Timothy J Wilson

Timothy J Wilson

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Timothy J Wilson

Timothy J Wilson

Publications by authors named "Timothy J Wilson"

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Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection.

Immunology 2019 Dec 27. Epub 2019 Dec 27.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/imm.13169DOI Listing
December 2019

Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.

J Am Chem Soc 2019 May 2;141(19):7865-7875. Epub 2019 May 2.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex , The University of Dundee , Dow Street , Dundee DD1 5EH , U.K.

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http://dx.doi.org/10.1021/jacs.9b02141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523996PMC
May 2019

Structure-guided design of a high-affinity ligand for a riboswitch.

RNA 2019 04 4;25(4):423-430. Epub 2019 Jan 4.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1261/rna.069567.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426286PMC
April 2019

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

J Allergy Clin Immunol 2018 07 6;142(1):311-314.e6. Epub 2018 Mar 6.

Cancer Research UK Cambridge Institute, Cambridge, United Kingdom; Department of Clinical Immunology, Cambridge University Hospitals National Health Service Trust, Addenbrooke's Hospital, Cambridge, United Kingdom; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.01.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034011PMC
July 2018

Structure of the Guanidine III Riboswitch.

Cell Chem Biol 2017 Nov 5;24(11):1407-1415.e2. Epub 2017 Oct 5.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696562PMC
November 2017

The structure of a nucleolytic ribozyme that employs a catalytic metal ion.

Nat Chem Biol 2017 05 6;13(5):508-513. Epub 2017 Mar 6.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nchembio.2333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392355PMC
May 2017

The Novel Chemical Mechanism of the Twister Ribozyme.

J Am Chem Soc 2016 05 6;138(19):6151-62. Epub 2016 May 6.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee , Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1021/jacs.5b11791DOI Listing
May 2016

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.

Cell Rep 2015 Dec 10;13(11):2565-2575. Epub 2015 Dec 10.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01357-1.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501357
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http://dx.doi.org/10.1016/j.celrep.2015.11.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695337PMC
December 2015

A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation.

Immunology 2015 Nov 13;146(3):392-400. Epub 2015 Sep 13.

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/imm.12513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610628PMC
November 2015

RNA catalysis--is that it?

RNA 2015 Apr;21(4):534-7

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, United Kingdom

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http://dx.doi.org/10.1261/rna.049874.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371269PMC
April 2015

Fine specificity and molecular competition in SLAM family receptor signalling.

PLoS One 2014 18;9(3):e92184. Epub 2014 Mar 18.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092184PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958483PMC
December 2014

Crystal structure and mechanistic investigation of the twister ribozyme.

Nat Chem Biol 2014 Sep 20;10(9):739-44. Epub 2014 Jul 20.

Cancer Research UK Nucleic Acid Structure Research Group, Medical Sciences Institute/Wellcome Trust Building (MSI/WTB) Complex, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/nchembio.1587DOI Listing
September 2014

A mechanistic comparison of the Varkud satellite and hairpin ribozymes.

Prog Mol Biol Transl Sci 2013 ;120:93-121

Cancer Research UK Nucleic Acid Structure Research Group, The University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-381286-5.00003-2DOI Listing
April 2014

General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.

J Am Chem Soc 2012 Oct 25;134(40):16717-24. Epub 2012 Sep 25.

Cancer Research UK, Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1021/ja3067429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707309PMC
October 2012

Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG.

J Immunol 2012 May 9;188(10):4741-5. Epub 2012 Apr 9.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.4049/jimmunol.1102651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634363PMC
May 2012

Orientation of cyanine fluorophores terminally attached to DNA via long, flexible tethers.

Biophys J 2011 Sep;101(5):1148-54

Cancer Research UK Nucleic Acid Structure Research Group, The University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1016/j.bpj.2011.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164170PMC
September 2011

A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.

Nucleic Acids Res 2011 Mar 9;39(5):e31. Epub 2010 Dec 9.

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E. 57th Street, Room W406, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/nar/gkq1265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061073PMC
March 2011

Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data.

RNA 2011 Feb 20;17(2):213-21. Epub 2010 Dec 20.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD15EH, United Kingdom.

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http://dx.doi.org/10.1261/rna.2473711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022271PMC
February 2011

Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.

J Immunol 2010 Sep 28;185(5):2960-7. Epub 2010 Jul 28.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1001428
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http://dx.doi.org/10.4049/jimmunol.1001428DOI Listing
September 2010

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.

Hum Immunol 2010 Aug 16;71(8):799-803. Epub 2010 May 16.

Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil; Postgraduate Course in Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

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http://dx.doi.org/10.1016/j.humimm.2010.05.014DOI Listing
August 2010

Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response.

J Exp Med 2010 Jul 21;207(7):1485-500. Epub 2010 Jun 21.

Integrated Department of Immunology, University of Colorado, Denver, CO 80206, USA.

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http://dx.doi.org/10.1084/jem.20092695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901065PMC
July 2010

Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.

Proc Natl Acad Sci U S A 2010 Jun 14;107(26):11751-6. Epub 2010 Jun 14.

Cancer Research United Kingdom Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1004255107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900685PMC
June 2010

A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC.

