Timothy J Aitman

Timothy J Aitman

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Timothy J Aitman

Timothy J Aitman

Publications by authors named "Timothy J Aitman"

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A Dominantly Inherited 5' UTR Variant Causing Methylation-Associated Silencing of BRCA1 as a Cause of Breast and Ovarian Cancer.

Am J Hum Genet 2018 08;103(2):213-220

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK; Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Manchester M20 4BX, UK; Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080768PMC
August 2018

Multiplexed DNA Methylation Analysis of Target Regions Using Microfluidics (Fluidigm).

Methods Mol Biol 2018 ;1708:349-363

MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.

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http://link.springer.com/10.1007/978-1-4939-7481-8_18
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http://dx.doi.org/10.1007/978-1-4939-7481-8_18DOI Listing
July 2018

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.

Cell Rep 2017 Sep;20(11):2719-2734

Department of Medicine, Imperial College, London W12 0NN, UK; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH16 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608958PMC
September 2017

Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome.

Hypertension 2017 Jul 24. Epub 2017 Jul 24.

From the Centre for Genomic and Experimental Medicine, MRC Institute for Genetics and Molecular Medicine, Edinburgh, United Kingdom (P.M.C., M.B., N.A., S.M.P., X.C.D., D.R., J.M., T.J.A.); British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute (P.M.C., M.B., N.A., R.N.C., A.T., L.H.J.-J., N.M.M., T.J.A.) and Royal (Dick) School of Veterinary Studies (X.C.D.), University of Edinburgh, United Kingdom; Department of Medicine (A.G.D., T.J.A) and Embryonic Stem Cell and Transgenics Facility, MRC Clinical Sciences Centre (B.M., Z.W.), Imperial College London, United Kingdom; and Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, United Kingdom (M.J.A.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548512PMC
July 2017

Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.

Neurobiol Aging 2017 03 21;51:178.e11-178.e20. Epub 2016 Dec 21.

The Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302213PMC
March 2017

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat.

Dis Model Mech 2017 03 26;10(3):297-306. Epub 2017 Jan 26.

Centre for Genomic and Experimental Medicine & Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1242/dmm.026716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374317PMC
March 2017

De novo mutations in autosomal recessive congenital malformations.

Genet Med 2016 12 9;18(12):1325-1326. Epub 2016 Jun 9.

Department of Pathology, NHS Lothian, Edinburgh, UK.

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http://dx.doi.org/10.1038/gim.2016.62DOI Listing
December 2016

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study.

Lancet Diabetes Endocrinol 2015 Jul 18;3(7):526-534. Epub 2015 Jun 18.

​ (J C Chambers PhD, M Loh PhD, B Lehne PhD, W R Scott MRCP, W Zhang PhD, G Campanella MSc, M Chadeau-Hyam PhD, U Afzal MRCP, Prof P Froguel PhD, Prof P Vineis MD, Prof M-R Jarvelin PhD, Prof P Elliott PhD) (J C Chambers, Prof M-R Jarvelin, Prof P Elliott, Prof J S Kooner FRCP) (W R Scott, S-T Tan MRCP, Prof J Scott PhD, Prof J S Kooner) (J Abbott PhD) (J C Chambers, W Zhang, S-T Tan, U Afzal, Prof J S Kooner) (J C Chambers, P Punjabi FRCS, Prof J S Kooner) (M Loh) (C Blancher PhD) (A Drong PhD, Prof M I McCarthy MD) (Prof M I McCarthy) (J Kriebel PhD, S Wahl MSc, C Gieger PhD, H Grallert PhD) (C Gieger) (J Kriebel, S Wahl, C Gieger, B Thorand PhD, H Grallert) (H Prokisch PhD) (J Kriebel, S Wahl, B Thorand, H Grallert) (V Motta PhD, F Rota PhD, L Tarantini PhD, B Albetti PhD, Prof P A Bertazzi MD, V Bollati PhD) (Prof M Ala-Korpela PhD) (H R Elliott Dip Biol, R C Richmond BA, R Caiazzo PhD, T R Gaunt FRCP, Prof C L Relton PhD) (L Yengo PhD, Prof F Pattou PhD, R Caiazzo, S Cauchi PhD, Prof P Froguel) (L Yengo, S Cauchi, Prof P Froguel) (L Yengo, Prof F Pattou, S Cauchi, Prof P Froguel) (M Adamowicz-Brice PhD, Prof T J Aitman PhD) (K Bozaoglu PhD, R Caiazzo, J Jowett PhD) (Z Y Mok BSc, H K Ng BSc, M A Rozario BSc, R Soong PhD) (E-S Tai PhD) (E-S Tai) (Prof F Pattou) (H Prokisch) (Prof M Ala-Korpela, A J Kangas MSc, P Soininen PhD) (M Loh, Prof M-R Jarvelin) (Prof M-R Jarvelin) (Prof M Ala-Korpela, P Soininen) (Prof M-R Jarvelin) (Prof M Ala-Korpela) (Prof O Ammerpohl PhD) (Prof C Schafmayer MD) (Prof J Danesh FRCP) (Prof S de Lusignan PhD, Prof S Jones PhD) (Prof T Illig PhD) (S Jha MRCP) (A Kasturiratne MD, Prof A R Wickremasinghe PhD) (N Kato PhD) (N Kotea PhD) (S Kowlessur Dip Pub Health Admin) (J Pitkäniemi PhD) (Prof J Tuomilehto PhD) (J Pitkäniemi) (D Saleheen PhD) (D Saleheen) (D Saleheen) (E-S Tai) (Prof S A Kyrtopoulos PhD) (C Herder PhD) (C Herder) (Prof J Hampe MD) (R Soong) (Prof P Vineis) (Prof M I McCarthy).

