Publications by authors named "Ting Lu"

301 Publications

Effect of Linc-POU3F3 on radiotherapy resistance and cancer stem cell markers of esophageal cancer cells.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Jun;46(6):583-590

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011. [email protected] csu.edu.cn.

Objectives: Long non-coding RNA (LncRNA) is an important transcriptional and post-transcriptional regulatory molecule in the body. In recent years, relationship between LncRNA and malignant phenotype of tumor cells has been revealed gradually. This study aims to investigate the expression characteristics of pit-oct-unc class 3 homeobox 3 related long non-coding RNA (Linc-POU3F3) in esophageal cancer and its relationship with radiation resistance (IR) as well as the expressions of cancer stem cell (CSC) markers in esophageal cancer cells.

Methods: The expression characteristics and potential interaction molecules of Linc-POU3F3 in esophageal cancer were collected from the public database via bioinformatics retrieval. Forty-two pair samples of esophageal cancer tissues and corresponding adjacent tissues were collected. Human normal esophageal epithelial cells (HEEC) and human esophageal cancer cell lines (ECA109, TE-1, TE-2, TE-13) were cultured. Real-time quantitative PCR (qPCR) was used to detect the expression level of Linc-POU3F3 in clinical tissues and cells. The formation of TE-13 IR cell line induced by different doses of radiation served as IR group cells, and the same condition treated with 0 Gy dose was set as control group (control) cells. Meanwhile, we used cell transfection technology to construct random interference sequence (siControl) cells and interference (siLinc-POU3F3) cells. In ECA109 cells, we transfected blank and over expressed Linc-POU3F3 plasmids as vector and over-expressed group (oeLinc-POU3F3). The mRNA and protein expressions of CD44, CD133 and CD90 were detected by qPCR and Western blotting, respectively. MTS [3-(4,5-dimenthylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt] was used to detect the cell viability under different radiation doses, and the resistance of IR cells was verified by clone formation experiment.

Results: The expression of Linc-POU3F3 was correlated with the tumor progression and poor prognosis of esophageal cancer. The level of Linc-POU3F3 mRNA expression was significantly higher in esophageal cancer tissues and cell lines than that in normal adjacent tissues and cell lines (all <0.01). The expressions of Linc-POU3F3 mRNA and protein expressions of CD44, CD133, and CD90 in IR cells were significantly higher than those in control cells (all <0.01). The expression of Linc-POU3F3 in siLinc-POU3F3 cell was significantly lower than that in the siControl cells (<0.01), and the inhibition rate was 87.21%. The mRNA and protein expressions of CD44, CD133, and CD90 in the siLinc-POU3F3 cells were significantly lower than those in the siControl cells (all <0.05). The expressions of linc-POU3F3, CD44, CD133, and CD90 mRNA and protein in the oeLinc-POU3F3 cells were significantly higher than those in the vector cells. The relative activity and clone formation ability in the IR cells were significantly higher than those in the control cells at 2, 4, and 8 Gy doses (all <0.01). The relative activity in the siLinc-POU3F3 cells was significantly lower than that in the siControl cells at 4 and 8 Gy doses (<0.01). The relative activity in the oeLinc-POU3F3 cells was significantly higher than that in the vector cells at 4 and 8 Gy doses (<0.01).

Conclusions: Linc-POU3F3 is up-regulated in esophageal cancer and can promote IR and the expression of CSC markers in esophageal cancer cells.
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http://dx.doi.org/10.11817/j.issn.1672-7347.2021.190758DOI Listing
June 2021

In-situ fabrication of few-layered MoS wrapped on TiO-decorated MXene as anode material for durable lithium-ion storage.

J Colloid Interface Sci 2021 Jul 6;604:30-38. Epub 2021 Jul 6.

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, PR China. Electronic address:

Rational construction of hybrid materials integrating the collective virtues of individual building blocks has spurred significant interest in electrode materials for energy storage. Herein, a smart hybrid was fabricated via in-situ assembling of the few-layered MoS (f-MoS) coated on the multi-layered TiC MXene decorated with the TiO nanoparticles by the scalable hydrothermal and annealing approaches. In the unique architecture, the multi-layered TiC with the expanded interspaces as the conductive backbone can facilitate the electron transport, provide adequate space to facilitate the infiltration of organic electrolyte into the interior of electrode, and inhibit the aggregation of MoS nanosheets, while the f-MoS with enlarged interlayer can be beneficial for the lithium-ion diffusion and prevent the multi-layered TiCfrom restacking. Moreover, the TiO decorated on the TiC can effectively inhibit the instability of long-chain lithium polysulfides dissolved in organic electrolyte to improve the cycling stability. Thanks to the synergistic effect of the building blocks, the TiC/[email protected] hybrid employed as lithium storage anode delivers an extraordinary endurable ability with a high storage capacity of 403.1 mA h g after 1200 cycles at 2 A g. Importantly, the smart hybridization strategy in this work paves an efficient way to explore the high-performance MXene-based hybrid materials in energy storage fields.
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http://dx.doi.org/10.1016/j.jcis.2021.07.013DOI Listing
July 2021

Targeted delivery of dexamethasone in acute pneumonia.

Biomater Sci 2021 Jul 9. Epub 2021 Jul 9.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China.

Pneumonia has contributed to significant mortality owing to the irreversible injury to the lungs and severe inflammation of the tissue. Dexamethasone (DEX) is regarded as an effective drug to relieve the level of pneumonia, while the adverse effect of which is non-negligible. Here, we developed a targeted delivery strategy based on platelet-derived extracellular vesicles (PEVs), which are naturally occurring nanoparticles released by platelets, for DEX delivery in acute pneumonia, aiming to reduce the side effects and improve the therapeutic efficacy. Our strategy may shed light on the problems in DEX-based acute pneumonia therapy clinically.
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http://dx.doi.org/10.1039/d1bm00924aDOI Listing
July 2021

Forensic age estimation based on magnetic resonance imaging of the proximal humeral epiphysis in Chinese living individuals.

Int J Legal Med 2021 Jul 7. Epub 2021 Jul 7.

