Timothy Hughes

Timothy Hughes

UNVERIFIED PROFILE

Are you Timothy Hughes?   Register this Author

Register author
Timothy Hughes

Timothy Hughes

Publications by authors named "Timothy Hughes"

Are you Timothy Hughes?   Register this Author

100Publications

2395Reads

38Profile Views

Copolymerization of Pentafluorophenylmethacrylate with Hydrophilic Methacrylamide Monomers Induces Premature Hydrolytic Cleavage.

Macromol Rapid Commun 2019 Oct 22;40(19):e1900278. Epub 2019 Jul 22.

CSIRO Manufacturing, Private Bag 10, Clayton South, VIC, 3169, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.201900278DOI Listing
October 2019

Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.

J Am Coll Cardiol 2019 Sep;74(9):1237-1263

University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Division of Nephrology and Hypertension, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2019.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719727PMC
September 2019

Physical Activity, Injurious Falls, and Physical Function in Aging: An Umbrella Review.

Med Sci Sports Exerc 2019 06;51(6):1303-1313

Office of Disease Prevention and Health Promotion, Office of the Assistant Secretary for Health, U.S. Department of Health and Human Services, Rockville, MD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1249/MSS.0000000000001942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527126PMC
June 2019

Similarity regression predicts evolution of transcription factor sequence specificity.

Nat Genet 2019 06 27;51(6):981-989. Epub 2019 May 27.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0411-1DOI Listing
June 2019

Light-Healable Epoxy Polymer Networks via Anthracene Dimer Scission of Diamine Crosslinker.

ACS Appl Mater Interfaces 2019 May 17;11(21):19429-19443. Epub 2019 May 17.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b02521DOI Listing
May 2019

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alzheimers Dement (N Y) 2019 9;5:107-117. Epub 2019 Apr 9.

Molecular & Clinical Sciences Research Institute, St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23528737193000
Publisher Site
http://dx.doi.org/10.1016/j.trci.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461571PMC
April 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Motif models for RNA-binding proteins.

Curr Opin Struct Biol 2018 12 29;53:115-123. Epub 2018 Aug 29.

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2018.08.001DOI Listing
December 2018

Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes.

Clin Sci (Lond) 2018 12 5;132(23):2509-2518. Epub 2018 Dec 5.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A.

View Article

Download full-text PDF

Source
http://clinsci.org/lookup/doi/10.1042/CS20180690
Publisher Site
http://dx.doi.org/10.1042/CS20180690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512318PMC
December 2018

How bacterial xenogeneic silencer rok distinguishes foreign from self DNA in its resident genome.

Nucleic Acids Res 2018 11;46(19):10514-10529

Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, School of Life Sciences, Peking University, Beijing 100871, China.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/advance-article/doi/10.1093/nar
Publisher Site
http://dx.doi.org/10.1093/nar/gky836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212790PMC
November 2018

Molecular monitoring in CML: how deep? How often? How should it influence therapy?

Blood 2018 11;132(20):2125-2133

Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-05
Publisher Site
http://dx.doi.org/10.1182/blood-2018-05-848630DOI Listing
November 2018

Molecular monitoring in CML: how deep? How often? How should it influence therapy?

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):168-176

Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/asheducation-2018.1.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246017PMC
November 2018

Patients with low OCT-1 activity and high ABCB1 fold rise have poor long-term outcomes in response to tyrosine kinase inhibitor therapy.

Leukemia 2018 10 23;32(10):2288-2291. Epub 2018 Mar 23.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-018-0101-5DOI Listing
October 2018

Treatment-Free Remission After Second-Line Nilotinib Treatment.

Ann Intern Med 2018 10;169(7):510

South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia (T.P.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7326/L18-0431DOI Listing
October 2018

Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant + cell lines.

Oncotarget 2018 Oct 5;9(78):34735-34747. Epub 2018 Oct 5.

South Australian Health and Medical Research Institute (SAHMRI), Cancer Theme, Adelaide, SA, Australia.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/26187
Publisher Site
http://dx.doi.org/10.18632/oncotarget.26187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205183PMC
October 2018

Management of Pregnancy in Women With Chronic Myeloid Leukemia.

J Clin Oncol 2018 09 31;36(25):2657-2658. Epub 2018 May 31.

