Timothy Thornton

Timothy Thornton

UNVERIFIED PROFILE

Are you Timothy Thornton?   Register this Author

Register author
Timothy Thornton

Timothy Thornton

Publications by authors named "Timothy Thornton"

Are you Timothy Thornton?   Register this Author

76Publications

3027Reads

45Profile Views

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Authors:
Joshua C Bis Xueqiu Jian Brian W Kunkle Yuning Chen Kara L Hamilton-Nelson William S Bush William J Salerno Daniel Lancour Yiyi Ma Alan E Renton Edoardo Marcora John J Farrell Yi Zhao Liming Qu Shahzad Ahmad Najaf Amin Philippe Amouyel Gary W Beecham Jennifer E Below Dominique Campion Laura Cantwell Camille Charbonnier Jaeyoon Chung Paul K Crane Carlos Cruchaga L Adrienne Cupples Jean-François Dartigues Stéphanie Debette Jean-François Deleuze Lucinda Fulton Stacey B Gabriel Emmanuelle Genin Richard A Gibbs Alison Goate Benjamin Grenier-Boley Namrata Gupta Jonathan L Haines Aki S Havulinna Seppo Helisalmi Mikko Hiltunen Daniel P Howrigan M Arfan Ikram Jaakko Kaprio Jan Konrad Amanda Kuzma Eric S Lander Mark Lathrop Terho Lehtimäki Honghuang Lin Kari Mattila Richard Mayeux Donna M Muzny Waleed Nasser Benjamin Neale Kwangsik Nho Gaël Nicolas Devanshi Patel Margaret A Pericak-Vance Markus Perola Bruce M Psaty Olivier Quenez Farid Rajabli Richard Redon Christiane Reitz Anne M Remes Veikko Salomaa Chloe Sarnowski Helena Schmidt Michael Schmidt Reinhold Schmidt Hilkka Soininen Timothy A Thornton Giuseppe Tosto Christophe Tzourio Sven J van der Lee Cornelia M van Duijn Otto Valladares Badri Vardarajan Li-San Wang Weixin Wang Ellen Wijsman Richard K Wilson Daniela Witten Kim C Worley Xiaoling Zhang Celine Bellenguez Jean-Charles Lambert Mitja I Kurki Aarno Palotie Mark Daly Eric Boerwinkle Kathryn L Lunetta Anita L Destefano Josée Dupuis Eden R Martin Gerard D Schellenberg Sudha Seshadri Adam C Naj Myriam Fornage Lindsay A Farrer

Mol Psychiatry 2019 Oct 21. Epub 2019 Oct 21.

Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41380-019-0529-7DOI Listing
October 2019

Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.

Authors:
Rachel Dalton Seung-Been Lee Katrina G Claw Bhagwat Prasad Brian R Phillips Danny D Shen Lai Hong Wong Mitch Fade Matthew G McDonald Maitreya J Dunham Douglas M Fowler Allan E Rettie Erin Schuetz Timothy A Thornton Deborah A Nickerson Andrea Gaedigk Kenneth E Thummel Erica L Woodahl

Clin Transl Sci 2019 Sep 19. Epub 2019 Sep 19.

Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/cts.12695DOI Listing
September 2019

Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics.

Authors:
Elizabeth E Blue Andréa R V R Horimoto Shubhabrata Mukherjee Ellen M Wijsman Timothy A Thornton

Alzheimers Dement 2019 Sep 25. Epub 2019 Sep 25.

Department of Biostatistics, University of Washington, Seattle, WA, USA; Department of Statistics, University of Washington, Seattle, WA, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2019.07.016DOI Listing
September 2019

Genetic association testing using the GENESIS R/Bioconductor package.

Authors:
Stephanie M Gogarten Tamar Sofer Han Chen Chaoyu Yu Jennifer A Brody Timothy A Thornton Kenneth M Rice Matthew P Conomos

Bioinformatics 2019 Jul 22. Epub 2019 Jul 22.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btz567DOI Listing
July 2019

Genetic analyses of diverse populations improves discovery for complex traits.

Authors:
Genevieve L Wojcik Mariaelisa Graff Katherine K Nishimura Ran Tao Jeffrey Haessler Christopher R Gignoux Heather M Highland Yesha M Patel Elena P Sorokin Christy L Avery Gillian M Belbin Stephanie A Bien Iona Cheng Sinead Cullina Chani J Hodonsky Yao Hu Laura M Huckins Janina Jeff Anne E Justice Jonathan M Kocarnik Unhee Lim Bridget M Lin Yingchang Lu Sarah C Nelson Sung-Shim L Park Hannah Poisner Michael H Preuss Melissa A Richard Claudia Schurmann Veronica W Setiawan Alexandra Sockell Karan Vahi Marie Verbanck Abhishek Vishnu Ryan W Walker Kristin L Young Niha Zubair Victor Acuña-Alonso Jose Luis Ambite Kathleen C Barnes Eric Boerwinkle Erwin P Bottinger Carlos D Bustamante Christian Caberto Samuel Canizales-Quinteros Matthew P Conomos Ewa Deelman Ron Do Kimberly Doheny Lindsay Fernández-Rhodes Myriam Fornage Benyam Hailu Gerardo Heiss Brenna M Henn Lucia A Hindorff Rebecca D Jackson Cecelia A Laurie Cathy C Laurie Yuqing Li Dan-Yu Lin Andres Moreno-Estrada Girish Nadkarni Paul J Norman Loreall C Pooler Alexander P Reiner Jane Romm Chiara Sabatti Karla Sandoval Xin Sheng Eli A Stahl Daniel O Stram Timothy A Thornton Christina L Wassel Lynne R Wilkens Cheryl A Winkler Sachi Yoneyama Steven Buyske Christopher A Haiman Charles Kooperberg Loic Le Marchand Ruth J F Loos Tara C Matise Kari E North Ulrike Peters Eimear E Kenny Christopher S Carlson

Nature 2019 06 19;570(7762):514-518. Epub 2019 Jun 19.

Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41586-019-1310-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785182PMC
June 2019

GWAS of QRS duration identifies new loci specific to Hispanic/Latino populations.

Authors:
Brenton R Swenson Tin Louie Henry J Lin Raúl Méndez-Giráldez Jennifer E Below Cathy C Laurie Kathleen F Kerr Heather Highland Timothy A Thornton Kelli K Ryckman Charles Kooperberg Elsayed Z Soliman Amanda A Seyerle Xiuqing Guo Kent D Taylor Jie Yao Susan R Heckbert Dawood Darbar Lauren E Petty Barbara McKnight Susan Cheng Natalie A Bello Eric A Whitsel Craig L Hanis Mike A Nalls Daniel S Evans Jerome I Rotter Tamar Sofer Christy L Avery Nona Sotoodehnia

PLoS One 2019 28;14(6):e0217796. Epub 2019 Jun 28.

