Timothy M Olson

Timothy M Olson

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Timothy M Olson

Timothy M Olson

Publications by authors named "Timothy M Olson"

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Model System Identification of Novel Congenital Heart Disease Gene Candidates: focus on RPL13.

Hum Mol Genet 2019 Oct 18. Epub 2019 Oct 18.

Development, Aging and Regeneration Program, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1093/hmg/ddz213DOI Listing
October 2019

Hypoplastic Left Heart Syndrome: An Overview for Primary Care Providers.

Pediatr Rev 2019 Jul;40(7):344-353

Wanek Family Program for Hypoplastic Left Heart Syndrome.

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http://dx.doi.org/10.1542/pir.2018-0005DOI Listing
July 2019

Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection.

Circ Genom Precis Med 2019 Apr 19;12(4):e002437. Epub 2019 Mar 19.

Cardiovascular Genetics Research Laboratory (T.N.T., J.L.T., R.S.S., T.M.O.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCGEN.118.002437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625931PMC
April 2019

Idiopathic Restrictive Cardiomyopathy in Children and Young Adults.

Am J Cardiol 2018 05 12;121(10):1266-1270. Epub 2018 Feb 12.

Department of Pediatric and Adolescent Medicine/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Diseases/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2018.01.045DOI Listing
May 2018

Characteristic Morphologies of the Bicuspid Aortic Valve in Patients with Genetic Syndromes.

J Am Soc Echocardiogr 2018 02 28;31(2):194-200. Epub 2017 Nov 28.

Department of Pediatrics/Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota; Department of Medicine/Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.echo.2017.10.008DOI Listing
February 2018

Diagnostic Yield of Whole Exome Sequencing in Pediatric Dilated Cardiomyopathy.

J Cardiovasc Dev Dis 2017 Aug 8;4(3). Epub 2017 Aug 8.

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.3390/jcdd4030011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715713PMC
August 2017

A breakthrough in spontaneous coronary artery dissection pathogenesis: is it an inherited condition?

Expert Rev Cardiovasc Ther 2017 01 14;15(1):1-2. Epub 2016 Dec 14.

b Department of Cardiovascular Diseases , Mayo Clinic , Rochester MN , USA.

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http://dx.doi.org/10.1080/14779072.2017.1266254DOI Listing
January 2017

A modifier screen identifies as a cardiomyopathy susceptibility gene.

JCI Insight 2016 Sep;1(14)

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1172/jci.insight.88797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023154PMC
September 2016

Ebstein anomaly, left ventricular non-compaction, and early onset heart failure associated with a de novo α-tropomyosin gene mutation.

Am J Med Genet A 2016 08 13;170(8):2186-90. Epub 2016 May 13.

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.

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http://doi.wiley.com/10.1002/ajmg.a.37745
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http://dx.doi.org/10.1002/ajmg.a.37745DOI Listing
August 2016

De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.

Hum Genet 2016 08 27;135(8):909-917. Epub 2016 May 27.

Cardiovascular Genetics Research Laboratory, Mayo Clinic, Rochester MN.

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http://dx.doi.org/10.1007/s00439-016-1685-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947566PMC
August 2016

Spontaneous coronary artery dissection and its association with heritable connective tissue disorders.

Heart 2016 06 10;102(11):876-81. Epub 2016 Feb 10.

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.

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http://heart.bmj.com/content/early/2016/02/16/heartjnl-2015-
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http://content.onlinejacc.org/data/Journals/JAC/933568/00079
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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2015-308645
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http://dx.doi.org/10.1136/heartjnl-2015-308645DOI Listing
June 2016

Modeling -Associated Dilated Cardiomyopathy in Adult Zebrafish.

J Cardiovasc Dev Dis 2016 Mar 26;3(1). Epub 2016 Jan 26.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First St. SW Rochester, MN 55905, USA.

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http://dx.doi.org/10.3390/jcdd3010006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611887PMC
March 2016

Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells.

Hum Mol Genet 2016 Jan 24;25(2):254-65. Epub 2015 Nov 24.

Center for Regenerative Medicine, Division of General Internal Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Division of Pediatric Cardiology, Transplant Center, Mayo Clinic, Rochester, MN 55905, USA and

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http://dx.doi.org/10.1093/hmg/ddv468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706113PMC
January 2016

LRRC10 is required to maintain cardiac function in response to pressure overload.

Am J Physiol Heart Circ Physiol 2016 Jan 25;310(2):H269-78. Epub 2015 Nov 25.

Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin;

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http://dx.doi.org/10.1152/ajpheart.00717.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747898PMC
January 2016

Familial Incidence of Cardiovascular Malformations in Hypoplastic Left Heart Syndrome.

Am J Cardiol 2015 Dec 10;116(11):1762-6. Epub 2015 Sep 10.

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.amjcard.2015.08.045DOI Listing
December 2015

Exome Sequencing Identifies Pathogenic and Modifier Mutations in a Child With Sporadic Dilated Cardiomyopathy.

