Timothy W Behrens

Timothy W Behrens

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Timothy W Behrens

Timothy W Behrens

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncomms16021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

Identifying and mitigating batch effects in whole genome sequencing data.

BMC Bioinformatics 2017 Jul 24;18(1):351. Epub 2017 Jul 24.

Bioinformatics and Computational Biology Department, Genentech Inc, 1 DNA Way, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1186/s12859-017-1756-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525370PMC
July 2017

Thinking differently about lupus.

Elife 2016 03 29;5. Epub 2016 Mar 29.

Genentech Inc., South San Francisco, United States.

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http://dx.doi.org/10.7554/eLife.15352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821793PMC
March 2016

Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.

JAMA Neurol 2015 Sep;72(9):1043-51

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York2Gertrude H. Sergievsky Center, Columbia University, New York, New York3Department of Epidemiology, School of Public Health, Columbia Univer.

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http://dx.doi.org/10.1001/jamaneurol.2015.1424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010776PMC
September 2015

RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency.

J Allergy Clin Immunol 2015 May 12;135(5):1380-4.e1-5. Epub 2014 Dec 12.

Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426222PMC
May 2015

Using gene expression to improve the power of genome-wide association analysis.

Hum Hered 2014 30;78(2):94-103. Epub 2014 Jul 30.

Division of Biostatistics, University of Minnesota, Minneapolis, Minn., USA.

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http://dx.doi.org/10.1159/000362837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152945PMC
April 2015

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:
Li-San Wang Adam C Naj Robert R Graham Paul K Crane Brian W Kunkle Carlos Cruchaga Josue D Gonzalez Murcia Lisa Cannon-Albright Clinton T Baldwin Henrik Zetterberg Kaj Blennow Walter A Kukull Kelley M Faber Nicole Schupf Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran Ekaterina Rogaeva Chiao-Feng Lin Beth A Dombroski Laura B Cantwell Amanda Partch Otto Valladares Hakon Hakonarson Peter St George-Hyslop Robert C Green Alison M Goate Tatiana M Foroud Regina M Carney Eric B Larson Timothy W Behrens John S K Kauwe Jonathan L Haines Lindsay A Farrer Margaret A Pericak-Vance Richard Mayeux Gerard D Schellenberg Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Michael Barmada Lisa L Barnes Thomas G Beach James T Becker Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Steven L Carroll Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky F Yesim Demirci Malcolm Dick Dennis W Dickson Ranjan Duara Nilufer Ertekin-Taner Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass Neill R Graff-Radford John H Growdon Ronald L Hamilton Kara L Hamilton-Nelson Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun Gyungah Jun M Ilyas Kamboh Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Gei Li Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Constantine G Lyketsos Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee W Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Jill R Murrell John M Olichney Joseph E Parisi William Perry Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2015 Feb;72(2):209-16

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2014.2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324097PMC
February 2015

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Personalizing medicine for autoimmune and inflammatory diseases.

Nat Immunol 2013 Feb;14(2):106-9

Genentech, South San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2473DOI Listing
February 2013

The genetics of type I interferon in systemic lupus erythematosus.

Curr Opin Immunol 2012 Oct 10;24(5):530-7. Epub 2012 Aug 10.

Department of Human Genetics, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.coi.2012.07.008DOI Listing
October 2012

Selective IgA deficiency in autoimmune diseases.

Mol Med 2011 4;17(11-12):1383-96. Epub 2011 Aug 4.

Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.2119/molmed.2011.00195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321806PMC
August 2012

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

PLoS Genet 2011 Oct 27;7(10):e1002341. Epub 2011 Oct 27.

Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1002341
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http://dx.doi.org/10.1371/journal.pgen.1002341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203198PMC
October 2011

Lyp breakdown and autoimmunity.

Nat Genet 2011 Aug 29;43(9):821-2. Epub 2011 Aug 29.

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http://dx.doi.org/10.1038/ng.914DOI Listing
August 2011

Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants.

Ann Hum Genet 2011 May 14;75(3):383-97. Epub 2011 Mar 14.

Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, UK.