Cardiovascular Health Research Unit, University of Washington, Seattle, WA, United States of America.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217796PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599128PMC
June 2019

VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People.

Authors:
Lindsay M Henderson Renee F Robinson Lily Ray Burhan A Khan Tianran Li Denise A Dillard Brian D Schilling Mike Mosley Patricia L Janssen Alison E Fohner Allan E Rettie Kenneth E Thummel Timothy A Thornton David L Veenstra

Clin Transl Sci 2019 May 1;12(3):312-320. Epub 2019 Mar 1.

Department of Pharmacy, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/cts.12611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510382PMC
May 2019

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.

Authors:
Brian E Cade Han Chen Adrienne M Stilp Tin Louie Sonia Ancoli-Israel Raanan Arens Richard Barfield Jennifer E Below Jianwen Cai Matthew P Conomos Daniel S Evans Alexis C Frazier-Wood Sina A Gharib Kevin J Gleason Daniel J Gottlieb David R Hillman W Craig Johnson David J Lederer Jiwon Lee Jose S Loredo Hao Mei Sutapa Mukherjee Sanjay R Patel Wendy S Post Shaun M Purcell Alberto R Ramos Kathryn J Reid Ken Rice Neomi A Shah Tamar Sofer Kent D Taylor Timothy A Thornton Heming Wang Kristine Yaffe Phyllis C Zee Craig L Hanis Lyle J Palmer Jerome I Rotter Katie L Stone Gregory J Tranah James G Wilson Shamil R Sunyaev Cathy C Laurie Xiaofeng Zhu Richa Saxena Xihong Lin Susan Redline

PLoS Genet 2019 04 16;15(4):e1007739. Epub 2019 Apr 16.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pgen.1007739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467367PMC
April 2019

Accuracy of Gene Expression Prediction From Genotype Data With PrediXcan Varies Across and Within Continental Populations.

Authors:
Anna V Mikhaylova Timothy A Thornton

Front Genet 2019 3;10:261. Epub 2019 Apr 3.

Department of Biostatistics, University of Washington, Seattle, WA, United States.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fgene.2019.00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456650PMC
April 2019

Genome-wide Significance Thresholds for Admixture Mapping Studies.

Authors:
Kelsey E Grinde Lisa A Brown Alexander P Reiner Timothy A Thornton Sharon R Browning

Am J Hum Genet 2019 03 14;104(3):454-465. Epub 2019 Feb 14.

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00029297193000
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407497PMC
March 2019

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.

Authors:
Kelsey E Grinde Qibin Qi Timothy A Thornton Simin Liu Aladdin H Shadyab Kei Hang K Chan Alexander P Reiner Tamar Sofer

Genet Epidemiol 2019 02 15;43(1):50-62. Epub 2018 Oct 15.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1002/gepi.22166
Publisher Site
http://dx.doi.org/10.1002/gepi.22166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330129PMC
February 2019

Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.

Authors:
Heming Wang Brian E Cade Tamar Sofer Scott A Sands Han Chen Sharon R Browning Adrienne M Stilp Tin L Louie Timothy A Thornton W Craig Johnson Jennifer E Below Matthew P Conomos Daniel S Evans Sina A Gharib Xiuqing Guo Alexis C Wood Hao Mei Kristine Yaffe Jose S Loredo Alberto R Ramos Elizabeth Barrett-Connor Sonia Ancoli-Israel Phyllis C Zee Raanan Arens Neomi A Shah Kent D Taylor Gregory J Tranah Katie L Stone Craig L Hanis James G Wilson Daniel J Gottlieb Sanjay R Patel Ken Rice Wendy S Post Jerome I Rotter Shamil R Sunyaev Jianwen Cai Xihong Lin Shaun M Purcell Cathy C Laurie Richa Saxena Susan Redline Xiaofeng Zhu

Hum Mol Genet 2019 02;28(4):675-687

Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.

View Article

Download full-text PDF

 Source
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
Publisher Site
http://dx.doi.org/10.1093/hmg/ddy387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360325PMC
February 2019

Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study.

Authors:
Tsegaselassie Workalemahu Daniel A Enquobahrie Bizu Gelaye Timothy A Thornton Fasil Tekola-Ayele Sixto E Sanchez Pedro J Garcia Henry G Palomino Anjum Hajat Roberto Romero Cande V Ananth Michelle A Williams

Am J Obstet Gynecol 2018 12 5;219(6):617.e1-617.e17. Epub 2018 Sep 5.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajog.2018.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497388PMC
December 2018

Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease.

Authors:
Gary W Beecham Badri Vardarajan Elizabeth Blue William Bush James Jaworski Sandra Barral Anita DeStefano Kara Hamilton-Nelson Brian Kunkle Eden R Martin Adam Naj Farid Rajabli Christiane Reitz Timothy Thornton Cornelia van Duijn Allison Goate Sudha Seshadri Lindsay A Farrer Eric Boerwinkle Gerard Schellenberg Jonathan L Haines Ellen Wijsman Richard Mayeux Margaret A Pericak-Vance

Neurol Genet 2018 Dec 21;4(6):e286. Epub 2018 Nov 21.

John P. Hussman Institute for Human Genomics (G.W.B., J.J., K.H.-N., B.K., E.R.M., F.R., M.A.P.-V.), University of Miami, Miller School of Medicine; Dr. John T. Macdonald Foundation Department of Human Genetics (G.W.B., E.R.M., M.A.P.-V.), University of Miami, Miller School of Medicine, FL; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain (B.V., S.B., C.R., R.M.), Columbia University; The Gertrude H. Segievsky Center (B.V., S.B., C.R., R.M.), Columbia University, New York Presbyterian Hospital; Division of Medical Genetics (E. Blue, E.W.), Department of Medicine, University of Washington, Seattle; Institute for Computational Biology (W.B., J.L.H.), Case Western Reserve University, Cleveland, OH; Department of Neurology (A.D., S.S., L.A.F.), Boston University School of Medicine; Department of Biostatistics (A.D., S.S., L.A.F.), Boston University School of Medicine, MA; School of Medicine (A.N., G.S.), University of Pennsylvania, Philadelphia; Department of Biostatistics (T.T., E.W.), University of Washington, Seattle; Erasmus Medical University (C.D.), Rotterdam, The Netherlands; Icahn School of Medicine at Mount Sinai (A.G.), New York, NY; Department of Medicine (L.A.F.), Boston University School of Medicine, MA; and University of Texas (E. Boerwinkle), Houston.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1212/NXG.0000000000000286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278241PMC
December 2018

Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project.

