Timothy Triche

Timothy Triche

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Timothy Triche

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DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin.

Leuk Lymphoma 2019 Jun 22;60(6):1429-1437. Epub 2019 Jan 22.

a Department of Preventive Medicine , University of Southern California , Los Angeles , CA , USA.

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http://dx.doi.org/10.1080/10428194.2018.1533128DOI Listing
June 2019

Landscape of Germline and Somatic Mitochondrial DNA Mutations in Pediatric Malignancies.

Cancer Res 2019 Apr 1;79(7):1318-1330. Epub 2019 Feb 1.

Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445760PMC
April 2019

SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions.

Nucleic Acids Res 2018 11;46(20):e123

Center for Epigenetics, Van Andel Research Institute, 333 Bostwick Ave., N.E., Grand Rapids, MI 49503 USA.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237738PMC
November 2018

OncoKids: A Comprehensive Next-Generation Sequencing Panel for Pediatric Malignancies.

J Mol Diagn 2018 11 20;20(6):765-776. Epub 2018 Aug 20.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California; Department of Pathology, Keck School of Medicine of USC, Los Angeles, California.

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https://linkinghub.elsevier.com/retrieve/pii/S15251578183010
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http://dx.doi.org/10.1016/j.jmoldx.2018.06.009DOI Listing
November 2018

Transposable Element Expression in Acute Myeloid Leukemia Transcriptome and Prognosis.

Sci Rep 2018 11 6;8(1):16449. Epub 2018 Nov 6.

Jane Anne Nohl Division of Division of Hematology and Center for the Study of Blood Diseases, Keck School of Medicine of University of Southern California, Los Angeles, California, 90033, USA.

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http://www.nature.com/articles/s41598-018-34189-x
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http://dx.doi.org/10.1038/s41598-018-34189-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219593PMC
November 2018

Profiling targetable immune checkpoints in osteosarcoma.

Oncoimmunology 2018 11;7(12):e1475873. Epub 2018 Sep 11.

Department of Translational Genomics.

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http://dx.doi.org/10.1080/2162402X.2018.1475873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279416PMC
September 2018

Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes.

Cell Rep 2018 07;24(1):238-251

Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX; Gill Center for Cancer and Blood Disorders, Children's Health, Children's Medical Center, Dallas, TX. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.006DOI Listing
July 2018

Author Correction: Suppression of Transposable Elements in Leukemic Stem Cells.

Sci Rep 2018 Mar 6;8(1):4240. Epub 2018 Mar 6.

Keck School of Medicine of University of Southern California, Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Los Angeles, California, 90033, USA.

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http://dx.doi.org/10.1038/s41598-018-21280-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840359PMC
March 2018

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT.

Blood Adv 2017 Sep 28;1(20):1635-1644. Epub 2017 Aug 28.

Division of Hematology, Department of Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2017005694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728330PMC
September 2017

Response: Making "perfect" the enemy of good.

Blood 2017 08 28;130(9):1168-1169. Epub 2017 Jul 28.

Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2017-07-789107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580277PMC
August 2017

Suppression of Transposable Elements in Leukemic Stem Cells.

Sci Rep 2017 08 1;7(1):7029. Epub 2017 Aug 1.

Keck School of Medicine of University of Southern California, Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, Los Angeles, California, 90033, USA.

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http://dx.doi.org/10.1038/s41598-017-07356-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539300PMC
August 2017

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.

Blood 2017 06 9;129(26):3465-3475. Epub 2017 May 9.

Division of Hematology, Department of Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA; and.

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http://dx.doi.org/10.1182/blood-2016-05-718585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492089PMC
June 2017

Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi.

Bioinformatics 2017 02;33(4):558-560

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408810PMC
February 2017

A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families.

J Mol Diagn 2016 07 4;18(4):480-93. Epub 2016 May 4.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California; Department of Pathology, USC Roski Eye Institute, University of Southern California, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820122PMC
July 2016

Synergisitic and Antagonistic AML Cell Type-specific Responses to 5-Aza-2-deoxycitidine and 1-h-D-Arabinofuranoside.

Anticancer Res 2016 Feb;36(2):691-6

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, U.S.A.

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February 2016

Clinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group.

