Publications by authors named "Ting Han"

293 Publications

Investigating socially assistive systems from system design and evaluation: a systematic review.

Univers Access Inf Soc 2021 Nov 15:1-25. Epub 2021 Nov 15.

Department of Design, Shanghai Jiao Tong University, Shanghai, 800 Dongchuan RD. Minhang District China.

The development of assistive technologies that support people in social interactions has attracted increased attention in HCI. This paper presents a systematic review of studies of Socially Assistive Systems targeted at older adults and people with disabilities. The purpose is threefold: (1) Characterizing related assistive systems with a special focus on the system design, primarily including HCI technologies used and user-involvement approach taken; (2) Examining their ways of system evaluation; (3) Reflecting on insights for future design research. A systematic literature search was conducted using the keywords "social interactions" and "assistive technologies" within the following databases: Scopus, Web of Science, ACM, Science Direct, PubMed, and IEEE Xplore. Sixty-five papers met the inclusion criteria and were further analyzed. Our results showed that there were 11 types of HCI technologies that supported social interactions for target users. The most common was cognitive and meaning understanding technologies, often applied with wearable devices for compensating users' sensory loss; 33.85% of studies involved end-users and stakeholders in the design phase; Four types of evaluation methods were identified. The majority of studies adopted laboratory experiments to measure user-system interaction and system validation. Proxy users were used in system evaluation, especially in initial experiments; 42.46% of evaluations were conducted in field settings, primarily including the participants' own homes and institutions. We contribute an overview of Socially Assistive Systems that support social interactions for older adults and people with disabilities, as well as illustrate emerging technologies and research opportunities for future work.
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http://dx.doi.org/10.1007/s10209-021-00852-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591319PMC
November 2021

Two phenanthroimidazole turn-on probes for the rapid detection of selenocysteine and its application in living cells imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Nov 6:120585. Epub 2021 Nov 6.

Key Laboratory of Theoretical Organic Chemistry and Function Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China. Electronic address:

Detection of selenocysteine (Sec) content in cells by fluorescence probe is of great significance for the identification of human related diseases. To achieve fast and sensitive detection of Sec, two isomers A4 and B4 as turn-on fluorescent probes to detect Sec were designed and synthesized. Both A4 and B4 display fast turn-on response, high selectivity and sensitivity toward Sec, which can be applied for fluorescence imaging of Sec in living cells. Compared with B4, A4 has a larger Stokes shift (125 nm), wider pH range (5-10) and lower detection limit (65.4 nM) due to its ESIPT (excited state intramolecular proton transfer) effect. In view of the detection performance of these two probes, they can be used as effective tools for detecting Sec in biological systems.
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http://dx.doi.org/10.1016/j.saa.2021.120585DOI Listing
November 2021

Natural products for the treatment of stress-induced depression: Pharmacology, mechanism and traditional use.

J Ethnopharmacol 2021 Nov 3:114692. Epub 2021 Nov 3.

Department of Pharmacognosy, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address:

Ethnopharmacological Relevance: Depression, one of the most common psychiatric disorders, is the fourth leading cause of long-term disability worldwide. A series of causes triggered depression, including psychological stress and conflict, as well as biological derangement, among which stress has a pivotal role in the development of depression. Traditional herbal medicine has been used for the treatment of various disorders including depression for a long history with multi-targets, multi-levels and multi-ways, attracting great attention from scholars. Recently, natural products have been commercialized as antidepressants which have become increasingly popular in the world health drug markets. Major research contributions in ethnopharmacology have generated and updated vast amount of data associated with natural products in antidepressant-like activity.

Aims Of The Review: This review aims to briefly discuss the pathological mechanism, animal models of stress-induced depression, traditional use of herbal medicines and especially recapitulate the natural products with antidepressant activity and their pharmacological functions and mechanism of action, which may contribute to a better understanding of potential therapeutic effects of natural products and the development of promising drugs with high efficacy and low toxicity for the treatment of stress-induced depression.

Materials And Methods: The contents of this review were sourced from electronic databases including PubMed, Sci Finder, Web of Science, Science Direct, Elsevier, Google Scholar, Chinese Knowledge On frastructure (CNKI), Wan Fang, Chinese Scientific and Technological Periodical Database (VIP) and Chinese Biomedical Database (CBM). Additional information was collected from Yao Zhi website (https://db.yaozh.com/). Data were obtained from April 1992 to June 2021. Only English language was applied to the search. The search terms were 'stress-induced depression', 'pathological mechanism' in the title and 'stress', 'depression', 'animal model' and 'natural products' in the whole text.

Results: Stress-induced depression is related to the monoaminergic system, hypothalamic-pituitary-adrenal (HPA) axis, neuronal plasticity and a series of inflammatory factors. Four main types of animal models of stress-induced depression were represented. Fifty-eight bioactive phytochemical compounds, fifty-six herb medicines and five formulas from traditional Chinese medicine were highlighted, which exert antidepressant effects by inhibiting monoamine oxidase (MAO) reaction, alleviating dysfunction of the HPA axis and nerve injury, and possessing anti-inflammatory activities.

Conclusions: Natural products provide a large number of compounds with antidepressant-like effects, and their therapeutic impacts has been highlighted for a long time. This review summarized the pathological mechanism and animal models of stress-induced depression, and the natural products with antidepressant activity in particular, which will shed light on the action mechanism and clinical potential of these compounds. Natural products also have been a vital and promising source for future antidepressant drug discovery.
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http://dx.doi.org/10.1016/j.jep.2021.114692DOI Listing
November 2021

In Situ Generation of Heterocyclic Polymers by Triple-Bond Based Polymerizations.