J Am Heart Assoc 2015 Dec 9;4(12). Epub 2015 Dec 9.

Cardiovascular Genetics Research Laboratory, Mayo Clinic, Rochester, MN (P.A.L., T.M.O.) Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN (T.M.O.) Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN (T.M.O.).

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http://dx.doi.org/10.1161/JAHA.115.002443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845292PMC
December 2015

Recessive MYH6 Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction.

Circ Cardiovasc Genet 2015 Aug 17;8(4):564-71. Epub 2015 Jun 17.

From the Cardiovascular Genetics Research Laboratory (J.L.T., T.M.O.), Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (M.Y.Q., P.W.O'L., T.M.O.), Division of Cardiovascular Diseases, Department of Internal Medicine (T.M.O.), Departments of Health Sciences Research and Biomedical Statistics and Informatics (M.T.Z., J.M.E.), Medical Genome Facility (B.W.E., E.D.W.), and Department of Biochemistry and Molecular Biology (E.D.W.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001070DOI Listing
August 2015

Familial spontaneous coronary artery dissection: evidence for genetic susceptibility.

JAMA Intern Med 2015 May;175(5):821-6

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota.

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http://dx.doi.org/10.1001/jamainternmed.2014.8307DOI Listing
May 2015

Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish.

Circ Cardiovasc Genet 2015 Apr 11;8(2):261-9. Epub 2015 Jan 11.

From the Department of Biochemistry and Molecular Biology (Y.-H.S., Y.D., X.X.), Information Technology (C.A.R.), Department of Molecular Pharmacology and Experimental Therapeutics (H.L.), Department of Pediatric and Adolescent Medicine (T.M.O.), and Division of Cardiovascular Diseases (T.M.O., X.X.), Mayo Clinic, Rochester, MN; Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Cancer Center, Baltimore (Y.Z.); and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore (Y.Z.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406804PMC
April 2015

Exome sequencing establishes diagnosis of Alström syndrome in an infant presenting with non-syndromic dilated cardiomyopathy.

Am J Med Genet A 2015 Apr 23;167A(4):886-90. Epub 2015 Feb 23.

Mayo Graduate School, Molecular Pharmacology and Experimental Therapeutics Track, Mayo Clinic, Rochester, Minnesota; Cardiovascular Genetics Research Laboratory, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1002/ajmg.a.36994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518724PMC
April 2015

Regenerative therapy for hypoplastic left heart syndrome: first report of intraoperative intramyocardial injection of autologous umbilical-cord blood-derived cells.

J Thorac Cardiovasc Surg 2015 Mar 24;149(3):e35-7. Epub 2014 Oct 24.

Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minn; Division of General Internal Medicine, Mayo Clinic, Rochester, Minn; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minn; Transplant Center, Mayo Clinic, Rochester, Minn; Center for Regenerative Medicine, Mayo Clinic, Rochester, Minn.

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http://dx.doi.org/10.1016/j.jtcvs.2014.10.093DOI Listing
March 2015

Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites.

Circ Cardiovasc Genet 2015 Feb 1;8(1):141-9. Epub 2014 Dec 1.

From the Division of Cardiovascular Diseases, Department of Internal Medicine (N.L.P., T.M.O., R.J.R., M.M.R., J.C.B.), Department of Biomedical Statistics and Informatics (N.T., C.G.S, G.D.J., N.P.), and Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (N.L.P., R.M.W.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387792PMC
February 2015

TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy.

Hum Mol Genet 2014 Nov 11;23(21):5793-804. Epub 2014 Jun 11.

Cardiovascular Genetics Research Laboratory, Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine,

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http://dx.doi.org/10.1093/hmg/ddu297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189907PMC
November 2014

Characterizing genetic variation of adrenergic signalling pathways in Takotsubo (stress) cardiomyopathy exomes.

Eur J Heart Fail 2014 Sep 8;16(9):942-9. Epub 2014 Aug 8.

Mayo Medical School, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1002/ejhf.145DOI Listing
September 2014

Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.

Hum Mol Genet 2014 Jul 28;23(14):3779-91. Epub 2014 Feb 28.

Center of Regenerative Medicine, Molecular Pharmacology and Experimental Therapeutics, General Internal Medicine and Transplant Center, Mayo Clinic, Rochester, MN 55905, USA

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http://dx.doi.org/10.1093/hmg/ddu091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065152PMC
July 2014

Transcriptional atlas of cardiogenesis maps congenital heart disease interactome.

Physiol Genomics 2014 Jul 6;46(13):482-95. Epub 2014 May 6.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota; Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Center for Regenerative Medicine, Mayo Clinic, Rochester, Minnesota; Transplant Center, Mayo Clinic, Rochester, Minnesota; and Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota

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http://dx.doi.org/10.1152/physiolgenomics.00015.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080280PMC
July 2014

Late outcomes for surgical repair of supravalvar aortic stenosis.

Ann Thorac Surg 2012 Sep 22;94(3):854-9. Epub 2012 Jun 22.