Authors:
Elizabeth E Blue Joshua C Bis Michael O Dorschner Debby W Tsuang Sandra M Barral Gary Beecham Jennifer E Below William S Bush Mariusz Butkiewicz Carlos Cruchaga Anita DeStefano Lindsay A Farrer Alison Goate Jonathan Haines Jim Jaworski Gyungah Jun Brian Kunkle Amanda Kuzma Jenny J Lee Kathryn L Lunetta Yiyi Ma Eden Martin Adam Naj Alejandro Q Nato Patrick Navas Hiep Nguyen Christiane Reitz Dolly Reyes William Salerno Gerard D Schellenberg Sudha Seshadri Harkirat Sohi Timothy A Thornton Otto Valadares Cornelia van Duijn Badri N Vardarajan Li-San Wang Eric Boerwinkle Josée Dupuis Margaret A Pericak-Vance Richard Mayeux Ellen M Wijsman

Dement Geriatr Cogn Disord 2018 27;45(1-2):1-17. Epub 2018 Feb 27.

University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1159/000485503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971141PMC
October 2018

Analysis of pedigree data in populations with multiple ancestries: Strategies for dealing with admixture in Caribbean Hispanic families from the ADSP.

Authors:
Rafael A Nafikov Alejandro Q Nato Harkirat Sohi Bowen Wang Lisa Brown Andrea R Horimoto Badri N Vardarajan Sandra M Barral Giuseppe Tosto Richard P Mayeux Timothy A Thornton Elizabeth Blue Ellen M Wijsman

Genet Epidemiol 2018 09 3;42(6):500-515. Epub 2018 Jun 3.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/gepi.22133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160322PMC
September 2018

Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Authors:
Joshua C Bis Xueqiu Jian Brian W Kunkle Yuning Chen Kara L Hamilton-Nelson William S Bush William J Salerno Daniel Lancour Yiyi Ma Alan E Renton Edoardo Marcora John J Farrell Yi Zhao Liming Qu Shahzad Ahmad Najaf Amin Philippe Amouyel Gary W Beecham Jennifer E Below Dominique Campion Laura Cantwell Camille Charbonnier Jaeyoon Chung Paul K Crane Carlos Cruchaga L Adrienne Cupples Jean-François Dartigues Stéphanie Debette Jean-François Deleuze Lucinda Fulton Stacey B Gabriel Emmanuelle Genin Richard A Gibbs Alison Goate Benjamin Grenier-Boley Namrata Gupta Jonathan L Haines Aki S Havulinna Seppo Helisalmi Mikko Hiltunen Daniel P Howrigan M Arfan Ikram Jaakko Kaprio Jan Konrad Amanda Kuzma Eric S Lander Mark Lathrop Terho Lehtimäki Honghuang Lin Kari Mattila Richard Mayeux Donna M Muzny Waleed Nasser Benjamin Neale Kwangsik Nho Gaël Nicolas Devanshi Patel Margaret A Pericak-Vance Markus Perola Bruce M Psaty Olivier Quenez Farid Rajabli Richard Redon Christiane Reitz Anne M Remes Veikko Salomaa Chloe Sarnowski Helena Schmidt Michael Schmidt Reinhold Schmidt Hilkka Soininen Timothy A Thornton Giuseppe Tosto Christophe Tzourio Sven J van der Lee Cornelia M van Duijn Otto Valladares Badri Vardarajan Li-San Wang Weixin Wang Ellen Wijsman Richard K Wilson Daniela Witten Kim C Worley Xiaoling Zhang Celine Bellenguez Jean-Charles Lambert Mitja I Kurki Aarno Palotie Mark Daly Eric Boerwinkle Kathryn L Lunetta Anita L Destefano Josée Dupuis Eden R Martin Gerard D Schellenberg Sudha Seshadri Adam C Naj Myriam Fornage Lindsay A Farrer

Mol Psychiatry 2018 Aug 14. Epub 2018 Aug 14.

Departments of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41380-018-0112-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375806PMC
August 2018

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.

Authors:
Deepak Kumar Bhatt Abdul Basit Haeyoung Zhang Andrea Gaedigk Seung-Been Lee Katrina G Claw Aanchal Mehrotra Amarjit Singh Chaudhry Robin E Pearce Roger Gaedigk Ulrich Broeckel Timothy A Thornton Deborah A Nickerson Erin G Schuetz John K Amory J Steven Leeder Bhagwat Prasad

Drug Metab Dispos 2018 06 30;46(6):888-896. Epub 2018 Mar 30.

Departments of Pharmaceutics (D.K.B., A.B., H.Z., K.G.C., A.M., B.P.), Genome Sciences (S.L., D.A.N.), Biostatistics (T.A.T.), and Medicine (J.K.A.), University of Washington, Seattle, Washington; Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Missouri (A.G., R.E.P., R.G., J.S.L.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (A.S.C., E.G.S.); and Section of Genomic Pediatrics, Department of Pediatrics, and Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin (U.B.)

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1124/dmd.118.080952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938891PMC
June 2018

Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies.

Authors:
Tsegaselassie Workalemahu Daniel A Enquobahrie Bizu Gelaye Sixto E Sanchez Pedro J Garcia Fasil Tekola-Ayele Anjum Hajat Timothy A Thornton Cande V Ananth Michelle A Williams

Placenta 2018 06 16;66:8-16. Epub 2018 Apr 16.

Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.placenta.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995331PMC
June 2018

Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People.

Authors:
Burhan A Khan Renee Robinson Alison E Fohner LeeAnna I Muzquiz Brian D Schilling Julie A Beans Matthew J Olnes Laura Trawicki Holly Frydenlund Cindi Laukes Patrick Beatty Brian Phillips Deborah Nickerson Kevin Howlett Denise A Dillard Timothy A Thornton Kenneth E Thummel Erica L Woodahl

Clin Transl Sci 2018 05 13;11(3):312-321. Epub 2018 Feb 13.

Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/cts.12542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944577PMC
May 2018

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D-3--Sulfate, a Major Circulating Vitamin D Metabolite in Humans.

Authors:
Timothy Wong Zhican Wang Brian D Chapron Mizuki Suzuki Katrina G Claw Chunying Gao Robert S Foti Bhagwat Prasad Alenka Chapron Justina Calamia Amarjit Chaudhry Erin G Schuetz Ronald L Horst Qingcheng Mao Ian H de Boer Timothy A Thornton Kenneth E Thummel

Drug Metab Dispos 2018 04 17;46(4):367-379. Epub 2018 Jan 17.

