Publications by authors named "Timothy W Synold"

60Publications

Systemic Anti-PD-1 Immunotherapy Results in PD-1 Blockade on T Cells in the Cerebrospinal Fluid.

JAMA Oncol 2020 Oct 8. Epub 2020 Oct 8.

Department of Hematology and Hematopoietic Cell Transplantation, T Cell Therapeutics Research Laboratories, City of Hope Beckman Research Institute and Comprehensive Cancer Center, Duarte, California.

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http://dx.doi.org/10.1001/jamaoncol.2020.4508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545351PMC
October 2020

In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model.

Proc Natl Acad Sci U S A 2020 07 13;117(30):17535-17542. Epub 2020 Jul 13.

Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;

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http://dx.doi.org/10.1073/pnas.2006569117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395490PMC
July 2020

A Pilot Study of Vinorelbine Safety and Pharmacokinetics in Patients with Varying Degrees of Liver Dysfunction.

Oncologist 2019 08 1;24(8):1137-1145. Epub 2019 Feb 1.

Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California, USA

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http://dx.doi.org/10.1634/theoncologist.2018-0336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693729PMC
August 2019

HIV Replication and Latency in a Humanized NSG Mouse Model during Suppressive Oral Combinational Antiretroviral Therapy.

J Virol 2018 04 14;92(7). Epub 2018 Mar 14.

Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, USA

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http://dx.doi.org/10.1128/JVI.02118-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972864PMC
April 2018

Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing.

Cancer Chemother Pharmacol 2015 Mar 4;75(3):495-503. Epub 2015 Jan 4.

University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.

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http://dx.doi.org/10.1007/s00280-014-2667-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344382PMC
March 2015

Iron chelators induce autophagic cell death in multiple myeloma cells.

Leuk Res 2014 Aug 17;38(8):988-96. Epub 2014 Jun 17.

Department of Medical Oncology, City of Hope Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.1016/j.leukres.2014.06.005DOI Listing
August 2014

A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.

Cancer Res 2013 Nov 26;73(21):6484-93. Epub 2013 Sep 26.

Authors' Affiliations: Departments of Molecular Pharmacology, Molecular Medicine, and Immunology, City of Hope National Medical Center, Duarte, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823501PMC
November 2013

A phase I trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors.

Cancer Chemother Pharmacol 2013 Jul 28;72(1):85-91. Epub 2013 May 28.

USC/Norris Comprehensive Cancer Center, Oncology, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s00280-013-2171-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779138PMC
July 2013

Bioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice.

J Pharmacol Exp Ther 2013 Jun 26;345(3):438-45. Epub 2013 Mar 26.

Department of Cancer Biology, Beckman Research Institute at City of Hope, Duarte, California, USA.

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http://dx.doi.org/10.1124/jpet.113.203562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657110PMC
June 2013

Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice.

Cancer Chemother Pharmacol 2012 Oct 21;70(4):617-25. Epub 2012 Aug 21.

Department of Molecular Pharmacology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1007/s00280-012-1954-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456924PMC
October 2012

A pharmacokinetic, pharmacodynamic, and electrocardiographic study of liposomal mifamurtide (L-MTP-PE) in healthy adult volunteers.

Eur J Clin Pharmacol 2012 Oct 30;68(10):1347-55. Epub 2012 Mar 30.

Millennium Pharmaceuticals, Inc., Clinical Pharmacology, 35 Landsdowne Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1007/s00228-012-1262-1DOI Listing
October 2012

Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway.

Cardiovasc Res 2011 Feb 16;89(2):426-35. Epub 2010 Sep 16.

Department of Molecular Medicine, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/cvr/cvq296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020130PMC
February 2011

Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.

Inflamm Bowel Dis 2010 Dec;16(12):2043-54

Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, USA.

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http://dx.doi.org/10.1002/ibd.21317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991606PMC
December 2010

The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation.

Clin Cancer Res 2009 Nov 27;15(22):7092-8. Epub 2009 Oct 27.

Department of Medical Oncology and Experimental Therapeutics, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908372PMC
November 2009

A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging.

Proc Natl Acad Sci U S A 2009 Mar 12;106(13):5394-9. Epub 2009 Mar 12.

Division of Tumor Cell Biology, Beckman Research Institute at City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1073/pnas.0807343106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654810PMC
March 2009

Biologic markers of angiogenesis: circulating endothelial cells in patients with advanced malignancies treated on phase I protocol with metronomic chemotherapy and celecoxib.

Cancer Invest 2008 Feb;26(1):53-9

Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA.

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http://dx.doi.org/10.1080/07357900701681541DOI Listing
February 2008

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

Cancer Chemother Pharmacol 2008 Jul 26;62(2):363-8. Epub 2007 Sep 26.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-007-0603-8DOI Listing
July 2008

Oblimersen and alpha-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium.

J Cancer Res Clin Oncol 2007 Oct 17;133(10):705-11. Epub 2007 May 17.

Division of Medical Oncology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-3000, USA.

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http://dx.doi.org/10.1007/s00432-007-0200-6DOI Listing
October 2007

DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene.

Proc Natl Acad Sci U S A 2005 Jul 11;102(29):10058-63. Epub 2005 Jul 11.

Division of Biology, Beckman Research Institute, and Department of Medical Oncology, The City of Hope National Medical Center, 1450 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1073/pnas.0502311102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1174921PMC
July 2005

Similar mutagenicity of photoactivated porphyrins and ultraviolet A radiation in mouse embryonic fibroblasts: involvement of oxidative DNA lesions in mutagenesis.

Biochemistry 2004 Dec;43(49):15557-66

Division of Biology and Department of Medical Oncology, Beckman Research Institute of the City of Hope National Medical Center, 1450 East Duarte Road, Duarte, California 91010, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi048717c
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http://dx.doi.org/10.1021/bi048717cDOI Listing
December 2004

G-to-T transversions and small tandem base deletions are the hallmark of mutations induced by ultraviolet a radiation in mammalian cells.

Biochemistry 2004 Jun;43(25):8169-77

Division of Biology, Beckman Research Institute of the City of Hope National Medical Center, 1450 East Duarte Road, Duarte, California 91010, USA.

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http://dx.doi.org/10.1021/bi049761vDOI Listing
June 2004

Phase II trial of carboplatin and infusional cyclosporine in platinum-resistant recurrent ovarian cancer.

Cancer Chemother Pharmacol 2004 Oct 4;54(4):283-9. Epub 2004 Jun 4.

Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1500 E. Duarte Rd, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1007/s00280-004-0818-xDOI Listing
October 2004

Effect of valspodar on the pharmacokinetics of unbound paclitaxel.

Invest New Drugs 2003 Aug;21(3):291-8

Department of Medical Oncology, Erasmus MC--Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1023/a:1025412509730DOI Listing
August 2003