Publications by authors named "Ting Chen"

1,320 Publications

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The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students.

Psychiatry Investig 2021 Jul 22;18(7):636-644. Epub 2021 Jul 22.

Mental Health Center and Psychiatric Laboratory, Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China.

Objective: The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders.

Methods: Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors.

Results: We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups.

Conclusion: IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.
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http://dx.doi.org/10.30773/pi.2020.0277DOI Listing
July 2021

Assisted reproductive technology and birth defects in a Chinese birth cohort study.

Lancet Reg Health West Pac 2021 Feb 22;7:100090. Epub 2021 Jan 22.

State Key Laboratory of Reproductive Medicine, Centre for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Background: It has been consistently shown in several meta-analyses that infants born after ART have an excess of birth defects compared with those after spontaneous conception, however, the prevalence of birth defects among ART offspring in China is incompletely studied. Moreover, it is unclear to what extent the risk of birth defects is associated with parental infertility characteristics, specific ART procedures and twinning.

Methods: In the prospective cohort study, we included women who participated in the cohort, and had pregnancies of at least 20 gestational weeks between August 2016 and May 2019, and followed them until their children reached 1 year of age. Exposures of interest were ART, as well as infertility-related characteristics, certain ART procedures and specific medication usage. The primary outcome was birth defects including both major and minor defects, which we analysed with logistic generalized estimating equations to investigate the association with ART and certain ART characteristics.

Findings: A total of 1,825 women with ART-pregnancy and 3,483 women with spontaneous-pregnancy were included in the analysis. The prevalence of any defects was significantly higher among ART-births than their non-ART counterparts at each follow-up, specifically at prenatal screening (2•2% vs. 1•2%), at delivery (4•9% vs. 2•9%), at 6 months (10•4% vs. 5•3%) and 1 year of age (13•9% vs. 7•0%), and the associations between ART and increased risk of birth defects at each follow-up were similarly robust. Among ART-births, GnRH antagonist regimen for ovulation induction in women was associated with an increased risk of birth defects in their offspring after taking into account potential influencing factors (Multivariable model: adjusted risk ratio [aRR] 1•47, 1•04-2•07). Additionally, mediation through twinning accounted for 31•1% of the risk of ART-associated birth defects.

Interpretation: The results suggest that ART confers an increased risk for birth defects in offspring. The risk is partly attributable to infertility characteristics, certain ovulation induction regimen, and to some extent mediated by twinning. Our findings highlight the importance of long-term follow-up of children conceived via ART for health conditions.

Funding: National Key Research and Development Program of China, National Natural Science Foundation of China and Natural Science Foundation of Jiangsu Province.
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http://dx.doi.org/10.1016/j.lanwpc.2020.100090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315325PMC
February 2021

Effect of Maternal Triclosan Exposure on Neonatal Birth Weight and Children Triclosan Exposure on Children's BMI: A Meta-Analysis.

Front Public Health 2021 8;9:648196. Epub 2021 Jul 8.

Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Triclosan (TCS) is an environmental chemical with endocrine disrupting effects and can enter the body through the skin or oral mucosa. Human data about the effect of TCS exposure during pregnancy on neonatal birth weight and TCS exposure during childhood on children's growth are scarce. To investigate the association between maternal urinary TCS level and neonatal birth weight, as well as children's urinary TCS level and children's body mass index (BMI). A systematic literature search was conducted using PubMed, Cochrane Library, and Web of Science. Finally, seven epidemiological articles with 5,006 participants from September 25, 2014 to August 10, 2018 were included in the meta-analysis to identify the relationship between maternal exposure to TCS and neonatal birth weight. On the other hand, three epidemiological articles with 5,213 participants from July 22, 2014 to September 1, 2017 were included in another meta-analysis to identify the relationship between children's exposure to TCS and children's BMI. We used Stata 16.0 to test the heterogeneity among the studies and calculating the combined effect value 95% confidence interval (CI) of the selected corresponding models. TCS exposure during pregnancy was not significant associated with neonatal birth weight. The results of forest plots were as follows: ES (Estimate) = 0.41 (95% CI: -11.97-12.78). Children's urinary TCS level was also irrelevant associated with children's BMI: ES = 0.03 (95% CI: -0.54-0.60). This meta-analysis demonstrated that there was no significant association between maternal TCS level and neonatal birth weight, also there has no relationship between children's urinary TCS level and children's BMI.
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http://dx.doi.org/10.3389/fpubh.2021.648196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298024PMC
July 2021

Interannual variation in food choice of white-headed langur inhabiting limestone forests in Fusui, southwest Guangxi, China.

Ecol Evol 2021 Jul 12;11(14):9349-9360. Epub 2021 Jun 12.

College of Biology and the Environment Nanjing Forestry University Nanjing China.