Department of Forensic Pathology, West China School of Basic Medical Science & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.

Forensic age estimation in living individuals is mainly based on radiological features, but direct radiography and computed tomography lead to a rise in ethical concerns due to radiation exposure. Thus, the contribution of magnetic resonance imaging (MRI) to age estimation of living individuals is a subject of ongoing research. In the current study, MRIs of shoulder were retrospectively collected from a modern Chinese Han population and data from 835 individuals (599 males and 236 females) in the age group 12 to 30 years were obtained. A staging technique based on (Schmidt et al. Int J Legal Med 121(4):321-324, 2007) and (Kellinghaus et al. Int J Legal Med 124(4):321-325, 2010) was used and all images were evaluated with T1-wieghted turbo spin echo (T1-TSE) sequence and T2-weighed fat suppression (T2-FS) sequence. One-sided images were assessed because data from both sides were considered coincidental, as no significant differences were found (P > 0.05). Two MRI sequences were evaluated separately and subsequently compared. Regression models and supportive vector classification (SVC) models were established accordingly. The intraobserver and interobserver agreement levels were good. Compared with T1-TSE sequence, the R values of T2-FS sequence were generally higher, while the mean absolute deviation (MAD) values were slightly lower. For T2-FS sequence, the MAD value was 1.49 years in males and 2.19 years in females. With two MRI sequences incorporated, the SVC model obtained with 85.7% correctly classified minors and 96.2% correctly classified adults in males, while 83.3% and 98.0% respectively in females. In conclusion, T2-FS sequence may slightly outperform the T1-TSE sequence in shoulder MRI analysis for age estimation, while shoulder MRIs could be a reliable prediction indicator for the 18-year threshold and two MRI sequences incorporated are encouraged.
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http://dx.doi.org/10.1007/s00414-021-02653-5DOI Listing
July 2021

Inflammation-related genes S100s, RNASE3, and CYBB and risk of leukemic transformation in patients with myelodysplastic syndrome with myelofibrosis.

Biomark Res 2021 Jul 2;9(1):53. Epub 2021 Jul 2.

Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine; Institute of Hematology, Zhejiang University; Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy; Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, 310003, Hangzhou, China.

Myelodysplastic syndrome with myelofibrosis (MDS-MF) has been associated with an inferior prognosis compared with MDS without MF. However, MDS-MF is not listed independently as a subtype of MDS, and its clinical and genetic characteristics remain poorly understood. We retrospectively compared 53 patients with MDS-MF (44 MF grade 1/MF; 9 MF grade 2-3/MF) and 31 with de novo MDS without MF (MDS). The leukemic transformation risks of both MDS-MF and MDS-MF were increased compared with the MDS group. To identify the potential mechanisms responsible for the leukemic transformation of MDS-MF, we performed single-cell sequencing for one MDS-MF patient before and after leukemic transformation to explore the variations in gene expression levels. In addition to upgraded expression levels of acute myeloid leukemia-related genes during leukemic transformation, expression levels of some inflammation-related genes (such as S100s, RNASE3, and CYBB) were also increased, and inflammation-related pathways were up-regulated. These results suggest that inflammation-related genes and pathways may play an important role in the leukemic transformation of MDS-MF.
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http://dx.doi.org/10.1186/s40364-021-00304-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259211PMC
July 2021

Case Report: Isolate Congenital Coronary Artery Fistula With Giant Artery Aneurysm in a Neonate.

Front Cardiovasc Med 2021 16;8:633840. Epub 2021 Jun 16.

Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

A rare case of neonatal congenital coronary artery, right ventricle fistula with giant coronary artery aneurysm formation, was reported. Computed tomography angiography demonstrated the dilated and tortuous tunnel arising from the right aortic sinus and traversing the epicardial surface before opening into the anterolateral aspect of the RV. Successful surgical repair was performed with a patch closure of the fistula and coronary angioplasty. The postoperative recovery was uneventful. Our experience of this rare congenital heart disease demonstrated that early surgical repair of coronary artery fistula and coronary angioplasty in the neonate can be performed safely. Further study is needed to seek the basis on this.
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http://dx.doi.org/10.3389/fcvm.2021.633840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241900PMC
June 2021

Pair Nodes Clock Synchronization Algorithm Based on Kalman Filter for Underwater Wireless Sensor Networks.

Sensors (Basel) 2021 Jun 28;21(13). Epub 2021 Jun 28.

School of Informatics, Xiamen University, Xiamen 361005, China.

Time synchronization is the basis of many applications. Aiming at the limitations of the existing clock synchronization algorithms in underwater wireless sensor networks, we propose a pairwise synchronization algorithm called K-Sync, which is based on the Kalman filter. The algorithm does not need the assistance of the position sensor or the speed sensor, and the high time synchronization accuracy can be realized only by utilizing the time-stamps information in the process of message exchange. The K-Sync uses the general constraints of the motion characteristics of the sensor nodes to establish the recursive equations of the clock skew, clock offset, relative mobility velocity, and relative distance. At the same time, the time-stamps are viewed as the observation variables and the system observation equation is obtained. The K-Sync estimates the normalized clock skew and offset of the node via the Kalman filter to achieve high-precision clock synchronization between the two nodes. The simulation shows that the K-Sync has obvious advantages in the key indicators such as the estimated accuracy of clock skew and clock offset, convergence speed, etc. In addition, the K-Sync is more robust to a variety of underwater motion scenes.
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http://dx.doi.org/10.3390/s21134426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272019PMC
June 2021

Precise and reliable control of gene expression in Agrobacterium tumefaciens.

Biotechnol Bioeng 2021 Jun 28. Epub 2021 Jun 28.