Departments of Pharmaceutics (T.W., Z.W., B.D.C., M.S., K.G.C., C.G., B.P., Al.C., J.C., Q.M., K.E.T.), Medicine and Kidney Research Institute (I.H.d.B.), and Biostatistics (T.A.T.), University of Washington, Seattle, Washington; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California (Z.W.); Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (R.S.F.); St. Jude Children's Research Hospital, Memphis, Tennessee (Am.C., E.G.S.); and Heartland Assays LLC, Ames, Iowa (R.L.H.)

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1124/dmd.117.078428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829543PMC
April 2018

Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease.

Authors:
Badri N Vardarajan Sandra Barral James Jaworski Gary W Beecham Elizabeth Blue Giuseppe Tosto Dolly Reyes-Dumeyer Martin Medrano Rafael Lantigua Adam Naj Timothy Thornton Anita DeStefano Eden Martin Li-San Wang Lisa Brown William Bush Cornelia van Duijn Allison Goate Lindsay Farrer Jonathan L Haines Eric Boerwinkle Gerard Schellenberg Ellen Wijsman Margaret A Pericak-Vance Richard Mayeux Li-San Wang

Ann Clin Transl Neurol 2018 Apr 13;5(4):406-417. Epub 2018 Mar 13.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain New York.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/acn3.537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899906PMC
April 2018

Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.

Authors:
Han Chen Brian E Cade Kevin J Gleason Andrew C Bjonnes Adrienne M Stilp Tamar Sofer Matthew P Conomos Sonia Ancoli-Israel Raanan Arens Ali Azarbarzin Graeme I Bell Jennifer E Below Sung Chun Daniel S Evans Ralf Ewert Alexis C Frazier-Wood Sina A Gharib José Haba-Rubio Erika W Hagen Raphael Heinzer David R Hillman W Craig Johnson Zoltan Kutalik Jacqueline M Lane Emma K Larkin Seung Ku Lee Jingjing Liang Jose S Loredo Sutapa Mukherjee Lyle J Palmer George J Papanicolaou Thomas Penzel Paul E Peppard Wendy S Post Alberto R Ramos Ken Rice Jerome I Rotter Scott A Sands Neomi A Shah Chol Shin Katie L Stone Beate Stubbe Jae Hoon Sul Mehdi Tafti Kent D Taylor Alexander Teumer Timothy A Thornton Gregory J Tranah Chaolong Wang Heming Wang Simon C Warby D Andrew Wellman Phyllis C Zee Craig L Hanis Cathy C Laurie Daniel J Gottlieb Sanjay R Patel Xiaofeng Zhu Shamil R Sunyaev Richa Saxena Xihong Lin Susan Redline

Am J Respir Cell Mol Biol 2018 03;58(3):391-401

4 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1165/rcmb.2017-0237OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854957PMC
March 2018

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.

Authors:
Laura M Raffield Jacob C Ulirsch Rakhi P Naik Samuel Lessard Robert E Handsaker Deepti Jain Hyun M Kang Nathan Pankratz Paul L Auer Erik L Bao Joshua D Smith Leslie A Lange Ethan M Lange Yun Li Timothy A Thornton Bessie A Young Goncalo R Abecasis Cathy C Laurie Deborah A Nickerson Steven A McCarroll Adolfo Correa James G Wilson Guillaume Lettre Vijay G Sankaran Alex P Reiner

PLoS Genet 2018 03 28;14(3):e1007293. Epub 2018 Mar 28.

Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pgen.1007293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891078PMC
March 2018

Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska.

Authors:
Nicholas T Au Tove Ryman Allan E Rettie Scarlett E Hopkins Bert B Boyer Jynene Black Jacques Philip Joseph Yracheta Alison E Fohner Morayma Reyes Timothy A Thornton Melissa A Austin Kenneth E Thummel

Mol Nutr Food Res 2018 02 29;62(3). Epub 2017 Dec 29.

Department of Pharmaceutics, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/mnfr.201700746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803412PMC
February 2018

Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits.

Authors:
Tamar Sofer Leslie J Baier Sharon R Browning Timothy A Thornton Gregory A Talavera Sylvia Wassertheil-Smoller Martha L Daviglus Robert Hanson Sayuko Kobes Richard S Cooper Jianwen Cai Daniel Levy Alex P Reiner Nora Franceschini

PLoS One 2017 20;12(11):e0188400. Epub 2017 Nov 20.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States of America.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188400PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695820PMC
December 2017

Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.

Authors:
Kathleen F Kerr Christy L Avery Henry J Lin Laura M Raffield Qian S Zhang Brian L Browning Sharon R Browning Matthew P Conomos Stephanie M Gogarten Cathy C Laurie Tamar Sofer Timothy A Thornton Chancellor Hohensee Rebecca D Jackson Charles Kooperberg Yun Li Raúl Méndez-Giráldez Marco V Perez Ulrike Peters Alexander P Reiner Zhu-Ming Zhang Jie Yao Nona Sotoodehnia Kent D Taylor Xiuqing Guo Leslie A Lange Elsayed Z Soliman James G Wilson Jerome I Rotter Susan R Heckbert Deepti Jain Eric A Whitsel

Heart Rhythm 2017 11 10;14(11):1675-1684. Epub 2017 Jun 10.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.hrthm.2017.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671896PMC
November 2017

Dietary and genetic influences on hemostasis in a Yup'ik Alaska Native population.

Authors:
Nicholas T Au Morayma Reyes Bert B Boyer Scarlett E Hopkins Jynene Black Diane O'Brien Alison E Fohner Joe Yracheta Timothy Thornton Melissa A Austin Wylie Burke Kenneth E Thummel Allan E Rettie

PLoS One 2017 4;12(4):e0173616. Epub 2017 Apr 4.

Department of Medicinal Chemistry, University of Washington, Seattle, Washington, United States of America.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173616PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380313PMC
August 2017

Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits.

Authors:
Xiang Zhan Ni Zhao Anna Plantinga Timothy A Thornton Karen N Conneely Michael P Epstein Michael C Wu

Genetics 2017 08 22;206(4):1779-1790. Epub 2017 Jun 22.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1534/genetics.116.199646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560787PMC
August 2017

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 08 2;8:16140. Epub 2017 Aug 2.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms16140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543301PMC
August 2017

Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States.

