Publications by authors named "Timothy R Billiar"

100Publications

Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding.

Mol Med 2020 Nov 25;26(1):115. Epub 2020 Nov 25.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1186/s10020-020-00227-6DOI Listing
November 2020

Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma.

Front Immunol 2020 25;11:1987. Epub 2020 Sep 25.

Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2020.01987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546816PMC
September 2020

Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling.

Nat Microbiol 2020 Dec 19;5(12):1576-1587. Epub 2020 Oct 19.

Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41564-020-00795-7DOI Listing
December 2020

Biomarkers to Distinguish Sepsis From Sterile Inflammation.

Ann Surg 2020 10;272(4):611

University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/SLA.0000000000004376DOI Listing
October 2020

TBK1/IKKε Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation.

Shock 2020 Sep 9. Epub 2020 Sep 9.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.

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http://dx.doi.org/10.1097/SHK.0000000000001632DOI Listing
September 2020

Platelet-Monocyte Aggregates: Understanding Mechanisms and Functions in Sepsis.

Shock 2020 Jul 15. Epub 2020 Jul 15.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1097/SHK.0000000000001619DOI Listing
July 2020

Disparities in rural versus urban field triage: Risk and mitigating factors for undertriage.

J Trauma Acute Care Surg 2020 07;89(1):246-253

From the Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000002690DOI Listing
July 2020

Author Correction: Caspase-11 signaling enhances graft-versus-host disease.

Nat Commun 2020 Mar 9;11(1):1349. Epub 2020 Mar 9.

Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University, Changsha, 410000, PR China.

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http://dx.doi.org/10.1038/s41467-020-15161-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062846PMC
March 2020

TMEM173 Drives Lethal Coagulation in Sepsis.

Cell Host Microbe 2020 04 5;27(4):556-570.e6. Epub 2020 Mar 5.

The Third Affiliated Hospital, Protein Modification and Degradation Lab of Guangzhou and Guangdong, Guangzhou Medical University, Guang Zhou, Guangdong 510600, China; Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2020.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316085PMC
April 2020

Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway.

J Exp Clin Cancer Res 2019 Dec 30;38(1):505. Epub 2019 Dec 30.

Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China, 430030.

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http://dx.doi.org/10.1186/s13046-019-1508-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936093PMC
December 2019

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure.

Immunity 2019 12 10;51(6):983-996.e6. Epub 2019 Dec 10.

Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University, Changsha 410000, P.R. China; Department of Pathophysiology, School of Basic Medical Science, Central South University, Changsha, Hunan Province 410000, P.R. China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, Changsha, Hunan Province 410000, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.11.005DOI Listing
December 2019

Caspase-11 signaling enhances graft-versus-host disease.

Nat Commun 2019 09 6;10(1):4044. Epub 2019 Sep 6.

Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University, Changsha, 410000, P.R. China.

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http://www.nature.com/articles/s41467-019-11895-2
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http://dx.doi.org/10.1038/s41467-019-11895-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731232PMC
September 2019

NO and hepatocellular cancer.

Br J Pharmacol 2019 Aug 18. Epub 2019 Aug 18.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/bph.14838DOI Listing
August 2019

Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.

Am J Pathol 2019 10 2;189(10):1986-2001. Epub 2019 Aug 2.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan; Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892227PMC
October 2019

TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity.

J Clin Invest 2019 08 5;129(9):3657-3669. Epub 2019 Aug 5.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI127542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715390PMC
August 2019

Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock.

Front Immunol 2019 11;10:1501. Epub 2019 Jul 11.

Department of Surgery, F1281 Presbyterian University Hospital, University of Pittsburgh, Pittsburgh, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638190PMC
October 2020

Elevations in Circulating sST2 Levels Are Associated With In-Hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma.

J Surg Res 2019 12 3;244:23-33. Epub 2019 Jul 3.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative, Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815699PMC
December 2019

Defining geographic emergency medical services coverage in trauma systems.

J Trauma Acute Care Surg 2019 Jul;87(1):92-99

From the Division of Trauma and General Surgery, Department of Surgery (J.B.B., M.R.R., A.B.P., T.R.B., J.L.S.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://Insights.ovid.com/crossref?an=01586154-201907000-0001
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http://dx.doi.org/10.1097/TA.0000000000002296DOI Listing
July 2019

Identifying patients with time-sensitive injuries: Association of mortality with increasing prehospital time.

