Publications by authors named "Timothy R Hercus"

23Publications

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.

MAbs 2018 10 12;10(7):1018-1029. Epub 2018 Sep 12.

a St. Vincent's Institute of Medical Research , Australian Cancer Research Foundation Rational Drug Discovery Centre , Fitzroy , Victoria , Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19420862.2018.1494107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204844PMC
October 2018

GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells .

Clin Transl Immunology 2016 Dec 23;5(12):e119. Epub 2016 Dec 23.

Translational Oncology, Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, Australia; Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, Australia; Discipline of Medicine, University of Adelaide, Adelaide, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cti.2016.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192067PMC
December 2016

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

Structure 2016 08 7;24(8):1271-1281. Epub 2016 Jul 7.

ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2016.05.017DOI Listing
August 2016

The βc receptor family - Structural insights and their functional implications.

Cytokine 2015 Aug 14;74(2):247-58. Epub 2015 May 14.

Australian Cancer Research Foundation Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10434666150006
Publisher Site
http://dx.doi.org/10.1016/j.cyto.2015.02.005DOI Listing
August 2015

Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

Mol Cell Oncol 2014 Oct-Dec;1(4):e969129. Epub 2014 Dec 31.

The Centre for Cancer Biology; SA Pathology and the University of South Australia ; Adelaide, South Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/23288604.2014.969129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905208PMC
June 2016

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

Acta Crystallogr F Struct Biol Commun 2014 Mar 19;70(Pt 3):358-61. Epub 2014 Feb 19.

Australian Cancer Research Foundation Rational Drug Discovery Centre and Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X14002593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944702PMC
March 2014

Signalling by the βc family of cytokines.

Cytokine Growth Factor Rev 2013 Jun 25;24(3):189-201. Epub 2013 Mar 25.

The Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, South Australia 5000, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2013.03.002DOI Listing
June 2013

Cytokine receptor activation at the cell surface.

Curr Opin Struct Biol 2012 Jun 20;22(3):350-9. Epub 2012 Apr 20.

St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2012.03.015DOI Listing
June 2012

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

Cell 2008 Aug;134(3):496-507

Biota Structural Biology Laboratory, St. Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2008.05.053DOI Listing
August 2008

Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 Aug 5;64(Pt 8):711-4. Epub 2008 Jul 5.

Biota Structural Biology Laboratory, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

View Article

Download full-text PDF

Source
http://scripts.iucr.org/cgi-bin/paper?S1744309108019404
Publisher Site
http://dx.doi.org/10.1107/S1744309108019404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494959PMC
August 2008

Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.

Blood 2003 Feb 10;101(4):1308-15. Epub 2002 Oct 10.

Cytokine Receptor Laboratory and Protein Laboratory, Division of Human Immunology, Institute of Medical and Veterinary Science (IMVS), Adelaide, South Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-06-1903DOI Listing
February 2003