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Agrobacterium tumefaciens is a soil-borne bacterium that is known for its DNA delivery ability and widely exploited for plant transformation. Despite continued interest in improving the utility of the organism, the lack of well-characterized engineering tools limits the realization of its full potential. Here, we present a synthetic biology toolkit that enables precise and effective control of gene expression in A. tumefaciens. We constructed and characterized six inducible expression systems. Then, we optimized the one regulated by cumic acid through amplifier introduction and promoter engineering and evaluated its 15 cognate promoters. To establish fine-tunability, we constructed a series of spacers and a promoter library to systematically modulate both translational and transcriptional rates. We finally demonstrated the application of the tools by co-expressing genes with altered expression levels using a single signal. This study provides precise expression tools for A. tumefaciens, facilitating rational engineering of the bacterium for advanced plant biotechnological applications.
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http://dx.doi.org/10.1002/bit.27872DOI Listing
June 2021

Effects of Wise Intervention on Perceived Discrimination Among College Students Returning Home From Wuhan During the COVID-19 Outbreak.

Front Psychol 2021 7;12:689251. Epub 2021 Jun 7.

Department of Psychology, Faculty of Education, Hubei University, Wuhan, China.

At the beginning of the coronavirus disease 2019 (COVID-19) outbreak, college students returning home from Wuhan, Hubei Province, experienced various degrees of discrimination. This study first investigates perceived discrimination among college students returning home from Wuhan. Then, an experimental method is used to investigate the effectiveness of an intervention designed to reduce the perceived discrimination among those who returned to towns outside of Hubei Province. A total of 63 college students participated in the experiment. In the experimental group ( = 31), a wise intervention based on reading and writing was adopted to intervene in perceived discrimination among the participants. The results showed that the perceived discrimination among students returning from Wuhan to towns outside of Hubei Province was significantly higher than that among students returning to towns within Hubei Province. The wise intervention reduced the perceived discrimination in the experimental group but not in the control group. Further analysis found that perceived social support fully mediated the relationship between the intervention and perceived discrimination. These results provide insights on how the content of intervention (perceived social support) and the form of intervention (wise intervention) can prevent the occurrence of psychological problems in epidemic situations.
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http://dx.doi.org/10.3389/fpsyg.2021.689251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215144PMC
June 2021

Does an increase in serum FGF21 level predict 28-day mortality of critical patients with sepsis and ARDS?

Respir Res 2021 Jun 22;22(1):182. Epub 2021 Jun 22.

Department of Critical Care, Changsha of Traditional Chinese Medicine Hospital, No. 22, Xingsha Road, Changsha, 410010, Hunan Province, People's Republic of China.

Background: Sepsis may be accompanied by acute respiratory distress syndrome (ARDS) in patients admitted to intensive care units (ICUs). It is essential to identify prognostic biomarkers in patients with sepsis and ARDS.

Objective: Determine whether changes in the level of serum fibroblast growth factor 21 (FGF21) can predict the 28-day mortality of ICU patients with sepsis and ARDS.

Methods: Consecutive sepsis patients were divided into two groups (Sepsis + ARDS and Sepsis-only), and the Sepsis + ARDS group was further classified as survivors or non-survivors. Demographic data and comorbidities were recorded. The Sequential Organ Failure Assessment (SOFA) score and serum levels of cytokines and other biomarkers were recorded 3 times after admission. Multiple Cox proportional hazards regression was used to identify risk factors associated with 28-day mortality in the Sepsis + ARDS group. Multivariate receiver operating characteristic curve analysis was used to assess the different predictive value of FGF21 and SOFA.

Results: The Sepsis + ARDS group had a greater baseline SOFA score and serum levels of cytokines and other biomarkers than the Sepsis-only group; the serum level of FGF21 was almost twofold greater in the Sepsis + ARDS group (P < 0.05). Non-survivors in the Sepsis + ARDS group had an almost fourfold greater level of FGF21 than survivors in this group (P < 0.05). The serum level of FGF21 persistently increased from the baseline to the peak of shock and death in the non-survivors, but persistently decreased in survivors (P < 0.05). Changes in the serum FGF21 level between different time points were independent risk factors for mortality. No statistical difference was observed between the AUC of FGF21 and SOFA at baseline.  CONCLUSION: A large increase of serum FGF21 level from baseline is associated with 28-day mortality in ICU patients with sepsis and ARDS.
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http://dx.doi.org/10.1186/s12931-021-01778-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216835PMC
June 2021

Novel Model for Rate Transient Analysis in Stress-Sensitive Shale Gas Reservoirs.

ACS Omega 2021 Jun 27;6(22):14015-14029. Epub 2021 May 27.

SINOPEC Key Laboratory of Shale Oil/Gas Exploration & Production, Beijing 100083, China.

Technical advances in hydraulic fracturing and horizontal drilling technologies enable shale to be commercially exploited. Due to the technical and economic limitations of well testing in shale gas plays, rate transient analysis has become a more attractive option. After hydraulic fracturing, flow mechanisms in multiple scaled pores of shale become extraordinarily complicated: adsorption in nanopores, diffusion in micropores, and non-Darcy flow in macropores. Moreover, shale gas reservoirs are stress-sensitive because of ultralow permeability and diffusivity in a matrix. Furthermore, the porosity and permeability of natural fractures are stress-dependent as well. Accounting for all of these complex flow mechanisms, especially the aforementioned stress-sensitive parameters, a semianalytical production solution of a multiple fractured horizontal well (MFHW) can rapidly predict the entire production behavior. Scholars have done much work on the complex flow mechanisms of shale. Most models regarded permeability as a stress-sensitive parameter while diffusivity and porosity were considered to be a constant. However, diffusivity and porosity were proved to be stress-sensitive as experimental science developed. In this study, we present a novel semianalytical model for rate transient analysis of MFHW, which simultaneously incorporates multiple stress-sensitive parameters into flow mechanisms. Substituting stress-dependent parameters (diffusivity, porosity, and permeability) into governing equations resulted in strong nonlinearities, which was solved by employing the perturbation method. Production behaviors with only stress-sensitive permeability were compared with multiple stress-dependent parameters. The new model with multiple stress-sensitive parameters declined slower than the permeability-sensitive model, and the new model matched better with the field data. In addition, the effects of major stress-sensitive parameters on production decline curves were analyzed by the proposed model. The sensitivity analysis indicated that different parameters had their own degree of sensitivity intensity and influence on the production period. Finally, 1001 wells from the Marcellus shale play were divided into three well groups. Estimated inversion values of reservoir parameters from the three well groups and relevant single wells were consistent with the field data. The inverted values of single wells fluctuate within the inversion values of well groups, which indicates that the production behavior of well groups could be a guide for rate transient analysis of a single well in shale gas reservoirs.
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http://dx.doi.org/10.1021/acsomega.1c00259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190796PMC
June 2021

High FAM189B Expression and Its Prognostic Value in Patients with Gastric Cancer.