J Trauma Acute Care Surg 2019 06;86(6):1015-1022

From the Division of General Surgery and Trauma, Department of Surgery (X.C., A.B.P., T.R.B., J.L.S., J.B.B.B), and Department of Emergency Medicine (F.X.G.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000002251DOI Listing
June 2019

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury.

Hepatology 2019 09 24;70(3):995-1010. Epub 2019 Jun 24.

Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1002/hep.30691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717545PMC
September 2019

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

J Leukoc Biol 2019 07 4;106(1):161-169. Epub 2019 Apr 4.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1002/JLB.3MIR1218-497RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597316PMC
July 2019

TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.

Mol Med 2018 12 27;24(1):66. Epub 2018 Dec 27.

Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The 3rd Xiangya Hospital, Central South University, Changsha, 410000, People's Republic of China.

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https://molmed.biomedcentral.com/articles/10.1186/s10020-018
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http://dx.doi.org/10.1186/s10020-018-0065-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307235PMC
December 2018

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury.

J Am Coll Surg 2019 02 16;228(2):148-160.e7. Epub 2018 Nov 16.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10727515183215
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http://dx.doi.org/10.1016/j.jamcollsurg.2018.10.019DOI Listing
February 2019

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Immunity 2018 10 9;49(4):740-753.e7. Epub 2018 Oct 9.

Department of Hematology and Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The 3rd Xiangya Hospital, Central South University, Changsha 410000, P.R. China; Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan Province 410000, P.R. China; Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University, Changsha, Hunan Province 410000, P.R. China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183037
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http://dx.doi.org/10.1016/j.immuni.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300139PMC
October 2018

iNOS promotes CD24CD133 liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway.

Proc Natl Acad Sci U S A 2018 10 8;115(43):E10127-E10136. Epub 2018 Oct 8.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213

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http://dx.doi.org/10.1073/pnas.1722100115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205478PMC
October 2018

The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner.

Shock 2019 09;52(3):e1-e11

Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1097/SHK.0000000000001260DOI Listing
September 2019

Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages.

Mil Med Res 2018 07 30;5(1):24. Epub 2018 Jul 30.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1186/s40779-018-0173-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065058PMC
July 2018

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

N Engl J Med 2018 Jul;379(4):315-326

From the Division of Trauma and General Surgery, Department of Surgery (J.L.S., J.B.B., L.H.A., B.S.Z., M.D.N., M.R.R., R.M.F., T.R.B., A.B.P., M.S.Z.), and the Departments of Emergency Medicine (F.X.G., C.W.C., D.M.Y.) and Critical Care Medicine (B.J.E.-Y., P.W.A.), University of Pittsburgh Medical Center, and the Department of Pathology, University of Pittsburgh and Institute for Transfusion Medicine (M.H.Y., D.J.T.), Pittsburgh, and University of Pittsburgh Medical Center, Altoona Hospital, Altoona (A.T.P.) - all in Pennsylvania; the Department of Surgery, University of Tennessee Health Science Center, Knoxville (B.J.D.), and the Department of Surgery, Vanderbilt University Medical Center, Nashville (R.S.M.) - both in Tennessee; the Department of Surgery, University of Louisville, Louisville, KY (B.G.H.); MetroHealth Medical Center, Case Western Reserve University, Cleveland (J.A.C.); and the Department of Surgery, University of Texas Southwestern, Parkland Memorial Hospital, Dallas (H.A.P.) and Texas Health Harris Methodist Hospital (W.R.W.) and the John Peter Smith Health Network (T.M.D.), Fort Worth - all in Texas.

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http://dx.doi.org/10.1056/NEJMoa1802345DOI Listing
July 2018

Blunt cerebrovascular injury in elderly fall patients: are we screening enough?

World J Emerg Surg 2018 4;13:30. Epub 2018 Jul 4.

Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213 USA.

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http://dx.doi.org/10.1186/s13017-018-0188-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031193PMC
December 2018

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.

Cell Rep 2018 07;24(2):366-378

The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Protein Modification and Degradation of Guangdong Higher Education Institutes, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 510510, China; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183092
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http://dx.doi.org/10.1016/j.celrep.2018.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094382PMC
July 2018

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.

Cell Host Microbe 2018 07 21;24(1):97-108.e4. Epub 2018 Jun 21.

The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Protein Modification and Degradation Laboratory of Guangdong Higher Education Institutes, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong 510510, China; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043361PMC
July 2018

Logistics of air medical transport: When and where does helicopter transport reduce prehospital time for trauma?