Authors:
Lisa A Brown Tamar Sofer Adrienne M Stilp Leslie J Baier Holly J Kramer Ivica Masindova Daniel Levy Robert L Hanson Ashley E Moncrieft Susan Redline Sylvia E Rosas James P Lash Jianwen Cai Cathy C Laurie Sharon Browning Timothy Thornton Nora Franceschini

J Am Soc Nephrol 2017 Jul 30;28(7):2211-2220. Epub 2017 Jan 30.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1681/ASN.2016091010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491288PMC
July 2017

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Authors:
Gyungah R Jun Jaeyoon Chung Jesse Mez Robert Barber Gary W Beecham David A Bennett Joseph D Buxbaum Goldie S Byrd Minerva M Carrasquillo Paul K Crane Carlos Cruchaga Philip De Jager Nilufer Ertekin-Taner Denis Evans M Danielle Fallin Tatiana M Foroud Robert P Friedland Alison M Goate Neill R Graff-Radford Hugh Hendrie Kathleen S Hall Kara L Hamilton-Nelson Rivka Inzelberg M Ilyas Kamboh John S K Kauwe Walter A Kukull Brian W Kunkle Ryozo Kuwano Eric B Larson Mark W Logue Jennifer J Manly Eden R Martin Thomas J Montine Shubhabrata Mukherjee Adam Naj Eric M Reiman Christiane Reitz Richard Sherva Peter H St George-Hyslop Timothy Thornton Steven G Younkin Badri N Vardarajan Li-San Wang Jens R Wendlund Ashley R Winslow Jonathan Haines Richard Mayeux Margaret A Pericak-Vance Gerard Schellenberg Kathryn L Lunetta Lindsay A Farrer

Alzheimers Dement 2017 Jul 7;13(7):727-738. Epub 2017 Feb 7.

Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jalz.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496797PMC
July 2017

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 06 14;8:15805. Epub 2017 Jun 14.

Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms15805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474732PMC
June 2017

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.

Authors:
Raymond Noordam Colleen M Sitlani Christy L Avery James D Stewart Stephanie M Gogarten Kerri L Wiggins Stella Trompet Helen R Warren Fangui Sun Daniel S Evans Xiaohui Li Jin Li Albert V Smith Joshua C Bis Jennifer A Brody Evan L Busch Mark J Caulfield Yii-Der I Chen Steven R Cummings L Adrienne Cupples Qing Duan Oscar H Franco Rául Méndez-Giráldez Tamara B Harris Susan R Heckbert Diana van Heemst Albert Hofman James S Floyd Jan A Kors Lenore J Launer Yun Li Ruifang Li-Gao Leslie A Lange Henry J Lin Renée de Mutsert Melanie D Napier Christopher Newton-Cheh Neil Poulter Alexander P Reiner Kenneth M Rice Jeffrey Roach Carlos J Rodriguez Frits R Rosendaal Naveed Sattar Peter Sever Amanda A Seyerle P Eline Slagboom Elsayed Z Soliman Nona Sotoodehnia David J Stott Til Stürmer Kent D Taylor Timothy A Thornton André G Uitterlinden Kirk C Wilhelmsen James G Wilson Vilmundur Gudnason J Wouter Jukema Cathy C Laurie Yongmei Liu Dennis O Mook-Kanamori Patricia B Munroe Jerome I Rotter Ramachandran S Vasan Bruce M Psaty Bruno H Stricker Eric A Whitsel

J Med Genet 2017 05 30;54(5):313-323. Epub 2016 Dec 30.

Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1136/jmedgenet-2016-104112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406254PMC
May 2017

Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?

Authors:
Laura M Raffield Tin Louie Tamar Sofer Deepti Jain Eli Ipp Kent D Taylor George J Papanicolaou Larissa Avilés-Santa Leslie A Lange Cathy C Laurie Matthew P Conomos Timothy A Thornton Yii-Der Ida Chen Qibin Qi Scott Cotler Bharat Thyagarajan Neil Schneiderman Jerome I Rotter Alex P Reiner Henry J Lin

Hum Mol Genet 2017 05;26(10):1966-1978

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, and the David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/hmg/ddx082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075359PMC
May 2017

A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL.

Authors:
Tamar Sofer Ruth Heller Marina Bogomolov Christy L Avery Mariaelisa Graff Kari E North Alex P Reiner Timothy A Thornton Kenneth Rice Yoav Benjamini Cathy C Laurie Kathleen F Kerr

Genet Epidemiol 2017 04 15;41(3):251-258. Epub 2017 Jan 15.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/gepi.22029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340573PMC
April 2017

Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis.

Authors:
Chelle L Wheat Cynthia W Ko Kindra Clark-Snustad David Grembowski Timothy A Thornton Beth Devine

BMC Gastroenterol 2017 Apr 14;17(1):52. Epub 2017 Apr 14.

Department of Health Services, School of Public Health, University of Washington, 1959 NE Pacific Street, Magnuson Health Sciences Center, Room H-680, Box 357660, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12876-017-0602-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391579PMC
April 2017

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.

Authors:
Chani J Hodonsky Deepti Jain Ursula M Schick Jean V Morrison Lisa Brown Caitlin P McHugh Claudia Schurmann Diane D Chen Yong Mei Liu Paul L Auer Cecilia A Laurie Kent D Taylor Brian L Browning Yun Li George Papanicolaou Jerome I Rotter Ryo Kurita Yukio Nakamura Sharon R Browning Ruth J F Loos Kari E North Cathy C Laurie Timothy A Thornton Nathan Pankratz Daniel E Bauer Tamar Sofer Alex P Reiner

PLoS Genet 2017 04 28;13(4):e1006760. Epub 2017 Apr 28.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pgen.1006760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428979PMC
April 2017

African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.

Authors:
Holly J Kramer Adrienne M Stilp Cathy C Laurie Alex P Reiner James Lash Martha L Daviglus Sylvia E Rosas Ana C Ricardo Bamidele O Tayo Michael F Flessner Kathleen F Kerr Carmen Peralta Ramon Durazo-Arvizu Matt Conomos Timothy Thornton Jerome Rotter Kent D Taylor Jainwen Cai John Eckfeldt Han Chen George Papanicolau Nora Franceschini

J Am Soc Nephrol 2017 Mar 20;28(3):915-922. Epub 2016 Sep 20.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1681/ASN.2016030357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328161PMC
March 2017

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

Authors:
Deepti Jain Chani J Hodonsky Ursula M Schick Jean V Morrison Sharon Minnerath Lisa Brown Claudia Schurmann Yongmei Liu Paul L Auer Cecelia A Laurie Kent D Taylor Brian L Browning George Papanicolaou Sharon R Browning Ruth J F Loos Kari E North Bharat Thyagarajan Cathy C Laurie Timothy A Thornton Tamar Sofer Alexander P Reiner

Hum Mol Genet 2017 03;26(6):1193-1204

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/hmg/ddx024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968624PMC
March 2017

Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.

