Timothy N C Wells

Timothy N C Wells

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Timothy N C Wells

Timothy N C Wells

Publications by authors named "Timothy N C Wells"

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Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.

J Med Chem 2019 04 28;62(7):3367-3380. Epub 2019 Mar 28.

School of Pharmaceutical Sciences , Nanjing Tech University , No. 30 South Puzhu Road , Nanjing 211816 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01790DOI Listing
April 2019

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis.

Int J Parasitol Drugs Drug Resist 2018 12 31;8(3):440-450. Epub 2018 Oct 31.

Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, 3012, Bern, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22113207183012
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http://dx.doi.org/10.1016/j.ijpddr.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216040PMC
December 2018

Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin.

Biochim Biophys Acta Gen Subj 2018 Mar 28;1862(3):600-614. Epub 2017 Nov 28.

Institut Pasteur de Tunis, LR11IPT04/LR16IPT04 Laboratoire d'Epidémiologie Moléculaire et Pathologie Expérimentale Appliquée Aux Maladies Infectieuses, 1002 Tunis, Tunisia; Université de Tunis El Manar, 1068 Tunis, Tunisia. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.11.019DOI Listing
March 2018

Malaria.

Nat Rev Dis Primers 2017 Aug 3;3:17050. Epub 2017 Aug 3.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrdp.2017.50DOI Listing
August 2017

Managing intellectual property to develop medicines for the world's poorest.

Nat Rev Drug Discov 2017 Apr 24;16(4):223-224. Epub 2017 Feb 24.

Medicines for Malaria Venture, 20 route des Pre-Bois, 1215 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrd.2017.24DOI Listing
April 2017

Screening of the 'Pathogen Box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm.

Int J Parasitol Drugs Drug Resist 2016 12 28;6(3):329-334. Epub 2016 Jul 28.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5196485PMC
December 2016

Open data in drug discovery and development: lessons from malaria.

Nat Rev Drug Discov 2016 10 12;15(10):661-2. Epub 2016 Aug 12.

Medicines for Malaria Venture, 20 Route de Pré-Bois, Geneva 1215, Switzerland.

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http://dx.doi.org/10.1038/nrd.2016.154DOI Listing
October 2016

Ferroquine: welcome to the next generation of antimalarials.

Lancet Infect Dis 2015 Dec 3;15(12):1365-6. Epub 2015 Sep 3.

Medicines for Malaria Venture, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.1016/S1473-3099(15)00148-6DOI Listing
December 2015

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine.

Proc Natl Acad Sci U S A 2015 Dec 22;112(52):15773-6. Epub 2015 Dec 22.

Medicines for Malaria Venture, 1215 Geneva, Switzerland.

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http://dx.doi.org/10.1073/pnas.1520952112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702971PMC
December 2015

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.

PLoS Negl Trop Dis 2015 Oct 8;9(10):e0003987. Epub 2015 Oct 8.

Medicines for Malaria Venture, Geneva, Switzerland; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598153PMC
October 2015

Malaria medicines: a glass half full?

Nat Rev Drug Discov 2015 Jun 22;14(6):424-42. Epub 2015 May 22.

1] Medicines for Malaria Venture, 20 Route de Pré-Bois, 1215 Geneva 15, Switzerland. [2] Division of Allergy and Infectious Diseases, Department of Medicine and Departments of Global Health and Microbiology, University of Washington, 750 Republican Street, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nrd4573DOI Listing
June 2015

Orally active antischistosomal early leads identified from the open access malaria box.

PLoS Negl Trop Dis 2014 9;8(1):e2610. Epub 2014 Jan 9.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland ; University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pntd.0002610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886923PMC
September 2014

Open source drug discovery - a limited tutorial.

Parasitology 2014 Jan 28;141(1):148-57. Epub 2013 Aug 28.

School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1017/S0031182013001121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884843PMC
January 2014

Discovering and developing new medicines for malaria control and elimination.

Infect Disord Drug Targets 2013 Aug;13(4):292-302

Medicines for Malaria Venture, ICC, Block G, 3rd Floor, 20 Rue de Pre-Bois, PO Box 1826, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.2174/1871526513666131129160156DOI Listing
August 2013

Designing the next generation of medicines for malaria control and eradication.

Malar J 2013 Jun 6;12:187. Epub 2013 Jun 6.

Medicines for Malaria Venture-MMV, PO Box 1826, Route de Pré-Bois 20, Geneva 151215, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-12-187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685552PMC
June 2013

Malaria in South America: a drug discovery perspective.

Malar J 2013 May 24;12:168. Epub 2013 May 24.

Medicines for Malaria Venture, 20 route de Pré-Bois, Geneva, CH 1215, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-12-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665683PMC
May 2013

The global pipeline of new medicines for the control and elimination of malaria.