Macromol Rapid Commun 2021 Oct 15:e2100524. Epub 2021 Oct 15.

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Institute of Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Stemming from unique ring structures, heterocyclic polymers exhibit distinguished electrical, mechanical, and photophysical properties and have been widely used in a variety of important applications. Along with the technological significance are the challenges in their synthesis. Traditional synthetic strategies toward heterocyclic polymers often require the direct attachment of heterocycles to polymer backbones, which are generally limited by the lack of suitable and low-cost heterocyclic monomers, tedious reaction process, difficulties in incorporation of multiple substitutents, etc. Alternatively, in situ construction of heterocyclic polymers via triple-bond based polymerization offers promising prospects. This review summarized the recent progress on polymerizations of triple-bond based monomers including alkynes, nitriles, and isonitriles that can in situ generate heterocyclic polymers. The properties and advanced applications of the derived heterocyclic polymers will also be discussed. Finally, the future perspectives and challenges in this field will be addressed.
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http://dx.doi.org/10.1002/marc.202100524DOI Listing
October 2021

A Facile Strategy of Boosting Photothermal Conversion Efficiency through State Transformation for Cancer Therapy.

Adv Mater 2021 Oct 14:e2105999. Epub 2021 Oct 14.

Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China.

Improving photothermal conversion efficiency (PCE) is critical to facilitate therapeutic performance during photothermal therapy (PTT). However, current strategies of prompting PCE always involve complex synthesis or modification of photothermal agents, thereby significantly inhibiting the practical applications and fundamental understanding of photothermal conversion. A facile strategy is herein present for boosting PCE by transforming photothermal agents from aggregated state to dispersed state. Compared to aggregated state, the developed photothermal agents with semiconducting nature can rotate freely in dispersed state, which allows for an efficient nonradiative dissipation through twisted intramolecular charge transfer (TICT) effect, consequentially offering excellent photothermal performance. Noteworthy, the state transformation can be achieved by virtue of releasing photothermal molecules from nanoparticles on the basis of a pH-responsive polymer nanocarrier, and the PCE is elevated from 43% to 60% upon changing the pH values from 7.4 to 5.0. Moreover, the nanoparticle disassembly and state transformation behaviors can also smoothly proceed in lysosome of cancer cells, demonstrating a distinct photothermal therapeutic performance for cancer ablation. It is hoped that this strategy of transforming state to boost PCE would be a new platform for practical applications of PTT technique.
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http://dx.doi.org/10.1002/adma.202105999DOI Listing
October 2021

Flashing light alleviates photoinhibition and promotes biomass concentration in purple non- sulfur bacteria wastewater treatment.

Bioresour Technol 2022 Jan 9;343:126107. Epub 2021 Oct 9.

Nan Tong Ju Yi Cheng Guang Biotechnology Co. LTD., Nantong 226321, PR China.

High light is beneficial for purple non-sulfur bacteria (PNSB) growth. However, excessive light causes photoinhibition. In this novel study, flashing light was used to alleviate photoinhibition and promote biomass growth in PNSB wastewater treatment. Results showed that flashing light effectively increased biomass production. The highest biomass concentration (2688.8 mg/L) and chemical oxygen demand removal (in 177 μmol/m/s-0.75 duty cycle-1000 Hz group) were 41.5% and 28.4% higher than that in the constant stress light group (same incident light). This group also increased biomass concentration by 21.3% and reduced energy consumption by 26.2% compared with the constant normal light group (same energy input). The shortened single light provision time of flashing light increased the relative electron transportation rate by 116.6%, avoiding photoinhibition, promoting energy utilisation, and enhancing substance synthesis. Flashing light can be used as a light regulation strategy to enhance biomass accumulation and reduce energy consumption in PNSB-based industries.
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http://dx.doi.org/10.1016/j.biortech.2021.126107DOI Listing
January 2022

Aggregation-Induced Emission-Active Poly(phenyleneethynylene)s for Fluorescence and Raman Dual-Modal Imaging and Drug-Resistant Bacteria Killing.

Adv Healthc Mater 2021 Oct 4:e2101167. Epub 2021 Oct 4.

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.

Poly(phenyleneethynylene) (PPE) is a widely used functional conjugated polymer with applications ranging from organic optoelectronics and fluorescence sensors to optical imaging and theranostics. However, the fluorescence efficiency of PPE in aggregate states is generally not as good as their solution states, which greatly compromises their performance in fluorescence-related applications. Herein, a series of PPE derivatives with typical aggregation-induced emission (AIE) properties is designed and synthesized. In these PPEs, the diethylamino-substituted tetraphenylethene units function as the long-wavelength AIE source and the alkyl side chains serve as the functionalization site. The obtained AIE-active PPEs with large π-conjugation show strong aggregate-state fluorescence, interesting self-assembly behaviors, inherently enhanced alkyne vibrations in the Raman-silent region of cells, and efficient antibacterial activities. The PPE nanoparticles with good cellular uptake capability can clearly and sensitively visualize the tumor region and residual tumors via their fluorescence and Raman signals, respectively, to benefit the precise tumor resection surgery. After post-functionalization, the obtained PPE-based polyelectrolyte can preferentially image bacteria over mammalian cells and possesses efficient photodynamic killing capability against Gram-positive and drug-resistant bacteria. This work provides a feasible design strategy for developing functional conjugated polymers with multimodal imaging capability as well as photodynamic antimicrobial ability.
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http://dx.doi.org/10.1002/adhm.202101167DOI Listing
October 2021

CHPF promotes gastric cancer tumorigenesis through the activation of E2F1.