Food habits are important factors in the adaptation of wild nonhuman primates. White-headed langurs () are endemic to heavily fragmented limestone forests and adapt to unique living environments via flexible food selection strategies. In this study, we compared the dietary data for white-headed langurs living in Chongzuo White-headed Langur National Nature Reserve in 2013 and 2016 to evaluate interannual variations in diet. Our results indicated that young leaves were the main food source for langurs, accounting for 52.4% ( 25.4%) and 65.2% ( 22.4%) of their diet in 2013 and 2016, respectively. The pattern of plant part consumption was similar between the two years. The consumption of young leaves varied with the availability of young leaves, whereas the consumption of mature leaves was negatively correlated with young leaf availability. The consumption of plant species and diet diversity were higher in 2013 than in 2016. In both 2013 and 2016, although diet diversity varied with the consumption of mature leaves, it was negatively correlated with the consumption and availability of young leaves. Dietary interannual variation is likely to either be linked to phenological variations or indicate that white-headed langurs have a flexible ecological adaptation coping with habitat fragmentation.
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http://dx.doi.org/10.1002/ece3.7726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293718PMC
July 2021

Identification of a Novel Cleavage Site and Confirmation of the Effectiveness of NgAgo Gene Editing on RNA Targets.

Mol Biotechnol 2021 Jul 23. Epub 2021 Jul 23.

Laboratory Medicine Center, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, 518000, Guangdong, People's Republic of China.

Clusters of regularly interspaced short palindromic repeats (CRISPR)/Cas systems have a powerful ability to edit DNA and RNA targets. However, the need for a specific recognition site, protospacer adjacent motif (PAM), of the CRISPR/Cas system limits its application in gene editing. Some Argonaute (Ago) proteins have endonuclease functions under the guidance of 5' phosphorylated or hydroxylated guide DNA (gDNA). The NgAgo protein might perform RNA gene editing at 37 °C, suggesting its application in mammalian cells; however, its mechanisms are unclear. In the present study, the target of NgAgo in RNA was confirmed in vitro and in vivo. Then, an in vitro RNA cleavage system was designed and the cleavage site was verified by sequencing. Furthermore, NgAgo and gDNA were transfected into cells to cleave an intracellular target sequence. We demonstrated targeted degradation of GFP, HCV, and AKR1B10 RNAs in a gDNA-dependent manner by NgAgo both in vitro and in vivo, but no effect on DNA was observed. Sequencing demonstrated that the cleavage sites are located at the 3' of the target RNA which is recognized by 5' sequence of the gDNA. These results confirmed that NgAgo-gDNA cleaves RNA not DNA. We observed that the cleavage site is located at the 3' of the target RNA, which is a new finding that has not been reported in the past.
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http://dx.doi.org/10.1007/s12033-021-00372-1DOI Listing
July 2021

Efficacy of lenvatinib plus pembrolizumab in hepatocellular carcinoma with metachronous lung metastasis: a report of two cases.

Tumori 2021 Jul 23:3008916211033353. Epub 2021 Jul 23.

Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Introduction: Immune checkpoint inhibitors (ICIs) and a combination of ICIs with targeted antiangiogenic agents are effective in treatment of advanced hepatocellular carcinoma (HCC). Studies have not explored effective biomarkers for prediction of HCC sensitivity to immunotherapy.

Case Description: The current study explored two consecutive patients with HCC with metachronous lung metastasis who were treated with lenvatinib and pembrolizumab as first-line treatment and third-line treatment, respectively. The two cases showed significant tumor shrinkage and long progression-free survival (>19 months and 12 months, respectively).

Conclusions: The findings of the current study and recently published data indicate lung metastasis as a potential clinical therapeutic indicator for efficacy of immunotherapy against HCC.
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http://dx.doi.org/10.1177/03008916211033353DOI Listing
July 2021

The interactions between childhood adversities and recent stress were associated with early-adulthood depression among Chinese undergraduate students.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Background: It is widely acknowledged that childhood adversities (CAs) and recent stress are potential risk factors for adult depression. However, the mechanism(s) by which interactions of CAs with recent stress affect adult depression remain unclear.

Aims: To investigate the predictive association of the interaction among CAs and recent stress with early-adult depression.

Method: We conducted an annual survey of all freshmen for the period of 2016-2018 in a Chinese comprehensive university, with a sample size of 23,206. An online questionnaire including standardized self-report instruments was used to assess sociodemographic factors, childhood experiences of left-behind (CELB), and maltreatments (CEMTs) including beating (CEB), neglect (CEN), sexual abuse (CESA), recent stress, and current depression (measured by the 9-item Patient Health Questionnaire).

Results: The correlation of Individual CAs and recent stress was significant. In addition to their significant independent/direct incremental effects, all surveyed CAs were associated with increased severity of early-adult depression, and increased frequency of clinically significant depression (CSD), through significant associations with recent stress (mediation effect). History of CEMTs including CEB, CEN, and CESA significantly increased the effects of recent stress on depression (moderation effect).

Conclusions: Chinese undergraduate students reported frequent history of exposure to CAs, which increased the likelihood of depression in early adulthood, not only directly but also through the increasing the likelihood (mediation effect) and impact (moderation effect) of recent stress on depression. These novel findings may help to extend our understanding of environmental determinants of depression, and to guide further research, clinical practice, and policy in this context.
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http://dx.doi.org/10.1002/da.23201DOI Listing
July 2021

Comparison of pediatric empyema secondary to tuberculosis or non-tuberculosis community-acquired pneumonia in those who underwent surgery in high TB burden areas.