J Trauma Acute Care Surg 2018 07;85(1):174-181

From the Division of Trauma and General Surgery, Department of Surgery (X.C., M.R.R., A.B.P., T.R.B., J.L.S., J.B.B.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Division of Acute Care Surgery, Department of Surgery (M.G.L.), University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1097/TA.0000000000001935DOI Listing
July 2018

Interleukin-33 contributes to ILC2 activation and early inflammation-associated lung injury during abdominal sepsis.

Immunol Cell Biol 2018 10 17;96(9):935-947. Epub 2018 May 17.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1111/imcb.12159DOI Listing
October 2018

REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activation.

FASEB J 2018 08 16;32(8):4585-4599. Epub 2018 Mar 16.

Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, South Korea.

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http://dx.doi.org/10.1096/fj.201701436RDOI Listing
August 2018

Characterizing injury severity in nonaccidental trauma: Does Injury Severity Score miss the mark?

J Trauma Acute Care Surg 2018 Oct;85(4):668-673

From the Division of Trauma and General Surgery, Department of Surgery (J.B.B., C.M.L., J.L.S., A.B.P., T.R.B.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Division of Acute Care Surgery, Department of Surgery (M.L.G.), University of Rochester Medical Center, Rochester, New York; Golisano Children's Hospital (M.L.G.), University of Rochester, Rochester, New York; and Division of Pediatric General and Thoracic Surgery, Department of Surgery (C.M.L., B.A.G.), Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097954PMC
October 2018

Toll-Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide From Bacterial Outer Membrane Vesicles.

Shock 2019 02;51(2):256-265

Department of Hematology and Key Laboratory of Non-Resolving Inflammation and Cancer of Human Province, The 3rd Xiangya Hospital, Central South University, Changsha, Hunan Province, PR China.

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http://dx.doi.org/10.1097/SHK.0000000000001129DOI Listing
February 2019

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma.

J Orthop Trauma 2018 Mar;32 Suppl 1:S1-S6

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://Insights.ovid.com/crossref?an=00005131-201803003-0000
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http://dx.doi.org/10.1097/BOT.0000000000001114DOI Listing
March 2018

Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury.

J Trauma Acute Care Surg 2018 07;85(1):12-17

From the Division of General Surgery and Trauma, Department of Surgery (C.M.L., M.D.N., T.R.B., J.L.S.), Division of Pediatric General and Thoracic Surgery, University of Pittsburgh Medical Center; and Children's Hospital of Pittsburgh of UPMC (C.M.L., B.A.G.), Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001836DOI Listing
July 2018

Speed is not everything: Identifying patients who may benefit from helicopter transport despite faster ground transport.

J Trauma Acute Care Surg 2018 04;84(4):549-557

From the Division of Trauma and General Surgery, Department of Surgery (X.C., M.R.R., T.R.B., A.B.P., J.L.S., J.B.B.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Division of Acute Care Surgery, Department of Surgery (M.L.G.), University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1097/TA.0000000000001769DOI Listing
April 2018

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Gastroenterology 2018 04 14;154(5):1480-1493. Epub 2017 Dec 14.

The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Protein Modification and Degradation of Guangdong Higher Education Institutes, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou Medical University, Guangzhou, Guangdong, 510510, China; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880694PMC
April 2018

NO and COX2: Dual targeting for aggressive cancers.

Proc Natl Acad Sci U S A 2017 12 13;114(52):13591-13593. Epub 2017 Dec 13.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

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http://dx.doi.org/10.1073/pnas.1717440114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748226PMC
December 2017

High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis.

Hepatology 2018 05 1;67(5):1823-1841. Epub 2018 Apr 1.

Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Protein Modification and Degradation Laboratory, Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.1002/hep.29663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906197PMC
May 2018

Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury.

Hepatology 2018 03 24;67(3):1056-1070. Epub 2018 Jan 24.

Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

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http://dx.doi.org/10.1002/hep.29605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826835PMC
March 2018

ALK is a therapeutic target for lethal sepsis.

Sci Transl Med 2017 Oct;9(412)

The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory of Protein Modification and Degradation of Guangdong Higher Education Institutes, Guangzhou Medical University, Guangzhou, Guangdong 510510, China.

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http://dx.doi.org/10.1126/scitranslmed.aan5689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737927PMC
October 2017

Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation.

Shock 2018 09;50(3):339-345

State Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan, China.