Cell Death Dis 2021 09 25;12(10):876. Epub 2021 Sep 25.

Department of Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.

Chondroitin polymerizing factor (CHPF) is an important glycosyltransferase involved in the biosynthesis of chondroitin sulfate. However, the relationship between CHPF and gastric cancer has not been fully investigated. CHPF expression in gastric cancer tissues was detected by immunohistochemistry and correlated with gastric cancer patient prognosis. Cultured gastric cancer cells and human gastric epithelial cell line GES1 were used to investigate the effects of shCHPF and shE2F1 on the development and progression of gastric cancer by MTT, western blotting, flow cytometry analysis of cell apoptosis, colony formation, transwell and gastric cancer xenograft mouse models, in vitro and in vivo. In gastric cancer tissues, CHPF was found to be significantly upregulated, and its expression correlated with tumor infiltration and advanced tumor stage and shorter patient survival in gastric cancer. CHPF may promote gastric cancer development by regulating cell proliferation, colony formation, cell apoptosis and cell migration, while knockdown induced the opposite effects. Moreover, the results from in vivo experiments demonstrated that tumor growth was suppressed by CHPF knockdown. Additionally, E2F1 was identified as a potential downstream target of CHPF in the regulation of gastric cancer, and its knockdown decreased the CHPF-induced promotion of gastric cancer. Mechanistic study revealed that CHPF may regulate E2F1 through affecting UBE2T-mediated E2F1 ubiquitination. This study showed, for the first time, that CHPF is a potential prognostic indicator and tumor promoter in gastric cancer whose function is likely carried out through the regulation of E2F1.
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http://dx.doi.org/10.1038/s41419-021-04148-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464597PMC
September 2021

Author Correction: BDNF contributes to IBS-like colonic hypersensitivity via activating the enteroglia-nerve unit.

Sci Rep 2021 Sep 21;11(1):19139. Epub 2021 Sep 21.

Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China.

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http://dx.doi.org/10.1038/s41598-021-98826-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455588PMC
September 2021

Highly stable fluorescent probe based on mesoporous silica coated quantum dots for sensitive and selective detection of Cd.

Nanotechnology 2021 Oct 6;32(50). Epub 2021 Oct 6.

Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Luoshi Road 122, Wuhan 430070, People's Republic of China.

Cadmium ions have been of crucial concern due to the high biological toxicity and serious environmental risks. Various fluorescent Cd-sensitive probes have been reported with improved sensing properties, but still severely suffer from poor stability and insufficient selectivity. In this work, a stable fluorescent probe based on silica encapsulated quantum dots (QDs) have been developed for rapid, sensitive and selective detection of cadmium ion. To improve fluorescence stability, the strategy of mesoporous silica encapsulation was adopted, in which the mesoporous silica shell offers numerous channels for Cd. Further, the Forster Resonance Energy Transfer (FRET) system, where [email protected] rhodamine B (RB) are used as donors and acceptors respectively, has been constructed, in which the mesoporous silica shell also serves as spacers with tunable thickness for controlling the QD-RB distance. Under optimal conditions, the probes possess a sensitive fluorescence response with a detection limit of 1.25M. Visual detection can be realized by the obvious fluorescence changes of the FRET system. In addition, the FRET system shows promising sensing performances both in tap water samples and rice-washed water samples, confirming a great potential for practical application.
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http://dx.doi.org/10.1088/1361-6528/ac280fDOI Listing
October 2021

Identification of novel survival-related lncRNA-miRNA-mRNA competing endogenous RNA network associated with immune infiltration in colorectal cancer.

Am J Transl Res 2021 15;13(6):5815-5834. Epub 2021 Jun 15.

Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University Luzhou 646000, Sichuan, P. R. China.

Increasing studies have reported that long noncoding RNAs (lncRNAs) play critical roles in the initiation and progression of carcinogenesis. However, the underlying regulatory mechanisms of lncRNA-related competing endogenous RNA (ceRNA) network in colorectal cancer (CRC) are not fully understood. In the present study, we systematically analyzed the expression levels and prognostic values of dysregulated microRNAs (miRNAs) in human CRC to identify novel survival-related lncRNA-miRNA-mRNA ceRNA regulatory network. As a result, 28 dysregulated miRNAs were obtained, and hsa-miR-195-5p was identified as a key oncogene in human CRC based on analyses of expression levels and prognostic values. By means of stepwise prediction and validation, two upstream lncRNAs (NEAT1, XIST) and eight downstream mRNAs (ACOX1, CYP26B1, IRF4, ITPR1, LITAF, PHLPP2, RECK, and TPM2) were identified as key genes that interact with hsa-miR-195-5p. A ceRNA regulatory network consisted of these key genes was constructed, and Gene Set Enrichment Analysis (GSEA) indicated the possible association of key mRNAs with CRC onset and progression. Importantly, immune infiltration analysis revealed that the ceRNA network was remarkably associated with infiltration abundance of multiple immune cells and expression levels of immune checkpoints. These findings indicate that NEAT1 and XIST are potential prognostic factors that affect CRC onset and progression by targeting miR-195-5p.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290742PMC
June 2021

Significant Improvements in Dielectric Constant and Energy Density of Ferroelectric Polymer Nanocomposites Enabled by Ultralow Contents of Nanofillers.