Pediatr Pulmonol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Introduction: Tuberculous empyema (TE) in children is common in high-TB burden and medical resource-limited areas. However, studies that evaluate the characteristics of TE in children are sparse. This study aimed to analyze the clinical features of pediatric TE receiving surgical intervention.

Methods: We performed a retrospective study of children with empyema secondary to community-acquired pneumonia who underwent surgery in our institution. The clinical characteristics were compared between TE and empyema secondary non-tuberculosis infection (non-tuberculosis empyema, NTE).

Results: One hundred patients were included (27 with TE and 73 with NTE). Stage 3 empyema occupied 81.5% and 45.2% of TE and NTE in this study. The TE children had older age, longer duration of illness, and milder symptoms. Pleural fluid culture was positive for Mycobacterium tuberculosis in 7.4% of patients with TE. Lymph node enlargement, lymph node calcification, and pleural nodules presented in TE with high specificity (93.2%, 98.6%, and 98.5%) but low sensitivity (33.3%, 14.8%, and 29.6%) on CT scan. Thoracoscopy surgery was performed in 14 (51.9%) in TE and 39 (53.4%) in NTE. Postoperative chest-tube indwelling time was longer (7.85 ± 5.00 vs. 4.89 ± 1.81 days, p < .001), and more patients had incomplete lung expansion after 3 months in TE.

Conclusion: Tuberculosis infection should be screened in management of children with empyema in high-TB burden areas. Pediatric TE usually presented at older age and with milder respiratory symptoms. Pleural biopsy during surgery is often necessary to confirm the cause of infection. Thoracotomy is still required in some pediatric TE or NTE with delayed treatment in medical resource-limited area.
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http://dx.doi.org/10.1002/ppul.25591DOI Listing
July 2021

Predicting local failure of brain metastases after stereotactic radiosurgery with radiomics on planning MR images and dose maps.

Med Phys 2021 Jul 20. Epub 2021 Jul 20.

Department of Radiation Oncology, NYU Langone Medical Center, New York University, New York, New York, USA.

Purpose: Stereotactic radiosurgery (SRS) has become an important modality in the treatment of brain metastases. The purpose of this study is to investigate the potential of radiomic features from planning magnetic resonance (MR) images and dose maps to predict local failure after SRS for brain metastases.

Materials/methods: Twenty-eight patients who received Gamma Knife (GK) radiosurgery for brain metastases were retrospectively reviewed in this IRB-approved study. 179 irradiated tumors included 42 that locally failed within one-year follow-up. Using SRS tumor volumes, radiomic features were calculated on T1-weighted contrast-enhanced MR images acquired for treatment planning and planned dose maps. 125 radiomic features regarding tumor shape, dose distribution, MR intensities and textures were extracted for each tumor. Logistic regression with automatic feature selection was built to predict tumor progression from local control after SRS. Feature selection and model evaluation using receiver operating characteristic (ROC) curves were performed in a nested cross validation (CV) scheme. The associations between selected radiomic features and treatment outcomes were statistically assessed by univariate analysis.

Results: The logistic model with feature selection achieved ROC AUC of 0.82 ± 0.09 on 5-fold CV, providing 83% sensitivity and 70% specificity for predicting local failure. A total of 10 radiomic features including 1 shape feature, 6 MR images and 3 dose distribution features were selected. These features were significantly associated with treatment outcomes (p < 0.05). The model was validated on independent holdout data with an AUC of 0.78.

Conclusions: Radiomic features from planning MR images and dose maps provided prognostic information in SRS for brain metastases. A model built on the radiomic features shows promise for early prediction of tumor local failure after treatment, potentially aiding in personalized care for brain metastases.
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http://dx.doi.org/10.1002/mp.15110DOI Listing
July 2021

Correction for: Prediction of cognitive performance in old age from spatial probability maps of white matter lesions.

Aging (Albany NY) 2021 07 14;13(13):17948. Epub 2021 Jul 14.

School of Biomedical Engineering, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.18632/aging.203325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312423PMC
July 2021

Identification of DNA-Repair-Related Five-Gene Signature to Predict Prognosis in Patients with Esophageal Cancer.

Pathol Oncol Res 2021 30;27:596899. Epub 2021 Mar 30.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Esophageal cancer (ESCA) is a leading cause of cancer-related mortality, with poor prognosis worldwide. DNA damage repair is one of the hallmarks of cancer. Loss of genomic integrity owing to inactivation of DNA repair genes can increase the risk of cancer progression and lead to poor prognosis. We aimed to identify a novel gene signature related to DNA repair to predict the prognosis of ESCA patients. Based on gene expression profiles of ESCA patients from The Cancer Genome Atlas and gene set enrichment analysis, 102 genes related to DNA repair were identified as candidates. After stepwise Cox regression analysis, we established a five-gene prognostic model comprising DGCR8, POM121, TAF9, UPF3B, and BCAP31. Kaplan-Meier survival analysis confirmed a strong correlation between the prognostic model and survival. Moreover, we verified the clinical value of the prognostic signature under the influence of different clinical parameters. We found that small-molecule drugs (trametinib, selumetinib, and refametinib) could help to improve patient survival. In summary, our study provides a novel and promising prognostic signature based on DNA-repair-related genes to predict survival of patients with ESCA. Systematic data mining provides a theoretical basis for further exploring the molecular pathogenesis of ESCA and identifying therapeutic targets.
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http://dx.doi.org/10.3389/pore.2021.596899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262199PMC
March 2021

Measuring the Interactions Between Health Demand, Informatics Supply, and Technological Applications in Digital Medical Innovation for China: Content Mapping and Analysis.