David M. Ross, Royal Adelaide Hospital, South Australian Health and Medical Research Institute, and Flinders University and Medical Centre, Adelaide, South Australia, Australia; Kate L. Burbury, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, and University of Melbourne, Melbourne, Victoria, Australia; Andrew P. Grigg, Austin Hospital, Melbourne, Victoria, Australia; Timothy P. Hughes, Royal Adelaide Hospital and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; and John F. Seymour, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, and University of Melbourne, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2018.78.6137DOI Listing
September 2018

An optimized FAIRE procedure for low cell numbers in yeast.

Yeast 2018 08 28;35(8):507-512. Epub 2018 May 28.

Department of Medical Genetics, Oslo University Hospital and University of Oslo, 0450, Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/yea.3316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099244PMC
August 2018

Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline.

Neurology 2018 08 25;91(8):e759-e768. Epub 2018 Jul 25.

From the Department of Epidemiology (A.M.R., S.P.J., E.S., A.R.S., R.F.G.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; School of Biological and Population Health Sciences (A.M.R.), Oregon State University, Corvallis; Departments of Medicine (S.P.J.) and Neurology (R.F.G.), Johns Hopkins School of Medicine, Baltimore, MD; Harvard Medical School and Beth Israel Deaconess Medical Center (S.P.J.), Boston MA; Department of Epidemiology (G.H., M.L.M.), University of North Carolina at Chapel Hill; Department of Internal Medicine (T.M.H.), Division of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC; and Division of Geriatrics (B.G.W.), Department of Medicine, University of Mississippi Medical Center, Jackson.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107267PMC
August 2018

Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance.

Sci Rep 2018 08 23;8(1):12654. Epub 2018 Aug 23.

NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-30898-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107676PMC
August 2018

Apolipoproteins and Alzheimer's pathophysiology.

Alzheimers Dement (Amst) 2018 10;10:545-553. Epub 2018 Aug 10.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dadm.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199693PMC
August 2018

Neurospora crassa developmental control mediated by the FLB-3 transcription factor.

Fungal Biol 2018 06 1;122(6):570-582. Epub 2018 Mar 1.

Departamento de Bioquímica e Tecnologia Química, Instituto de Química, UNESP, Universidade Estadual Paulista, 14800-060, Araraquara, SP, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.funbio.2018.01.004DOI Listing
June 2018

Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.

J Biol Chem 2018 05 22;293(19):7344-7354. Epub 2018 Mar 22.

From the Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7,

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.001785
Publisher Site
http://dx.doi.org/10.1074/jbc.RA118.001785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949999PMC
May 2018

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression.

Br J Cancer 2018 04 13;118(7):1000-1004. Epub 2018 Mar 13.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-018-0022-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931087PMC
April 2018

Silicone Microemulsion Structures Are Maintained During Polymerization with Reactive Surfactants.

Langmuir 2018 04 27;34(14):4374-4381. Epub 2018 Mar 27.

Department of Chemistry and Chemical Biology , McMaster University , 1280 Main St. W. , Hamilton , Ontario L8S 4M1 , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.langmuir.8b00240DOI Listing
April 2018

Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study.

Neurology 2018 04 16;90(14):e1248-e1256. Epub 2018 Mar 16.

From the Departments of Internal Medicine (T.M.H., S.C.) and Radiology (A.M.), and Division of Public Health Sciences (L.E.W.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Epidemiology (G.H., P.P.), University of North Carolina at Chapel Hill; Departments of Radiology (D.W., Y.Z.) and Neurology (R.F.G.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (D.K.), Mayo Clinic, Rochester, MN; and Department of Medicine (T.H.M.), University of Mississippi Medical Center, Jackson.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000005259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890613PMC
April 2018

Gelatin-Based Photocurable Hydrogels for Corneal Wound Repair.

ACS Appl Mater Interfaces 2018 Apr 16;10(16):13283-13292. Epub 2018 Apr 16.

CSIRO Manufacturing , Clayton , Victoria 3169 , Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.7b17054DOI Listing
April 2018

Left Ventricular Hypertrophy and Remodeling and Risk of Cognitive Impairment and Dementia: MESA (Multi-Ethnic Study of Atherosclerosis).

Hypertension 2018 03 29;71(3):429-436. Epub 2018 Jan 29.