Authors:
Brian E Cade Han Chen Adrienne M Stilp Kevin J Gleason Tamar Sofer Sonia Ancoli-Israel Raanan Arens Graeme I Bell Jennifer E Below Andrew C Bjonnes Sung Chun Matthew P Conomos Daniel S Evans W Craig Johnson Alexis C Frazier-Wood Jacqueline M Lane Emma K Larkin Jose S Loredo Wendy S Post Alberto R Ramos Ken Rice Jerome I Rotter Neomi A Shah Katie L Stone Kent D Taylor Timothy A Thornton Gregory J Tranah Chaolong Wang Phyllis C Zee Craig L Hanis Shamil R Sunyaev Sanjay R Patel Cathy C Laurie Xiaofeng Zhu Richa Saxena Xihong Lin Susan Redline

Am J Respir Crit Care Med 2016 Oct;194(7):886-897

1 Division of Sleep and Circadian Disorders and.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1164/rccm.201512-2431OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074655PMC
October 2016

Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data.

Authors:
Mohamad Saad Alejandro Q Nato Fiona L Grimson Steven M Lewis Lisa A Brown Elizabeth M Blue Timothy A Thornton Elizabeth A Thompson Ellen M Wijsman

BMC Proc 2016 18;10(Suppl 7):295-301. Epub 2016 Oct 18.

Department of Biostatistics, University of Washington, Seattle, WA USA ; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA USA ; Department of Genome Sciences, University of Washington, Seattle, WA USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12919-016-0046-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133511PMC
October 2016

Estimating relationships between phenotypes and subjects drawn from admixed families.

Authors:
Elizabeth M Blue Lisa A Brown Matthew P Conomos Jennifer L Kirk Alejandro Q Nato Alice B Popejoy Jesse Raffa John Ranola Ellen M Wijsman Timothy Thornton

BMC Proc 2016 18;10(Suppl 7):357-362. Epub 2016 Oct 18.

Department of Biostatistics, University of Washington, Seattle, WA 98195 USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12919-016-0056-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133521PMC
October 2016

Detecting Heterogeneity in Population Structure Across the Genome in Admixed Populations.

Authors:
Caitlin McHugh Lisa Brown Timothy A Thornton

Genetics 2016 Sep 20;204(1):43-56. Epub 2016 Jul 20.

Department of Biostatistics, University of Washington, Seattle, Washington 98195

View Article

Download full-text PDF

 Source
http://www.genetics.org/lookup/doi/10.1534/genetics.115.1841
Publisher Site
http://dx.doi.org/10.1534/genetics.115.184184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012403PMC
September 2016

Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity.

Authors:
Anubha Mahajan Aylin R Rodan Thu H Le Kyle J Gaulton Jeffrey Haessler Adrienne M Stilp Yoichiro Kamatani Gu Zhu Tamar Sofer Sanjana Puri Jeffrey N Schellinger Pei-Lun Chu Sylvia Cechova Natalie van Zuydam Johan Arnlov Michael F Flessner Vilmantas Giedraitis Andrew C Heath Michiaki Kubo Anders Larsson Cecilia M Lindgren Pamela A F Madden Grant W Montgomery George J Papanicolaou Alex P Reiner Johan Sundström Timothy A Thornton Lars Lind Erik Ingelsson Jianwen Cai Nicholas G Martin Charles Kooperberg Koichi Matsuda John B Whitfield Yukinori Okada Cathy C Laurie Andrew P Morris Nora Franceschini

Am J Hum Genet 2016 Sep;99(3):636-646

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2016.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011075PMC
September 2016

Improved imputation accuracy in Hispanic/Latino populations with larger and more diverse reference panels: applications in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Authors:
Sarah C Nelson Adrienne M Stilp George J Papanicolaou Kent D Taylor Jerome I Rotter Timothy A Thornton Cathy C Laurie

Hum Mol Genet 2016 08 26;25(15):3245-3254. Epub 2016 Jun 26.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/hmg/ddw174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179925PMC
August 2016

Worldwide Incidence of Colorectal Cancer, Leukemia, and Lymphoma in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis.

Authors:
Chelle L Wheat Kindra Clark-Snustad Beth Devine David Grembowski Timothy A Thornton Cynthia W Ko

Gastroenterol Res Pract 2016 16;2016:1632439. Epub 2016 May 16.

Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1155/2016/1632439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884856PMC
June 2016

The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable.

Authors:
Jesse Mez Shubhabrata Mukherjee Timothy Thornton David W Fardo Emily Trittschuh Sheila Sutti Richard Sherva John S Kauwe Adam C Naj Gary W Beecham Alden Gross Andrew J Saykin Robert C Green Paul K Crane

Neurobiol Aging 2016 May 21;41:115-121. Epub 2016 Feb 21.

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.neurobiolaging.2016.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843522PMC
May 2016

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models.

Authors:
Han Chen Chaolong Wang Matthew P Conomos Adrienne M Stilp Zilin Li Tamar Sofer Adam A Szpiro Wei Chen John M Brehm Juan C Celedón Susan Redline George J Papanicolaou Timothy A Thornton Cathy C Laurie Kenneth Rice Xihong Lin

Am J Hum Genet 2016 Apr 24;98(4):653-66. Epub 2016 Mar 24.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2016.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833218PMC
April 2016

Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska.

Authors:
Alison E Fohner Zhican Wang Joseph Yracheta Diane M O'Brien Scarlett E Hopkins Jynene Black Jacques Philip Howard W Wiener Hemant K Tiwari Patricia L Stapleton Jesse M Tsai Timothy A Thornton Bert B Boyer Kenneth E Thummel

J Nutr 2016 Feb 9;146(2):318-25. Epub 2015 Dec 9.

Departments of Pharmaceutics,

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3945/jn.115.223388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725435PMC
February 2016

Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL).

Authors:
Jean Morrison Cathy C Laurie Mary L Marazita Anne E Sanders Steven Offenbacher Christian R Salazar Matthew P Conomos Timothy Thornton Deepti Jain Cecelia A Laurie Kathleen F Kerr George Papanicolaou Kent Taylor Linda M Kaste James D Beck John R Shaffer

Hum Mol Genet 2016 Feb 11;25(4):807-16. Epub 2015 Dec 11.

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA,

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/hmg/ddv506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743689PMC
February 2016

Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.