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http://dx.doi.org/10.1111/j.1469-1809.2011.00641.xDOI Listing
May 2011

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.

Dev Dyn 2011 Feb;240(2):384-93

Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.

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http://dx.doi.org/10.1002/dvdy.22549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079332PMC
February 2011

TRAPing a new gene for autoimmunity.

Nat Genet 2011 Feb;43(2):90-1

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http://dx.doi.org/10.1038/ng0211-90DOI Listing
February 2011

Clinical and biological data integration for biomarker discovery.

Drug Discov Today 2010 Sep 15;15(17-18):741-8. Epub 2010 Jun 15.

Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.drudis.2010.06.005DOI Listing
September 2010

Recent advances in the genetics of systemic lupus erythematosus.

Expert Rev Clin Immunol 2010 May;6(3):461-79

ITGR Human Genetics, Genentech Research & Early Development, 1 DNA Way, South San Francisco, CA 94080-94990, USA.

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http://dx.doi.org/10.1586/eci.10.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897739PMC
May 2010

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.

Arthritis Res Ther 2008 19;10(5):R113. Epub 2008 Sep 19.

Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.

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http://dx.doi.org/10.1186/ar2516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592800PMC
February 2009

B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements.

J Immunol 2008 Apr;180(7):4728-41

Center for Immunology, Department of Medicine, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4049/jimmunol.180.7.4728DOI Listing
April 2008

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.

Nat Genet 2008 Jan 2;40(1):83-9. Epub 2007 Dec 2.

Section of Molecular Genetics and Rheumatology, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1038/ng.2007.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705866PMC
January 2008

Overexpression of Bcl(XL) in B cells promotes Th1 response and exacerbates collagen-induced arthritis.

J Immunol 2007 Nov;179(10):7087-92

Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.4049/jimmunol.179.10.7087DOI Listing
November 2007

Genetics of autoimmune diseases--disorders of immune homeostasis.

Nat Rev Genet 2006 Dec;7(12):917-28

Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA.

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http://dx.doi.org/10.1038/nrg1944DOI Listing
December 2006

Peritoneal B-2 cells comprise a distinct B-2 cell population with B-1b-like characteristics.

Eur J Immunol 2006 May;36(5):1114-23

Department of Microbiology, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1002/eji.200535142DOI Listing
May 2006

Gene expression profiling in human autoimmunity.

Immunol Rev 2006 Apr;210:120-37

University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1111/j.0105-2896.2006.00367.xDOI Listing
April 2006

Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus.

Novartis Found Symp 2005 ;267:145-60; discussion 160-4

Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, 55455, USA.

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November 2005

In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance.

J Immunol 2005 Jul;175(2):909-16

Departments of Medicine and Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4049/jimmunol.175.2.909DOI Listing
July 2005

The emerging role of interferon in human systemic lupus erythematosus.

Curr Opin Immunol 2004 Dec;16(6):801-7

Center for Lupus Research, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA.

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http://dx.doi.org/10.1016/j.coi.2004.09.014DOI Listing
December 2004

Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc.

J Immunol 2004 Jun;172(11):6684-91

Department of Medicine, Cancer Center, and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4049/jimmunol.172.11.6684DOI Listing
June 2004

The use of microarrays to study autoimmunity.

J Investig Dermatol Symp Proc 2004 Jan;9(1):18-22

Department of Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1111/j.1087-0024.2004.00836.xDOI Listing
January 2004

Late immature B cells (IgMhighIgDneg) undergo a light chain receptor editing response to soluble self-antigen.

J Immunol 2003 Jul;171(2):678-82

Center for Immunology and Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4049/jimmunol.171.2.678DOI Listing
July 2003

Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.

J Exp Med 2003 Jun 9;197(12):1677-87. Epub 2003 Jun 9.

Department of Microbiology and Center for Immunology, University of Minnesota Medical School, MMC334, 420 Delaware St. S.E., Minneapolis, MN 55455,USA.

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http://dx.doi.org/10.1084/jem.20012065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193962PMC
June 2003

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.

Nat Immunol 2003 Mar 3;4(3):280-6. Epub 2003 Feb 3.

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1038/ni890DOI Listing
March 2003