Biomed Res Int 2021 25;2021:8875971. Epub 2021 May 25.

Department of Gastroenterology, Guangxi International Zhuang Medicine Hospital, Nanning, 530200 Guangxi, China.

The clinical significance of the family with sequence similarity 189 member B (FAM189B) gene remains largely unknown in gastric cancer (GC). A comprehensive investigation combining multiple detection methods was carried out in the current study to unveil the clinical implications and prospective molecular characterization of FAM189B protein and mRNA in GC. The protein level of FAM189B was clearly upregulated in the tumor tissues of GC as compared to noncancerous gastric tissues with 179 GC cases and 147 noncancerous gastric controls assessed by immunohistochemistry. The upregulation of the FAM189B protein was also found in the more deteriorating period of the tumor, as there were increasing trends in the groups of larger tumors, with lymph node metastasis, a further advanced clinical stage, and a higher histological grade. Next, we focused on the mRNA level of FAM189B in GC tissues using various high-throughput data. After the screening of GEO, ArrayExpress, and SRA, we finally achieved 18 datasets, including an RNA sequencing dataset of TCGA. Altogether, 1095 cases of GC tissue samples were collected, with 305 unique examples of noncancerous controls. Concerning the mRNA level of FAM189B in GC, the final standard mean difference (SMD) was 0.46 and the area under the curve (AUC) was 0.79 for the upregulation of FAM189B mRNA, which confirmed that the FAM189B mRNA level was also markedly upregulated in GC tissues and comparable to its protein level. The survival analysis showed that the higher expression of FAM189B was a risk factor for the overall survival, first progression, and postprogression survival of GC. For the Affymetrix ID 1555515_a_at of FAM189B, the higher expression level of FAM189B predicted a lower overall survival, first progression survival, and postprogression survival with the hazard ratio (HR) being 1.56 (1.24, 1.95), 1.69 (1.32, 2.17), and 1.97 (1.5, 2.6), respectively. For the Affymetrix ID 203550_s_at of FAM189B, a similar result could be found with corresponding HR being 1.49 (1.24, 1.8), 1.49 (1.21, 1.83), and 1.66 (1.32, 2.08), respectively. The interaction of MEM, COXPRESdb coexpressed genes, and DEGs of GC finally generated 368 genes, and the pathway of the cell cycle was the top pathway enriched by KEGG. In conclusion, the overexpression of the FAM189B protein and mRNA might enhance the incidence of GC.
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http://dx.doi.org/10.1155/2021/8875971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172284PMC
May 2021

Prognostic Prediction of Cytogenetically Normal Acute Myeloid Leukemia Based on a Gene Expression Model.

Front Oncol 2021 27;11:659201. Epub 2021 May 27.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Acute myeloid leukemia (AML) refers to a heterogeneous group of hematopoietic malignancies. The well-known European Leukemia Network (ELN) stratifies AML patients into three risk groups, based primarily on the detection of cytogenetic abnormalities. However, the prognosis of cytogenetically normal AML (CN-AML), which is the largest AML subset, can be hard to define. Moreover, the clinical outcomes associated with this subgroup are diverse. In this study, using transcriptome profiles collected from CN-AML patients in the BeatAML cohort, we constructed a robust prognostic Cox model named NEST (Nine-gEne SignaTure). The validity of NEST was confirmed in four external independent cohorts. Moreover, the risk score predicted by the NEST model remained an independent prognostic factor in multivariate analyses. Further analysis revealed that the NEST model was suitable for bone marrow mononuclear cell (BMMC) samples but not peripheral blood mononuclear cell (PBMC) samples, which indirectly indicated subtle differences between BMMCs and PBMCs. Our data demonstrated the robustness and accuracy of the NEST model and implied the importance of the immune dysfunction in the leukemogenesis that occurs in CN-AML, which shed new light on the further exploration of molecular mechanisms and treatment guidance for CN-AML.
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http://dx.doi.org/10.3389/fonc.2021.659201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190396PMC
May 2021

Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome.

BMC Med 2021 May 27;19(1):120. Epub 2021 May 27.

State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

Background: Gestational diabetes mellitus (GDM) is a metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes. The relationship between GDM and meconium microbiota and metabolome remains incompletely understood.

Methods: Four hundred eighteen mothers (147 women with GDM and 271 normal pregnant women) and their neonates from the GDM Mother and Child Study were included in this study. Meconium microbiota were profiled by 16S rRNA gene sequencing. Meconium and maternal serum metabolome were examined by UPLC-QE.

Results: Microbial communities in meconium were significantly altered in neonates from the GDM mothers. A reduction in alpha diversity was observed in neonates of GDM mothers. At the phylum level, the abundance of Firmicutes and Proteobacteria changed significantly in neonates of GDM mothers. Metabolomic analysis of meconium showed that metabolic pathways including taurine and hypotaurine metabolism, pyrimidine metabolism, beta-alanine metabolism, and bile acid biosynthesis were altered in GDM subjects. Several changed metabolites varying by the similar trend across the maternal serum and neonatal meconium were observed.

Conclusion: Altogether, these findings suggest that GDM could alter the serum metabolome and is associated with the neonatal meconium microbiota and metabolome, highlighting the importance of maternal factors on early-life metabolism.
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http://dx.doi.org/10.1186/s12916-021-01991-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157751PMC
May 2021

An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma.

Cancer Res 2021 Jul 18;81(13):3635-3648. Epub 2021 May 18.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, California.