Authors:
Ursula M Schick Deepti Jain Chani J Hodonsky Jean V Morrison James P Davis Lisa Brown Tamar Sofer Matthew P Conomos Claudia Schurmann Caitlin P McHugh Sarah C Nelson Swarooparani Vadlamudi Adrienne Stilp Anna Plantinga Leslie Baier Stephanie A Bien Stephanie M Gogarten Cecelia A Laurie Kent D Taylor Yongmei Liu Paul L Auer Nora Franceschini Adam Szpiro Ken Rice Kathleen F Kerr Jerome I Rotter Robert L Hanson George Papanicolaou Stephen S Rich Ruth J F Loos Brian L Browning Sharon R Browning Bruce S Weir Cathy C Laurie Karen L Mohlke Kari E North Timothy A Thornton Alex P Reiner

Am J Hum Genet 2016 Feb 21;98(2):229-42. Epub 2016 Jan 21.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746331PMC
February 2016

Model-free Estimation of Recent Genetic Relatedness.

Authors:
Matthew P Conomos Alexander P Reiner Bruce S Weir Timothy A Thornton

Am J Hum Genet 2016 Jan;98(1):127-48

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716688PMC
January 2016

Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos.

Authors:
Matthew P Conomos Cecelia A Laurie Adrienne M Stilp Stephanie M Gogarten Caitlin P McHugh Sarah C Nelson Tamar Sofer Lindsay Fernández-Rhodes Anne E Justice Mariaelisa Graff Kristin L Young Amanda A Seyerle Christy L Avery Kent D Taylor Jerome I Rotter Gregory A Talavera Martha L Daviglus Sylvia Wassertheil-Smoller Neil Schneiderman Gerardo Heiss Robert C Kaplan Nora Franceschini Alex P Reiner John R Shaffer R Graham Barr Kathleen F Kerr Sharon R Browning Brian L Browning Bruce S Weir M Larissa Avilés-Santa George J Papanicolaou Thomas Lumley Adam A Szpiro Kari E North Ken Rice Timothy A Thornton Cathy C Laurie

Am J Hum Genet 2016 Jan;98(1):165-84

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00029297150049
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716704PMC
January 2016

Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX.

Authors:
Alison E Fohner Renee Robinson Joseph Yracheta Denise A Dillard Brian Schilling Burhan Khan Scarlett Hopkins Bert Boyer Jynene Black Howard Wiener Hemant K Tiwari Adam Gordon Deborah Nickerson Jesse M Tsai Federico M Farin Timothy A Thornton Allan E Rettie Kenneth E Thummel

Pharmacogenet Genomics 2015 Jul;25(7):343-353

Department of Pharmaceutics, University of Washington, Seattle, WA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/FPC.0000000000000143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461509PMC
July 2015

Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.

Authors:
Paul L Auer Mike Nalls James F Meschia Bradford B Worrall W T Longstreth Sudha Seshadri Charles Kooperberg Kathleen M Burger Christopher S Carlson Cara L Carty Wei-Min Chen L Adrienne Cupples Anita L DeStefano Myriam Fornage John Hardy Li Hsu Rebecca D Jackson Gail P Jarvik Daniel S Kim Kamakshi Lakshminarayan Leslie A Lange Ani Manichaikul Aaron R Quinlan Andrew B Singleton Timothy A Thornton Deborah A Nickerson Ulrike Peters Stephen S Rich

JAMA Neurol 2015 Jul;72(7):781-8

Center for Public Health Genomics, University of Virginia, Charlottesville.

View Article

Download full-text PDF

 Source
http://kooperberg.fhcrc.org/papers/2015auer.pdf
Web Search
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2015.0582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673986PMC
July 2015

Robust inference of population structure for ancestry prediction and correction of stratification in the presence of relatedness.

Authors:
Matthew P Conomos Michael B Miller Timothy A Thornton

Genet Epidemiol 2015 May 23;39(4):276-93. Epub 2015 Mar 23.

Department of Biostatistics, University of Washington, Seattle, Washington, 98195, United States of America.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/gepi.21896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836868PMC
May 2015

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.

Authors:
Xiumei Hong Ke Hao Christine Ladd-Acosta Kasper D Hansen Hui-Ju Tsai Xin Liu Xin Xu Timothy A Thornton Deanna Caruso Corinne A Keet Yifei Sun Guoying Wang Wei Luo Rajesh Kumar Ramsay Fuleihan Anne Marie Singh Jennifer S Kim Rachel E Story Ruchi S Gupta Peisong Gao Zhu Chen Sheila O Walker Tami R Bartell Terri H Beaty M Daniele Fallin Robert Schleimer Patrick G Holt Kari Christine Nadeau Robert A Wood Jacqueline A Pongracic Daniel E Weeks Xiaobin Wang

Nat Commun 2015 Feb 24;6:6304. Epub 2015 Feb 24.

1] Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA [2] Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ncomms7304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086PMC
February 2015

Statistical methods for genome-wide and sequencing association studies of complex traits in related samples.

Authors:
Timothy A Thornton

Curr Protoc Hum Genet 2015 Jan 20;84:1.28.1-1.28.9. Epub 2015 Jan 20.

Department of Biostatistics, University of Washington, Seattle, Washington.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/0471142905.hg0128s84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327940PMC
January 2015

Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative.

Authors:
Thomas J Hoffmann Hua Tang Timothy A Thornton Bette Caan Mary Haan Amy E Millen Fridtjof Thomas Neil Risch

Hum Mol Genet 2014 Dec 15;23(24):6634-43. Epub 2014 Jul 15.

Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA, Division of Research, Kaiser Permanente, Oakland, CA 94612, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/hmg/ddu364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240199PMC
December 2014

Estimating and adjusting for ancestry admixture in statistical methods for relatedness inference, heritability estimation, and association testing.

Authors:
Timothy Thornton Matthew P Conomos Serge Sverdlov Elizabeth M Blue Charles Yk Cheung Christopher G Glazner Steven M Lewis Ellen M Wijsman

BMC Proc 2014 17;8(Suppl 1):S5. Epub 2014 Jun 17.

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA ; Department of Medicine, Division of Medical Genetics, University of Washington, Health Sciences Building, K-253, Box 357720, Seattle, WA 98195, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1753-6561-8-S1-S5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143704PMC
December 2014

Identity-by-descent graphs offer a flexible framework for imputation and both linkage and association analyses.

Authors:
Elizabeth Marchani Blue Charles Yk Cheung Christopher G Glazner Matthew P Conomos Steven M Lewis Serge Sverdlov Timothy Thornton Ellen M Wijsman

BMC Proc 2014 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S19. Epub 2014 Jun 17.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA ; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1753-6561-8-S1-S19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143703PMC
December 2014

Local and global ancestry inference and applications to genetic association analysis for admixed populations.

Authors:
Timothy A Thornton Justo Lorenzo Bermejo

Genet Epidemiol 2014 Sep;38 Suppl 1:S5-S12

Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1002/gepi.21819
Publisher Site
http://dx.doi.org/10.1002/gepi.21819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339867PMC
September 2014

Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association.