Eur J Immunol 2009 Mar;39(3):695-703

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/eji.200839116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544471PMC
March 2009

Synthesis of novel C4-linked C2-imidazole ribonucleoside phosphoramidite and its application to probing the catalytic mechanism of a ribozyme.

J Org Chem 2009 Mar;74(6):2350-6

Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

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http://dx.doi.org/10.1021/jo802556sDOI Listing
March 2009

Biochemistry. The evolution of ribozyme chemistry.

Science 2009 Mar;323(5920):1436-8

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1126/science.1169231DOI Listing
March 2009

Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids.

Proc Natl Acad Sci U S A 2008 Aug 1;105(32):11176-81. Epub 2008 Aug 1.

Cancer Research United Kingdom Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0801707105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516210PMC
August 2008

RNA folding and the origins of catalytic activity in the hairpin ribozyme.

Blood Cells Mol Dis 2007 Jan-Feb;38(1):8-14. Epub 2006 Dec 4.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.bcmd.2006.10.004DOI Listing
October 2007

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.

Blood 2007 May 9;109(9):3786-93. Epub 2007 Jan 9.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1182/blood-2006-06-030023DOI Listing
May 2007

A guanine nucleobase important for catalysis by the VS ribozyme.

EMBO J 2007 May 26;26(10):2489-500. Epub 2007 Apr 26.

Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868910PMC
May 2007

Nucleobase catalysis in the hairpin ribozyme.

RNA 2006 Jun 6;12(6):980-7. Epub 2006 Apr 6.

Cancer Research UK Nucleic Acid Structure Research Group, The University of Dundee.

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http://dx.doi.org/10.1261/rna.11706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464849PMC
June 2006

Induced fit of RNA on binding the L7Ae protein to the kink-turn motif.

RNA 2005 Aug 29;11(8):1192-200. Epub 2005 Jun 29.

Cancer Research-UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1261/rna.2680605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370803PMC
August 2005

Valence and anion binding of bovine ribonuclease A between pH 6 and 8.

Anal Biochem 2005 Jan;336(2):243-52

Center to Advance Molecular Interaction Science, Rudman Hall, 46 College Road, University of New Hampshire, Durham, NH 03824, USA.

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http://dx.doi.org/10.1016/j.ab.2004.09.009DOI Listing
January 2005

Observation of internal cleavage and ligation reactions of a ribozyme.

Nat Struct Mol Biol 2004 Nov 10;11(11):1107-13. Epub 2004 Oct 10.

Physics Department, University of Illinois, Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1038/nsmb842DOI Listing
November 2004

Vesicle encapsulation studies reveal that single molecule ribozyme heterogeneities are intrinsic.

Biophys J 2004 Oct;87(4):2798-806

Physics Department, University of Illinois, Urbana-Champaign, Urbana, Illinois USA.

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http://dx.doi.org/10.1529/biophysj.104.045971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304698PMC
October 2004

Folding of the natural hammerhead ribozyme is enhanced by interaction of auxiliary elements.

RNA 2004 May;10(5):880-8

Cancer Research UK Nucleic Acid Structure Research Group, Department of Biochemistry, The University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370577PMC
http://dx.doi.org/10.1261/rna.5268404DOI Listing
May 2004

Conformational flexibility of four-way junctions in RNA.

J Mol Biol 2004 Feb;336(1):69-79

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.jmb.2003.12.014DOI Listing
February 2004

A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate.

Proc Natl Acad Sci U S A 2003 Aug 25;100(16):9308-13. Epub 2003 Jul 25.

Department of Physics and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.1233536100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170914PMC
August 2003

The dynamic nature of the four-way junction of the hepatitis C virus IRES.

RNA 2003 Jul;9(7):809-20

Cancer Research UK Nucleic Acid Structure Research Group, Department of Biochemistry, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370448PMC
http://dx.doi.org/10.1261/rna.5130703DOI Listing
July 2003

Functional group requirements in the probable active site of the VS ribozyme.

J Mol Biol 2002 Oct;323(1):23-34

Cancer Research UK Nucleic Acid Structure Research Group, Department of Biochemistry, MSI/WTB Complex, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1016/s0022-2836(02)00910-5DOI Listing
October 2002

M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia.

EMBO J 2002 Aug;21(15):3936-48

Tayside Institute of Child Health, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK.

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http://dx.doi.org/10.1093/emboj/cdf388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126135PMC
August 2002

Suppression of tissue factor expression, cofactor activity, and metastatic potential of murine melanoma cells by the N-terminal domain of adenovirus E1A 12S protein.

J Cell Biochem 2002 ;85(1):54-71

Department of Biochemistry and Molecular Biology, Program in Tumor Biology, Mayo Clinic/Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1002/jcb.10099DOI Listing
June 2002

Metal ion binding and the folding of the hairpin ribozyme.

RNA 2002 May;8(5):587-600

Cancer Research-UK Nucleic Acid Structure Research Group, Department of Biochemistry, MSI/WTB Complex, The University of Dundee.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370280PMC
http://dx.doi.org/10.1017/s1355838202020514DOI Listing
May 2002