JMIR Med Inform 2021 Jul 6;9(7):e26393. Epub 2021 Jul 6.

National Institute of Health Data Science, Peking University, Beijing, China.

Background: There were 2 major incentives introduced by the Chinese government to promote medical informatics in 2009 and 2016. As new drugs are the major source of medical innovation, informatics-related concepts and techniques are a major source of digital medical innovation. However, it is unclear whether the research efforts of medical informatics in China have met the health needs, such as disease management and population health.

Objective: We proposed an approach to mapping the interplay between different knowledge entities by using the tree structure of Medical Subject Headings (MeSH) to gain insights into the interactions between informatics supply, health demand, and technological applications in digital medical innovation in China.

Methods: All terms under the MeSH tree parent node "Diseases [C]" or node "Health [N01.400]" or "Public Health [N06.850]" were labelled as H. All terms under the node "Information Science [L]" were labelled as I, and all terms under node "Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]" were labelled as T. The H-I-T interactions can be measured by using their co-occurrences in a given publication.

Results: The H-I-T interactions in China are showing significant growth and a more concentrated interplay were observed. Computing methodologies, informatics, and communications media (such as social media and the internet) constitute the majority of I-related concepts and techniques used for resolving the health promotion and diseases management problems in China. Generally there is a positive correlation between the burden and informatics research efforts for diseases in China. We think it is not contradictory that informatics research should be focused on the greatest burden of diseases or where it can have the most impact. Artificial intelligence is a competing field of medical informatics research in China, with a notable focus on diagnostic deep learning algorithms for medical imaging.

Conclusions: It is suggested that technological transfers, namely the functionality to be realized by medical/health informatics (eg, diagnosis, therapeutics, surgical procedures, laboratory testing techniques, and equipment and supplies) should be strengthened. Research on natural language processing and electronic health records should also be strengthened to improve the real-world applications of health information technologies and big data in the future.
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http://dx.doi.org/10.2196/26393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292943PMC
July 2021

Identification of Novel Environmental Substances Relevant to Pediatric Graves' Disease.

Front Endocrinol (Lausanne) 2021 23;12:691326. Epub 2021 Jun 23.

Department of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.

Graves' disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We investigated serum substances in 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We measured total iodine by inductively coupled plasma-mass spectrometry (ICP-MS), analyzed perfluorinated compounds ultra-high-performance liquid chromatography coupled with multiple reaction monitoring mass spectrometry (UHPLC-MRM-MS), and explored other environmental substances using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) analysis. Twenty-nine single-nucleotide polymorphisms (SNPs) in eight genes related to GD were analyzed by SNaPshot. The serum total iodine was significantly higher in GD group, but its association with GD onset was weak, only with Exp(B) value near 1. The perfluorinated compound levels were not different between the two groups. More importantly, we found 16 environmental substances significantly different between GD and control groups, among which ponasterone A is a risk factor ( = 0.007 and Exp(B) = 14.14), while confertifoline is a protective factor against GD onset ( = 0.002 and Exp(B) = 0.001). We also identified 10 substances correlated significantly with thyroid indices in GD patients, among which seven associated with levels of the thyroid autoantibody TPOAb. No known SNPs were found predisposing GD. In this study, we explored a broad variety of environmental substances and identified novel factors that are potentially involved in the pediatric GD pathogenesis.
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http://dx.doi.org/10.3389/fendo.2021.691326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261246PMC
June 2021

Correction to: Transmission of H7N9 influenza virus in mice by different infective routes.

Virol J 2021 Jul 6;18(1):140. Epub 2021 Jul 6.

Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, No. 5 Pan Jia Yuan Nan Li, Chaoyang District, Beijing, 100021, China.

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http://dx.doi.org/10.1186/s12985-021-01603-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261966PMC
July 2021

Decoding different working memory states during an operation span task from prefrontal fNIRS signals.

Biomed Opt Express 2021 Jun 18;12(6):3495-3511. Epub 2021 May 18.

School of Biomedical Engineering, Capital Medical University, Beijing, China.

We propose an effective and practical decoding method of different mental states for potential applications for the design of brain-computer interfaces, prediction of cognitive behaviour, and investigation of cognitive mechanism. Functional near infrared spectroscopy (fNIRS) signals that interrogated the prefrontal and parietal cortices and were evaluated by generalized linear model were recorded when nineteen healthy adults performed the operation span (OSPAN) task. The oxygenated hemoglobin changes during OSPAN, response, and rest periods were classified with a support vector machine (SVM). The relevance vector regression algorithm was utilized for prediction of cognitive performance based on multidomain features of fNIRS signals from the OSPAN task. We acquired decent classification accuracies for OSPAN vs. response (above 91.2%) and for OSPAN vs. rest (above 94.7%). Eight of the ten cognitive testing scores could be predicted from the combination of OSPAN and response features, which indicated the brain hemodynamic responses contain meaningful information suitable for predicting cognitive performance.
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http://dx.doi.org/10.1364/BOE.426731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221954PMC
June 2021

Moving online: reflections from conducting system dynamics workshops in virtual settings.