Authors:
Md Tauqeer Alam Robert A Petit Emily K Crispell Timothy A Thornton Karen N Conneely Yunxuan Jiang Sarah W Satola Timothy D Read

Genome Biol Evol 2014 Apr 30;6(5):1174-85. Epub 2014 Apr 30.

Division of Infectious Diseases, Department of Medicine, Emory University School of MedicineDepartment of Human Genetics, Emory University School of Medicine

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/gbe/evu092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040999PMC
April 2014

African American race but not genome-wide ancestry is negatively associated with atrial fibrillation among postmenopausal women in the Women's Health Initiative.

Authors:
Marco V Perez Thomas J Hoffmann Hua Tang Timothy Thornton Marcia L Stefanick Joseph C Larson Charles Kooperberg Alex P Reiner Bette Caan Carlos Iribarren Neil Risch

Am Heart J 2013 Sep 7;166(3):566-72. Epub 2013 Aug 7.

Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ahj.2013.05.024DOI Listing
September 2013

Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.

Authors:
Alison Fohner LeeAnna I Muzquiz Melissa A Austin Andrea Gaedigk Adam Gordon Timothy Thornton Mark J Rieder Mark A Pershouse Elizabeth A Putnam Kevin Howlett Patrick Beatty Kenneth E Thummel Erica L Woodahl

Pharmacogenet Genomics 2013 Aug;23(8):403-14

Department of Public Health Genetics, School of Public Health, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/FPC.0b013e3283629ce9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937472PMC
August 2013

Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative.

Authors:
Virginia G Kaklamani Thomas J Hoffmann Timothy A Thornton Geoffrey Hayes Rowan Chlebowski Linda Van Horn Christos Mantzoros

Breast Cancer Res Treat 2013 Jun 30;139(2):461-8. Epub 2013 Apr 30.

Division Hematology/Oncology, Department of Medicine, Northwestern University, Chicago, IL 60611, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s10549-013-2546-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773607PMC
June 2013

Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.

Authors:
Marc A Coram Qing Duan Thomas J Hoffmann Timothy Thornton Joshua W Knowles Nicholas A Johnson Heather M Ochs-Balcom Timothy A Donlon Lisa W Martin Charles B Eaton Jennifer G Robinson Neil J Risch Xiaofeng Zhu Charles Kooperberg Yun Li Alex P Reiner Hua Tang

Am J Hum Genet 2013 Jun 30;92(6):904-16. Epub 2013 May 30.

Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2013.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675231PMC
June 2013

Association of DXA-derived bone mineral density and fat mass with African ancestry.

Authors:
Heather M Ochs-Balcom Leah Preus Jean Wactawski-Wende Jing Nie Nicholas A Johnson Fouad Zakharia Hua Tang Chris Carlson Cara Carty Zhao Chen Thomas Hoffman Carolyn M Hutter Rebecca D Jackson Robert C Kaplan Li Li Song Liu Marian L Neuhouser Ulrike Peters John Robbins Michael F Seldin Timothy A Thornton Cheryl L Thompson Charles Kooperberg Lara E Sucheston

J Clin Endocrinol Metab 2013 Apr 22;98(4):E713-7. Epub 2013 Feb 22.

Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY14214-8001, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1210/jc.2012-3921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615193PMC
April 2013

XM: association testing on the X-chromosome in case-control samples with related individuals.

Authors:
Timothy Thornton Qian Zhang Xiaochen Cai Carole Ober Mary Sara McPeek

Genet Epidemiol 2012 Jul 2;36(5):438-50. Epub 2012 May 2.

Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA.

View Article

Download full-text PDF

 Source
http://doi.wiley.com/10.1002/gepi.21638
Publisher Site
http://dx.doi.org/10.1002/gepi.21638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762984PMC
July 2012

Estimating kinship in admixed populations.

Authors:
Timothy Thornton Hua Tang Thomas J Hoffmann Heather M Ochs-Balcom Bette J Caan Neil Risch

Am J Hum Genet 2012 Jul 28;91(1):122-38. Epub 2012 Jun 28.

Department of Biostatistics, University of Washington, Seattle, 98195, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2012.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397261PMC
July 2012

Application of a new method for GWAS in a related case/control sample with known pedigree structure: identification of new loci for nephrolithiasis.

Authors:
Silvia Tore Stefania Casula Giuseppina Casu Maria Pina Concas Paola Pistidda Ivana Persico Alessandro Sassu Giovanni Battista Maestrale Caterina Mele Maria Rosa Caruso Bibiana Bonerba Paolo Usai Ivo Deiana Timothy Thornton Mario Pirastu Paola Forabosco

PLoS Genet 2011 Jan 20;7(1):e1001281. Epub 2011 Jan 20.

Istituto di Genetica delle Popolazioni-CNR, Sassari, Italy.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1371/journal.pgen.1001281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024262PMC
January 2011

Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand.

Authors:
Nopasak Phasukkijwatana Bussaraporn Kunhapan Jim Stankovich Wanicha L Chuenkongkaew Russell Thomson Timothy Thornton Melanie Bahlo Taisei Mushiroda Yusuke Nakamura Surakameth Mahasirimongkol Aung Win Tun Chatchawan Srisawat Chanin Limwongse Chayanon Peerapittayamongkol Thanyachai Sura Wichit Suthammarak Patcharee Lertrit

Hum Genet 2010 Jul 21;128(1):39-49. Epub 2010 Apr 21.

Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00439-010-0821-8DOI Listing
July 2010

ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure.

Authors:
Timothy Thornton Mary Sara McPeek

Am J Hum Genet 2010 Feb 4;86(2):172-84. Epub 2010 Feb 4.

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ajhg.2010.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820184PMC
February 2010

Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease.

Authors:
Liesel M FitzGerald Briony Patterson Russell Thomson Andrea Polanowski Stephen Quinn Jesper Brohede Timothy Thornton David Challis David A Mackey Terence Dwyer Simon Foote Garry N Hannan James Stankovich James D McKay Joanne L Dickinson

Eur J Hum Genet 2009 Mar 1;17(3):368-77. Epub 2008 Oct 1.

Genetics Unit, Menzies Research Institute, University of Tasmania, Hobart, Australia.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/ejhg.2008.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2986161PMC
March 2009

Case-control association testing with related individuals: a more powerful quasi-likelihood score test.

Authors:
Timothy Thornton Mary Sara McPeek

Am J Hum Genet 2007 Aug 10;81(2):321-37. Epub 2007 Jul 10.

Department of Statistics, University of Chicago, Chicago, IL 60637, USA.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00029297076119
Publisher Site
http://dx.doi.org/10.1086/519497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950805PMC
August 2007