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http://dx.doi.org/10.1016/S2213-8587(15)00127-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724884PMC
July 2015

Systems biology with high-throughput sequencing reveals genetic mechanisms underlying the metabolic syndrome in the Lyon hypertensive rat.

Circ Cardiovasc Genet 2015 Apr 8;8(2):316-26. Epub 2015 Jan 8.

From the Department of Internal Medicine (J.W., A.K.M., J.M.P., Y. Xu, L.L., Y. Xing, A.E.K.), Department of Pharmacology (M.C.J.M., A.K.M., J.M.P., Y. Xu, M.G.T., J.J., A.E.K.), and Iowa Institute of Human Genetics (A.E.K.), University of Iowa, Iowa City; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles (J.W., L.L., Y. Xing); and Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom (S.S.A., T.J.A.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406788PMC
April 2015

The use of next-generation sequencing in clinical diagnosis of familial hypercholesterolemia.

Genet Med 2013 Dec 16;15(12):948-57. Epub 2013 May 16.

MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/gim.2013.55DOI Listing
December 2013

Familial hypercholesterolaemia: a pressing issue for European health care.

Atherosclerosis 2013 Dec 2;231(2):223-6. Epub 2013 Oct 2.

PHG Foundation, 2 Worts Causeway, Cambridge CB1 8RN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.09.019DOI Listing
December 2013

Experimental crescentic glomerulonephritis: a new bicongenic rat model.

Dis Model Mech 2013 Nov 15;6(6):1477-86. Epub 2013 Aug 15.

MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1242/dmm.012328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820270PMC
November 2013

JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis.

BMC Syst Biol 2013 Sep 22;7:93. Epub 2013 Sep 22.

MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1186/1752-0509-7-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849178PMC
September 2013

Target enrichment and high-throughput sequencing of 80 ribosomal protein genes to identify mutations associated with Diamond-Blackfan anaemia.

Br J Haematol 2013 Aug 30;162(4):530-6. Epub 2013 May 30.

Imperial Molecular Pathology Laboratory, Imperial College Healthcare NHS Trust and Academic Health Sciences Centre, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1111/bjh.12397DOI Listing
August 2013

Single nucleotide analysis of cytosine methylation by whole-genome shotgun bisulfite sequencing.

Curr Protoc Mol Biol 2012 Jul;Chapter 21:Unit21.23

National Heart & Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1002/0471142727.mb2123s99DOI Listing
July 2012

Role of novel rat-specific Fc receptor in macrophage activation associated with crescentic glomerulonephritis.

J Biol Chem 2012 Feb 19;287(8):5710-9. Epub 2011 Dec 19.

Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.260695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285343PMC
February 2012

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.

Physiol Genomics 2011 Nov 16;43(21):1207-18. Epub 2011 Aug 16.

Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://physiolgenomics.physiology.org/content/physiolgenomic
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http://physiolgenomics.physiology.org/cgi/doi/10.1152/physio
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http://dx.doi.org/10.1152/physiolgenomics.00210.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217321PMC
November 2011

AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression.

Am J Pathol 2011 Jul 3;179(1):134-40. Epub 2011 May 3.

Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.ajpath.2011.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123878PMC
July 2011

The future of model organisms in human disease research.

Nat Rev Genet 2011 07 18;12(8):575-82. Epub 2011 Jul 18.

Medical Research Council Clinical Sciences Centre, Imperial College, London, UK.

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http://dx.doi.org/10.1038/nrg3047DOI Listing
July 2011

Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis.