Syst Dyn Rev 2021 Jan-Mar;37(1):59-71. Epub 2020 Dec 1.

UCL Institute for Environmental Design and Engineering University College London Gower Street London WC1E 6BT UK.

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http://dx.doi.org/10.1002/sdr.1667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246820PMC
December 2020

Growth Responses and Accumulation of Vanadium in Alfalfa, Milkvetch Root, and Swamp Morning Glory and Their Potential in Phytoremediation.

Bull Environ Contam Toxicol 2021 Jul 3. Epub 2021 Jul 3.

College of Architecture and Environment, Sichuan University, Chengdu, 610065, China.

Pot experiments with alfalfa, milkvetch root and swamp morning glory were conducted to elucidate the effect of soil vanadium (V) on plant growth and to evaluate their phytoremediation potential under V(V) exposure. Based on biomass analysis, swamp morning glory showed higher tolerance than alfalfa and milkvetch root in response to different soil V(V) levels. The accumulation of V in plants increased with the increasing soil V and the V concentration in roots was 1.95-4.31 times that in shoots. After planting, soil total V, V(V), bioavailable V and water-soluble V all reduced, and the decreases in bioavailable V and V(V) showed significant. The decreased percentage of V(V) in total V in soils demonstrated that the planting process may stimulate the mechanism of V(V) reduction to V(IV). Therefore, the three tested plants, particularly swamp morning glory can be promising phytostabilizers applied to V phytoremediation practices.
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http://dx.doi.org/10.1007/s00128-021-03309-1DOI Listing
July 2021

[Spatial variation and optimization of ecological carrying capacity in Jiangsu coastal area, China].

Ying Yong Sheng Tai Xue Bao 2021 Jun;32(6):2158-2168

Engineering Technology Research Center of Resources Environment and GIS, School of Geography and Tourism, Anhui Normal University, Wuhu 241003, Anhui, China.

The research on spatial pattern and optimization of regional ecological carrying capacity is especially necessary to promote the overall development of economic transformation, upgrading and ecological protection and restoration. This study chose the natural, social and economic complex ecosystem of Jiangsu coastal area as subject. The concept model of pressure-state-potential (PSP) of ecological carrying capacity was established. A total of 15 indices were used to represent the interaction of three level states. With the support of GIS and other space technologies, the magnitude, spatial variation of regional ecological carrying capacity were examined through comprehensive evaluation of multiple indices and analysis of single index. Results showed that the spatial pattern of the suitability of single factor ecological carrying capacity in Jiangsu coastal area showed a variety of trends. There were significant differences in the area, proportion and layout of the same index across different cities and counties. The spatial differentiation of pressure and state superposition index showed that low pressure suitable bearing, low pressure generally suitable bearing, low pressure unsuitable bearing, high pressure suitable bearing, high pressure generally suitable bearing, bearing high pressure unsuitable bearing area was 3971.42, 6885.21, 3705.23, 4597.03, 6853.26, and 6403.97 km, accounting for 12.3%, 21.2%, 11.4%, 14.2%, 21.1% and 19.8% of the total area, respectively. The results of spatial differentiation of superposition index of state and potential showed that the area integral of low potential suitable bearing, low potential general sui-table bearing, low potential unsuitable bearing, high potential suitable bearing, high potential general sui-table bearing and high potential unsuitable bearing was 3030.79, 6545.30, 5874.31, 3253.31, 7614.38, and 6097.83 km, accounting for 9.4%, 20.2%, 18.1%, 10.0%, 23.5% and 18.8% of the total area, respectively. Most areas showed distribution characteristics of low pressure bearing area corresponding to high potential bearing area and high pressure bearing area corresponding to low potential bearing area in spatial pattern. There was an interaction of mutual influence, mutual promotion and collaborative promotion between pressure and state superposition index and state and potential superposition index.
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http://dx.doi.org/10.13287/j.1001-9332.202106.015DOI Listing
June 2021

Revealing Microbiome Structure and Assembly Process in Three Rhizocompartments of Under Continuous Monoculture Regimes.

Front Microbiol 2021 14;12:677654. Epub 2021 Jun 14.

Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.

The complex composition and interaction of root-associated microbes are critical to plant health and performance. In this study, we presented a detailed characterization of three rhizocompartment (rhizosphere, rhizoplane, and root) microbiomes of under different years of consecutive monoculture by deep sequencing in order to determine keystone microorganisms co-occurrence network analysis. The network analysis showed that multiple consecutive monoculture (MCM, represented 5Y and 10Y) soils generated some distinct beneficial bacterial taxa such as , , , , and . For fungi, substituted for in occupying an important position in different rhizocompartments under monoculture. Quantitative PCR analysis confirmed a significant increase in , , and spp. The results of the inoculation assay showed that addition of beneficial bacteria 74 and 75 significantly increased the root length and fresh weight of Furthermore, three types of phytosterones, as the main allochemicals, were identified both in the rhizosphere soil and in culture medium under sterile conditions by LC-MS/MS. When looking at interactions, it was found that phytosterones displayed a positive interaction with dominant beneficial species ( 4 and 75) and had a negative effect on the presence of the pathogenic fungi and . Overall, this study demonstrated that consecutive monoculture of can alter the bacterial and fungal community by secreting root exudates, leading to recruitment of beneficial microbes and replacement of plant-specific pathogenic fungi with plant beneficial fungi.
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http://dx.doi.org/10.3389/fmicb.2021.677654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236951PMC
June 2021

Hyperoside promotes pollen tube growth by regulating the depolymerization effect of actin-depolymerizing factor 1 on microfilaments in okra.

