Timothy J Hohman

Department of Chemistry, Vanderbilt University, Nashville, TN 37235, United States of America; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN 37212, United States of America; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, United States of America; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, United States of America; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States of America. Electronic address:

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December 2020

Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel.

Authors:

Amy R Dunn Niran Hadad Sarah M Neuner Ji-Gang Zhang Vivek M Philip Logan Dumitrescu Timothy J Hohman Jeremy H Herskowitz Kristen M S O'Connell Catherine C Kaczorowski

Front Cell Dev Biol 2020 11;8:562662. Epub 2020 Sep 11.

The Jackson Laboratory, Bar Harbor, ME, United States.

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September 2020

Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment.

Authors:

Elizabeth E Moore Dandan Liu Corey W Bown Hailey A Kresge Deepak K Gupta Kimberly R Pechman Lisa A Mendes L Taylor Davis Katherine A Gifford Adam W Anderson Thomas J Wang Bennett A Landman Timothy J Hohman Angela L Jefferson

Brain Imaging Behav 2020 Oct 10. Epub 2020 Oct 10.

Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 1207 17th Avenue South, Suite 204, Nashville, TN, 37212, USA.

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October 2020

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.

Authors:

Nicolai Franzmeier M Suárez-Calvet Lukas Frontzkowski Annah Moore Timothy J Hohman Estrella Morenas-Rodriguez Brigitte Nuscher Leslie Shaw John Q Trojanowski Martin Dichgans Gernot Kleinberger Christian Haass Michael Ewers

Mol Neurodegener 2020 10 8;15(1):57. Epub 2020 Oct 8.

Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig Maximilian University (LMU), Munich, Germany.

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October 2020

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.

Cell Rep 2020 09;32(9):108091

The Jackson Laboratory, Bar Harbor, ME 04609, USA; Graduate School of Biomedical Science and Engineering, The University of Maine, Orono, ME 04469, USA. Electronic address:

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September 2020

Genetic variants and functional pathways associated with resilience to Alzheimer's disease.

Brain 2020 08;143(8):2561-2575

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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August 2020

Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline.

Authors:

Rachel F Buckley Matthew R Scott Heidi I L Jacobs Aaron P Schultz Michael J Properzi Rebecca E Amariglio Timothy J Hohman Danielle V Mayblyum Zoe B Rubinstein Lyssa Manning Bernard J Hanseeuw Elizabeth C Mormino Dorene M Rentz Keith A Johnson Reisa A Sperling

Ann Neurol 2020 11 31;88(5):921-932. Epub 2020 Aug 31.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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November 2020

Modifiable Lifestyle Factors in Alzheimer Disease: An Opportunity to Transform the Therapeutic Landscape Through Transdisciplinary Collaboration.

Authors:

Timothy J Hohman Catherine C Kaczorowski

JAMA Neurol 2020 Jun 29. Epub 2020 Jun 29.

The Jackson Laboratory, Bar Harbor, Maine.

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June 2020

Association of hippocampal volume polygenic predictor score with baseline and change in brain volumes and cognition among cognitively healthy older adults.

Authors:

Nicole M Armstrong Logan Dumitrescu Chiung-Wei Huang Yang An Toshiko Tanaka Dena Hernandez Jimit Doshi Guray Erus Christos Davatzikos Luigi Ferrucci Susan M Resnick Timothy J Hohman

Neurobiol Aging 2020 10 21;94:81-88. Epub 2020 May 21.

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.

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October 2020

Mild Cognitive Impairment Staging Yields Genetic Susceptibility, Biomarker, and Neuroimaging Differences.

Authors:

Elizabeth E Moore Dandan Liu Kimberly R Pechman Lealani Mae Y Acosta Susan P Bell L Taylor Davis Kaj Blennow Henrik Zetterberg Bennett A Landman Matthew S Schrag Timothy J Hohman Katherine A Gifford Angela L Jefferson

Front Aging Neurosci 2020 5;12:139. Epub 2020 Jun 5.

Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

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June 2020

Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.

JAMA Neurol 2020 Jun 22. Epub 2020 Jun 22.

Department of Neurology, Columbia University Medical Center, New York, New York.