IL15 is a pleiotropic cytokine with multiple roles that improve immune responses to tumor cells. Oncolytic viruses (OV) specifically lyse tumors and activate immune responses. Systemic administration of IL15 or its complex with the IL15Rα and chimeric antigen receptor (CAR) natural killer (NK) cells are currently being tested in the clinic. Here, we generated a herpes simplex 1-based OV-expressing human IL15/IL15Rα sushi domain fusion protein (named OV-IL15C), as well as off-the-shelf EGFR-CAR NK cells, and studied their monotherapy and combination efficacy and in multiple glioblastoma (GBM) mouse models. , soluble IL15/IL15Rα complex was secreted from OV-IL15C-infected GBM cells, which promoted GBM cytotoxicity and improved survival of NK and CD8 T cells. Frozen, readily available off-the-shelf EGFR-CAR NK cells showed enhanced killing of tumor cells compared with empty vector-transduced NK cells. , OV-IL15C significantly inhibited tumor growth and prolonged survival of GBM-bearing mice in the presence of CD8 T cells compared with parental OV. OV-IL15C plus EGFR-CAR NK cells synergistically suppressed tumor growth and significantly improved survival compared with either monotherapy, correlating with increased intracranial infiltration and activation of NK and CD8 T cells and elevated persistence of CAR NK cells in an immunocompetent model. Collectively, OV-IL15C and off-the-shelf EGFR-CAR NK cells represent promising therapeutic strategies for GBM treatment to improve the clinical management of this devastating disease. SIGNIFICANCE: The combination of an oncolytic virus expressing the IL15/IL15Rα complex and frozen, ready-to-use EGFR-CAR NK cells elicits strong antitumor responses in glioblastoma.
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http://dx.doi.org/10.1158/0008-5472.CAN-21-0035DOI Listing
July 2021

Consumer perceptions on the origin of infant formula: a survey with urban Chinese mothers.

J Dairy Res 2021 May 17;88(2):226-237. Epub 2021 May 17.

School of Public Health, Physiotherapy and Sports Science, Woodview House, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

The consumer survey reported in this research paper aims to understand how Chinese mothers learn about and confirm the origin of powdered infant formulas (henceforward formulas), their knowledge level and preferences between formulas from different origins. With globalization, dairy companies can source ingredients for domestic production and manufacture finished products across the world. Chinese consumers are now facing a variety of formulas with different brand origin, main ingredient origin ('nai yuan'), manufacturing origin, and country-of-purchase. Drawing on a large representative sample of Chinese mothers who have purchased formulas, we found that most of them had intensively engaged in learning about and confirming formulas' origin through different strategies. However, they may not interpret related cues correctly: a majority of Chinese mothers incorrectly considered the 'main ingredient origin' as the 'manufacturing place' and could not necessarily recognize between 'foreign' and 'domestic' brands. Among formulas from different origins, authentic foreign branded, produced and packaged formulas showed a high popularity in Tier 1 & 2 cities and among more knowledgeable consumers. In low-tier cities, these products were equally popular as domestically branded and produced formulas using imported milk powders and other ingredients. Formulas directly acquired from overseas markets through unofficial channels were least favoured by consumers. The study shows that Chinese consumers' previous one-sided endorsement towards foreign formulas appears to have weakened. Decisions made by formula companies on the origin of the main ingredient and the place of manufacture would influence product attractiveness, and the segments of Chinese consumers to target.
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http://dx.doi.org/10.1017/S0022029921000364DOI Listing
May 2021

Effects of gallic acid alkyl esters and their combinations with other antioxidants on oxidative stability of DHA algae oil.

Food Res Int 2021 05 9;143:110280. Epub 2021 Mar 9.

School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China; National Engineering Research Center of Seafood, Dalian 116034, PR China; Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, PR China. Electronic address:

The most effective composite antioxidants for DHA algae oil were optimized by combining the selected gallic acid (GA) alkyl ester with other commonly used antioxidants. Results of Rancimat induction time, peroxide value, thiobarbituric acid-reactive substances, and free radical generation indicated that octyl gallate (OG) was the best one in DHA algae oil among GA alkyl esters with various chain lengths. Therefore, OG was used to combine other antioxidants (antioxidant of bamboo leaves, rosemary extract, tea polyphenols, tea polyphenol palmitate (TPP), ascorbyl palmitate, vitamin E, phytic acid and phospholipid) for further improving the oxidative stability of DHA algae oil. The combination of OG + TPP showed the best antioxidant effect among the composite antioxidants of two and three components. Through optimization of mixture ratio, the combination of 53.20 mg/kg OG + 360 mg/kg TPP demonstrated the best antioxidant capacity, which prolonged the shelf life of DHA algae oil by 4.24 folds.
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http://dx.doi.org/10.1016/j.foodres.2021.110280DOI Listing
May 2021

Long-term outcomes of mitral valve replacement in patients weighing less than 10 kg.

J Cardiothorac Surg 2021 Mar 31;16(1):63. Epub 2021 Mar 31.

Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.

Background: The outcomes of mitral valve replacement (MVR) in pediatrics especially in the patients weighing less than 10 kg are not always favorable. This study aimed to measure long-term outcomes of MVR in our institution.

Methods: Nine young children weighing less than 10 kg underwent MVR with mechanical prostheses were enrolled in this retrospectively study. Kaplan-Meier survival analysis was used for the prediction of freedom from death and adverse events. Chi-square test was performed to compare outcomes for patients with different ratios of mechanical prosthesis size and body weight. Fourteen related literatures were also reviewed to support our study.

Results: All patients received bileaflet mechanical prostheses replacement. The surgical technique varied among the patients with prostheses implanted in the intra-annular (n = 5), supra-annular (n = 1), or with a Dacron conduit segment in the supra-annular position (n = 3). The valve size/weight ratio ranged from 2.11 to 5.00. There were two early death and one late death post-operation. The mean follow-up period was 80.67 ± 63.37 months, the transvalvular gradient was 10.5 ± 1.76 mmHg (range 8 to 12) and the peak gradient of LVOT was 5.00 ± 0.64 mmHg. One (11.1%) patient underwent an immediate revision MVR after initial MVR due to the periprosthetic leak. No patients required surgical reintervention or permanent pacemaker placement during long-term follow-up.