Hortic Res 2021 Jul 1;8(1):145. Epub 2021 Jul 1.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, College of Forestry, Beijing Forestry University, Beijing, 100000, China.

Mature pollen germinates rapidly on the stigma, extending its pollen tube to deliver sperm cells to the ovule for fertilization. The success of this process is an important factor that limits output. The flavonoid content increased significantly during pollen germination and pollen tube growth, which suggests it may play an important role in these processes. However, the specific mechanism of this involvement has been little researched. Our previous research found that hyperoside can prolong the flowering period of Abelmoschus esculentus (okra), but its specific mechanism is still unclear. Therefore, in this study, we focused on the effect of hyperoside in regulating the actin-depolymerizing factor (ADF), which further affects the germination and growth of pollen. We found that hyperoside can prolong the effective pollination period of okra by 2-3-fold and promote the growth of pollen tubes in the style. Then, we used Nicotiana benthamiana cells as a research system and found that hyperoside accelerates the depolymerization of intercellular microfilaments. Hyperoside can promote pollen germination and pollen tube elongation in vitro. Moreover, AeADF1 was identified out of all AeADF genes as being highly expressed in pollen tubes in response to hyperoside. In addition, hyperoside promoted AeADF1-mediated microfilament dissipation according to microfilament severing experiments in vitro. In the pollen tube, the gene expression of AeADF1 was reduced to 1/5 by oligonucleotide transfection. The decrease in the expression level of AeADF1 partially reduced the promoting effect of hyperoside on pollen germination and pollen tube growth. This research provides new research directions for flavonoids in reproductive development.
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http://dx.doi.org/10.1038/s41438-021-00578-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245483PMC
July 2021

Gut microbiota are associated with sex and age of host: Evidence from semi-provisioned rhesus macaques in southwest Guangxi, China.

Ecol Evol 2021 Jun 14;11(12):8096-8122. Epub 2021 May 14.

Guangxi Key Laboratory of Rare and Endangered Animal Ecology Guangxi Normal University Guilin China.

Host characteristics, such as sex and age, are closely associated with the structure and function of gut microbiota; however, less is known about the effects of age and sex on the gut microbiota of nonhuman primates, and therefore, our knowledge of interindividual variability in host gut microbiota is limited. In this study, 153 fecal samples from rhesus macaques () were analyzed using high-throughput 16S rRNA sequencing in order to explore associations between age and sex of the host and their gut microbiota. The results indicated that female macaques had higher alpha diversity and a more unique gut microbiota than did males. The proportion of Proteobacteria, Tenericutes, Cyanobacteria, unclassified bacteria, and Verrucomicrobia was higher in females than that in males. We also found that adults of both sexes had a higher alpha diversity, a higher proportion of norank , , norank , norank Clostridiales, and and a lower proportion of than immatures. Functional analyses revealed that the richness of metabolic pathways was higher in females than males and in adults compared with immatures. These results could be attributed to differences in the nutritional requirements and hormone levels of macaques of different sex and age classes. We conclude that variation in the gut microbiota of different sex and age classes of rhesus macaques may be linked to age- and sex-specific differences in nutrient requirements and hormone levels. These results highlight the importance of host age and sex on the structure and function of the gut microbiota and the need to consider physiological traits when conducting studies on the gut microbiota.
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http://dx.doi.org/10.1002/ece3.7643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216961PMC
June 2021

Celastrol protects against early brain injury after subarachnoid hemorrhage in rats through alleviating blood-brain barrier disruption and blocking necroptosis.

Aging (Albany NY) 2021 06 28;13(12):16816-16833. Epub 2021 Jun 28.

Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310016, China.

Background: Subarachnoid hemorrhage (SAH) is a life-threatening disease worldwide, and effective pharmaceutical treatment is still lacking. Celastrol is a plant-derived triterpene which showed neuroprotective potential in several types of brain insults. This study aimed to investigate the effects of celastrol on early brain injury (EBI) after SAH.

Methods: A total of sixty-one male Sprague-Dawley rats were used in this study. Rat SAH endovascular perforation model was established to mimic the pathological changes of EBI after SAH. Multiple methods such as 3.0T MRI scanning, immunohistochemistry, western blotting and propidium iodide (PI) labeling were used to explore the therapeutic effects of celastrol on SAH.

Results: Celastrol treatment attenuated SAH-caused brain swelling, reduced T2 lesion volume and ventricular volume in MRI scanning, and improved overall neurological score. Albumin leakage and the degradation of tight junction proteins were also ameliorated after celastrol administration. Celastrol protected blood-brain bairrer integrity through inhibiting MMP-9 expression and anti-neuroinflammatory effects. Additionally, necroptosis-related proteins RIP3 and MLKL were down-regulated and PI-positive cells in the basal cortex were less in the celastrol-treated SAH group than that in untreated SAH group.

