Timothy J Ley

Timothy J Ley

UNVERIFIED PROFILE

Are you Timothy J Ley?   Register this Author

Register author
Timothy J Ley

Timothy J Ley

Publications by authors named "Timothy J Ley"

Are you Timothy J Ley?   Register this Author

100Publications

3399Reads

32Profile Views

Immune Escape of AML Cells after Transplantation. Reply.

N Engl J Med 2019 03;380(13):1290

Washington University School of Medicine, St. Louis, MO

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1900424DOI Listing
March 2019

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.

N Engl J Med 2018 12 31;379(24):2330-2341. Epub 2018 Oct 31.

From the Division of Oncology, Department of Internal Medicine (M.J.C., A.A.P., M.P.R., C.A.M., E.C., N.M.H., L.D.W., J.S.W., S.E.H., D.C.L., M.J.W., P.W., T.J.L., J.F.D.), the McDonnell Genome Institute (A.A.P., C.A.M., M.O., C.C.F., R.S.F., L.D.W., T.J.L.), the Department of Pathology and Immunology (E.J.D., J.E.P.), and the Division of Biostatistics (J.D.B.), Washington University in St. Louis, St. Louis; the Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN (J.M.K.); the Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH (R.K.W.); and the Center for Cancer Research, Massachusetts General Hospital, Boston (T.A.G.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1808777
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1808777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322675PMC
December 2018

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.

N Engl J Med 2018 Sep;379(11):1028-1041

From the Department of Pathology and Immunology (E.J.D.), the Department of Medicine, Division of Oncology (M.A.J., C.A.M., N.E., J.S., K.E., J.R., S.E.H., K.B., L.D.W., M.J.C., I.P., J.S.W., G.L.U., D.C.L., J.F.D., P.W., T.J.L., M.J.W.), the McDonnell Genome Institute (G.S.C., C.A.M., H.A., R.S.F., C.C.F., M.O.), the Department of Medicine, Division of Hospital Medicine (R.S.), and Siteman Biostatistics Shared Resource, Siteman Cancer Center (K.T.), Washington University School of Medicine in St. Louis, St. Louis; and Massachusetts General Hospital Cancer Center, Boston (T.A.G.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1804714
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1804714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309244PMC
September 2018

DNMT3A-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A OCI-AML3 leukemia cell line.

Blood Cancer J 2018 04 4;8(4):38. Epub 2018 Apr 4.

Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41408-018-0072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884841PMC
April 2018

Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.

JAMA 2018 Apr;319(14):1497-1498

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, The McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2018.2281DOI Listing
April 2018

Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.

Exp Hematol 2017 11 28;55:19-33. Epub 2017 Jul 28.

The McDonnell Genome Institute, Washington University, St. Louis, MO; Department of Medicine, Washington University, St. Louis, MO; Siteman Cancer Center, Washington University, St. Louis, MO; Department of Biomedical Engineering, Washington University, St. Louis, MO. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772960PMC
November 2017

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.

Cell 2017 02 16;168(5):801-816.e13. Epub 2017 Feb 16.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The McDonnell Genome Institute, Washington University, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328582PMC
February 2017

Decitabine in TP53-Mutated AML.

N Engl J Med 2017 02;376(8):797-8

Washington University School of Medicine, St. Louis, MO

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1616062DOI Listing
February 2017

Visualizing tumor evolution with the fishplot package for R.

BMC Genomics 2016 11 7;17(1):880. Epub 2016 Nov 7.

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-016-3195-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100182PMC
November 2016

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

N Engl J Med 2016 11;375(21):2023-2036

the Department of Internal Medicine, Division of Oncology (J.S.W., L.D.W., G.L.U., A.G., M.H.T., I.P., R.R., T.A.F., K.E.S.-G., R.V., S.T.O., C.N.A., A.F.C., M.A.S., M.A.J., S.E.H., K.L., M.R.J., M.J.W., P.W., D.C.L., J.F.D., T.J.L.), and the Division of Biostatistics (J.D.B.), and the Department of Pathology and Immunology (E.J.D., B.T., Y.-S.L.), Washington University School of Medicine, and McDonnell Genome Institute, Washington University in St. Louis (A.A.P., C.A.M., C.C.F., M.O., R.S.F., R.K.W., L.D.W., T.J.L.) - both in St. Louis; the Departments of Internal Medicine (A.H., N.K., M.J.S., W.S.) and Pharmacy (R.W.K.), University of Chicago, Chicago; and the Department of Internal Medicine (T.A.G.), Massachusetts General Hospital, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1605949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217532PMC
November 2016

Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.

