Timothy Lewis

Timothy Lewis

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Timothy Lewis

Timothy Lewis

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Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.

Cell Chem Biol 2019 May 14;26(5):711-723.e14. Epub 2019 Mar 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.009DOI Listing
May 2019

Neuronal Dynamics Underlying Communication Signals in a Weakly Electric Fish: Implications for Connectivity in a Pacemaker Network.

Neuroscience 2019 03 11;401:21-34. Epub 2019 Jan 11.

Department of Biology, University of Ottawa, Ottawa K1N 6N5, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa K1N 6N5, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03064522193001
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http://dx.doi.org/10.1016/j.neuroscience.2019.01.004DOI Listing
March 2019

Correction to: Influence of Single-Dose Antibiotic Prophylaxis for Early-Onset Pneumonia in High-Risk Intubated Patients.

Neurocrit Care 2018 10;29(2):320

Division of Neurocritical Care, Departments of Neurology and Neurosurgery, University of North Carolina School of Medicine, 101 Manning Drive, CB #7025, Chapel Hill, NC, 27599-7025, USA.

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http://dx.doi.org/10.1007/s12028-018-0580-2DOI Listing
October 2018

The role of long-range coupling in crayfish swimmeret phase-locking.

Biol Cybern 2018 08 22;112(4):305-321. Epub 2018 Mar 22.

Department of Mathematics, University of California, One Shields Ave, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1007/s00422-018-0752-3DOI Listing
August 2018

Influence of Single-Dose Antibiotic Prophylaxis for Early-Onset Pneumonia in High-Risk Intubated Patients.

Neurocrit Care 2018 06;28(3):362-369

Division of Neurocritical Care, Departments of Neurology and Neurosurgery, University of North Carolina School of Medicine, 101 Manning Drive, CB #7025, Chapel Hill, NC, 27599-7025, USA.

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http://dx.doi.org/10.1007/s12028-017-0490-8DOI Listing
June 2018

Robust phase-waves in chains of half-center oscillators.

J Math Biol 2017 06 13;74(7):1627-1656. Epub 2016 Oct 13.

Department of Mathematics, University of California, Davis, One Shields Ave, Davis, CA, 95616, USA.

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http://dx.doi.org/10.1007/s00285-016-1066-5DOI Listing
June 2017

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.

ACS Med Chem Lett 2016 Dec 28;7(12):1112-1117. Epub 2016 Sep 28.

Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts 02142, United States; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States; Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150668PMC
December 2016

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Cell 2016 Sep 15;167(1):171-186.e15. Epub 2016 Sep 15.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674163115
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http://dx.doi.org/10.1016/j.cell.2016.08.057DOI Listing
September 2016

Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs.

PLoS One 2016 10;11(3):e0150761. Epub 2016 Mar 10.

Department of Pharmacology, University of California Davis, Davis, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150761PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786197PMC
August 2016

A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation.

PLoS Comput Biol 2016 07 13;12(7):e1005005. Epub 2016 Jul 13.

Department of Pharmacology, University of California Davis, Davis, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943723PMC
July 2016

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).

Bioorg Med Chem Lett 2014 Dec 28;24(24):5801-5804. Epub 2014 Oct 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Ste 327 Johnson, 847, Monroe, Memphis, TN 38163, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X140108
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http://dx.doi.org/10.1016/j.bmcl.2014.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695681PMC
December 2014

Neural mechanism of optimal limb coordination in crustacean swimming.

Proc Natl Acad Sci U S A 2014 Sep 8;111(38):13840-5. Epub 2014 Sep 8.

Departments of Mathematics and

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http://dx.doi.org/10.1073/pnas.1323208111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183325PMC
September 2014

A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.

Mol Cancer Ther 2014 Jun 15;13(6):1492-502. Epub 2014 Apr 15.

Authors' Affiliations: Dana Farber Cancer Institute, Boston; Broad Institute; Novartis Institute for Biomedical Research; Department of Biological Engineering; and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MassachusettsAuthors' Affiliations: Dana Farber Cancer Institute, Boston; Broad Institute; Novartis Institute for Biomedical Research; Department of Biological Engineering; and Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154495PMC
June 2014

The robustness of phase-locking in neurons with dendro-dendritic electrical coupling.

J Math Biol 2014 Jan 22;68(1-2):303-40. Epub 2012 Dec 22.

Program in Applied and Computational Mathematics and Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA,

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http://dx.doi.org/10.1007/s00285-012-0635-5DOI Listing
January 2014

Phase response properties of half-center oscillators.

J Comput Neurosci 2013 Aug 28;35(1):55-74. Epub 2013 Feb 28.

Department of Mathematics, University of California, Davis, Davis, CA 95616, USA.

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http://dx.doi.org/10.1007/s10827-013-0440-1DOI Listing
August 2013

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.

Bioorg Med Chem Lett 2013 May 14;23(10):3039-43. Epub 2013 Mar 14.