Clin Cancer Res 2015 Oct;21(20):4733-9

Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Medical Center, Dallas, Texas. Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610152PMC
October 2015

Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma.

J Pediatr Hematol Oncol 2015 Aug;37(6):e356-60

*Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX †Department of Pathology and Laboratory Medicine ‡Division of Hematology, Oncology and BMT, Children's Hospital Los Angeles §Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1097/MPH.0000000000000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506202PMC
August 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression.

Clin Cancer Res 2015 Mar;21(5):1139-50

Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas. Departments of Cell Biology and Biochemistry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1882DOI Listing
March 2015

Epigenetic reprogramming and re-differentiation of a Ewing sarcoma cell line.

Front Cell Dev Biol 2015 9;3:15. Epub 2015 Mar 9.

Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Baltimore, MD, USA ; Ron Matricaria Institute of Molecular Medicine, Phoenix Children's Hospital, University of Arizona Phoenix, AZ, USA.

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http://journal.frontiersin.org/Article/10.3389/fcell.2015.00
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http://dx.doi.org/10.3389/fcell.2015.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353378PMC
March 2015

Discovery and validation of novel expression signature for postcystectomy recurrence in high-risk bladder cancer.

J Natl Cancer Inst 2014 Nov 24;106(11). Epub 2014 Oct 24.

Department of Pathology and Center for Personalized Medicine (APM, TJT) and Institute of Urology and Norris Comprehensive Cancer Center (SD), University of Southern California, Los Angeles, CA; GenomeDx Biosciences, Inc., Vancouver, BC (LLL, MG, NE, IAV, MA, CB, ZH, TS, TJT, ED); Department of Urology and the Stanford Cancer Institute, Stanford University, Stanford, CA (ECS); Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada (PCB).

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http://dx.doi.org/10.1093/jnci/dju290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241889PMC
November 2014

Second-generation antihistamines exhibit a protective effect on drivers in traffic-a preliminary population-based case-control study.

Traffic Inj Prev 2014 ;15(6):551-5

a Division of Forensic Toxicology, Hjelt-Institute , University of Helsinki, University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/15389588.2013.861597DOI Listing
September 2014

Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.

PLoS One 2013 2;8(12):e80060. Epub 2013 Dec 2.

Childrens Center for Cancer and Blood Diseases, Childrens Hospital Los Angeles, Los Angeles, California, United States of America ; Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America ; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080060PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846563PMC
August 2014

DrugPath: a database for academic investigators to match oncology molecular targets with drugs in development.

Cancer Chemother Pharmacol 2014 May 25;73(5):1089-93. Epub 2014 Mar 25.

Cancer Center and Departments of Cell Biology and Biochemistry, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th St, STOP 9445, Lubbock, TX, 79430, USA.

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http://link.springer.com/10.1007/s00280-014-2433-9
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http://dx.doi.org/10.1007/s00280-014-2433-9DOI Listing
May 2014

Reprogramming of the human intestinal epigenome by surgical tissue transposition.

Genome Res 2014 Apr 10;24(4):545-53. Epub 2014 Feb 10.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA;

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http://dx.doi.org/10.1101/gr.166439.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975055PMC
April 2014

Whole-transcriptome profiling of thyroid nodules identifies expression-based signatures for accurate thyroid cancer diagnosis.

J Clin Endocrinol Metab 2013 Oct 8;98(10):4072-9. Epub 2013 Aug 8.

Bsc, MD, FRCSC, Room C303, Burrard Building, Department of Surgery, St Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia, Canada V6Z 1Y6.

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http://dx.doi.org/10.1210/jc.2013-1991DOI Listing
October 2013

T lymphocyte abnormalities in juvenile systemic sclerosis patients.

Clin Immunol 2013 Oct 7;149(1):146-55. Epub 2013 Aug 7.

Division of Rheumatology, Children's Hospital Los Angeles, 4650 Sunset Blvd., Mail Stop 60, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2013.07.005DOI Listing
October 2013

PAX-FOXO1 fusion status drives unfavorable outcome for children with rhabdomyosarcoma: a children's oncology group report.

Pediatr Blood Cancer 2013 Sep 22;60(9):1411-7. Epub 2013 Mar 22.

Children's Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1002/pbc.24532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646073PMC
September 2013

A novel algorithm for simplification of complex gene classifiers in cancer.