From the Department of Cardiology (K.M., M.R.O., B.A.V., M.H., K.Y., I.P., J.A.C.L.) and Department of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD; Department of Medicine, Rutgers New Jersey Medical School, State University of New Jersey, Newark (K.M.); Office of Biostatistics, National Heart, Lung, and Blood Institute, Bethesda, MD (C.W.); Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (K.L.); Department of Family Medicine, School of Medicine (A.F.), Department of Epidemiology, School of Medicine (A.F.), Department of Global Health, School of Public Health (A.F.), Department of Biostatistics (R.L.M.), and Department of Epidemiology (S.H.), University of Washington, Seattle; Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, NY (S.S.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health Clinical Center, Bethesda, MD (D.A.B.); and Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (T.M.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812794PMC
March 2018

Microbial Quality and Shelf Life of Blueberry Purée Developed Using Cavitation Technology.

J Food Sci 2018 Mar 22;83(3):732-739. Epub 2018 Feb 22.

Kentville Research and Development Centre, Agriculture and Agri-Food Canada, Kentville, Nova Scotia B4N 1J5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1750-3841.14073DOI Listing
March 2018

The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression .

Oncotarget 2018 Mar 3;9(17):13423-13437. Epub 2018 Feb 3.

Cancer Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/24393
Publisher Site
http://dx.doi.org/10.18632/oncotarget.24393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862588PMC
March 2018

The Human Transcription Factors.

Cell 2018 02;172(4):650-665

Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2018.01.029DOI Listing
February 2018

Synthesis of Bioacrylic Polymers from Dihydro-5-hydroxyl furan-2-one (2H-HBO) by Free and Controlled Radical Polymerization.

ACS Omega 2018 Feb 20;3(2):2040-2048. Epub 2018 Feb 20.

Department of Materials Science and Engineering and New Horizons Research Centre and School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.7b01929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6641244PMC
February 2018

Blood Pressure's Role in Alzheimer Disease Pathology.

Am J Geriatr Psychiatry 2018 01 25;26(1):23-24. Epub 2017 Sep 25.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jagp.2017.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759321PMC
January 2018

Comparison of ChIP-Seq Data and a Reference Motif Set for Human KRAB C2H2 Zinc Finger Proteins.

G3 (Bethesda) 2018 01 4;8(1):219-229. Epub 2018 Jan 4.

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario M5S 1A8, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/g3.117.300296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765350PMC
January 2018

Absence of CD59 in Guinea Pigs: Analysis of the Genome Suggests the Evolution of a Pseudogene.

J Immunol 2018 01 22;200(1):327-335. Epub 2017 Nov 22.

Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom; and

View Article

Download full-text PDF

Source
http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1701238
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1701238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739282PMC
January 2018

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

Structure 2018 01 21;26(1):85-95.e3. Epub 2017 Dec 21.

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2017.11.022DOI Listing
January 2018

Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions.

Cancer Lett 2017 11 1;408:92-101. Epub 2017 Sep 1.

Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia; Australian Genomic Health Alliance, Adelaide, SA, Australia. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043835173052
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2017.08.034DOI Listing
November 2017

First Approved Kinase Inhibitor for AML.

Cell 2017 Nov;171(5):981

South Australian Health and Medical Research Institute (SAHMRI) and University of Adelaide, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2017.11.007DOI Listing
November 2017

A novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH.

Cancer Genet 2017 Oct 31;216-217:86-90. Epub 2017 Jul 31.

Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia; Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia; Australian Genomic Health Alliance, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergen.2017.07.008DOI Listing
October 2017

A Method for Next-Generation Sequencing of Paired Diagnostic and Remission Samples to Detect Mitochondrial DNA Mutations Associated with Leukemia.

J Mol Diagn 2017 09 18;19(5):711-721. Epub 2017 Jul 18.

Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; Australasian Leukaemia and Lymphoma Group, Melbourne, Victoria, Australia; Department of Haematology, Royal Adelaide Hospital and SA Pathology, Adelaide, South Australia, Australia; Department of Molecular Medicine and Pathology, Flinders University and Medical Centre, Adelaide, South Australia, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2017.05.009DOI Listing
September 2017

Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding.

Genome Biol 2017 09 6;18(1):167. Epub 2017 Sep 6.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-017-1287-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588721PMC
September 2017

CYP2C8 Genotype Significantly Alters Imatinib Metabolism in Chronic Myeloid Leukaemia Patients.

Clin Pharmacokinet 2017 08;56(8):977-985

Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, 5005, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-016-0494-0DOI Listing
August 2017

RNAcompete-S: Combined RNA sequence/structure preferences for RNA binding proteins derived from a single-step in vitro selection.

Methods 2017 08 24;126:18-28. Epub 2017 Jun 24.

Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada; Donnelly Centre, University of Toronto, Toronto M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto M5S 2E4, Canada; Department of Electrical and Computer Engineering, University of Toronto, Toronto M5S 3G4, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2017.06.024DOI Listing
August 2017

Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.

