Timothy P Hughes

Timothy P Hughes

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Timothy P Hughes

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Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia.

Leukemia 2020 Aug 19;34(8):2051-2063. Epub 2020 Feb 19.

Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia.

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http://dx.doi.org/10.1038/s41375-020-0751-yDOI Listing
August 2020

Treatment-free remission in patients with chronic myeloid leukaemia.

Nat Rev Clin Oncol 2020 Aug 6;17(8):493-503. Epub 2020 May 6.

Leukaemia Laboratory, Precision Medicine Theme, South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1038/s41571-020-0367-1DOI Listing
August 2020

High-risk B-cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse.

Br J Haematol 2020 Jul 30. Epub 2020 Jul 30.

Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

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http://dx.doi.org/10.1111/bjh.17002DOI Listing
July 2020

Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 transcripts in chronic myeloid leukemia.

Leuk Lymphoma 2020 Jun 6:1-3. Epub 2020 Jun 6.

Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.

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http://dx.doi.org/10.1080/10428194.2020.1772476DOI Listing
June 2020

Asciminib in Relapsed Chronic Myeloid Leukemia. Reply.

N Engl J Med 2020 04;382(14):1379

South Australian Health and Medical Research Institute, Adelaide, SA, Australia

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http://dx.doi.org/10.1056/NEJMc2000116DOI Listing
April 2020

Successful treatment-free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased natural killer cells.

Br J Haematol 2020 Apr 30. Epub 2020 Apr 30.

Precision Medicine Theme, South Australia Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1111/bjh.16718DOI Listing
April 2020

The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL.

Br J Cancer 2020 Feb 3;122(4):455-464. Epub 2019 Dec 3.

Cancer Program, Precision Medicine Theme, South Australian Health & Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

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http://dx.doi.org/10.1038/s41416-019-0647-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028932PMC
February 2020

What's NEXT for CML-NGS mutation screening.

Blood 2020 02;135(8):515-516

South Australian Health and Medical Research Institute.

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http://dx.doi.org/10.1182/blood.2019004559DOI Listing
February 2020

Early Management of CML.

Curr Hematol Malig Rep 2019 12;14(6):480-491

Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1007/s11899-019-00550-8DOI Listing
December 2019

Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.

N Engl J Med 2019 12;381(24):2315-2326

From the South Australian Health and Medical Research Institute and the University of Adelaide, Adelaide, SA, Australia (T.P.H., D.Y., D.M.R.); Memorial Sloan Kettering Cancer Center, New York (M.J.M., M.S.T., J.H.P.); University of Texas M.D. Anderson Cancer Center, Houston (J.E.C.); Kobe University Graduate School of Medicine, Kobe (H.M.), and the National Cancer Center Hospital East, Chiba (Y.M.) - both in Japan; Hôpital Saint-Louis, Paris (D.R.), and the University of Bordeaux, Bordeaux (F.-X.M.) - both in France; Dana-Farber Cancer Institute, Boston (D.J.D.); Sapienza University, Rome (M.B.); Singapore General Hospital, Singapore (Y.-T.G.); University of Michigan Comprehensive Cancer Center, Ann Arbor (M.T.); Universitätsklinikum Jena, Jena (A.H.), Charité Hospital, Berlin (P.C.), and the Department for Hematology-Oncology, Goethe University Hospital, Frankfurt am Main (F.L.) - all in Germany; University of Cardiff, Cardiff, United Kingdom (O.O.); Veterans Affairs Portland Health Care System (M.C.H.) and Oregon Health and Science University Knight Cancer Institute (M.C.H., B.J.D.), Portland; Hospital de la Princesa and Instituto de Investigación Sanitaria Princesa, Madrid (J.L.S.); Huntsman Cancer Institute, University of Utah, Salt Lake City (M.W.N.D.); Amsterdam University Medical Centers, VU University Medical Center, Amsterdam (J.J.W.M.J.); Novartis Pharma, Basel, Switzerland (D.H., Y.D., C.M., F.H.-P., K.G.V.); and Seoul St. Mary's Hematology Hospital, Catholic University of Korea, Seoul, South Korea (D.-W.K.).

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http://dx.doi.org/10.1056/NEJMoa1902328DOI Listing
December 2019

Molecular monitoring in CML: how deep? How often? How should it influence therapy?

Blood 2018 11;132(20):2125-2133

Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-05
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http://dx.doi.org/10.1182/blood-2018-05-848630DOI Listing
November 2018

Molecular monitoring in CML: how deep? How often? How should it influence therapy?

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):168-176

Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1182/asheducation-2018.1.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246017PMC
November 2018

Patients with low OCT-1 activity and high ABCB1 fold rise have poor long-term outcomes in response to tyrosine kinase inhibitor therapy.