Cancer Res 2013 Sep 2;73(18):5625-32. Epub 2013 Aug 2.

Authors' Affiliations: Division of Hematology/Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, Texas; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pathology, University of Southern California and Children's Hospital of Los Angeles, Los Angeles, California; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital and Department of Pathology and Pediatrics, The Ohio State University, Columbus, Ohio; National Cancer Institute, Bethesda, Maryland; Division of Hematology/Oncology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, Washington; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska; The Section of Pediatric Hematology/Oncology, Department of Pediatrics, Department of Pathology, Center for Research Informatics, and The Computation Institute, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233649PMC
September 2013

FOXM1 is an oncogenic mediator in Ewing Sarcoma.

PLoS One 2013 24;8(1):e54556. Epub 2013 Jan 24.

Division of Hematology-Oncology, Department of Pediatrics, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054556PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554707PMC
July 2013

Urokinase-type Plasminogen Activator (uPA) is Inhibited with QLT0267 a Small Molecule Targeting Integrin-linked Kinase (ILK).

Transl Oncogenomics 2007 23;2:85-97. Epub 2007 Jul 23.

Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, BC Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634623PMC
May 2013

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

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http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

Low-level processing of Illumina Infinium DNA Methylation BeadArrays.

Nucleic Acids Res 2013 Apr 9;41(7):e90. Epub 2013 Mar 9.

Department of Preventive Medicine, USC Keck School of Medicine of USC, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1093/nar/gkt090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627582PMC
April 2013

TARGETgene: a tool for identification of potential therapeutic targets in cancer.

PLoS One 2012 31;7(8):e43305. Epub 2012 Aug 31.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432038PMC
February 2013

A central role for long non-coding RNA in cancer.

Front Genet 2012 15;3:17. Epub 2012 Feb 15.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fgene.2012.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279698PMC
October 2012

Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor.

Sarcoma 2012 11;2012:126906. Epub 2012 Sep 11.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Mattel Children's Hospital and Gwynne Hazen Cherry Memorial Laboratories, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095-1781, USA.

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http://www.hindawi.com/journals/sarcoma/2012/126906/
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http://dx.doi.org/10.1155/2012/126906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447386PMC
October 2012

Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study.

J Pathol 2012 Sep 2;228(1):119-30. Epub 2012 Jul 2.

Department of Pathology, Northwestern University Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA.

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http://dx.doi.org/10.1002/path.4010DOI Listing
September 2012

Transcriptome-wide detection of differentially expressed coding and non-coding transcripts and their clinical significance in prostate cancer.

J Oncol 2012 16;2012:541353. Epub 2012 Aug 16.

Department of Research and Development, GenomeDx Biosciences Inc., Vancouver, BC, Canada V6J 1J8.

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http://dx.doi.org/10.1155/2012/541353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431106PMC
September 2012

An epigenomic mechanism in retinoblastoma: the end of the story?

Genome Med 2012 Feb 24;4(2):15. Epub 2012 Feb 24.

The Vision Center, Children's Hospital Los Angeles, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1186/gm314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392761PMC
February 2012

Influence of RNA labeling on expression profiling of microRNAs.

J Mol Diagn 2012 Jan 7;14(1):12-21. Epub 2011 Nov 7.

Department of Pathology, Children's Hospital Los Angeles Saban Research Institute and Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2011.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338349PMC
January 2012

Quantitative expression profiling in formalin-fixed paraffin-embedded samples by affymetrix microarrays.

J Mol Diagn 2010 Jul 3;12(4):409-17. Epub 2010 Jun 3.

Department of Pathology, Children's Hospital Los Angeles, Research Institute and Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.2353/jmoldx.2010.090155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893624PMC
July 2010

Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells.

Mol Cancer Ther 2010 May 27;9(5):1396-407. Epub 2010 Apr 27.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0604DOI Listing
May 2010

Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation.

FASEB J 2010 Mar 16;24(3):833-43. Epub 2009 Nov 16.

Department of Pathology, MS# 103, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1096/fj.09-142976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830139PMC
March 2010

Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group.

J Clin Oncol 2010 Mar 1;28(7):1240-6. Epub 2010 Feb 1.