PLoS One 2015 23;10(3):e0120585. Epub 2015 Mar 23.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120585PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370741PMC
December 2015

Optimizing cancer genome sequencing and analysis.

Cell Syst 2015 Sep;1(3):210-223

The McDonnell Genome Institute, Washington University, St. Louis, MO, USA, 63108 ; Department of Genetics, Washington University, St. Louis, MO, USA, 63108 ; Siteman Cancer Center, Washington University, St. Louis, MO, USA, 63108 ; Department of Medicine, Washington University, St. Louis, MO, USA, 63108.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cels.2015.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669575PMC
September 2015

Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nat Med 2014 Dec 19;20(12):1472-8. Epub 2014 Oct 19.

1] The Genome Institute, Washington University in St. Louis, St. Louis, Missouri, USA. [2] Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA. [3] Department of Genetics, Washington University in St. Louis, St. Louis, Missouri, USA. [4] Siteman Cancer Center, Washington University in St. Louis, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313872PMC
December 2014

SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.

PLoS Comput Biol 2014 Aug 7;10(8):e1003665. Epub 2014 Aug 7.

The Genome Institute, Washington University, St. Louis, Missouri, United States of America; Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Genetics, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1003665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125065PMC
August 2014

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.

PLoS Genet 2014 Jul 10;10(7):e1004462. Epub 2014 Jul 10.

Department of Internal Medicine, Division of Oncology, Washington University, St. Louis, Missouri, United States of America; Siteman Cancer Center, Washington University, St. Louis, Missouri, United States of America; Department of Pathology and Immunology, Washington University, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091781PMC
July 2014

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.

Cancer Cell 2014 Apr 20;25(4):442-54. Epub 2014 Mar 20.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University, St. Louis, MO 63110, USA; The Genome Institute, Washington University, St. Louis, MO 63110, USA; Department of Genetics, Washington University, St. Louis, MO 63110, USA; Siteman Cancer Center, Washington University, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018976PMC
April 2014

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Cancer Cell 2014 Mar 6;25(3):379-92. Epub 2014 Mar 6.

The Genome Institute, Washington University, St. Louis, MO 63110, USA; Division of Oncology, Section of Stem Cell Biology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983786PMC
March 2014

DGIdb: mining the druggable genome.

Nat Methods 2013 Dec 13;10(12):1209-10. Epub 2013 Oct 13.

1] The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [3].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.2689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851581PMC
December 2013

Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.

Blood 2013 Oct 5;122(15):e44-51. Epub 2013 Sep 5.

Jane Anne Nohl Division of Hematology, Department of Medicine, University of Southern California, Los Angeles, CA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-03-488007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795465PMC
October 2013

Notch signaling in acute promyelocytic leukemia.

Leukemia 2013 Jul 4;27(7):1548-1557. Epub 2013 Mar 4.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/leu.2013.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872828PMC
July 2013

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.

PLoS One 2012 8;7(10):e46529. Epub 2012 Oct 8.

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046529PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466302PMC
June 2013

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

N Engl J Med 2013 05 1;368(22):2059-74. Epub 2013 May 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1301689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767041PMC
May 2013

The Pediatric Cancer Genome Project.

Nat Genet 2012 May 29;44(6):619-22. Epub 2012 May 29.

St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, Memphis, Tennessee, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619412PMC
May 2012

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.

J Clin Invest 2011 Apr;121(4):1636-45

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63119, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI42953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068978PMC
April 2011

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.

Blood 2011 Feb 29;117(8):2460-8. Epub 2010 Dec 29.

Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-08-300087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317790PMC
February 2011

A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.

Blood 2010 Nov 20;116(18):3604-10. Epub 2010 Jul 20.

Section of Stem Cell Biology, Division of Oncology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-11-189282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981479PMC
November 2010

Latent herpesvirus infection arms NK cells.

Blood 2010 Jun 4;115(22):4377-83. Epub 2010 Feb 4.

Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-09-245464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881492PMC
June 2010

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

J Clin Invest 2010 Jun 17;120(6):2109-18. Epub 2010 May 17.

Department of Medicine, Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI39964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877934PMC
June 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature08987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902243PMC
April 2010

Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.