Leukemia 2018 10 23;32(10):2288-2291. Epub 2018 Mar 23.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

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http://dx.doi.org/10.1038/s41375-018-0101-5DOI Listing
October 2018

Treatment-Free Remission After Second-Line Nilotinib Treatment.

Ann Intern Med 2018 10;169(7):510

South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia (T.P.H.).

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http://dx.doi.org/10.7326/L18-0431DOI Listing
October 2018

Management of Pregnancy in Women With Chronic Myeloid Leukemia.

J Clin Oncol 2018 09 31;36(25):2657-2658. Epub 2018 May 31.

David M. Ross, Royal Adelaide Hospital, South Australian Health and Medical Research Institute, and Flinders University and Medical Centre, Adelaide, South Australia, Australia; Kate L. Burbury, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, and University of Melbourne, Melbourne, Victoria, Australia; Andrew P. Grigg, Austin Hospital, Melbourne, Victoria, Australia; Timothy P. Hughes, Royal Adelaide Hospital and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; and John F. Seymour, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, and University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1200/JCO.2018.78.6137DOI Listing
September 2018

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression.

Br J Cancer 2018 04 13;118(7):1000-1004. Epub 2018 Mar 13.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.

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http://dx.doi.org/10.1038/s41416-018-0022-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931087PMC
April 2018

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression .

Oncotarget 2018 Mar 3;9(17):13423-13437. Epub 2018 Feb 3.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia.

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http://www.oncotarget.com/fulltext/24393
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http://dx.doi.org/10.18632/oncotarget.24393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862588PMC
March 2018

Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions.

Cancer Lett 2017 11 1;408:92-101. Epub 2017 Sep 1.

Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia; Australian Genomic Health Alliance, Adelaide, SA, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835173052
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http://dx.doi.org/10.1016/j.canlet.2017.08.034DOI Listing
November 2017

First Approved Kinase Inhibitor for AML.

Cell 2017 Nov;171(5):981

South Australian Health and Medical Research Institute (SAHMRI) and University of Adelaide, Australia.

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http://dx.doi.org/10.1016/j.cell.2017.11.007DOI Listing
November 2017

A novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH.

Cancer Genet 2017 Oct 31;216-217:86-90. Epub 2017 Jul 31.

Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia; Australian Genomic Health Alliance, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2017.07.008DOI Listing
October 2017

A Method for Next-Generation Sequencing of Paired Diagnostic and Remission Samples to Detect Mitochondrial DNA Mutations Associated with Leukemia.

J Mol Diagn 2017 09 18;19(5):711-721. Epub 2017 Jul 18.

Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; Australasian Leukaemia and Lymphoma Group, Melbourne, Victoria, Australia; Department of Haematology, Royal Adelaide Hospital and SA Pathology, Adelaide, South Australia, Australia; Department of Molecular Medicine and Pathology, Flinders University and Medical Centre, Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2017.05.009DOI Listing
September 2017

CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients.

Clin Pharmacokinet 2017 08;56(8):977-985

Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1007/s40262-016-0494-0DOI Listing
August 2017

ABCB1 Overexpression Is a Key Initiator of Resistance to Tyrosine Kinase Inhibitors in CML Cell Lines.

PLoS One 2016 18;11(8):e0161470. Epub 2016 Aug 18.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161470PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990177PMC
July 2017

Comment on "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study".

Leuk Res 2017 04 9;55:55-57. Epub 2017 Jan 9.

Department of Haematology, SA Pathology, Adelaide, South Australia, Australia; Cancer Theme, South Australia Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; The University of Adelaide, School of Medicine, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1016/j.leukres.2017.01.009DOI Listing
April 2017

Targeted therapies: Remembrance of things past - discontinuation of second-generation TKI therapy for CML.

Nat Rev Clin Oncol 2017 04 7;14(4):201-202. Epub 2017 Feb 7.

Cancer Theme, South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, South Australia 5001, Australia.

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http://dx.doi.org/10.1038/nrclinonc.2017.11DOI Listing
April 2017

CML patients with deep molecular responses to TKI have restored immune effectors and decreased PD-1 and immune suppressors.

Blood 2017 03 3;129(9):1166-1176. Epub 2017 Jan 3.

Department of Haematology, SA Pathology, Adelaide, SA, Australia.

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http://dx.doi.org/10.1182/blood-2016-10-745992DOI Listing
March 2017

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.