Adv Mater 2021 Sep 24;33(35):e2102392. Epub 2021 Jul 24.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Polymer dielectrics with excellent processability and high breakdown strength (E ) enable the development of high-energy-density capacitors. Although the improvement of dielectric constant (K) of polymer dielectric has been realized by adding high-K inorganic fillers with high contents (>10 vol%), this approach faces significant challenges in scalable film processing. Here, the incorporation of ultralow ratios (<1 vol%) of low-K Cd Zn Se S nanodots into a ferroelectric polymer is reported. The polymer composites exhibit substantial and concurrent increase in both K and E , yielding a discharged energy density of 26.0 J cm , outperforming the current dielectric polymers and nanocomposites measured at ≤600 MV m . The observed unconventional dielectric enhancement is attributed to the structural changes induced by the nanodot fillers, including transformation of polymer chain conformation and induced interfacial dipoles, which have been confirmed by density function theory calculations. The dielectric model established in this work addresses the limitations of the current volume-average models on the polymer composites with low filler contents and gives excellent agreement to the experimental results. This work provides a new experimental route to scalable high-energy-density polymer dielectrics and also advances the fundamental understanding of the dielectric behavior of polymer nanocomposites at atomistic scales.
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http://dx.doi.org/10.1002/adma.202102392DOI Listing
September 2021

Heterogeneous Degradation in Thick Nickel-Rich Cathodes During High-Temperature Storage and Mitigation of Thermal Instability by Regulating Cationic Disordering.

Small 2021 Aug 19;17(34):e2102055. Epub 2021 Jul 19.

Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center, Tsinghua Shenzhen International Graduate School, Shenzhen, 518055, China.

The thermal instability is a major problem in high-energy nickel-rich layered cathode materials for large-scale battery application. Due to the scarce investigation of thick electrodes at the practical full-cell level, the understanding of thermal failure mechanism is still insufficient. Herein, an intrinsic origin of thermal instability in fully charged industrial pouch cells during high-temperature storage is discovered. Through the investigation from crystals to particles, and from electrodes to cells, it is shown that serious top-down heterogeneous degradation occurs along the depth direction of the thick electrode, including phase transition, cationic disordering, intergranular/intragranular cracks, and side reactions. Such degradation originates from the abundant oxygen vacancies and reduced catalytic Ni at cathode surface, causing microstructural defects and directly leading to the thermal instability. Nonmagnetic elements doping and surface modification are suggested to be effective in mitigating the thermal instability through modulating cationic disordering.
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http://dx.doi.org/10.1002/smll.202102055DOI Listing
August 2021

A phase I study of the safety and activity of K-001 in patients with advanced pancreatic ductal adenocarcinoma.

BMC Cancer 2021 Jun 7;21(1):672. Epub 2021 Jun 7.

Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study aimed to evaluate safety and antitumor activity of K-001 in patients with advanced PDAC.

Methods: In this phase I, open-label trial, patients with advanced PDAC were recruited to a dose-escalation study in a standard 3 + 3 design. K-001 was administered twice daily in four-week cycles, and dose escalation from 1350 mg to 2160 mg was evaluated twice daily. Physical examination and laboratory tests were done at screening and then weekly. The safety, dose-limiting toxicity (DLT), and maximum tolerated dose (MTD) of K-001 were assessed while tumor response was estimated by Response Evaluation Criteria in Solid Tumor (RECIST).

Results: Eighteen patients with advanced PDAC were screened, and twelve eligible patients were analyzed in the study. No DLT was observed. Totally, 47 adverse events (AEs) presented, and 14 drug-related AEs were reported in 7 patients, including 8 grade 1 events (57.1%) and 6 grade 2 events (42.9%). There was no grade 3 or 4 drug-related AE. In these 14 drug-related AEs, the most frequent ones were dyspepsia (21.4%), followed by flatulence, constipation, and hemorrhoid bleeding (above 10% of each). Among all 12 patients, 10 patients (83.3%) maintained stable disease (SD), and 2 patients (16.7%) had progressive disease (PD). The objective response rate (ORR) was 0% and the disease control rate (DCR) was 83.3%.

Conclusions: K-001 manifests satisfactory safety and tolerability, as well as meaningful antitumor activity in advanced PDAC patients. Further evaluation of K-001 in phase II/III appears warranted.

Trial Registration: NCT02720666 . Registered 28 Match 2016 - Retrospectively registered.
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http://dx.doi.org/10.1186/s12885-021-08375-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183060PMC
June 2021

Effects of nano metal oxide particles on activated sludge system: Stress and performance recovery mechanism.

Environ Pollut 2021 Sep 19;285:117408. Epub 2021 May 19.

School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, China; School of Environmental and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:

Nano metal oxide particles (NMOPs) are widely used in daily life because of their superior performance, and inevitably enter the sewage treatment system. Pollutants in sewage are adsorbed and degraded in wastewater treatment plants (WWTPs) depending on the microbial aggregates of activated sludge system to achieve sewage purification. NMOPs may cause ecotoxicity to the microbial community and metabolism due to their complex chemical behavior, resulting in a potential threat to the safe and steady operation of activated sludge system. It is of great significance to clarify the influencing mechanism of NMOPs on activated sludge system and reduce the risk of WWTPs. Herein, we first introduce the physicochemical behavior of six typical engineering NMOPs including ZnO, TiO, CuO, CeO, MgO, and MnO in water environment, then highlight the principal mechanisms of NMOPs for activated sludge system. In particular, the performance recovery mechanisms of activated sludge systems in the presence of NMOPs and their future development trends are well documented and discussed extensively. This review can provide a theoretical guidance and technical support for predicting and evaluating the potential threat of NMOPs on activated sludge systems, and promoting the establishment of effective control strategies and performance recovery measures of biological wastewater treatment process under the stress of NMOPs.
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http://dx.doi.org/10.1016/j.envpol.2021.117408DOI Listing
September 2021

Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.