Conclusions: The tailored surgical strategy utilized for MVR in infants resulted in reliable valve function and excellent survival. Although revision is inevitable due to somatic growth, the bileaflet mechanical prostheses displayed appropriate durability.
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http://dx.doi.org/10.1186/s13019-021-01443-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010278PMC
March 2021

Three-dimensional hydrated vanadium pentoxide/MXene composite for high-rate zinc-ion batteries.

J Colloid Interface Sci 2021 Jul 9;593:417-423. Epub 2021 Mar 9.

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China. Electronic address:

Aqueous zinc-ion batteries (ZIBs) have been considered to be potential energy storage devices because of their cost-effectiveness and environmental friendliness. However, most of the cathode materials reported in ZIBs exhibit poor electrochemical performances like capacity fading during cycling and inferior performance at high current densities, which significantly hinder the further development of ZIBs. Here, we reported a novel three-dimensional hydrated vanadium pentoxide (VO·nHO)/MXene composite via a simple one-step hydrothermal method. Owing to the unique structure and high electrical conductivity of MXene, VO·nHO/TiCT MXene shows a remarkable electrochemical performance with a reversible capacity of 323 mAh g at 0.1 A g and exceptional rate capability (262 mAh g at 1 A g and 225 mAh g at 2 A g) when used as the cathode for aqueous ZIBs. This work offers a new insight into fabricating novel vanadium oxide-based cathode material for aqueous ZIBs.
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http://dx.doi.org/10.1016/j.jcis.2021.02.090DOI Listing
July 2021

Repulsive expansion dynamics in colony growth and gene expression.

PLoS Comput Biol 2021 03 18;17(3):e1008168. Epub 2021 Mar 18.

Department of Biomedical Engineering, Duke University, Durham, North Carolina.

Spatial expansion of a population of cells can arise from growth of microorganisms, plant cells, and mammalian cells. It underlies normal or dysfunctional tissue development, and it can be exploited as the foundation for programming spatial patterns. This expansion is often driven by continuous growth and division of cells within a colony, which in turn pushes the peripheral cells outward. This process generates a repulsion velocity field at each location within the colony. Here we show that this process can be approximated as coarse-grained repulsive-expansion kinetics. This framework enables accurate and efficient simulation of growth and gene expression dynamics in radially symmetric colonies with homogenous z-directional distribution. It is robust even if cells are not spherical and vary in size. The simplicity of the resulting mathematical framework also greatly facilitates generation of mechanistic insights.
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http://dx.doi.org/10.1371/journal.pcbi.1008168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009408PMC
March 2021

VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis.

Genesis 2021 Apr 7;59(4):e23415. Epub 2021 Mar 7.

Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

VPS4B (vacuolar protein sorting 4B), a member of the ATPase associated with diverse cellular activities (AAA) protein family, is a component of the endosomal sorting complexes required for transport machinery which regulates the internalization and lysosomal degradation of membrane proteins. We previously reported that VPS4B is one of the pathogenic genes related to dentin dysplasia type I, although its function was largely unknown. To investigate the role of VPS4B in tooth development, we deleted the Vps4b gene in mice. We found that heterozygous knockout mice (Vps4b ) developed normally and were fertile. However, homozygous deletion of the Vps4b gene resulted in early embryonic lethality of Vps4b mice at approximately embryonic day 9.5 (E9.5). To investigate the underlying molecular mechanisms, we examined the molecular functions of VPS4B in vivo and in vitro. Cell experiments showed that VPS4B influenced the proliferation, apoptosis, and cell cycle of transfected human neuroblastoma cells (IMR-32 cells) with over-expression or knockdown of VPS4B. Moreover, qRT-PCR detection showed that the mRNA expression levels of apoptosis-, cell cycle-, and endocytosis-related genes was significantly down or up-regulated in RNA interference-mediated knockdown of VPS4B in IMR-32 cells and Vps4b E12.5 embryos. We accordingly speculated that signal transduction disorders of cell endocytosis are a contributing factor to the prenatal lethality of Vps4b mice.
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http://dx.doi.org/10.1002/dvg.23415DOI Listing
April 2021

Comparison of Transcatheter Mitral-Valve Repair and Surgical Mitral-Valve Repair in Elderly Patients with Mitral Regurgitation.

Heart Surg Forum 2021 02 15;24(1):E108-E115. Epub 2021 Feb 15.

Department of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Purpose: To summarize comparative studies of MitraClip versus surgical repair in typical, real-world elderly patients with severe mitral regurgitation (MR) and analyze the safety and effectiveness of these therapeutic options.

Methods: PubMed, Medline, Embase, and Cochrane Controlled Register of Trials (CENTRAL) were searched for comparative studies of transcatheter mitral-valve repair (TMVR) versus surgical mitral-valve repair (SMVR) in elderly patients with severe MR from January 2000 to June 2020. Statistical pooling for incidence estimates was performed according to a random-effects model with generic inverse-variance weighting, computing risk estimates with 95% confidence intervals (CIs), using RevMan 5.3.

Results: A total of 14 reports comparing MitraClip with SMVR, enrolling 3355 patients with severe MR, were included in this study. Mean age, Logistic EuroSCORE, and incidence of diabetes mellitus (DM) were significantly higher in the MitraClip group, except the rate of patients with New York Heart Association (NYHA) class of >II and mean value of ejection fraction (EF). The arithmetic mean of freedom from acute mobility was similar. The 2 groups had equal all-cause mortality at 30 days, but different at 1 year (14% versus 9%) and 3 years in 7 studies (37% versus 25%). The freedom from recurrent MR ≥3+ was 88% and 97.3% at 30 days, 76.0% and 90.0% at 1 year, and 79% and 95% at 3 years in the MitraClip and surgical repair group, respectively.

Conclusion: Although MitraClip is safe and effective in selected high-risk patients, the surgery may be the only gold standard for "gray" patients. Further studies are needed to determine whether MitraClip should be recommended.
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http://dx.doi.org/10.1532/hsf.3433DOI Listing
February 2021

Suppressing the oxygen-related parasitic reactions in NaTi(PO)-based hybrid capacitive deionization with cation exchange membrane.