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http://dx.doi.org/10.1097/SHK.0000000000001012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882614PMC
September 2018

High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice.

Acta Biochim Biophys Sin (Shanghai) 2017 Oct;49(10):907-915

Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

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http://dx.doi.org/10.1093/abbs/gmx085DOI Listing
October 2017

Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria.

J Immunol 2017 11 25;199(9):3176-3186. Epub 2017 Sep 25.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

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http://dx.doi.org/10.4049/jimmunol.1700140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679440PMC
November 2017

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.

Cell Rep 2017 08;20(7):1692-1704

The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Protein Modification and Degradation Laboratory, Guangzhou Medical University, Guangzhou, Guangdong 510510, China; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.055DOI Listing
August 2017

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

J Leukoc Biol 2018 02 28;103(2):175-183. Epub 2017 Dec 28.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://doi.wiley.com/10.1189/jlb.3HI0517-173R
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http://dx.doi.org/10.1189/jlb.3HI0517-173RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346432PMC
February 2018

TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice.

Plast Reconstr Surg 2017 Aug;140(2):296e-306e

Shanghai, People's Republic of China; Pittsburgh, Pa.; and Baltimore, Md. From the Department of Stomatology, Tenth People's Hospital of Tongji University; the Departments of Plastic Surgery, Surgery, Oral Biology, and Bioengineering, University of Pittsburgh; and the Department of Surgery, The Johns Hopkins University.

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http://dx.doi.org/10.1097/PRS.0000000000003541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542792PMC
August 2017

Inflammasome and autophagy regulation - a two-way street.

Mol Med 2017 09 24;23:188-195. Epub 2017 Jul 24.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.

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http://dx.doi.org/10.2119/molmed.2017.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588408PMC
September 2017

Time for trauma immunology.

PLoS Med 2017 Jul 11;14(7):e1002342. Epub 2017 Jul 11.

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507395PMC
July 2017

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.

J Trauma Acute Care Surg 2017 09;83(3):520-531

From the Acute Care Surgery division (F.A.M., L.L.M.), University of Florida, Gainesville, Florida; Department of Surgery (E.E.M., A.B.), Denver Health, University of Colorado, Denver, Colorado; and Department of Surgery (T.R.B., Y.V.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573617PMC
September 2017

Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans.

Int Urol Nephrol 2017 Aug 22;49(8):1409-1417. Epub 2017 May 22.

Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.

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http://dx.doi.org/10.1007/s11255-017-1626-7DOI Listing
August 2017

Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions.

J Trauma Acute Care Surg 2017 07;83(1):111-118

From the Division of Trauma and General Surgery, Department of Surgery (J.B.B., M.R.R., T.R.B., A.B.P., J.L.S.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478426PMC
July 2017

Aging-related Atg5 defect impairs neutrophil extracellular traps formation.

Immunology 2017 08 16;151(4):417-432. Epub 2017 May 16.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/imm.12740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506403PMC
August 2017

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer.

Cell Res 2017 Jul 4;27(7):916-932. Epub 2017 Apr 4.

The Third Affiliated Hospital, Center for DAMP Biology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Protein Modification and Degradation Laboratory, Guangzhou Medical University, Guangzhou, Guangdong 510510, China.

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http://dx.doi.org/10.1038/cr.2017.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518983PMC
July 2017

Enhanced Calvarial Bone Healing in CD11c-TLR4-/- and MyD88-/- Mice.

Plast Reconstr Surg 2017 Apr;139(4):933e-940e

Shanghai, People's Republic of China; Pittsburgh, Pa.; and Baltimore, Md. From the Department of Stomatology, Tenth People's Hospital of Tongji University; the Departments of Plastic Surgery, Surgery, Oral Biology, and Bioengineering, University of Pittsburgh; and the Department of Surgery, The Johns Hopkins University.

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http://dx.doi.org/10.1097/PRS.0000000000003206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404756PMC
April 2017

The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury?

J Trauma Acute Care Surg 2017 06;82(6):995-1001

From the Division of Trauma and General Surgery, Department of Surgery (J.B.B., C.M.L., J.L.S., A.B.P., T.R.B.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Division of Acute Care Surgery, Department of Surgery (M.L.G.), University of Rochester Medical Center, Rochester, New York; Golisano Children's Hospital (M.L.G.), University of Rochester, Rochester, New York; and Division of Pediatric General and Thoracic Surgery, Department of Surgery (C.M.L., B.A.G.), Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464600PMC
June 2017