Department of Pathology, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1200/JCO.2008.21.1268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040045PMC
March 2010

Prediction of human functional genetic networks from heterogeneous data using RVM-based ensemble learning.

Bioinformatics 2010 Mar 4;26(6):807-13. Epub 2010 Feb 4.

Department of Biomedical Engineering, University of Southern California, Los Angeles, 90089, USA.

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http://dx.doi.org/10.1093/bioinformatics/btq044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832827PMC
March 2010

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.

BMC Genomics 2009 Dec 23;10:625. Epub 2009 Dec 23.

Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1471-2164-10-625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803201PMC
December 2009

Extraosseous Ewing's sarcoma: 25 years later.

J Clin Oncol 2008 Sep;26(26):4230-2

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http://dx.doi.org/10.1200/JCO.2008.16.5308DOI Listing
September 2008

Sparse representation and Bayesian detection of genome copy number alterations from microarray data.

Bioinformatics 2008 Feb 18;24(3):309-18. Epub 2008 Jan 18.

Signal and Image Processing Institute, Ming Hsieh Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, EEB 400, 3740 McClintock Ave, Los Angeles, CA 90089-2564, USA.

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http://dx.doi.org/10.1093/bioinformatics/btm601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704547PMC
February 2008

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation.

Genet Epidemiol 2007 Dec;31(8):871-82

Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089-9011, USA.

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http://dx.doi.org/10.1002/gepi.20248DOI Listing
December 2007

Experimental comparison and evaluation of the Affymetrix exon and U133Plus2 GeneChip arrays.

PLoS One 2007 Sep 19;2(9):e913. Epub 2007 Sep 19.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000913PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976394PMC
September 2007

Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.

J Natl Cancer Inst 2007 Jul 10;99(14):1107-19. Epub 2007 Jul 10.

Institute for Pediatric Clinical Research and Division of Hematology-Oncology, Childrens Hospital Los Angeles, University of South California, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1093/jnci/djm044DOI Listing
July 2007

Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease.

Ophthalmology 2007 Jan;114(1):99-103

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1016/j.ophtha.2006.07.043DOI Listing
January 2007

Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha.

FASEB J 2006 Oct 25;20(12):2142-4. Epub 2006 Aug 25.

Department of Pathology, Childrens Hospital Los Angeles Saban Research Institute, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1096/fj.06-5900fjeDOI Listing
October 2006

Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas.

Cancer Res 2006 Jul;66(14):6936-46

Department of Pathology and Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California 90027, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4578DOI Listing
July 2006

The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.

Cancer Res 2006 Feb;66(4):1982-9

Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2360DOI Listing
February 2006

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.

Mol Cell Biol 2006 Jan;26(1):277-92

Department of Pathology, British Columbia Research Institute for Children's and Women's Health, Vancouver, BC, Canada V5Z 163.

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http://dx.doi.org/10.1128/MCB.26.1.277-292.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317623PMC
January 2006

A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 2. In vitro and in vivo uptake results.

Bioconjug Chem 2005 Sep-Oct;16(5):1071-80

Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/bc0501146DOI Listing
December 2005

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor.

Proc Natl Acad Sci U S A 2005 Nov 28;102(45):16239-44. Epub 2005 Oct 28.

Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA.

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http://dx.doi.org/10.1073/pnas.0503137102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283417PMC
November 2005

Affymetrix oligonucleotide analysis of gene expression in the injured heart.

Methods Mol Med 2005 ;112:305-20

The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital/Providence Health Care, University of British Columbia, Vancouver, Canada.

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August 2005

EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.

Cancer Res 2005 Jun;65(11):4633-44

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2857DOI Listing
June 2005

Lack of interferon response in animals to naked siRNAs.

Nat Biotechnol 2004 Dec 21;22(12):1579-82. Epub 2004 Nov 21.

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http://dx.doi.org/10.1038/nbt1038DOI Listing
December 2004

Retinoid-modulated MAT1 ubiquitination and CAK activity.

FASEB J 2004 Nov 2;18(14):1734-6. Epub 2004 Sep 2.

Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1096/fj.04-2182fjeDOI Listing
November 2004

Selective usage of D-Type cyclins by Ewing's tumors and rhabdomyosarcomas.

Cancer Res 2004 Sep;64(17):6026-34

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-2594DOI Listing
September 2004