Timothy M Hughes

Timothy M Hughes

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Timothy M Hughes

Timothy M Hughes

Publications by authors named "Timothy M Hughes"

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White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alzheimers Dement (N Y) 2019 9;5:107-117. Epub 2019 Apr 9.

Molecular & Clinical Sciences Research Institute, St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S23528737193000
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http://dx.doi.org/10.1016/j.trci.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461571PMC
April 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes.

Clin Sci (Lond) 2018 12 5;132(23):2509-2518. Epub 2018 Dec 5.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A.

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http://clinsci.org/lookup/doi/10.1042/CS20180690
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http://dx.doi.org/10.1042/CS20180690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512318PMC
December 2018

Apolipoproteins and Alzheimer's pathophysiology.

Alzheimers Dement (Amst) 2018 10;10:545-553. Epub 2018 Aug 10.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.dadm.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199693PMC
August 2018

Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study.

Neurology 2018 04 16;90(14):e1248-e1256. Epub 2018 Mar 16.

From the Departments of Internal Medicine (T.M.H., S.C.) and Radiology (A.M.), and Division of Public Health Sciences (L.E.W.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Epidemiology (G.H., P.P.), University of North Carolina at Chapel Hill; Departments of Radiology (D.W., Y.Z.) and Neurology (R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (D.K.), Mayo Clinic, Rochester, MN; and Department of Medicine (T.H.M.), University of Mississippi Medical Center, Jackson.

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http://dx.doi.org/10.1212/WNL.0000000000005259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890613PMC
April 2018

Left Ventricular Hypertrophy and Remodeling and Risk of Cognitive Impairment and Dementia: MESA (Multi-Ethnic Study of Atherosclerosis).

Hypertension 2018 03 29;71(3):429-436. Epub 2018 Jan 29.

From the Department of Cardiology (K.M., M.R.O., B.A.V., M.H., K.Y., I.P., J.A.C.L.) and Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Department of Medicine, Rutgers New Jersey Medical School, State University of New Jersey, Newark (K.M.); Office of Biostatistics, National Heart, Lung, and Blood Institute, Bethesda, MD (C.W.); Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (K.L.); Department of Family Medicine, School of Medicine (A.F.), Department of Epidemiology, School of Medicine (A.F.), Department of Global Health, School of Public Health (A.F.), Department of Biostatistics (R.L.M.), and Department of Epidemiology (S.H.), University of Washington, Seattle; Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, NY (S.S.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health Clinical Center, Bethesda, MD (D.A.B.); and Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (T.M.H.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812794PMC
March 2018

Blood Pressure's Role in Alzheimer Disease Pathology.

Am J Geriatr Psychiatry 2018 01 25;26(1):23-24. Epub 2017 Sep 25.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.jagp.2017.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759321PMC
January 2018

Acute interatrial block is a distinct risk factor for ischemic stroke.

Neurology 2016 07 24;87(4):344-5. Epub 2016 Jun 24.

From the Department of Internal Medicine (T.M.H.), Wake Forest School of Medicine, Winston-Salem, NC; and Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia School of Medicine, Charlottesville, VA.

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http://dx.doi.org/10.1212/WNL.0000000000002905DOI Listing
July 2016

The role of insulin in the vascular contributions to age-related dementia.

Biochim Biophys Acta 2016 05 2;1862(5):983-91. Epub 2015 Dec 2.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Wake Forest University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.11.013DOI Listing
May 2016

Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future.

Am J Hypertens 2016 Feb 11;29(2):149-57. Epub 2015 Nov 11.

Department of Internal Medicine, Division of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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http://dx.doi.org/10.1093/ajh/hpv180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989128PMC
February 2016

Review of 'the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease'.

Neurodegener Dis Manag 2015 ;5(2):121-35

Department of Internal Medicine, Division of Gerontology & Geriatric Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1207, USA.

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http://dx.doi.org/10.2217/nmt.14.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423756PMC
January 2016

Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.

Neurology 2013 Nov 16;81(19):1711-8. Epub 2013 Oct 16.

From the Department of Epidemiology, Graduate School of Public Health (T.M.H., L.H.K., E.J.M.B.-M., R.H.M.), and the Departments of Neurology (E.M.M., B.E.S., O.L.L.), Psychiatry (W.E.K., H.J.A., A.D.C.), and Radiology (C.A.M.), School of Medicine, University of Pittsburgh, PA; and the Office of the Dean and Department of Neurology (S.T.D.), School of Medicine, University of Virginia, Charlottesville.

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http://dx.doi.org/10.1212/01.wnl.0000435301.64776.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812104PMC
November 2013

Brain cholesterol metabolism, oxysterols, and dementia.

J Alzheimers Dis 2013 ;33(4):891-911

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-2012-121585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354887PMC
October 2013

Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease.

J Alzheimers Dis 2012 ;30(1):53-61

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 N. Bellefield Street, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.3233/JAD-2012-111460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348402PMC
September 2012

Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial.

Cardiovasc Diabetol 2012 Sep 22;11:114. Epub 2012 Sep 22.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1186/1475-2840-11-114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468408PMC
September 2012

Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study.

Ann Neurol 2011 Nov;70(5):774-80

Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ana.22520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241005PMC
November 2011

Identification and elimination of polysiloxane curing agent interference encountered in the quantification of low-picogram per milliliter methyl tert-butyl ether in blood by solid-phase microextraction headspace analysis.

Anal Chem 2005 May;77(9):2912-9

Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.

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http://dx.doi.org/10.1021/ac048456cDOI Listing
May 2005