Timothy J Vyse

Timothy J Vyse

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Timothy J Vyse

Timothy J Vyse

Publications by authors named "Timothy J Vyse"

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Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

Genet Epidemiol 2019 Aug 13. Epub 2019 Aug 13.

Center for Neuroengineering and Therapeutics, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/gepi.22242DOI Listing
August 2019

Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus.

J Autoimmun 2018 07 22;91:1-12. Epub 2018 Mar 22.

Department of Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2018.02.009DOI Listing
July 2018

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.

Hum Mol Genet 2018 Jul;27(13):2392-2404

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1093/hmg/ddy140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005081PMC
July 2018

Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.

Arthritis Res Ther 2018 05 3;20(1):92. Epub 2018 May 3.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Sandy Bay, Hong Kong.

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http://dx.doi.org/10.1186/s13075-018-1590-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934841PMC
May 2018

Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.

PLoS Genet 2017 Oct 23;13(10):e1007071. Epub 2017 Oct 23.

Department of Medical & Molecular Genetics, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695635PMC
October 2017

Genetic advances in systemic lupus erythematosus: an update.

Curr Opin Rheumatol 2017 Sep;29(5):423-433

aDivision of Genetics and Molecular Medicine bDivision of Immunology, Infection & Inflammatory Disease, King's College London, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1097/BOR.0000000000000411DOI Listing
September 2017

Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.

Eur J Immunol 2017 07 22;47(7):1200-1210. Epub 2017 May 22.

Division of Genetics and Molecular Medicine, Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1002/eji.201646822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507296PMC
July 2017

Transancestral mapping and genetic load in systemic lupus erythematosus.

Authors:
Carl D Langefeld Hannah C Ainsworth Deborah S Cunninghame Graham Jennifer A Kelly Mary E Comeau Miranda C Marion Timothy D Howard Paula S Ramos Jennifer A Croker David L Morris Johanna K Sandling Jonas Carlsson Almlöf Eduardo M Acevedo-Vásquez Graciela S Alarcón Alejandra M Babini Vicente Baca Anders A Bengtsson Guillermo A Berbotto Marc Bijl Elizabeth E Brown Hermine I Brunner Mario H Cardiel Luis Catoggio Ricard Cervera Jorge M Cucho-Venegas Solbritt Rantapää Dahlqvist Sandra D'Alfonso Berta Martins Da Silva Iñigo de la Rúa Figueroa Andrea Doria Jeffrey C Edberg Emőke Endreffy Jorge A Esquivel-Valerio Paul R Fortin Barry I Freedman Johan Frostegård Mercedes A García Ignacio García de la Torre Gary S Gilkeson Dafna D Gladman Iva Gunnarsson Joel M Guthridge Jennifer L Huggins Judith A James Cees G M Kallenberg Diane L Kamen David R Karp Kenneth M Kaufman Leah C Kottyan László Kovács Helle Laustrup Bernard R Lauwerys Quan-Zhen Li Marco A Maradiaga-Ceceña Javier Martín Joseph M McCune David R McWilliams Joan T Merrill Pedro Miranda José F Moctezuma Swapan K Nath Timothy B Niewold Lorena Orozco Norberto Ortego-Centeno Michelle Petri Christian A Pineau Bernardo A Pons-Estel Janet Pope Prithvi Raj Rosalind Ramsey-Goldman John D Reveille Laurie P Russell José M Sabio Carlos A Aguilar-Salinas Hugo R Scherbarth Raffaella Scorza Michael F Seldin Christopher Sjöwall Elisabet Svenungsson Susan D Thompson Sergio M A Toloza Lennart Truedsson Teresa Tusié-Luna Carlos Vasconcelos Luis M Vilá Daniel J Wallace Michael H Weisman Joan E Wither Tushar Bhangale Jorge R Oksenberg John D Rioux Peter K Gregersen Ann-Christine Syvänen Lars Rönnblom Lindsey A Criswell Chaim O Jacob Kathy L Sivils Betty P Tsao Laura E Schanberg Timothy W Behrens Earl D Silverman Marta E Alarcón-Riquelme Robert P Kimberly John B Harley Edward K Wakeland Robert R Graham Patrick M Gaffney Timothy J Vyse

Nat Commun 2017 07 17;8:16021. Epub 2017 Jul 17.

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/ncomms16021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018PMC
July 2017

Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.

Am J Hum Genet 2017 Jun 25;100(6):885-894. Epub 2017 May 25.

Department of Psychiatry and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mental Illness Research Education and Clinical Center, James J. Peters VA Medical Center, Bronx, New York, NY 10468, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474225PMC
June 2017

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

PLoS Genet 2017 Jun 22;13(6):e1006820. Epub 2017 Jun 22.

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501660PMC
June 2017

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.

Sci Signal 2016 10 4;9(448):ra99. Epub 2016 Oct 4.

Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, Faculty of Life Sciences and Medicine, King's College London, London SE1 1UL, U.K.

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http://dx.doi.org/10.1126/scisignal.aaf2195DOI Listing
October 2016

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Arthritis Rheumatol 2016 05;68(5):1290-1300

College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.1002/art.39560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019501PMC
May 2016

Reduced Fluorescence versus Forward Scatter Time-of-Flight and Increased Peak versus Integral Fluorescence Ratios Indicate Receptor Clustering in Flow Cytometry.

J Immunol 2015 Jul 29;195(1):377-85. Epub 2015 May 29.