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June 2020

Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline.

Authors:

Derek B Archer Elizabeth E Moore Niranjana Shashikumar Logan Dumitrescu Kimberly R Pechman Bennett A Landman Katherine A Gifford Angela L Jefferson Timothy J Hohman

Neurobiol Aging 2020 10 12;94:15-23. Epub 2020 May 12.

Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Neurology, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA.

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October 2020

Cerebrospinal fluid biomarkers of neurodegeneration, synaptic dysfunction, and axonal injury relate to atrophy in structural brain regions specific to Alzheimer's disease.

Authors:

Elizabeth E Moore Katherine A Gifford Omair A Khan Dandan Liu Kimberly R Pechman Lealani Mae Y Acosta Susan P Bell Maxim Turchan Bennett A Landman Kaj Blennow Henrik Zetterberg Timothy J Hohman Angela L Jefferson

Alzheimers Dement 2020 06 6;16(6):883-895. Epub 2020 May 6.

Department of Neurology, Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee.

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June 2020

Lower Left Ventricular Ejection Fraction Relates to Cerebrospinal Fluid Biomarker Evidence of Neurodegeneration in Older Adults.

Authors:

Hailey A Kresge Dandan Liu Deepak K Gupta Elizabeth E Moore Katie E Osborn Lealani Mae Y Acosta Susan P Bell Kimberly R Pechman Katherine A Gifford Lisa A Mendes Thomas J Wang Kaj Blennow Henrik Zetterberg Timothy J Hohman Angela L Jefferson

J Alzheimers Dis 2020 ;74(3):965-974

Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.

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January 2020

Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

Authors:

Iris E Jansen Jeanne E Savage Kyoko Watanabe Julien Bryois Dylan M Williams Stacy Steinberg Julia Sealock Ida K Karlsson Sara Hägg Lavinia Athanasiu Nicola Voyle Petroula Proitsi Aree Witoelar Sven Stringer Dag Aarsland Ina S Almdahl Fred Andersen Sverre Bergh Francesco Bettella Sigurbjorn Bjornsson Anne Brækhus Geir Bråthen Christiaan de Leeuw Rahul S Desikan Srdjan Djurovic Logan Dumitrescu Tormod Fladby Timothy J Hohman Palmi V Jonsson Steven J Kiddle Arvid Rongve Ingvild Saltvedt Sigrid B Sando Geir Selbæk Maryam Shoai Nathan G Skene Jon Snaedal Eystein Stordal Ingun D Ulstein Yunpeng Wang Linda R White John Hardy Jens Hjerling-Leffler Patrick F Sullivan Wiesje M van der Flier Richard Dobson Lea K Davis Hreinn Stefansson Kari Stefansson Nancy L Pedersen Stephan Ripke Ole A Andreassen Danielle Posthuma

Nat Genet 2020 03;52(3):354

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.

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March 2020

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.

Authors:

Uma V Mahajan Vijay R Varma Michael E Griswold Chad T Blackshear Yang An Anup M Oommen Sudhir Varma Juan C Troncoso Olga Pletnikova Richard O'Brien Timothy J Hohman Cristina Legido-Quigley Madhav Thambisetty

PLoS Med 2020 01 24;17(1):e1003012. Epub 2020 Jan 24.

Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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January 2020

Telomere length associations with cognition depend on Alzheimer's disease biomarkers.

Authors:

Emily R Mahoney Logan Dumitrescu Mabel Seto Kelly N H Nudelman Rachel F Buckley Katie A Gifford Andrew J Saykin Angela J Jefferson Timothy J Hohman

Alzheimers Dement (N Y) 2019 9;5:883-890. Epub 2019 Dec 9.

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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December 2019

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.

Authors:

Annah M Moore Emily Mahoney Logan Dumitrescu Philip L De Jager Mary Ellen I Koran Vladislav A Petyuk Renã As Robinson Douglas M Ruderfer Nancy J Cox Julie A Schneider David A Bennett Angela L Jefferson Timothy J Hohman

Neurobiol Aging 2020 03 5;87:18-25. Epub 2019 Nov 5.

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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March 2020