Front Pharmacol 2021 29;12:676589. Epub 2021 Apr 29.

Department of Pharmacy, Second Military Medical University, Shanghai, China.

The α7 nicotinic acetylcholine receptor (α7nAChR) belongs to the superfamily of cys loop cationic ligand-gated channels, which consists of homogeneous α7 subunits. Although our lab found that activation of α7nAChR could alleviate ischemic stroke, the mechanism is still unknown. Herein, we explored whether autophagy is involved in the neuroprotective effect mediated by α7nAChR in ischemic stroke. Transient middle cerebral artery occlusion (tMCAO) and oxygen and glucose deprivation (OGD/R) exposure were applied to and models of ischemic stroke, respectively. Neurological deficit score and infarct volume were used to evaluate outcomes of tMCAO in the study. Autophagy-related proteins were detected by Western blot, and autophagy flux was detected by using tandem fluorescent mRFP-GFP-LC3 lentivirus. At 24 h after tMCAO, α7nAChR knockout mice showed worse neurological function and larger infarct volume than wild-type mice. PNU282987, an α7nAChR agonist, protected against OGD/R-induced neuronal injury, enhanced autophagy, and promoted autophagy flux. However, the beneficial effects of PNU282987 were eliminated by 3-methyladenine (3-MA), an autophagy inhibitor. Moreover, we found that PNU282987 treatment could activate the AMPK-mTOR-p70S6K signaling pathway in the study, while the effect was attenuated by compound C, an AMPK inhibitor. Our results demonstrated that the beneficial effect on neuronal survival via activation of α7nAChR was associated with enhanced autophagy, and the AMPK-mTOR-p70S6K signaling pathway was involved in α7nAChR activation-mediated neuroprotection.
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http://dx.doi.org/10.3389/fphar.2021.676589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117007PMC
April 2021

Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways.

J Pharm Pharmacol 2021 Aug;73(9):1230-1239

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, ShanghaiChina.

Objectives: Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. In this study, we investigated whether Xanthohumol could ameliorate memory impairment of APP/PS1 mice, and explored its potential mechanism of action.

Methods: APP/PS1 mice were used for in vivo test and were treated with N-acetylcysteine and Xanthohumol for 2 months. Learning and memory levels were evaluated by the Morris water maze. Inflammatory and oxidative markers in serum and hippocampus and the deposition of Aβ in the hippocampus were determined. Moreover, the expression of autophagy and apoptosis proteins was also evaluated by western blot.

Key Findings: Xanthohumol significantly reduced the latency and increased the residence time of mice in the target quadrant. Additionally, Xanthohumol increased superoxide dismutase level and reduced Interleukin-6 and Interleukin-1β levels both in serum and hippocampus. Xanthohumol also significantly reduced Aβ deposition in the hippocampus and activated autophagy and anti-apoptotic signals.

Conclusions: Xanthohumol effectively ameliorates memory impairment of APP/PS1 mice by activating mTOR/LC3 and Bax/Bcl-2 signalling pathways, which provides new insight into the neuroprotective effects of Xanthohumol.
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http://dx.doi.org/10.1093/jpp/rgab052DOI Listing
August 2021

LINC00665 activates Wnt/β-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1.

Exp Mol Pathol 2021 06 16;120:104639. Epub 2021 Apr 16.

Department of Clinical Nutrition, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Background LINC00665 is a newly identified oncogene, which has been reported to be oncogene in various cancers. Nevertheless, its role in the progression of colorectal cancer (CRC) remains obscure to the extent. This study aimed at exploring the role and mechanism of LINC00665 in CRC progression. Materials and methods RNA and protein expression were detected via qRT-PCR and western blot. Functional assays were conducted to investigate the role of LINC00665 in the CRC cellular processes. TOP/FOP assay was performed to detect the activity of Wnt/β-catenin signaling pathway. Mechanism investigations were carried out to explore the regulatory relationship among genes. Results LINC00665 was overtly expressed in CRC cell lines at high levels. Functionally, silencing of LINC00665 could curb in vitro CRC cell growth, migration and invasion, while stimulating cell apoptosis. Mechanically, LINC00665 sponged miR-214-3p to up-regulate CTNNB1 expression, consequently activating Wnt/β-catenin signaling pathway. Furthermore, LINC00665 could bind to U2AF2 and enhance the association between U2AF2 and CTNNB1, increasing the stability of CTNNB1. CTNNB1 overexpression could reverse the suppressive effects of LINC00665 downregulation. Conclusion LINC00665 stimulates CRC progression through the activation of Wnt/β-catenin signaling pathway, which hopefully might be a therapeutic target for CRC.
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http://dx.doi.org/10.1016/j.yexmp.2021.104639DOI Listing
June 2021

Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in .

Front Plant Sci 2021 24;12:622011. Epub 2021 Feb 24.

School of Pharmacy, Second Military Medical University, Shanghai, China.

Bunge is a common Chinese herbal medicine, and its major active ingredients are phenolic acids and tanshinones, which are widely used to treat vascular diseases. However, the wild form of possess low levels of these important pharmaceutical agents; thus, improving their levels is an active area of research. Transcription factors, which promote or inhibit the expressions of multiple genes involved in one or more biosynthetic pathways, are powerful tools for controlling gene expression in biosynthesis. Several families of transcription factors have been reported to participate in regulating phenolic acid and tanshinone biosynthesis and influence their accumulation. This review summarizes the current status in this field, with focus on the transcription factors which have been identified in recent years and their functions in the biosynthetic regulation of phenolic acids and tanshinones. Otherwise, the new insight for further research is provided. Finally, the application of the biosynthetic regulation of active ingredients by the transcription factors in are discussed, and new insights for future research are explored.
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http://dx.doi.org/10.3389/fpls.2021.622011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943460PMC
February 2021

Bumpy structured nanofibrous membrane as a highly efficient air filter with antibacterial and antiviral property.