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648997PMC
May 2013

Neuroimaging in dementia: a practical guide.

Pract Neurol 2013 Apr;13(2):92-103

Department of Neuroradiology, Frenchay Hospital, Bristol, UK.

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http://dx.doi.org/10.1136/practneurol-2012-000337DOI Listing
April 2013

Making decisions: the process of HIV disclosure for rural African American men.

Am J Mens Health 2012 Nov 8;6(6):442-52. Epub 2012 Mar 8.

University of Alabama, Tuscaloosa, AL 35487, USA.

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http://dx.doi.org/10.1177/1557988312439405DOI Listing
November 2012

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

ACS Med Chem Lett 2012 Oct 30;3(10):808-813. Epub 2012 Aug 30.

Chemical Biology Platform and Probe Development Center and Howard Hughes Medical Institute, Broad Institute of Harvard and MIT , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/ml300172pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469069PMC
October 2012

Identification of a selective small molecule inhibitor of breast cancer stem cells.

Bioorg Med Chem Lett 2012 May 25;22(10):3571-4. Epub 2012 Jan 25.

Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.01.035DOI Listing
May 2012

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.

Proc Natl Acad Sci U S A 2011 May 9;108(21):8773-8. Epub 2011 May 9.

Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1105941108
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http://dx.doi.org/10.1073/pnas.1105941108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102385PMC
May 2011

Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.

J Virol 2011 Mar 5;85(6):2859-68. Epub 2011 Jan 5.

Samsung Biomedical Research Institutes, Samsung Medical Center, 50 Irwon-dong, Gangnam-gu, Seoul, South Korea 135-710.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01628-10
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http://dx.doi.org/10.1128/JVI.01628-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067954PMC
March 2011

Effects of dendritic load on the firing frequency of oscillating neurons.

Phys Rev E Stat Nonlin Soft Matter Phys 2011 Mar 14;83(3 Pt 1):031906. Epub 2011 Mar 14.

Department of Mathematics, One Shields Avenue, University of California, Davis, California 95616, USA.

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http://dx.doi.org/10.1103/PhysRevE.83.031906DOI Listing
March 2011

Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.

Bioconjug Chem 2010 Jan;21(1):14-9

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1021/bc900438aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902264PMC
January 2010

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Nat Chem Biol 2007 Jun 7;3(6):331-8. Epub 2007 May 7.

Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/nchembio883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635561PMC
June 2007

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.

J Comb Chem 2007 Mar-Apr;9(2):245-53

Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1021/cc060135mDOI Listing
May 2007

Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex.

Nat Neurosci 2007 Apr 4;10(4):462-8. Epub 2007 Mar 4.

Department of Neuroscience, Division of Biology & Medicine, Box G-LN, Brown University, Providence, Rhode Island 02912, USA.

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http://www.nature.com/articles/nn1861
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http://dx.doi.org/10.1038/nn1861DOI Listing
April 2007

Synchronization of electrically coupled pairs of inhibitory interneurons in neocortex.

J Neurosci 2007 Feb;27(8):2058-73

Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2715-06.2
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http://dx.doi.org/10.1523/JNEUROSCI.2715-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673558PMC
February 2007

Background-activity-dependent properties of a network model for working memory that incorporates cellular bistability.

Biol Cybern 2005 Aug 1;93(2):109-18. Epub 2005 Apr 1.

New York University Center for Neural Science, New York, NY 10003, USA.

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http://dx.doi.org/10.1007/s00422-005-0543-5DOI Listing
August 2005

Generalized integrate-and-fire models of neuronal activity approximate spike trains of a detailed model to a high degree of accuracy.

J Neurophysiol 2004 Aug;92(2):959-76

Laboratory of Computational Neuroscience, Swiss Federal Institute of Technology, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

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http://www.physiology.org/doi/10.1152/jn.00190.2004
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http://dx.doi.org/10.1152/jn.00190.2004DOI Listing
August 2004

Dynamics of spiking neurons connected by both inhibitory and electrical coupling.

J Comput Neurosci 2003 May-Jun;14(3):283-309

Center for Neural Science and Courant Institute for Mathematical Science, New York University, 4 Washington Place, Rm 809, NY 10003, USA.

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July 2003

The characterization of protein post-translational modifications by mass spectrometry.

Acc Chem Res 2003 Jun;36(6):453-61

Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA.

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http://pubs.acs.org/doi/abs/10.1021/ar020143l
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http://dx.doi.org/10.1021/ar020143lDOI Listing
June 2003

A minimal single-channel model for the regularity of beating in the sinoatrial node.

Chaos 1995 Mar;5(1):174-183

Department of Physiology and Centre for Nonlinear Dynamics in Physiology and Medicine, McGill University, Montreal H3G 1Y6, Canada.

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http://aip.scitation.org/doi/10.1063/1.166065
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http://dx.doi.org/10.1063/1.166065DOI Listing
March 1995