Blood 2010 Mar 13;115(9):1669-77. Epub 2009 Nov 13.

Section of Stem Cell Biology, Division of Oncology, Departments of Internal Medicine and Genetics, Washington University School of Medicine, St Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-07-233676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832813PMC
March 2010

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.

J Clin Invest 2009 Jun 18;119(6):1714-26. Epub 2009 May 18.

Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University Medical School, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://www.jci.org/articles/view/38248
Publisher Site
http://dx.doi.org/10.1172/JCI38248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689138PMC
June 2009

Differential expression of granzyme B and C in murine cytotoxic lymphocytes.

J Immunol 2009 May;182(10):6287-97

Department of Internal Medicine, Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0804333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714542PMC
May 2009

Sociology. The gender gap in NIH grant applications.

Science 2008 Dec;322(5907):1472-4

Department of Medicine, Washington University Medical School, St. Louis, MO 63130, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1165878DOI Listing
December 2008

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.

Blood 2008 Aug 13;112(4):1434-42. Epub 2008 Jun 13.

Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University School of Medicine, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-01-13
Publisher Site
http://dx.doi.org/10.1182/blood-2008-01-132084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515115PMC
August 2008

wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data.

Nucleic Acids Res 2008 Apr 11;36(7):e41. Epub 2008 Mar 11.

Department of Internal Medicine and Department of Genetics, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkn110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367727PMC
April 2008

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.

Immunity 2007 Oct 4;27(4):635-46. Epub 2007 Oct 4.

Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2007.08.014DOI Listing
October 2007

Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.

Immunity 2007 Jun 31;26(6):798-811. Epub 2007 May 31.

Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2007.04.010DOI Listing
June 2007

Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2.

Blood 2007 Feb 28;109(3):1237-40. Epub 2006 Sep 28.

Department of Medicine, Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-07-037465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785146PMC
February 2007

Commonly dysregulated genes in murine APL cells.

Blood 2007 Feb 28;109(3):961-70. Epub 2006 Sep 28.

Department of Medicine, Siteman Cancer Center, and Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-07-036640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785140PMC
February 2007

A high-resolution map of segmental DNA copy number variation in the mouse genome.

PLoS Genet 2007 Jan 22;3(1):e3. Epub 2006 Nov 22.

Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.0030003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761046PMC
January 2007

Hop cleavage and function in granzyme B-induced apoptosis.

J Biol Chem 2006 Dec 27;281(48):37130-41. Epub 2006 Sep 27.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M607969200DOI Listing
December 2006

Cold shock domain family members YB-1 and MSY4 share essential functions during murine embryogenesis.

Mol Cell Biol 2006 Nov 5;26(22):8410-7. Epub 2006 Sep 5.

Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01196-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636768PMC
November 2006

Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

Blood 2006 Sep 4;108(5):1708-15. Epub 2006 May 4.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-04-015040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895511PMC
September 2006

Use of protease proteomics to discover granzyme B substrates.

Immunol Res 2005 ;32(1-3):143-53

Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/IR:32:1-3:143DOI Listing
August 2006

The physician-scientist career pipeline in 2005: build it, and they will come.

JAMA 2005 Sep;294(11):1343-51

Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, Mo 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.294.11.1343DOI Listing
September 2005

Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.

Haematologica 2005 Aug;90(8):1042-9

Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
August 2005

Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.

Proc Natl Acad Sci U S A 2005 Aug 19;102(35):12513-8. Epub 2005 Aug 19.

Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0504247102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188022PMC
August 2005

YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.

Mol Cell Biol 2005 Jun;25(11):4625-37

Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.25.11.4625-4637.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140647PMC
June 2005

Retrospective: Stanley Joel Korsmeyer (1950-2005).

Authors:
Timothy J Ley

Science 2005 May;308(5723):803-4

Departments of Medicine and Genetics, Washington University, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1113842DOI Listing
May 2005

Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.

J Immunol 2005 Feb;174(4):2124-31

Division of Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.174.4.2124DOI Listing
February 2005

Neutrophil elastase is important for PML-retinoic acid receptor alpha activities in early myeloid cells.

Mol Cell Biol 2005 Jan;25(1):23-33

Departments of Medicine and Genetics, Division of Oncology, Siteman Cancer Center, Washington University, 660 S. Euclid Ave., Campus Box 8007, St. Louis, MO 63110-1093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.25.1.23-33.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC538790PMC
January 2005