Sci Total Environ 2021 Jul 15;777:145768. Epub 2021 Feb 15.

Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China. Electronic address:

Recently, the pandemic infectious diseases caused by coronavirus have prompted the development of air filter membranes to against infectious agents and protect human health. This research focuses on air filter membrane with antibacterial and antiviral property for high-efficiency particulate matter (PM) removal. Herein, polyamide-6 electrospun nanofibers were anchored with silver nanoparticles through hydrogen-bond. Bumpy nanorough surface and multilevel structure contribute to improve capture capacity, and silver nanoparticles provide a strong ability to inactivate bacteria and virus. In conclusion, this membrane exhibits high PM filtration efficiency of 99.99% and low pressure drop of 31 Pa; simultaneous removal of multiple aerosol pollutants, e.g., SO, NO, methylbenzene, L-Nicotine; superior antibacterial performance against Escherichia coli (Gram negative bacteria) and Staphylococcus aureus (Gram positive bacteria), antiviral property against Porcine Deltacoronavirus and not significant cytotoxicity. Research of air filtration material is important to remove air pollutants and to prevent infection and spread of respiratory infectious diseases.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954306PMC
July 2021

Regulating metal-organic frameworks as stationary phases and absorbents for analytical separations.

Anal Methods 2021 03 25;13(11):1318-1331. Epub 2021 Feb 25.

Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.

Metal-organic frameworks (MOFs) are highly ordered framework systems composed of metal centers and organic linkers formed through coordination bonds. The diversity of metal elements and easily modified organic ligands, together with controllable synthetic approaches, gives rise to the designability of various MOF structures and topologies and the capability of MOFs to be functionalized. Their structural diversity provides MOFs with many unique properties, such as permanent porosity, flexible structures, thermostability, and high adsorption capacity, leading to great practicability in technical applications. In this review, we concentrate on the applications of MOFs in the field of gas chromatography, high-performance liquid chromatography, and the enrichment of biomolecules, based on rational arrangements in the structures and functions of MOFs. Moreover, we emphasize the importance of structural and chemical regulations for the improvement of separation efficiency.
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http://dx.doi.org/10.1039/d0ay02310hDOI Listing
March 2021

Interactions between cerium dioxide nanoparticles and humic acid: Influence of light intensities and molecular weight fractions.

Environ Res 2021 04 15;195:110861. Epub 2021 Feb 15.

School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:

Cerium dioxide nanoparticles (CeO NPs) are ubiquitous in the water environment due to the extensive commercial applications. The complexity of heterogeneous humic acid (HA) plays a significant role in affecting the physicochemical properties of CeO NPs in aqueous environments. However, the effects of light intensities and HA fractions on the interaction mechanism between CeO NPs and HA are poorly understood. Here, we provided the evidence that both light intensities (>3 E L s) and molecular weights (>10 kDa) can effectively affect the interactions between CeO NPs and HA. The absolute content of reactive oxygen species (ROS) and quantum yield (Φ) of HA* were inhibited when HA (10 mg of C L) interacts with CeO NPs. However, they were positively correlated with the increasing irradiation time and simulated sunlight intensities. High molecular weights of HA fraction (>100 kDa) restrained the ROS generation and Φ of HA* due to surface adsorption between HA and CeO NPs blocking reactive sites, competitive absorption for simulated sunlight. Fourier transform infrared and three-dimensional excitation-emission matrix fluorescence spectroscopy confirmed that the carboxylic groups of HA have high complexation capacity with CeO NPs. These findings are essential for us to improve the understanding of the impacts of HA on CeO NPs under different conditions in natural waters.
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http://dx.doi.org/10.1016/j.envres.2021.110861DOI Listing
April 2021

Magnetoelectric effect in flexible nanocomposite films based on size-matching.

Nanoscale 2021 Feb;13(7):4177-4187

Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China. and School of Materials Science and Engineering, Wuhan University of Technology, 430070, Wuhan, China.

Flexible magnetoelectric (ME) nanocomposites with a strong coupling between ferromagnetism and ferroelectricity are of significant importance from the point of view of next-generation flexible electronic devices. However, a high loading of magnetic nanomaterials is needed to achieve preferable ME response due to the size mismatch of the magnetostrictive phase and piezoelectric phase. In this work, ultra-small CoFe2O4 nanoparticles were prepared to match the size of the polar crystal in poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)), and 1H,1H,2H,2H-perfluorooctyltriethoxysilane (POTS) is introduced to enhance the interplay between P(VDF-TrFE) and CoFe2O4. The above multiple effects promote a good connection between the magnetostrictive phase and the piezoelectric phase. Therefore, an effective transference of stress from CoFe2O4 to P(VDF-TrFE) can be achieved. The as-prepared P(VDF-TrFE)/[email protected] exhibits a high ME coupling coefficient of 34 mV cm-1 Oe-1 when the content of [email protected] is 20 wt%. The low loading of fillers ensures the flexibility of ME nanocomposite films.
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http://dx.doi.org/10.1039/d0nr08544hDOI Listing
February 2021

Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng.

Biomed Pharmacother 2021 Apr 20;136:111280. Epub 2021 Jan 20.