Malar J 2012 Sep 7;11:316. Epub 2012 Sep 7.

Medicines for Malaria Venture (MMV), 20 rte de Pré-Bois 1215, Geneva, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-11-316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472257PMC
September 2012

A framework for assessing the risk of resistance for anti-malarials in development.

Malar J 2012 Aug 22;11:292. Epub 2012 Aug 22.

Medicines for Malaria Venture, 20 rte de Pré Bois, Geneva CH 1215, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-11-292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478971PMC
August 2012

The state of the art in anti-malarial drug discovery and development.

Curr Top Med Chem 2011 ;11(10):1226-54

Medicines for Malaria Venture, ICC, Geneva, Switzerland.

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http://dx.doi.org/10.2174/156802611795429194DOI Listing
August 2011

Natural products as starting points for future anti-malarial therapies: going back to our roots?

Malar J 2011 Mar 15;10 Suppl 1:S3. Epub 2011 Mar 15.

Medicines for Malaria Venture, 20 rte de Pré-Bois, CH-1215 Geneva, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-10-S1-S3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059461PMC
March 2011

Microbiology. Is the tide turning for new malaria medicines?

Science 2010 Sep;329(5996):1153-4

Medicines for Malaria Venture/MMV, 20, Route de Pré-Bois-Post Office Box 1826, Geneva, Switzerland.

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http://dx.doi.org/10.1126/science.1194923DOI Listing
September 2010

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination.

Trends Parasitol 2010 Mar 3;26(3):145-51. Epub 2010 Feb 3.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S147149220900280
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http://dx.doi.org/10.1016/j.pt.2009.12.005DOI Listing
March 2010

New medicines to improve control and contribute to the eradication of malaria.

Nat Rev Drug Discov 2009 Nov 16;8(11):879-91. Epub 2009 Oct 16.

Medicines for Malaria Venture, 20 Route de Pré-Bois, 1215 Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrd2972DOI Listing
November 2009

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

Antimicrob Agents Chemother 2008 Oct 21;52(10):3710-7. Epub 2008 Jul 21.

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195-7185, USA.

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http://dx.doi.org/10.1128/AAC.00364-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565902PMC
October 2008

Differential effects of chemokines on oligodendrocyte precursor proliferation and myelin formation in vitro.

J Neuroimmunol 2006 May 30;174(1-2):133-46. Epub 2006 Mar 30.

Department of Immunology, Serono Pharmaceutical Research Institute 14, Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.jneuroim.2006.01.011DOI Listing
May 2006

Chemokine blockers--therapeutics in the making?

Trends Pharmacol Sci 2006 Jan 28;27(1):41-7. Epub 2005 Nov 28.

Serono Pharmaceutical Research Institute, 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.tips.2005.11.001DOI Listing
January 2006

Multi-faceted strategies to combat disease by interference with the chemokine system.

Trends Immunol 2005 May;26(5):268-74

Serono Pharmaceutical Research Institute, 14 chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S147149060500071
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http://dx.doi.org/10.1016/j.it.2005.03.001DOI Listing
May 2005

Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue.

Am J Respir Cell Mol Biol 2003 Apr;28(4):464-72

Medical Research Service, VA Puget Sound Medical Center, Seattle and Department of Medicine, University of Washington, Seattle, USA.

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http://dx.doi.org/10.1165/rcmb.2002-0084OCDOI Listing
April 2003

Strategies for chemokine antagonists as therapeutics.

Semin Immunol 2003 Feb;15(1):57-65

Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1016/s1044-5323(02)00128-8DOI Listing
February 2003

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines.

Proc Natl Acad Sci U S A 2003 Feb 5;100(4):1885-90. Epub 2003 Feb 5.

Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1073/pnas.0334864100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149928PMC
February 2003

New therapeutics that modulate chemokine networks.

Nat Rev Drug Discov 2002 May;1(5):347-58

Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrd795DOI Listing
May 2002

Tissue-specific mechanisms control the retention of IL-8 in lungs and skin.

J Immunol 2002 Apr;168(7):3550-6

Medical Research Service and Division of Pulmonary/Critical Care Medicine, Department of Medicine, Seattle Department of Veterans Affairs Medical Center, Seattle, WA 98108, USA.

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http://dx.doi.org/10.4049/jimmunol.168.7.3550DOI Listing
April 2002

Alboluxin, a snake C-type lectin from Trimeresurus albolabris venom is a potent platelet agonist acting via GPIb and GPVI.

Thromb Haemost 2002 Apr;87(4):692-8

Theodor Kocher Institute, University of Berne, Switzerland.

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April 2002