J Am Soc Nephrol 2010 Jul 20;21(7):1136-44. Epub 2010 May 20.

Department of Renal Medicine, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1681/ASN.2009090968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152224PMC
July 2010

New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.

PLoS Comput Biol 2010 Apr 8;6(4):e1000737. Epub 2010 Apr 8.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1000737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851562PMC
April 2010

Genetic mapping and positional cloning.

Methods Mol Biol 2010 ;597:13-32

Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Section of Molecular Genetics and Rheumatology, Imperial College, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1007/978-1-60327-389-3_2DOI Listing
February 2010

Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.

Nat Genet 2008 May;40(5):553-9

Physiological Genomics and Medicine Group, Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://www.nature.com/articles/ng.137
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http://dx.doi.org/10.1038/ng.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742200PMC
May 2008

Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci.

Endocrinology 2008 Feb 15;149(2):651-61. Epub 2007 Nov 15.

Department of Reproductive Biology, Physiological Genomics and Medicine Group, Medical Research Council, Clinical Sciences Center, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1210/en.2007-0925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556873PMC
February 2008

Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.

Hypertension 2008 Jan 10;51(1):148-53. Epub 2007 Dec 10.

Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.100743DOI Listing
January 2008

A gene harvest revealing the archeology and complexity of human disease.

Nat Genet 2007 Nov;39(11):1299-301

Faculty of Medicine, Imperial College, London W12 0NN, UK.

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http://dx.doi.org/10.1038/ng1107-1299DOI Listing
November 2007

Heritability and tissue specificity of expression quantitative trait loci.

PLoS Genet 2006 Oct 28;2(10):e172. Epub 2006 Aug 28.

Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.0020172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617131PMC
October 2006

Integrated gene expression profiling and linkage analysis in the rat.

Mamm Genome 2006 Jun 12;17(6):480-9. Epub 2006 Jun 12.

MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1007/s00335-005-0181-1DOI Listing
June 2006

Glycomics investigation into insulin action.

Biochim Biophys Acta 2006 Apr 10;1760(4):652-68. Epub 2006 Jan 10.

Division of Molecular Biosciences, Imperial College, London, South Kensington, UK.

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http://dx.doi.org/10.1016/j.bbagen.2005.12.013DOI Listing
April 2006

eQTL Explorer: integrated mining of combined genetic linkage and expression experiments.

Bioinformatics 2006 Feb 15;22(4):509-11. Epub 2005 Dec 15.

MRC Clinical Sciences Centre, Imperial College London, W12 0NN, UK.

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http://dx.doi.org/10.1093/bioinformatics/btk007DOI Listing
February 2006

The rat comes clean.

Nat Genet 2004 May;36(5):441-2

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http://dx.doi.org/10.1038/ng1349DOI Listing
May 2004

A novel role for CD36 in VLDL-enhanced platelet activation.

Diabetes 2003 May;52(5):1248-55

Endocrinology and Metabolism Unit, University of Southampton, Southhampton General Hospital, Tremona Road, Southampton SO16 6YD, U.K.

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http://dx.doi.org/10.2337/diabetes.52.5.1248DOI Listing
May 2003

Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene.

Exp Nephrol 2002 ;10(5-6):402-7

Renal Section, Division of Medicine, MRC Clinical Sciences Centre and Imperial College Genetics and Genomics Research Institute, Imperial College, Hammersmith Hospital, London, UK.

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http://dx.doi.org/10.1159/000065297DOI Listing
April 2003

Gene expression profiling in hypertension research: a critical perspective.

Hypertension 2003 Jan;41(1):3-8

Institute of Physiology, Czech Academy of Sciences and The Center for Integrated Genomics, Prague, Czech Republic.

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http://dx.doi.org/10.1161/01.hyp.0000050927.96979.41DOI Listing
January 2003

Finding genes that underlie complex traits.

Science 2002 Dec;298(5602):2345-9

Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, Ducane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1126/science.1076641DOI Listing
December 2002

Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature.

Transfusion 2002 Sep;42(9):1173-9

Platelet and Neutrophil Immunology Lab, Blood Center of Southeastern Wisconsin, Milwaukee 53233, USA.

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http://dx.doi.org/10.1046/j.1537-2995.2002.00176.xDOI Listing
September 2002

Radiation hybrid mapping of 70 rat genes from a data set of differentially expressed genes.

Mamm Genome 2002 Apr;13(4):194-7

Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1007/s00335-001-2140-9DOI Listing
April 2002

Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism.

Mamm Genome 2002 Feb;13(2):108-13

Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s00335-001-2132-9DOI Listing
February 2002