Conclusions: Celastrol exhibits neuroprotective effects on EBI after SAH and deserves to be further investigated as an add-on pharmaceutical therapy.
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http://dx.doi.org/10.18632/aging.203221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266331PMC
June 2021

Maternal and neonatal outcomes in transverse and vertical skin incision for placenta previa : Skin incision for placenta previa.

BMC Pregnancy Childbirth 2021 Jun 24;21(1):441. Epub 2021 Jun 24.

Foshan Institute of Fetal Medicine, Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan, 528000, Guangdong, China.

Background: Placenta previa, a serious obstetric issue, should be managed by experienced teams. The safe and appropriate mode of delivery for placenta previa is by cesarean delivery. However, no studies were found comparing either maternal or neonatal outcomes for different skin incision in women with placenta previa. The aim of this study was to compare maternal and neonatal outcomes by skin incision types (transverse compared with vertical) in a large cohort of women with placenta previa who were undergoing cesarean delivery.

Methods: This was a retrospective cohort study carried out between January 2014 and June 2019. All pregnant women with placenta previa had confirmed by ultrasonologist before delivery and obstetrician at delivery. The primary outcome was the estimated blood loss during the surgery and within the first 24 hours postoperatively. Mean (standard deviation), median (interquartile range) or frequency (percentage) was reported to variables. Appropriate parametric and nonparametric tests were used to analyses.

Results: The study included 1098 complete records, 332 (30.24%) cases in the vertical skin incision group and 766 (69.76%) cases in the transverse skin incision group. Those with vertical incision showed a higher percentage of preterm delivery, anterior placenta, abnormally invasive placenta, and history of previous cesarean delivery, and a lower percentage of first pregnancy, in vitro fertilization, and emergency cesarean delivery. After controlling for confounding factors, higher incidence of post-partum hemorrhage (OR 5.47, 95% CI 3.84-7.79), maternal intensive care unit (OR 4.30, 95% CI 2.86-6.45), transfusion (OR 5.97, 95% CI 4.15-8.58), and 5-min APGAR< 7 (OR 9.03, 95% CI 1.83-44.49), a more estimated blood loss (β 601.85, 95%CI 458.78-744.91), and a longer length of hospital stay after delivery (β 0.54, 95%CI 0.23-0.86) were found in the vertical skin incision group.

Conclusions: Our data demonstrated that transverse skin incision group showed the better perinatal outcomes in women with placenta previa. Future collaborative studies are needed to be done by centers for placenta previa to have a better understanding of the characteristics and the outcomes of the disease in the choosing skin incision.
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http://dx.doi.org/10.1186/s12884-021-03923-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229347PMC
June 2021

The value of coronary CTA in the diagnosis of coronary artery disease.

Am J Transl Res 2021 15;13(5):5287-5293. Epub 2021 May 15.

Department of Radiology, Affiliated People's Hospital of Ningbo University Ningbo, Zhejiang Province, China.

Objective: To investigate the diagnostic value of coronary computed tomography angiography (CTA) in the detection of coronary artery disease.

Methods: From January 2017 to December 2019, 150 patients with suspected coronary artery disease admitted to the Affiliated People's Hospital of Ningbo University were recruited as the research cohort for this study. All the patients underwent a coronary CTA and a coronary angiography. The results of the patients' coronary CTAs and coronary angiographies were compared. Analyses were performed on the practical implications of coronary CTA in the detection of coronary artery disease and the detection and coincidence rates of coronary CTA for determining the severity of coronary stenosis.

Results: There were no statistical differences in the detection of positive results of coronary artery diseases or the identification of coronary stenosis between the coronary CTAs and the coronary angiographies. The sensitivity of coronary CTA in the examination of coronary artery diseases was 81.8%. The specificity was 87.5%, the negative predictive value was 63.6%, and the positive predictive value was 94.7%. In contrast to the coronary angiography, the coincidence rates of coronary CTA for determining the location of coronary lesions were 89.1% for LAD lesions, 80.0% for LCX lesions, and 100% for RCA lesions.

Conclusions: Coronary CTA has a significant value in the detection of coronary artery diseases, as it can accurately examine the severity of coronary stenoses and locate the sites of the stenotic lesions. It is worthy of clinical use.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205783PMC
May 2021

Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis.

Front Psychol 2021 3;12:669000. Epub 2021 Jun 3.

Department of Cardiology, Guanganmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, China.

