Timothy P Heffernan

Timothy P Heffernan

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Timothy P Heffernan

Timothy P Heffernan

Publications by authors named "Timothy P Heffernan"

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39Publications

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Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research.

Cancers (Basel) 2019 Sep 6;11(9). Epub 2019 Sep 6.

Department of Genomic Medicine, UT MD Anderson cancer center, Houston, TX 77054, USA.

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http://dx.doi.org/10.3390/cancers11091321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770280PMC
September 2019

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell 2019 02;35(2):204-220.e9

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.01.006DOI Listing
February 2019

Dual Roles of RNF2 in Melanoma Progression.

Cancer Discov 2015 Dec 8;5(12):1314-27. Epub 2015 Oct 8.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Health Transformation, The University of Texas System, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670809PMC
December 2015

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer.

Cancer Res 2015 Mar 3;75(6):1091-101. Epub 2015 Mar 3.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446709PMC
March 2015

A systems biology approach to personalizing therapeutic combinations.

Cancer Discov 2013 Dec;3(12):1339-44

1Department of Genomic Medicine and 2Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864744PMC
December 2013

ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.

J Invest Dermatol 2009 Jul 26;129(7):1805-15. Epub 2009 Feb 26.

Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153439
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http://dx.doi.org/10.1038/jid.2008.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829385PMC
July 2009

Cdc7-Dbf4 and the human S checkpoint response to UVC.

J Biol Chem 2007 Mar 2;282(13):9458-68. Epub 2007 Feb 2.

Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1074/jbc.M611292200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839878PMC
March 2007

Checkpoint regulation of replication dynamics in UV-irradiated human cells.

Cell Cycle 2006 Sep 15;5(18):2160-7. Epub 2006 Sep 15.

Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7525 USA.

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http://dx.doi.org/10.4161/cc.5.18.3236DOI Listing
September 2006

Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function.

J Carcinog 2005 Oct 6;4:18. Epub 2005 Oct 6.

Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, CB 7295, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1186/1477-3163-4-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262734PMC
October 2005

Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.

DNA Repair (Amst) 2005 Jun;4(6):714-24

Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7525, USA.

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http://dx.doi.org/10.1016/j.dnarep.2005.04.002DOI Listing
June 2005

Spine-board transfer techniques and the unstable cervical spine.

Spine (Phila Pa 1976) 2004 Apr;29(7):E134-8

Department of Exercise and Sport Sciences, University of Miami, School of Education, Coral Gables, FL 33124-2040, USA.

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http://dx.doi.org/10.1097/01.brs.0000116986.48166.d0DOI Listing
April 2004

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.

Mol Cell Biol 2002 Dec;22(24):8552-61

Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139882PMC
http://dx.doi.org/10.1128/mcb.22.24.8552-8561.2002DOI Listing
December 2002