J Colloid Interface Sci 2021 Jun 8;591:139-147. Epub 2021 Feb 8.

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China. Electronic address:

The parasitic reactions leading to capacity fading and charge loss remain a serious issue for capacitive deionization (CDI). NaTi(PO) (NTP) has recently emerged as a promising faradaic cathode in hybrid CDI (HCDI) with high Na uptake capacity and good Na selectivity, but it is still challenged by serious parasitic reactions. Although the irreversible faradaic reactions on carbon electrode are raising growing attention in CDI research field, the parasitic reactions on faradaic materials are seldom studied in HCDI by now. In this work, we evaluated the parasitic reactions of NTP-reduced graphene oxide (rGO) electrode in both three-electrode mode and full-cell HCDI mode. By using deaired electrolyte, the coulombic efficiency of NTP-rGO is significantly enhanced from 75.0% to 98.2% in 3rd cycle, and the capacity retention rate is promoted from 37.5% to 80.3% at the low current density of 0.1 mA g in 100 cycles, suggesting that electrochemical reduction of oxygen and its derived reactions are the main parasitic reactions in NTP-based HCDI. In full-cell HCDI desalination tests, by introducing cation exchange membrane to block the penetration of dissolved oxygen, the parasitic reactions and pH fluctuations are successfully suppressed. The study here provides an insight into understanding and suppressing the parasitic reactions in HCDI, and should be of value to the development of efficient and stable HCDI for practical applications.
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http://dx.doi.org/10.1016/j.jcis.2021.02.013DOI Listing
June 2021

Penehyclidine mitigates postoperative nausea and vomiting and intraoperative oculocardiac reflex in patients undergoing strabismus surgery: a prospective, randomized, double-blind comparison.

BMC Anesthesiol 2021 02 13;21(1):49. Epub 2021 Feb 13.

Department of Anesthesiology and Perioperative Medicine, First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China.

Background: Postoperative nausea and vomiting (PONV) is one of the most frequent complications following strabismus surgery. Penehyclidine, an anticholinergic agent, is widely used as premedication. This study investigated the effect of preoperative penehyclidine on PONV in patients undergoing strabismus surgery.

Methods: In this prospective, randomized, double-blind study, patients scheduled for strabismus surgery under general anesthesia were randomly assigned to either penehyclidine (n = 114) or normal saline (n = 104) group. Penehyclidine was administrated immediately after anesthesia induction, and normal saline was substituted as control. PONV was investigated from 0 to 48 h after surgery. Intraoperative oculocardiac reflex (OCR) was also recorded.

Results: Compared with normal saline, penehyclidine significantly reduced PONV incidence (30.7% vs. 54.8%, P < 0.01) and mitigated PONV severity as indicated by severity scoring (P < 0.01). Compared with normal saline, penehyclidine also significantly reduced OCR incidence (57.9% vs. 77.9%, P < 0.01) and mitigated OCR severity, as indicated by the requirement for atropine rescue (77.3% vs. 90.1%, P < 0.05) and the maximum decrease of heart rate during OCR (23.1 ± 9.4 bpm vs. 27.3 ± 12.4 bpm, P < 0.05). The recovery course did not differ between groups.

Conclusions: Penehyclidine administrated after anesthesia induction significantly reduced the incidence of PONV and alleviated intraoperative OCR in patients undergoing strabismus surgery.

Trial Registration: ClinicalTrials.gov ( NCT04054479 ). Retrospectively registered August 13, 2019.
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http://dx.doi.org/10.1186/s12871-021-01266-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881589PMC
February 2021

A comparative phenotypic and genomic analysis of Clostridium beijerinckii mutant with enhanced solvent production.

J Biotechnol 2021 Mar 5;329:49-55. Epub 2021 Feb 5.

Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address:

The acetone-butanol-ethanol (ABE) fermentation by solventogenic clostridia has a long history of industrial butanol production. The Clostridium beijerinckii mutant BA101 has been widely studied for ABE fermentation owing to its enhanced butanol production capacity. Here, we characterized the BA101 mutant under controlled environmental conditions in parallel with the parental strain C. beijerinckii NCIMB 8052. To investigate the correlation between phenotype and genotype, we carried out the genome sequencing of BA101. Through comparative genomic analysis, several mutations in the genes encoding transcriptional regulator, sensor kinase, and phosphatase were identified in the BA101 genome as well as other sibling mutants. Among them, the SNP in the Cbei_3078 gene encoding PAS/PAC sensor hybrid histidine kinase was unique to the BA101 strain. The identified mutations relevant to the observed physiological behaviors of BA101 could be potential genetic targets for rational engineering of solventogenic clostridia toward desired phenotypes.
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http://dx.doi.org/10.1016/j.jbiotec.2021.02.002DOI Listing
March 2021

The effectiveness of specialized nursing interventions for patients with Parkinson disease: A randomized controlled study protocol.

Medicine (Baltimore) 2021 Jan;100(2):e23972

Department of Neurology.

Background: The purpose of this experiment is to evaluate the impact of the care of Parkinson disease nurse specialist on improving motor symptoms and life quality for patients with Parkinson disease (PD).

Method: This is a randomized controlled research, and it will be conducted from April 2021 to October 2021 at Sichuan Provincial People's Hospital. The experiment was granted through the Research Ethics Committee of Sichuan Provincial People's Hospital (004510293). All the patients suffer from PD, age 18 years or older, both female and male, regardless of the duration or severity of this disease are eligible. The exclusion criteria contains: lack sufficient knowledge to complete questionnaires, serious physical comorbidities or refuse to take part in the program. In our experiment, the major result measures are motor symptoms and life quality. For the measurement of life quality, we will utilize Parkinson disease Questionnaire-39, the most extensively utilized the scale of life quality in PD. The evaluation of motor symptoms severity is carried out with the revision of Unified Parkinson Disease Rating Scale sponsored by Movement Disorder Society.

Results: Table 1 indicates clinical outcomes at different time points.

Conclusion: The Parkinson's disease nurse specialist care may promote the life quality in the PD patients.