Cancer Cell 2017 07;32(1):101-114.e8

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539779PMC
July 2017

Transcription factors read epigenetics.

Science 2017 05;356(6337):489-490

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aan2927DOI Listing
May 2017

RNAcompete methodology and application to determine sequence preferences of unconventional RNA-binding proteins.

Methods 2017 04 10;118-119:3-15. Epub 2016 Dec 10.

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411283PMC
April 2017

Comment on "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study".

Leuk Res 2017 04 9;55:55-57. Epub 2017 Jan 9.

Department of Haematology, SA Pathology, Adelaide, South Australia, Australia; Cancer Theme, South Australia Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia; The University of Adelaide, School of Medicine, Adelaide, South Australia, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2017.01.009DOI Listing
April 2017

Targeted therapies: Remembrance of things past - discontinuation of second-generation TKI therapy for CML.

Nat Rev Clin Oncol 2017 04 7;14(4):201-202. Epub 2017 Feb 7.

Cancer Theme, South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, South Australia 5001, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrclinonc.2017.11DOI Listing
April 2017

CML patients with deep molecular responses to TKI have restored immune effectors and decreased PD-1 and immune suppressors.

Blood 2017 03 3;129(9):1166-1176. Epub 2017 Jan 3.

Department of Haematology, SA Pathology, Adelaide, SA, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-10-745992DOI Listing
March 2017

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia.

N Engl J Med 2017 03;376(10):917-927

From Abteilung Hämatologie-Onkologie, Universitätsklinikum Jena, Jena, Germany (A.H.); the Department of Medicine, University of Chicago, Chicago (R.A.L.); INSERM Centre d'Investigation Clinique 1402, Centre Hospitalier Universitaire de Poitiers, Poitiers, France (F.G.); Fred Hutchinson Cancer Research Center, Seattle (J.P.R.); Centre for Cancer Biology, SA Pathology, University of South Australia and University of Adelaide (S.B.), and the South Australian Health and Medical Research Institute and University of Adelaide (T.P.H.), Adelaide, SA, Australia; University of Bologna, Bologna, Italy (M.B.); the University of Utah Huntsman Cancer Institute, Salt Lake City (M.W.D.); the Hematology Department, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona (F.C.); Novartis, Basel, Switzerland (S.F., C.-E.O., H.D.M.); M.D. Anderson Cancer Center, Houston (H.K.); the University of Newcastle, Newcastle, United Kingdom (S.G.O.); and Knight Cancer Institute, Oregon Health and Science University and Howard Hughes Medical Institute, Portland (B.J.D.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1609324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901965PMC
March 2017

Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation.

Front Neurol 2017 7;8:78. Epub 2017 Mar 7.

Laboratorio de Fisiología Animal, Facultad de Ciencias, Departamento de Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga , Málaga , Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2017.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339270PMC
March 2017

Photo-Modulated Therapeutic Protein Release from a Hydrogel Depot Using Visible Light.

Angew Chem Int Ed Engl 2017 01 5;56(4):966-971. Epub 2016 Dec 5.

CSIRO Manufacturing, Bayview Avenue, Clayton, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201610618DOI Listing
January 2017

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.

J Clin Oncol 2017 Jan 7;35(2):175-184. Epub 2016 Nov 7.

Sieghart Sopper, Günther Gastl, Matthias Baldauf, Zlatko Trajanoski, and Dominik Wolf, Medical University Innsbruck; Sieghart Sopper and Dominik Wolf, Tyrolean Cancer Research Institute; Matthias Baldauf, Oncotyrol, Innsbruck; Peter Valent, Medical University of Vienna, Vienna, Austria; Satu Mustjoki and Kimmo Porkka, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Deborah White and Timothy Hughes, South Australian Health and Medical Research Institute and University of Adelaide School of Medicine, Adelaide, South Australia, Australia; Andreas Burchert, Universitätsklinikum Gießen und Marburg and Philipps Universität Marburg, Marburg; Andreas Hochhaus, Thomas Ernst, and Thomas Schenk, Universitätsklinikum Jena, Jena; Dominik Wolf, University Hospital of Bonn, Bonn, Germany; Bjørn T. Gjertsen, University of Bergen, Bergen, Norway; Frank Giles, Northwestern University, Chicago, IL; and Jeroen J.W.M. Janssen and Gert J. Ossenkoppele, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.67.0893DOI Listing
January 2017