Center of TCM Processing Research, Beijing University of Chinese Medicine, Higher Education Park, Fangshan District, Beijing, 102488, China; Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica, Beijing University of Chinese Medicine, Higher Education Park, Fangshan District, Beijing, 102488, China. Electronic address:

Ginseng has been widely applied in clinical practice, but the cultivation age cannot be ignored as it influences the quality of ginseng and its products. In this work, different cultivation ages of fresh ginseng (FG) from four to seven years were analysed by UPLC-Q-TOF-MS/MS. Principal component analysis and supervised orthogonal partial least squared discrimination analysis, which belong to the normal method of multivariate statistical analysis, were applied to discover the characteristic components of FG at different cultivation ages. The components of new type of red ginseng (NRG) derived from FG at different cultivation ages were compared by HPLC analysis. The pharmacological anti-inflammatory activity was evaluated by ELISA and qPCR. The result showed that the characteristic components of both 6- and 7-year-old ginseng were ginsenoside Rb1, mal-ginsenoside Rb1, ginsenoside Rc, mal-ginsenoside Rc, mal-ginsenoside Rb1 isomer, and mal-ginsenoside Rb2. Moreover, the characteristic components of both 4- and 5-year-old ginseng were ADP-glucose and 3-hydroxyhexanoyl CoA. In addition, 6-year-old NRG has higher rare ginsenosides than 4-year-old NRG, which possesses great anti-inflammatory activity in vitro. The results reveal the ginsenoside transformation law of NRG processing and suggest that the cultivation age of FG influences the content of ginsenosides in NRG. Therefore, 6-year-old ginseng is more suitable for red ginseng processing and clinical use.
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http://dx.doi.org/10.1016/j.biopha.2021.111280DOI Listing
April 2021

Functional Polymer Systems with Aggregation-Induced Emission and Stimuli Responses.

Top Curr Chem (Cham) 2021 Jan 11;379(1). Epub 2021 Jan 11.

Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.

Functional polymer systems with stimuli responses have attracted great attention over the years due to their diverse range of applications. Such polymers are capable of altering their chemical and/or physical properties, such as chemical structures, chain conformation, solubility, shape, morphologies, and optical properties, in response to single or multiple stimuli. Among various stimuli-responsive polymers, those with aggregation-induced emission (AIE) properties possess the advantages of high sensitivity, fast response, large contrast, excellent photostability, and low background noise. The changes in fluorescence signal can be conveniently detected and monitored using portable instruments. The integration of AIE and stimuli responses into one polymer system provides a feasible and effective strategy for the development of smart polymers with high sensitivity to environmental variations. Here, we review the recent advances in the design, preparation, performance, and applications of functional synthetic polymer systems with AIE and stimuli responses. Various AIE-based polymer systems with responsiveness toward single physical or chemical stimuli as well as multiple stimuli are summarized with specific examples. The current challenges and perspectives on the future development of this research area will also be discussed at the end of this review.
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http://dx.doi.org/10.1007/s41061-020-00321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797498PMC
January 2021

Lipid Metabolic Disorders and Ovarian Hyperstimulation Syndrome: A Retrospective Analysis.

Front Physiol 2020 19;11:491892. Epub 2020 Nov 19.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objectives: To evaluate the effect of dyslipidemia on the incidence of moderate and severe Ovarian hyperstimulation syndrome (OHSS) in the duration of assisted reproduction technique (ART).

Methods: The study included 233 moderate and severe OHSS patients who received hospitalization after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles to avoid severe complications. They were divided into dyslipidemia group and normal lipid metabolism group to evaluate whether dyslipidemia contributes to the development of severe OHSS. Subgroup analysis was set to avoid deviation including the freeze-all group and fresh embryo transfer (ET) group according to whether the eligible women chose fresh embryo transfer immediately after their IVF or ICSI cycles. The main outcome measures included the incidence of moderate OHSS and severe OHSS, total gonadotropin dose, number of oocytes retrieved, age and body mass index (BMI). In the ET groups, the rate of pregnancy is also included for analysis.

Results: In the freeze-all group, lipid metabolism was ultimately identified as the factor affecting the morbidity of severe OHSS and the ones with dyslipidemia were more likely to develop to severe OHSS ( < 0.05), while the incidence of severe OHSS among the ET groups had no statistical significance ( > 0.05).

Conclusion: The findings of this study suggested that dyslipidemia might contribute to the development of OHSS, especially for those patients who chose the cryopreservation of all embryos. It is essential to consider the risk of OHSS in patients with dyslipidemia although they required cryopreservation of all embryos.
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http://dx.doi.org/10.3389/fphys.2020.491892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711040PMC
November 2020

Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma.

Cancer Biol Med 2020 11 15;17(4):953-969. Epub 2020 Dec 15.

Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

Objective: Pancreatic ductal adenocarcinoma (PDAC) is a disease with high mortality. Many so-called "junk" noncoding RNAs need to be discovered in PDAC. The purpose of this study was therefore to investigate the function and regulatory mechanism of the long noncoding RNA MEG3 in PDAC.

Methods: The Gene Expression Omnibus database (GEO database) was used to determine the differential expression of long noncoding RNAs in PDAC, and MEG3 was selected for subsequent verification. Tissue and cell samples were used to verify MEG3 expression, followed by functional detection and . Microarrays were used to characterize long noncoding RNA and mRNA expression profiles. Competing endogenous RNA analyses were used to detect differential MEG3 and relational miRNA expression in PDAC. Finally, promoter analyses were conducted to explain the downregulation of MEG3 PDAC.