Trial Registration Number: researchregistry 6284.
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http://dx.doi.org/10.1097/MD.0000000000023972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808514PMC
January 2021

Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.

J Immunol 2021 02 8;206(4):677-685. Epub 2021 Jan 8.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010;

The E3 ubiquitin ligase Cbl-b has been characterized as an intracellular checkpoint in T cells; however, the function of Cbl-b in primary human NK cells, an innate immune anti-tumor effector cell, is not well defined. In this study, we show that the expression of Cbl-b is significantly upregulated in primary human NK cells activated by IL-15, IL-2, and the human NK cell-sensitive tumor cell line K562 that lacks MHC class I expression. Pretreatment with JAK or AKT inhibitors prior to IL-15 stimulation reversed Cbl-b upregulation. Downregulation of Cbl-b resulted in significant increases in granzyme B and perforin expression, IFN-γ production, and cytotoxic activity against tumor cells. Collectively, we demonstrate upregulation of Cbl-b and its inhibitory effects in IL-15/IL-2/K562-activated human NK cells, suggesting that Cbl-b plays a negative feedback role in human NK cells.
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http://dx.doi.org/10.4049/jimmunol.2000177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184061PMC
February 2021

Experimental study on static and dynamic mechanical properties of phosphogypsum.

Environ Sci Pollut Res Int 2021 Apr 4;28(14):17468-17481. Epub 2021 Jan 4.

State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing, 400044, China.

Phosphogypsum (PG) is a solid waste product of the wet-process phosphoric acid industry that accumulates in large amounts on the ground, forming PG ponds. In recent years, the amount of PG produced and discharged into ponds has increased significantly with the increase in the market demand for phosphate fertilizers. To enrich the basic knowledge of PG properties and provide basic data for the stability analysis of PG dams, a series of laboratory geotechnical tests, including permeability tests, compressibility tests, triaxial shear tests, and dynamic triaxial tests, were conducted in this study. During the preparation of the test samples, solubility and high-temperature dehydration of PG were considered. The results indicated that PG exhibits medium compressibility and medium to weak permeability characteristics. The stress-strain curves of the triaxial shear tests were divided into three typical stages: initial deformation stage, strain hardening stage, and destruction stage. With increasing dry density and consolidation confining pressure, both the shear strength and deformation modulus significantly increased. The relationship between the deformation modulus and confining pressure gradually changed from linear to logarithmic with increasing density. The liquefaction resistance curves (CSR-N curves) of PG were expressed by power functions. With increasing dry density, the curves shifted higher and became steeper. Compared with the Hardin-Drnevich model, the Davidenkov model was found to be more suitable for describing the relationship between the dynamic shear modulus ratio and damping ratio of PG and the dynamic shear strain. Furthermore, compared with those of tailings and natural soils, the engineering mechanical properties of PG were relatively poor, which may be related to its uniform particle distribution and neat particle stacking structure.
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http://dx.doi.org/10.1007/s11356-020-12148-2DOI Listing
April 2021

Construction of two-dimensional bimetal (Fe-Ti) oxide/carbon/MXene architecture from titanium carbide MXene for ultrahigh-rate lithium-ion storage.

J Colloid Interface Sci 2021 Apr 31;588:147-156. Epub 2020 Dec 31.

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China. Electronic address:

The development of battery systems with high specific capacity and power density could fuel various energy-related applications from personal electronics to grid storage. (FeTi)O possessing high theoretical specific capacity has been considered as a promising high rate anode material for lithium ion batteries due to the replacement of Fe (0.64 Å) by Ti (0.68 Å) with a larger radius to expand the interlayer space for ion intercalation. However, its extreme volume variation upon cycling as well as poor electrical conductivity hinder its further application. To tackle the above problems, in this work, we successfully synthesized two-dimensional (2D) (FeTi)O/C/MXene architecture derived from TiCT MXene via solvo-hydrothermal, ultrasound hybridizing and high temperature annealing processes. The (FeTi)O/C/MXene shows a high discharge capacity of 757.2 mAh g after 800 cycles at a current density of 3 A g with excellent rate performance. The superior electrochemical performances are triggered primarily by the incorporation of carbon and MXene into (FeTi)O moiety to construct a 2D layered structure, which can improve the ion diffusion and electron transport. In addition, the synergistic contributions from diffusion controlled and capacitive processes for (FeTi)O/C/MXene improve the ion diffusion rate and offer high specific capacity at high current density. The MXene-derived synthesis strategy in this work should be a promising pathway to synthesize other anode materials with 2D layered architecture for high performance lithium storage.
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http://dx.doi.org/10.1016/j.jcis.2020.12.071DOI Listing
April 2021

Nitrogen and sulfur co-doped vanadium carbide MXene for highly reversible lithium-ion storage.

J Colloid Interface Sci 2021 Apr 17;587:489-498. Epub 2020 Dec 17.

Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China. Electronic address:

As an emerging group of two-dimensional (2D) layered material, MXenes have received significant attention in the direction of energy storage. However, the restacking of MXene flakes severely hinders the ion transport within electrodes, which limits their application for lithium-ion batteries (LIBs). To address this issue, herein, we rationally designed and optimized the structure of N, S co-doped VCT MXene, which exhibits excellent electrochemical performance with a high reversible capacity of 590 mAh g after 100 cycles at 0.1 A g when used as anode of LIBs. Even at a high current density of 2 A g, a reversible capacity of 298 mAh g is obtained after 300 cycles, which outperforms most of the VCT-based anode materials reported so far. The lithium-ion storage mechanism of N, S co-doped VCT MXene was studied by a series of characterizations. The results show that the significant improvement of electrochemical performance should be attributed to the facilitated charge transfer after N and S co-doping in VCT MXene, which can effectively improve the ion transfer kinetics during the lithiation-delithiation process. Furthermore, the expanded interlayer spacing of N, S co-doped VCT provides more active sites for the adsorption of lithium ions, promoting the insertion capacity of lithium ions. This work indicates that the N, S co-doped 2D VCT MXene should be a promising anode material for high-performance LIBs.
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http://dx.doi.org/10.1016/j.jcis.2020.12.044DOI Listing
April 2021