This study aimed to conduct a bibliometric analysis of published studies on the association between coronary heart disease (CHD) and depression or anxiety. The study also aimed to identify leading authors, institutions, and countries to determine research hotspots and obtain some hints from the speculated future frontiers. Publications about CHD and depression or anxiety between 2004 and 2020 were collected from the Web of Science Core Collection (WOSCC) database. Bibliographic information, such as authorship, country, citation frequency, and interactive visualization, was generated using VOSviewer1.6.16 and CiteSpace5.6.R5. In total, 8,073 articles were identified in the WOSCC database. The United States (2,953 publications), Duke University and Harvard University (214 publications), Psychosomatic Medicine (297 publications), and Denollet Johan. (99 publications) were the most productive country, institutions, journal, and author, respectively. The three hotspots of the research were "The relationship between depression and CHD," "depression and myocardial infarction," and "The characteristic of women suffering depression after MI." The four future research frontiers are predicted to be "treating depression in CHD patients with multimorbidity," "psychometric properties of instruments for assessing depression and anxiety in CHD patients," "depression or anxiety in post-PCI patients," and "other mental diseases in CHD patients." Bibliometric analysis of the association between CHD and depressive disorders might identify new directions for future research.
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http://dx.doi.org/10.3389/fpsyg.2021.669000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211422PMC
June 2021

Prevalence and risk factors of refractive error in Qinghai, China: a cross-sectional study in Han and Tibetan adults in Xining and surrounding areas.

BMC Ophthalmol 2021 Jun 19;21(1):260. Epub 2021 Jun 19.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifu Yuan, Dongcheng District, Beijing, 100730, China.

Background: Our study aimed to explore the prevalence and risk factors of refractive error (RE) in Han and Tibetan population aged 50-79 years in Xining and surrounding areas in Qinghai Province on Qinghai-Tibet Plateau.

Methods: As part of the China National Health Survey, our cross-sectional study compared the age-adjusted prevalence of RE in Han and Tibetan older adults aged 50-79 years in Xining and surrounding areas. A multivariate logistic regression model was used to identify risk factors for myopia and hyperopia.

Results: Among 769 Han participants and 476 Tibetan participants, the age-adjusted prevalence of myopia (spherical equivalent (SE) < - 0.5D), hyperopia (SE > + 0.5D), high myopia (SE < -6.0D) and astigmatism (cylindrical equivalent > = 0.5D) is 28.56, 22.82, 2.80, and 69.38%. Han participants have higher age-adjusted prevalence of myopia (32.93% vs 21.64%, p < 0.001), high myopia (3.93% vs 1.02%, p = 0.001) and astigmatism (72.14% vs 64.94%, p = 0.021) compared to Tibetan participants. Being Tibetan is the protective factor of myopia compared to being Han (OR 0.58, 95%CI 0.42-0.79, p < 0.001). Older age (p = 0.032), longer time length in rural area (p = 0.048), undergraduate/graduate education level (p = 0.031), lighter active level (p = 0.007) and lower BMI (p = 0.015) are risk factors for myopia. Older age (all p < 0.001) and pterygium status of the same eye (p = 0.013) also increase the hyperopia risk.

Conclusions: Our study found an overall prevalence of myopia of 28.56% in Xining and surrounding areas in adults older than 50 years. Han population has higher myopia risk than Tibetan population. More medical and social resources should be allocated to improve the vision and life quality of older adults.
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http://dx.doi.org/10.1186/s12886-021-01996-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214277PMC
June 2021

Protective effects of baicalin in a model of Parkinson's disease.

Toxicol Res (Camb) 2021 May 26;10(3):409-417. Epub 2021 Apr 26.

Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P. R. China.

Parkinson's disease (PD) is a common neurodegenerative disorder of the central nervous system. However, the pathogenetic mechanisms of PD are far from understood. The aim of this study was to determine the protective effect of baicalin in a model of PD. worms were stimulated for 24 h with 6-hydroxydopamine (6-OHDA, 50 mM) and treated with or without baicalin (1, 10, or 100 μM). At all tested concentrations, baicalin improved the reversal and omega turn behavioral phenotypes, as well as the survival, of 6-OHDA-stimulated worms. It also inhibited 6-OHDA-induced oxidative stress by decreasing malondialdehyde levels, increasing superoxide dismutase, glutathione reductase, catalase, and glutathione levels and up-regulating mRNA expression of the antioxidant-related genes , , , , and . Additionally, it significantly decreased the expression of the apoptosis-related gene and increased that of the anti-apoptosis-related gene . The expression levels of cleaved caspase-3 and B-cell lymphoma 2 in 6-OHDA-treated worms were reversed by baicalin. Apoptosis was suppressed by 6-OHDA in loss-of-function strains via the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Furthermore, the apoptotic effects of 6-OHDA were blocked in and mutants. Finally, the mRNA expression of and and the protein expression of p38 MAPK and stress-activated protein kinase/extracellular signal-regulated kinase 1 were up-regulated by 6-OHDA and reversed by baicalin. Baicalin may protect against 6-OHDA injury by inhibiting apoptosis and decreasing oxidative stress through the p38 MAPK signaling pathway.
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http://dx.doi.org/10.1093/toxres/tfaa107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201589PMC
May 2021

Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy.

Nanomicro Lett 2021 Mar 31;13(1):99. Epub 2021 Mar 31.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.

Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment. Herein, we have developed all-organic oxygen-independent hybrid nanobullets [email protected] for the "precise strike" of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid (HA) and hypoxia-dependent factor carbonic anhydrase IX (CA IX)-inhibitor acetazolamide (AZ). The core of nanobullets is the special zinc (II) phthalocyanine aggregates (ZPA) which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy (PTT), along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy (TDT). The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional (reactive oxygen species (ROS)-mediated) cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis.
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http://dx.doi.org/10.1007/s40820-021-00616-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012440PMC
March 2021
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