Division of Molecular Immunology, Department of Internal Medicine 3, University of Erlangen-Nuremberg, Nikolaus Fiebiger Centre, 91054 Erlangen, Germany;

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http://dx.doi.org/10.4049/jimmunol.1401889DOI Listing
July 2015

IFN-α production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases.

Hum Mol Genet 2015 Jun 16;24(12):3571-81. Epub 2015 Mar 16.

Department of Medical Sciences, Rheumatology, Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv095DOI Listing
June 2015

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.

Ann Rheum Dis 2015 May 13;74(5):912-20. Epub 2014 Jan 13.

Medical and Molecular Genetics and Division of Immunology, Infection, and Inflammatory Disease, King's College London, London, UK.

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http://dx.doi.org/10.1136/annrheumdis-2013-204343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152192PMC
May 2015

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Nat Genet 2013 Nov 6;45(11):1284-92. Epub 2013 Oct 6.

1] Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA. [2] Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://dx.doi.org/10.1038/ng.2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192PMC
November 2013

The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.

Ann Rheum Dis 2012 Dec 14;71(12):2028-34. Epub 2012 May 14.

Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Disease, King’s College London, London, UK.

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http://dx.doi.org/10.1136/annrheumdis-2012-201390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488763PMC
December 2012

Analysis of systemic lupus erythematosus sub-phenotype data for genetic association.

Curr Opin Rheumatol 2012 Sep;24(5):482-8

Divisions of Genetics and Molecular Medicine and Immunology, Infection and Inflammatory Disease Department of Medical and Molecular Genetics, Kings College, London, UK.

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http://dx.doi.org/10.1097/BOR.0b013e3283562282DOI Listing
September 2012

Selective IgA deficiency in autoimmune diseases.

Mol Med 2011 4;17(11-12):1383-96. Epub 2011 Aug 4.

Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.2119/molmed.2011.00195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321806PMC
August 2012

Clinical problem-solving. The wolf at the door.

N Engl J Med 2012 Jun;366(23):2216-21

Department of Haematology, Royal Free and University College Medical School, London, United Kingdom.

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http://dx.doi.org/10.1056/NEJMcps1010093DOI Listing
June 2012

Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.

Ann Rheum Dis 2012 May 10;71(5):777-84. Epub 2012 Jan 10.

Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.

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http://dx.doi.org/10.1136/annrheumdis-2011-200808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329227PMC
May 2012

The genetics of lupus: a functional perspective.

Arthritis Res Ther 2012 May 29;14(3):211. Epub 2012 May 29.

Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King's College London, Great Maze Pond, London, SE1 9RT, UK.

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http://dx.doi.org/10.1186/ar3844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446495PMC
May 2012

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

PLoS Genet 2011 Oct 27;7(10):e1002341. Epub 2011 Oct 27.

Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom.

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https://dx.plos.org/10.1371/journal.pgen.1002341
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http://dx.doi.org/10.1371/journal.pgen.1002341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203198PMC
October 2011

Investigation of the HIN200 locus in UK SLE families identifies novel copy number variants.

Ann Hum Genet 2011 May 14;75(3):383-97. Epub 2011 Mar 14.

Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, UK.

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http://dx.doi.org/10.1111/j.1469-1809.2011.00641.xDOI Listing
May 2011

C-reactive protein in rheumatology: biology and genetics.

Nat Rev Rheumatol 2011 May 5;7(5):282-9. Epub 2011 Apr 5.

King's College London, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, UK.

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http://dx.doi.org/10.1038/nrrheum.2011.37DOI Listing
May 2011

Risk alleles in idiopathic membranous nephropathy.

N Engl J Med 2011 05;364(21):2072; author reply 2073-4

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http://dx.doi.org/10.1056/NEJMc1103117DOI Listing
May 2011

Dense mapping of IL18 shows no association in SLE.

Hum Mol Genet 2011 Mar 13;20(5):1026-33. Epub 2010 Dec 13.

Rheumatology Section, Imperial College, London W12 0NN, UK.

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http://dx.doi.org/10.1093/hmg/ddq536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033184PMC
March 2011

HLA has strongest association with IgA nephropathy in genome-wide analysis.

J Am Soc Nephrol 2010 Oct 1;21(10):1791-7. Epub 2010 Jul 1.

The John Walls Renal Unit, Leicester General Hospital and Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1681/ASN.2010010076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013538PMC
October 2010

Using genetics to deliver personalized SLE therapy-a realistic prospect?

Nat Rev Rheumatol 2010 06 4;6(6):373-7. Epub 2010 May 4.

Rheumatology Section, Division of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1038/nrrheum.2010.67DOI Listing
June 2010

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7881-5. Epub 2010 Apr 12.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 0XY, United Kingdom.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0915133107
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http://dx.doi.org/10.1073/pnas.0915133107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867866PMC
April 2010

Genetics of rheumatic disease.

Arthritis Res Ther 2009 14;11(5):248. Epub 2009 Oct 14.

Imperial College London, Faculty of Medicine, Section of Molecular Genetics and Rheumatology, Fifth Floor, Commonwealth Building, Hammersmith Hospital, London W12 0NN, UK.

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http://dx.doi.org/10.1186/ar2781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787281PMC
February 2010

Narcolepsy and the T-cell receptor.

Authors:
Timothy J Vyse

Nat Genet 2009 Jun;41(6):640-1

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http://dx.doi.org/10.1038/ng0609-640DOI Listing
June 2009

Genetics: unraveling the genetics of autoimmune disease.

Authors:
Timothy J Vyse

Nat Rev Rheumatol 2009 Apr;5(4):187-8

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http://dx.doi.org/10.1038/nrrheum.2009.42DOI Listing
April 2009