Division of Cardiovascular Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2012.04.022DOI Listing
September 2012

Advances in cardiac ATP-sensitive K+ channelopathies from molecules to populations.

Circ Arrhythm Electrophysiol 2011 Aug;4(4):577-85

Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Internal Medicine, Department of Molecular Pharmacology and Experimental Therapeutics, Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1161/CIRCEP.110.957662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158387PMC
August 2011

Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation.

Am J Cardiol 2011 Jun 8;107(12):1802-5. Epub 2011 Apr 8.

Cardiovascular Genetics Research Laboratory, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.amjcard.2011.02.326DOI Listing
June 2011

Human K(ATP) channelopathies: diseases of metabolic homeostasis.

Pflugers Arch 2010 Jul 24;460(2):295-306. Epub 2009 Dec 24.

Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1007/s00424-009-0771-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883927PMC
July 2010

A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions.

J Am Coll Cardiol 2009 Sep;54(11):1024-32

Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1016/j.jacc.2009.04.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803058PMC
September 2009

Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation.

Am J Cardiol 2009 May 1;103(10):1426-8. Epub 2009 Apr 1.

Cardiovascular Genetics Laboratory, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.amjcard.2009.01.354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697665PMC
May 2009

Lone atrial fibrillation: influence of familial disease on gender predilection.

J Cardiovasc Electrophysiol 2008 Aug 21;19(8):802-6. Epub 2008 Mar 21.

Department of Medicine, Cardiovascular Division, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/j.1540-8167.2008.01126.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562911PMC
August 2008

X-linked nonsyndromic sinus node dysfunction and atrial fibrillation caused by emerin mutation.

J Cardiovasc Electrophysiol 2008 May 4;19(5):510-5. Epub 2008 Feb 4.

Department of Medicine, Division of Cardiovascular Diseases, and Pediatric and Adolescent Medicine, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1111/j.1540-8167.2007.01081.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367157PMC
May 2008

Can antiheart autoantibodies predict disease risk in asymptomatic relatives of patients with dilated cardiomyopathy?

Authors:
Timothy M Olson

Nat Clin Pract Cardiovasc Med 2007 Jun;4(6):308-9

Cardiovascular Genetics Laboratory, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/ncpcardio0862DOI Listing
June 2007

Natriuretic peptides and myocardial structure: insights from population genetics.

Hypertension 2007 Apr 19;49(4):765-6. Epub 2007 Feb 19.

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http://dx.doi.org/10.1161/01.HYP.0000258567.67263.96DOI Listing
April 2007

KATP channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation.

Nat Clin Pract Cardiovasc Med 2007 Feb;4(2):110-6

Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/ncpcardio0792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013306PMC
February 2007

Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation.

Hum Mol Genet 2006 Jul 13;15(14):2185-91. Epub 2006 Jun 13.

Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1093/hmg/ddl143DOI Listing
July 2006

What makes the heart fail? New insights from defective genes.

Authors:
Timothy M Olson

Acta Paediatr Suppl 2006 Jul;95(452):17-21

Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1080/08035320600649325DOI Listing
July 2006

Congenital heart defects in siblings with partial aneuploidy of chromosome 2p.

Cardiovasc Pathol 2006 Jan-Feb;15(1):33-5

Mayo Medical School, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.carpath.2005.08.004DOI Listing
March 2006

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy.

Mol Genet Metab 2006 Feb 19;87(2):169-74. Epub 2005 Oct 19.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ymgme.2005.08.006DOI Listing
February 2006

Cardiac KATP channels in health and disease.

J Mol Cell Cardiol 2005 Jun 25;38(6):937-43. Epub 2005 Apr 25.

Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280500075
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http://dx.doi.org/10.1016/j.yjmcc.2005.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736958PMC
June 2005

Sodium channel mutations and susceptibility to heart failure and atrial fibrillation.

JAMA 2005 Jan;293(4):447-54

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.

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http://dx.doi.org/10.1001/jama.293.4.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039897PMC
January 2005

ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating.

Nat Genet 2004 Apr 21;36(4):382-7. Epub 2004 Mar 21.

Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/ng1329
Publisher Site
http://dx.doi.org/10.1038/ng1329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995438PMC
April 2004

Frequency of development of idiopathic dilated cardiomyopathy among relatives of patients with idiopathic dilated cardiomyopathy.

Am J Cardiol 2003 Jun;91(11):1389-92

Department of Medical Genetics, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/s0002-9149(03)00341-2DOI Listing
June 2003

Familial atrial fibrillation is a genetically heterogeneous disorder.

J Am Coll Cardiol 2003 Jun;41(12):2185-92

Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1016/s0735-1097(03)00465-0DOI Listing
June 2003

Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology.

Circulation 2002 May;105(20):2337-40

Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1161/01.cir.0000018444.47798.94DOI Listing
May 2002

Metavinculin mutations alter actin interaction in dilated cardiomyopathy.

Circulation 2002 Jan;105(4):431-7

Department of Pediatrics and the Division of Cardiology, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1161/hc0402.102930DOI Listing
January 2002