N Engl J Med 2017 03;376(10):917-927

From Abteilung Hämatologie-Onkologie, Universitätsklinikum Jena, Jena, Germany (A.H.); the Department of Medicine, University of Chicago, Chicago (R.A.L.); INSERM Centre d'Investigation Clinique 1402, Centre Hospitalier Universitaire de Poitiers, Poitiers, France (F.G.); Fred Hutchinson Cancer Research Center, Seattle (J.P.R.); Centre for Cancer Biology, SA Pathology, University of South Australia and University of Adelaide (S.B.), and the South Australian Health and Medical Research Institute and University of Adelaide (T.P.H.), Adelaide, SA, Australia; University of Bologna, Bologna, Italy (M.B.); the University of Utah Huntsman Cancer Institute, Salt Lake City (M.W.D.); the Hematology Department, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona (F.C.); Novartis, Basel, Switzerland (S.F., C.-E.O., H.D.M.); M.D. Anderson Cancer Center, Houston (H.K.); the University of Newcastle, Newcastle, United Kingdom (S.G.O.); and Knight Cancer Institute, Oregon Health and Science University and Howard Hughes Medical Institute, Portland (B.J.D.).

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http://dx.doi.org/10.1056/NEJMoa1609324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901965PMC
March 2017

BCR-ABL1 expression, RT-qPCR and treatment decisions in chronic myeloid leukaemia.

J Clin Pathol 2016 Sep 2;69(9):817-21. Epub 2016 Feb 2.

Department of Haematology & Genetic Pathology, School of Medicine, Flinders University and Medical Centre, Bedford Park, South Australia, Australia Monoquant Pty Ltd, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1136/jclinpath-2015-203538DOI Listing
September 2016

Moving treatment-free remission into mainstream clinical practice in CML.

Blood 2016 07 24;128(1):17-23. Epub 2016 Mar 24.

Haematology, SA Pathology, School of Medicine, University of Adelaide, Adelaide, Australia; and South Australian Health & Medical Research Institute, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2016-01-694265DOI Listing
July 2016

The impact of multiple low-level BCR-ABL1 mutations on response to ponatinib.

Blood 2016 Apr 14;127(15):1870-80. Epub 2016 Jan 14.

Department of Genetics and Molecular Pathology and School of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia; School of Medicine, University of Adelaide, Adelaide, Australia; School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2015-09-666214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832506PMC
April 2016

Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients.

Blood 2016 Feb 24;127(6):703-12. Epub 2015 Nov 24.

Department of Genetics and Molecular Pathology, SA Pathology, Centre for Cancer Biology, School of Medicine and School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia; and School of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2015-08-660977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760131PMC
February 2016

KIR2DL5B genotype predicts outcomes in CML patients treated with response-directed sequential imatinib/nilotinib strategy.

Blood 2015 Dec 23;126(25):2720-3. Epub 2015 Oct 23.

Department of Haematology, SA Pathology, Adelaide, SA, Australia; School of Medicine and.

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http://dx.doi.org/10.1182/blood-2015-07-655589DOI Listing
December 2015

Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia.

Int J Hematol 2015 Nov 2;102(5):639-42. Epub 2015 Jul 2.

Department of Haematology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.

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http://dx.doi.org/10.1007/s12185-015-1824-yDOI Listing
November 2015

Living with CML: is death no longer the end (point)?

Blood 2015 Jul;126(1):2-4

SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE; UNIVERSITY OF ADELAIDE; AND SA PATHOLOGY.

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http://dx.doi.org/10.1182/blood-2015-05-644732DOI Listing
July 2015

A DNA real-time quantitative PCR method suitable for routine monitoring of low levels of minimal residual disease in chronic myeloid leukemia.

J Mol Diagn 2015 Mar 29;17(2):185-92. Epub 2014 Dec 29.

Department of Haematology and Genetic Pathology, School of Medicine, Flinders University and Medical Centre, Bedford Park, South Australia, Australia; Monoquant Pty. Ltd., Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.10.002DOI Listing
March 2015

TIDEL-II: first-line use of imatinib in CML with early switch to nilotinib for failure to achieve time-dependent molecular targets.

Blood 2015 Feb 17;125(6):915-23. Epub 2014 Dec 17.

Department of Haematology, and Discipline of Medicine, School of Medicine, University of Adelaide, Adelaide, Australia; Australasian Leukemia and Lymphoma Group, Melbourne, Australia; Cancer Theme, South Australia Health and Medical Research Institute, Adelaide, Australia;

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http://dx.doi.org/10.1182/blood-2014-07-590315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161008PMC
February 2015

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Potential mechanisms of disease progression and management of advanced-phase chronic myeloid leukemia.

Leuk Lymphoma 2014 Jul 12;55(7):1451-62. Epub 2013 Nov 12.

Department of Leukemia, University of Texas M. D. Anderson Cancer Center , Houston, TX , USA.

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http://dx.doi.org/10.3109/10428194.2013.845883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186697PMC
July 2014

How I determine if and when to recommend stopping tyrosine kinase inhibitor treatment for chronic myeloid leukaemia.