Results: We generated a catalogue of PDAC-associated long noncoding RNAs in the GEO database. The ectopic expression of MEG3 inhibited PDAC growth and metastasis and , which was statistically significant ( < 0.05). Microarray analysis showed that multiple microRNAs interacted with MEG3. We also showed that MEG3, as a competing endogenous RNA, directly sponged miR-374a-5p to regulate PTEN expression. The transcription factor, Sp1, recruited EZH2 and HDAC3 to the promoter and transcriptionally repressed MEG3 expression. Finally, clinical data showed that MEG3 and miR-374a-5p expressions were correlated with clinicopathological features. Statistically, Sp1, EZH2, HDAC3, and miR-374a-5p were negatively correlated with MEG3 ( < 0.05).

Conclusions: Reduced MEG3 levels played a crucial role in the PDAC malignant phenotype, which provided insight into novel and effective molecular targets of MEG3 for pancreatic cancer treatment.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721101PMC
November 2020

Discovery of a novel GLP-1/GIP dual receptor agonist CY-5 as long-acting hypoglycemic, anti-obesity agent.

Bioorg Chem 2021 01 19;106:104492. Epub 2020 Nov 19.

Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Glucagon-like peptide-1 (GLP-1) receptor agonists as an effective approach for type 2 diabetes mellitus (T2DM) has been explored extensively, multi agonists based on GLP-1 may have better clinical benefits on obesity, Nonalcoholic steatohepatitis (NASH) and other metabolic diseases. To get multi agonists based on GLP-1, 15 conjugates were designed, synthesized, and tested for biological activity. GLP-1/glucagon dual receptor agonist E1 showed moderate long-acting hypoglycemic effect, CY-5 and CY-16 with GLP-1/GIP dual receptor agonistic activity exhibited longer duration of continuous blood glucose stabilization. The long-acting hypoglycemic effect was equal to that of semaglutide. Although they have lost the agonistic activity on glucagon receptor, chronic in vivo studies on T2DM mice and diet-induced obesity (DIO) mice showed that CY-5 can effectively reduce food intake, inhibit body weight gain, repair islets damage and improve the glucose tolerance. One month treatment on NASH mice showed that CY-5 can significantly lower the TG, TC, AST, ALT and LDL-C and increase the HDL-C. CY-5 can also improve the liver vacuolation, reduce fat accumulation and delay the process of the fibrosis. The liver protection effect is better than that of semaglutide. In summary, CY-5 is a promising candidate for the treatment of metabolic diseases and worthy for further development.
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http://dx.doi.org/10.1016/j.bioorg.2020.104492DOI Listing
January 2021

Yes-Associated Protein Contributes to Cell Proliferation and Migration of Gastric Cancer via Activation of Gli1.

Onco Targets Ther 2020 27;13:10867-10876. Epub 2020 Oct 27.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, People's Republic of China.

Objective: In the present study, we aimed to explore the potential oncogenic property and the internal mechanism of yes-associated protein (YAP) in gastric cancer (GC).

Materials And Methods: YAP protein levels were evaluated in human GC tissues and paired normal tissues using immunohistochemistry (IHC). The role of YAP in regulating GC cell proliferation and migration was verified by genetic manipulation in vitro. Western blot analysis was used to determine the molecular signaling to explain the mechanism of the observed YAP effects in GC.

Results: Nuclear YAP protein expression was upregulated in GC tissues, and high nuclear YAP level was significantly correlated with lymph node metastasis (LNM) and tumor node metastasis (TNM) stage in patients suffered from GC. YAP knockdown inhibited GC cell proliferation, migration and epithelial-mesenchymal transition (EMT) progress in vitro, whereas YAP elevation did the opposite. YAP regulated glioma-associated oncogene-1 (Gli1) expression independent of smoothened homolog (SMO). YAP modulated protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway in GC cells.

Conclusion: YAP enhanced GC cell proliferation and migration potentially via its regulation of Gli1 expression through the non-classical Hedgehog pathway, indicating suppression of YAP/Gli1 signaling axis may highlight a new entry point for combination therapy of GC.
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http://dx.doi.org/10.2147/OTT.S266449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603417PMC
October 2020

Nitrous oxide emission during denitrifying phosphorus removal process: A review on the mechanisms and influencing factors.

J Environ Manage 2021 Jan 27;278(Pt 1):111561. Epub 2020 Oct 27.

School of Energy and Environment, Southeast University, Nanjing, 210096, China.

Excessive emissions of nitrogen (N) and phosphorus (P) pollutants are leading to increased eutrophication of water bodies. Biological N and P removal processes have become a research priority in the field of sewage treatment with the aim of improving sewage discharge standards in countries worldwide. Denitrifying P removal processes are more efficient for solving problems related to carbon source competition, sludge age conflict, and high aeration energy consumption compared to traditional biological N and P removal processes, but they are easy to produce nitrous oxide (NO) in the process of sewage treatment. NO is a greenhouse gas with a global warming potential approximately 190-270 times that of CO and 4-21 times that of CH, which was produced and released into the environmental in denitrifying P removal systems under conditions of a low C/N ratio, high dissolved oxygen, and low activity of denitrifying phosphorus accumulating organisms (DPAOs). This paper reviews the emission characteristics and influencing factors of NO during denitrifying P removal processes and proposes appropriate strategies for controlling the emission of NO. This work serves as a basis for the development of new sewage treatment processes and the reduction of greenhouse gas emissions in future wastewater treatment plants.
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http://dx.doi.org/10.1016/j.jenvman.2020.111561DOI Listing
January 2021
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