters derived fromF-FDG PET/CT were able to preoperatively predict the MSI status in CRC, with MTV demonstrating the highest predictive performance. PET/CT imaging could serve as a noninvasive tool in the guidance of immunotherapy and individualized treatment in CRC patients.
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http://dx.doi.org/10.3389/fimmu.2021.724464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426433PMC
August 2021

Suppressing mosquito populations with precision guided sterile males.

Nat Commun 2021 09 10;12(1):5374. Epub 2021 Sep 10.

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision-guided sterile insect technique (pgSIT) in Aedes aegypti. PgSIT uses a simple CRISPR-based approach to generate flightless females and sterile males that are deployable at any life stage. Supported by mathematical models, we empirically demonstrate that released pgSIT males can compete, suppress, and even eliminate mosquito populations. This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable, and reversible manner.
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http://dx.doi.org/10.1038/s41467-021-25421-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433431PMC
September 2021

Clinical Predictors of High Blood Eosinophils in Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2021 28;16:2467-2474. Epub 2021 Aug 28.

Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Purpose: Elevated blood eosinophils have been implicated in chronic obstructive pulmonary disease (COPD) progression and exacerbation. We aim to investigate clinical predictors of high blood eosinophils in a Chinese COPD cohort.

Patients And Methods: We conducted a retrospective cohort study in Sichuan province, a Southwest province with high prevalence of COPD in China. All patients in this cohort were extracted from the Chinese Pulmonary Health study, a large cross-sectional study on COPD epidemiology in China. Demographics, personal and family history, living condition, spirometry and blood eosinophil counts were obtained. Univariate and multiple linear regression analyses were performed to determine predictors of high blood eosinophils.

Results: A total of 375 COPD patients were included in this cohort. The median absolute blood eosinophil count was 138.8 cells/μL, and the prevalence of COPD with high blood eosinophils was 66.7% and 14.7% when using the thresholds of 100 cells/μL and 300 cells/μL, respectively. Univariate analyses indicated that male gender, lower body mass index, high-density lipoprotein (HDL), lower family income, raising pets and biomass use were significantly associated with high blood eosinophils (p < 0.05). Multiple linear regression model further revealed male gender (unstandardized coefficient (B)=66.125, 95% confidence intervals (CI) 16.350 to 115.900, p=0.009), age (B=2.819, 95% CI 0.639 to 5.000, p=0.012) predicted high blood eosinophil level, whereas HDL (B=-64.682, 95% CI -123.451 to -5.914, p=0.031) was a negative predictor for high blood eosinophils.

Conclusion: This retrospective cohort study suggests male gender, oldness and lower HDL could be clinical predictors of high blood eosinophils in Chinese COPD patients.
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http://dx.doi.org/10.2147/COPD.S324511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409512PMC
September 2021
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