Br J Haematol 2014 Jul 23;166(1):3-11. Epub 2014 Apr 23.

Haematology Directorate, SA Pathology, Adelaide, SA, Australia; School of Medicine, University of Adelaide, Adelaide, SA, Australia; Flinders University and Medical Centre, Bedford Park, SA, Australia.

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http://dx.doi.org/10.1111/bjh.12892DOI Listing
July 2014

Prognosis for patients with CML and >10% BCR-ABL1 after 3 months of imatinib depends on the rate of BCR-ABL1 decline.

Blood 2014 Jul 23;124(4):511-8. Epub 2014 May 23.

School of Medicine, and Department of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia; Australasian Leukaemia and Lymphoma Group, East Melbourne, Australia; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2014-03-566323DOI Listing
July 2014

Many BCR-ABL1 compound mutations reported in chronic myeloid leukemia patients may actually be artifacts due to PCR-mediated recombination.

Blood 2014 Jul;124(1):153-5

Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, AustraliaSchools of Medicine and Molecular and Biomedical Science, University of Adelaide, Adelaide, AustraliaSchool of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2014-05-573485DOI Listing
July 2014

Degree of kinase inhibition achieved in vitro by imatinib and nilotinib is decreased by high levels of ABCB1 but not ABCG2.

Leuk Lymphoma 2013 Mar 21;54(3):569-78. Epub 2012 Aug 21.

Division of Hematology, SA Pathology, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.3109/10428194.2012.715345DOI Listing
March 2013

Prospective histomorphometric and DXA evaluation of bone remodeling in imatinib-treated CML patients: evidence for site-specific skeletal effects.

J Clin Endocrinol Metab 2013 Jan 8;98(1):67-76. Epub 2012 Nov 8.

Myeloma Research Laboratory, Division of Hematology, Centre for Cancer Biology, SA Pathology, GPO Box 14, Adelaide, SA, Australia 5000.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2012-2426DOI Listing
January 2013

Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A.

Exp Hematol 2012 Aug 19;40(8):612-21.e6. Epub 2012 Apr 19.

Department of Haematology, SA Pathology, RAH Campus, Adelaide, South Australia, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0301472X1200137
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http://dx.doi.org/10.1016/j.exphem.2012.04.003DOI Listing
August 2012

Sudden blast crisis in chronic myeloid leukemia treated with tyrosine kinase inhibitors.

Leuk Lymphoma 2012 Jul 23;53(7):1251-2. Epub 2012 Apr 23.

Haematology Division, SA Pathology, Adelaide, Australia.

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http://dx.doi.org/10.3109/10428194.2012.682314DOI Listing
July 2012

Therapeutic targeting of BCR-ABL: prognostic markers of response and resistance mechanism in chronic myeloid leukaemia.

Crit Rev Oncog 2012 ;17(1):17-30

Haematology Department, SA Pathology (RAH Site), Centre for Cancer Biology, and University of Adelaide, Australia.

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http://dx.doi.org/10.1615/critrevoncog.v17.i1.30DOI Listing
May 2012

Suboptimal responses in chronic myeloid leukemia: implications and management strategies.

Cancer 2012 Mar 28;118(5):1181-91. Epub 2011 Oct 28.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.26391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412948PMC
March 2012

Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile.

Blood 2012 Mar 30;119(10):2234-8. Epub 2011 Dec 30.

Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.

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http://dx.doi.org/10.1182/blood-2011-08-375535DOI Listing
March 2012

Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways.

Leuk Lymphoma 2011 Nov 30;52(11):2139-47. Epub 2011 Jun 30.

Department of Haematology, SA Pathology, Adelaide, Australia.

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http://dx.doi.org/10.3109/10428194.2011.591013DOI Listing
November 2011

BCR-ABL transcript dynamics support the hypothesis that leukemic stem cells are reduced during imatinib treatment.

Clin Cancer Res 2011 Nov 8;17(21):6812-21. Epub 2011 Sep 8.

Oncology, Novartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0396DOI Listing
November 2011

Sensitive detection of BCR-ABL1 mutations in patients with chronic myeloid leukemia after imatinib resistance is predictive of outcome during subsequent therapy.

J Clin Oncol 2011 Nov 11;29(32):4250-9. Epub 2011 Oct 11.

SA Pathology, IMVS, e Rd, PO Box 14 Rundle Mall, Adelaide, SA, 5000, Australia.

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http://dx.doi.org/10.1200/JCO.2011.35.0934DOI Listing
November 2011

Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells.

Blood 2011 Aug 8;118(6):1622-31. Epub 2011 Jun 8.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-02-33
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http://dx.doi.org/10.1182/blood-2011-02-339267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156048PMC
August 2011