Publications by authors named "Timothy S C Hinks"

36Publications

Reply to: Don't Forget About Facilitatory Effects of Corticosteroids on beta-2 adrenoceptors in Acute Asthma.

Am J Respir Crit Care Med 2020 Sep 24. Epub 2020 Sep 24.

University of Tampere, 7840, Immunopharmacology reserach group, Tampere, Finland;

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http://dx.doi.org/10.1164/rccm.202008-3106LEDOI Listing
September 2020

Azithromycin in viral infections.

Rev Med Virol 2020 Sep 23:e2163. Epub 2020 Sep 23.

Nuffield Department of Medicine Experimental Medicine, Respiratory Medicine Unit and National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC), University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/rmv.2163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536932PMC
September 2020

A multi-centre open-label two-arm randomised superiority clinical trial of azithromycin versus usual care in ambulatory COVID-19: study protocol for the ATOMIC2 trial.

Trials 2020 Aug 17;21(1):718. Epub 2020 Aug 17.

Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxfordshire, OX3 9DU, UK.

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http://dx.doi.org/10.1186/s13063-020-04593-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429453PMC
August 2020

Boosting MAIT cells as immunotherapy: context is everything.

Mucosal Immunol 2020 Aug 12. Epub 2020 Aug 12.

Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1038/s41385-020-00337-8DOI Listing
August 2020

Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.

Am J Respir Crit Care Med 2020 Jun 25. Epub 2020 Jun 25.

University of Tampere, 7840, Immunopharmacology reserach group, Tampere, Finland;

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http://dx.doi.org/10.1164/rccm.202003-0729LEDOI Listing
June 2020

MAIT Cell Activation and Functions.

Front Immunol 2020 27;11:1014. Epub 2020 May 27.

Respiratory Medicine Unit and National Institute for Health Research (NIHR), Nuffield Department of Medicine Experimental Medicine, Oxford Biomedical Research Centre (BRC), University of Oxford, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2020.01014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267072PMC
May 2020

The role of interleukin-17 in asthma: a protective response?

ERJ Open Res 2020 Apr 26;6(2). Epub 2020 May 26.

Respiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Dept of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1183/23120541.00364-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248344PMC
April 2020

ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19.

J Allergy Clin Immunol 2020 07 22;146(1):208-211. Epub 2020 May 22.

National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (Respiratory theme) and College of Life Sciences, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2020.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243787PMC
July 2020

Treatment of COVID-19-exacerbated asthma: should systemic corticosteroids be used?

Am J Physiol Lung Cell Mol Physiol 2020 06 13;318(6):L1244-L1247. Epub 2020 May 13.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1152/ajplung.00144.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276980PMC
June 2020

Study of MAIT Cell Activation in Viral Infections In Vivo.

Methods Mol Biol 2020 ;2098:261-281

Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.1007/978-1-0716-0207-2_17DOI Listing
January 2020

Influenza A Virus-Infected Lung Epithelial Cell Co-Culture with Human Peripheral Blood Mononuclear Cells.

Methods Mol Biol 2020 ;2098:141-147

Respiratory Medicine Unit, Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxfordshire, UK.

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http://dx.doi.org/10.1007/978-1-0716-0207-2_9DOI Listing
January 2020

CD8 Tc2 cells: underappreciated contributors to severe asthma.

Eur Respir Rev 2019 Dec 20;28(154). Epub 2019 Nov 20.

Division of Cell Biology, Dept of Pediatrics, National Jewish Health, Denver, CO, USA

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http://dx.doi.org/10.1183/16000617.0092-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887553PMC
December 2019

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.

Cell Rep 2019 09;28(12):3077-3091.e5

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899450PMC
September 2019

Is there a role for type 2 CD8 T cells in patients with steroid-resistant asthma?

J Allergy Clin Immunol 2019 09 31;144(3):648-650. Epub 2019 Jul 31.

Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine Experimental Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.07.022DOI Listing
September 2019

Cytometric Gating Stringency Impacts Studies of Type 2 Innate Lymphoid Cells in Asthma.

Am J Respir Cell Mol Biol 2017 12;57(6):745-747

1 University of Oxford Oxford, United Kingdom and.

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http://dx.doi.org/10.1165/rcmb.2017-0201LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765422PMC
December 2017

Coal mine dust lung disease in the modern era.

Respirology 2017 05 30;22(4):662-670. Epub 2017 Mar 30.

Lung Health Research Centre (LHRC), The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/resp.13034DOI Listing
May 2017

Metabolomics analysis identifies different metabotypes of asthma severity.

Eur Respir J 2017 03 29;49(3). Epub 2017 Mar 29.

Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1183/13993003.01740-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399350PMC
March 2017

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.

J Allergy Clin Immunol 2016 07 3;138(1):61-75. Epub 2016 Feb 3.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929135PMC
July 2016

Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease.

Immunology 2016 May 9;148(1):1-12. Epub 2016 Feb 9.

Department for Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/imm.12582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819138PMC
May 2016

A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.

J Immunol 2015 Jun 1;194(12):6144-54. Epub 2015 May 1.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton SO16 6YD, United Kingdom; Southampton National Institute for Health Research Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton SO16 6YD, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1402283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456633PMC
June 2015

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms.

J Allergy Clin Immunol 2015 Aug 5;136(2):323-33. Epub 2015 Mar 5.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom. Electronic address:

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https://www.researchgate.net/profile/Borislav_D_Dimitrov/pub
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http://linkinghub.elsevier.com/retrieve/pii/S009167491500104
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http://dx.doi.org/10.1016/j.jaci.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534770PMC
August 2015

High background rates of positive tuberculosis-specific interferon-γ release assays in a low prevalence region of UK: a surveillance study.

BMC Infect Dis 2012 Dec 6;12:339. Epub 2012 Dec 6.

Academic Unit of Clinical and Experimental Sciences, Mailpoint 0810, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1186/1471-2334-12-339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537536PMC
December 2012

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.

J Allergy Clin Immunol 2012 Dec 14;130(6):1404-12.e7. Epub 2012 Sep 14.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2012.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805016PMC
December 2012

Mycobacterium tuberculosis-specific cellular immune profiles suggest bacillary persistence decades after spontaneous cure in untreated tuberculosis.

J Infect Dis 2010 Dec 19;202(11):1685-9. Epub 2010 Oct 19.

Tuberculosis Research Unit, Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1086/656772DOI Listing
December 2010

Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.

J Immunol 2007 Apr;178(8):5217-26

Tuberculosis Immunology Group, Department of Respiratory Medicine, National Heart and Lung Institute, Wright Fleming Institute of Infection and Immunity, Imperial College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743164PMC
http://dx.doi.org/10.4049/jimmunol.178.8.5217DOI Listing
April 2007